Title: Southeast Missouri Holidays 2026 | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide) ![](https://images.trvl-media.com/place/148078/1ef720df-0786-4e45-8a4f-890d982b757b.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southeast Missouri Holidays ## Book a Hotel + Flight or Car together to unlock savings Photo by JG Morris - ## Plan, book, travel with confidence - ### Better together Save up to £335 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Packages with flights are ATOL protected ### Your Southeast Missouri Holiday Make putting together your next travel adventure simple with a holiday package to Southeast Missouri. If it's family-friendly attractions, history and culture you're searching for, the city of Cape Girardeau is waiting for you. With so much to see and do on a trip to Southeast Missouri, it can be tricky to know where to begin. Kick off your travels in [Cape Girardeau](https://www.expedia.co.uk/Cape-Girardeau.d820.Destination-Travel-Guides) at Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre — two leading attractions here. Another city to add to your itinerary is [Sikeston](https://www.expedia.co.uk/Sikeston.d6058766.Destination-Travel-Guides). Be sure not to miss The Book Bug and Central Park. Whether you're planning to travel on a budget or in the lap of luxury, Expedia are here to help you tailor-make your next dream Southeast Missouri holiday. ## Southeast Missouri Essential Information | Language | English | | --------------- | ------------------------------------- | | Currency | U.S dollars | | Closest Airport | Lambert-St. Louis Intl. Airport (STL) | ## Top hotels in Southeast Missouri ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Baymont Inn and Suites by Wyndham Farmington, MO 1625 W Columbia St Farmington MO Fully refundableReserve now, pay when you stay £46 23 Dec - 24 Dec includes taxes & fees 7.8/10 Good! (1,003 reviews) The rooms where clean, the water was hot in the showers. The staff was family oriented and friendly felt like my family was safe. Reviewed on 7 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=23%2F12%2F2025&endDate=24%2F12%2F2025&selected=16153&PinnedHotelID=16153&HadPinnedHotel=true®ionId=6058763) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive Cape Girardeau MO Fully refundableReserve now, pay when you stay £76 24 Dec - 25 Dec includes taxes & fees 9.4/10 Exceptional! (1,004 reviews) Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife. Reviewed on 8 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=24%2F12%2F2025&endDate=25%2F12%2F2025&selected=17269948&PinnedHotelID=17269948&HadPinnedHotel=true®ionId=6058763) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO Fully refundableReserve now, pay when you stay £60 17 Dec - 18 Dec includes taxes & fees 7.8/10 Good! (1,005 reviews) Staff was amazing and super nice. Room was very clean. Reviewed on 11 Dec 2025 [](https://expedia.co.uk/Hotel-Search?startDate=17%2F12%2F2025&endDate=18%2F12%2F2025&selected=15689127&PinnedHotelID=15689127&HadPinnedHotel=true®ionId=6058763) [See all 620 properties in Southeast Missouri](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=6058763) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Holidays [](https://expedia.co.uk/lp/theme-holidays/all-inclusive-holidays?rfrr=editorial.All_Inclusive%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Holidays [](https://expedia.co.uk/lp/theme-holidays/beach-holidays?rfrr=editorial.Beach_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/kid-friendly-holidays?rfrr=editorial.Family_Friendly%20Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Holidays [](https://expedia.co.uk/lp/theme-holidays/golf-holidays?rfrr=editorial.Golf_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Holidays [](https://expedia.co.uk/lp/theme-holidays/luxury-holidays?rfrr=editorial.Luxury_Holidays.click) ![gay friendly holidays](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) LGBTQ+ Holidays [](https://expedia.co.uk/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ+_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Holidays [](https://expedia.co.uk/lp/theme-holidays/romantic-holidays?rfrr=editorial.Romantic_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Holidays [](https://expedia.co.uk/lp/theme-holidays/ski-holidays?rfrr=editorial.Ski_Holidays.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/22/hero-image-pet-friendly_copy.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Pet Friendly Holidays [](https://expedia.co.uk/lp/theme-holidays/pet-friendly-holidays?rfrr=editorial.Pet_Friendly%20Holidays.click) ![Holiday in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Where to go when [](https://expedia.co.uk/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click) ## Frequently asked questions ### Can I cancel my flight booking to Southeast Missouri due to COVID-19? ### What's the best way to find cheap flights to Southeast Missouri that have flexible change policies? ### What are some of the general tips for travellers to Southeast Missouri during the COVID-19 outbreak? > - Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight. > - When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry. > - Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection. > - One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning. > - Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening. > - Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings. ### Which airlines fly to Southeast Missouri? ### How can I find cheap tickets to Southeast Missouri? ### How much is a flight to Southeast Missouri? ### What are the most popular airports to fly into in Southeast Missouri? ### When is the cheapest time to fly to Southeast Missouri? ### How much is a plane ticket to Southeast Missouri? ### Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies? > - Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [Allenville Hotels ](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - 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