
Southeast Missouri Holidays
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Your Southeast Missouri Holiday
Make putting together your next travel adventure simple with a holiday package to Southeast Missouri. If it's family-friendly attractions, history and culture you're searching for, the city of Cape Girardeau is waiting for you. With so much to see and do on a trip to Southeast Missouri, it can be tricky to know where to begin. Kick off your travels in Cape Girardeau at Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre — two leading attractions here. Another city to add to your itinerary is Sikeston. Be sure not to miss The Book Bug and Central Park. Whether you're planning to travel on a budget or in the lap of luxury, Expedia are here to help you tailor-make your next dream Southeast Missouri holiday.
Southeast Missouri Essential Information
Language | English |
---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Top hotels in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
Reviewed on 10 Sep 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Reviewed on 10 Sep 2025

The Riverview
Reviewed on 9 Sep 2025
What to do in Southeast Missouri

St Louis: City Museum General Admission Ticket

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.