Title: Southeast Missouri Travel Guide: Best of Southeast Missouri, Missouri Travel 2026 | Expedia.co.uk

[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks)

# Southeast Missouri Travel Guide

## Tourist Guide

![Southeast Missouri](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Southeast Missouri](https://mediaim.expedia.com/destination/9/6c450e001334a84543e95019353aad53.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Southeast Missouri](https://mediaim.expedia.com/destination/9/a89308cd6725fa917758c794dd86c33d.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

![Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/4ddf292149c3402549f16eb8c5528744.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

[Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/4ddf292149c3402549f16eb8c5528744.jpg)

![Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/71071bca60cf5af304b1d202a4f54f4d.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh)

[Photo by Jessica Richter](https://mediaim.expedia.com/destination/2/71071bca60cf5af304b1d202a4f54f4d.jpg)

## Visit Southeast Missouri

Things to do

- Top hotels in Southeast Missouri
- Top Holiday Rentals in Southeast Missouri

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

£46

21 Dec - 22 Dec

includes taxes & fees

Stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking and an outdoor pool. Our guests praise the helpful staff and the clean ...

8/10 Very Good! (1,007 reviews)

The rooms where clean, the water was hot in the showers. The staff was family oriented and friendly felt like my family was safe.

Reviewed on 7 Dec 2025

[](https://expedia.co.uk/Hotel-Search?startDate=21%2F12%2F2025&endDate=22%2F12%2F2025&selected=16153&PinnedHotelID=16153&HadPinnedHotel=true&regionId=6058763)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

£76

18 Dec - 19 Dec

includes taxes & fees

Stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,000 reviews)

Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife.

Reviewed on 8 Dec 2025

[](https://expedia.co.uk/Hotel-Search?startDate=18%2F12%2F2025&endDate=19%2F12%2F2025&selected=17269948&PinnedHotelID=17269948&HadPinnedHotel=true&regionId=6058763)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

£60

15 Dec - 16 Dec

includes taxes & fees

Stay at this motel in Poplar Bluff. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in their ...

7.8/10 Good! (1,004 reviews)

Love the updated rooms and the vending area.

Reviewed on 6 Dec 2025

[](https://expedia.co.uk/Hotel-Search?startDate=15%2F12%2F2025&endDate=16%2F12%2F2025&selected=15689127&PinnedHotelID=15689127&HadPinnedHotel=true&regionId=6058763)

[See all 620 properties in Southeast Missouri](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=15%2F12%2F2025&endDate=16%2F12%2F2025&regionId=6058763)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

### 

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

7555 State Hwy Y French Village MO

Stay at this cabin in French Village. Enjoy free parking, patios and climate control.

9.8/10 Exceptional! (44 reviews)

The cabin was cozy and very peaceful such a good experience

Reviewed on 11 Nov 2025

[](https://expedia.co.uk/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

![Sam A Baker State Park](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Sam A Baker State Park

5732 State Hwy Missouri 143 Patterson MO

Stay at this cabin in Patterson. Enjoy free parking, a picnic area and furnished patios. Popular attraction Sam A. Baker State Park is located nearby.

9.2/10 Wonderful! (5 reviews)

We stayed two nights and we loved it. The property grounds and cabins are well maintained we will be back

Reviewed on 5 Oct 2025

[](https://expedia.co.uk/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

![Micro house cabin located near Silver Mines Recreation Area.](https://images.trvl-media.com/lodging/67000000/66890000/66883200/66883194/283ae672_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Micro house cabin located near Silver Mines Recreation Area.

 Fredericktown MO

Stay at this cabin in Fredericktown. Enjoy free Wi-Fi, a garden and an in-room coffee maker. Popular attractions Silver Mine Recreation Area and Millstream Gardens ...

10/10 Exceptional! (77 reviews)

Absolutely perfect. So clean. A perfect micro house located on a peaceful farm with everything you could need. The fenced in yard was perfect for my pup. Shirley truly cares for her guests. The handwritten notes made it feel extra special.

Reviewed on 5 Dec 2025

[](https://expedia.co.uk/Fredericktown-Hotels-Micro-House-Cabin-Located-Near-Silver-Mines-Recreation-Area.h66883194.Hotel-Information)

[See all properties in Southeast Missouri](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&regionId=6058763&sort=VACATION_RENTAL)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Southeast Missouri hotel availability

[Tonight

](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6058763&startDate=2025-12-14&endDate=2025-12-15)[14 Dec - 15 Dec](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6058763&startDate=2025-12-14&endDate=2025-12-15)

[Tomorrow night

](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6058763&startDate=2025-12-15&endDate=2025-12-16)[15 Dec - 16 Dec](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6058763&startDate=2025-12-15&endDate=2025-12-16)

[Next weekend

](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6058763&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025)[19 Dec - 21 Dec](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=6058763&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025)

### Popular places to visit

![Elephant Rocks State Park](https://mediaim.expedia.com/destination/2/86e50eabc9d5592586815e7688be64ef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. 

[](https://expedia.co.uk/Elephant-Rocks-State-Park-Ironton.d553248621532648464.Attraction)

![Lake Wappapello](https://mediaim.expedia.com/destination/2/a6135d9f1717ada26d9944dd5bb40459.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. 

[](https://expedia.co.uk/Lake-Wappapello-Wappapello.d553248621532648460.Attraction)

![Rocky Falls](https://mediaim.expedia.com/destination/2/f2325d7f040c776e314b23ad9fbdb813.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting. 

[](https://expedia.co.uk/Rocky-Falls-Winona.d553248621532648456.Attraction)

#### Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants. 

[](https://expedia.co.uk/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Attraction)

#### Century Casino Caruthersville

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants. 

[](https://expedia.co.uk/Lady-Luck-Casino-Caruthersville.d553248621532655201.Attraction)

#### Isle Casino Cape Girardeau

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants. 

[](https://expedia.co.uk/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Attraction)

## Cities near Southeast Missouri

![Poplar Bluff](https://mediaim.expedia.com/destination/9/6c450e001334a84543e95019353aad53.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Poplar Bluff

![Photo by Summer Williams](https://mediaim.expedia.com/destination/2/f2491779cf462fb153bab34fde97528f.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Fredericktown

![Photo by Alice Burghart](https://mediaim.expedia.com/destination/2/05bd52cb345646b3367dd8ecf4f9fbc5.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Bonne Terre

![Potosi](https://mediaim.expedia.com/destination/1/289e2bbc5a7419969a643da96ef0071d.jpg?impolicy=fcrop&w=512&h=288&q=medium)

### Potosi

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- Cities near Southeast Missouri

[Poplar Bluff](https://expedia.co.uk/Poplar-Bluff.dx9449)[Fredericktown](https://expedia.co.uk/Fredericktown.dx55114)[Bonne Terre](https://expedia.co.uk/Bonne-Terre.dx55598)[Potosi](https://expedia.co.uk/Potosi.dx181478)[Farmington](https://expedia.co.uk/Farmington.dx6058764)[Sikeston](https://expedia.co.uk/Sikeston.dx6058766)[Menard](https://expedia.co.uk/Menard.dx6125681)

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## Go further with the Expedia app

Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app