Compare and book 5 Star hotels in Southeast Missouri, Missouri

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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Southeast Missouri.
Urban Lofts

Urban Lofts

104 North Jackson Street, Perryville, MO
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Southeast Missouri?
The amount you pay for a 5-star hotel in Southeast Missouri can vary based on when you want to travel and how long you plan to stay, among a range of factors. Take advantage of our price per night filter and other search tools to score the best rate on an indulgent stay.

  • Search for the lowest price per night

What makes a hotel 5 stars in Southeast Missouri?
Exemplary guest service is the foundation of every 5-star hotel in Southeast Missouri. From the moment you arrive, staff cater to your every need, whether arranging customised tours or providing in-room massage treatments. Also, hotels must feature upscale amenities to obtain a 5-star rating. These can include luxury bathrooms, spas or saunas, swimming pools, gourmet kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Southeast Missouri?
Our handy filters are the best way to search for exactly what you want. Select "All inclusive" and "5-star" to see the most upscale resorts in Southeast Missouri where your meals, lodging, entertainment and activities are included in the upfront price. At these getaways, your trip is pure extravagance from the moment you put down your suitcase.