Southeast Missouri Holidays from £938
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Your Southeast Missouri Holiday
Make putting together your next travel adventure simple with a holiday package to Southeast Missouri. If it's family-friendly attractions, history and culture you're searching for, the city of Cape Girardeau is waiting for you. With so much to see and do on a trip to Southeast Missouri, it can be tricky to know where to begin. Kick off your travels in Cape Girardeau at Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre — two leading attractions here. Another city to add to your itinerary is Sikeston. Be sure not to miss The Book Bug and Central Park. Whether you're planning to travel on a budget or in the lap of luxury, Expedia are here to help you tailor-make your next dream Southeast Missouri holiday.
Top Southeast Missouri Flight + Hotel Deals
Price found within the past 48 hours. Click for updated prices.
Residence Inn by Marriott St. Louis West County
£1,065
per person
2 Nov - 7 Nov
found 18 hours ago
Return direct flight included
London (LHR) to St. Louis (STL)
9.2/10 Wonderful! (266 reviews)
Ive stayed here before. Rooms are nice because they have a desk kitchen snd couch. Bed was not good. We stayed here because our ac went out. I called and confirmed pet friendly booked and paid for the room only to arrive and be told its $100 pet fee. Thats not fair or ok.
Reviewed on 4 Sept 2026
Southeast Missouri Essential Information
Language | English |
|---|---|
Currency | U.S dollars |
Closest Airport | Lambert-St. Louis Intl. Airport (STL) |
Top hotels in Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
£83
20 Sept - 21 Sept
includes taxes & fees
9.6/10 Exceptional! (1,008 reviews)
"Great experience- food, cleanliness, friendly staff"
Reviewed on 13 Sept 2026
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
£60
20 Sept - 21 Sept
includes taxes & fees
9.2/10 Wonderful! (1,007 reviews)
"Clean room, nice comfortable beds. It was very quiet and we felt very safe. The only drawback was the toilet was too low."
Reviewed on 14 Sept 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
£46
28 Sept - 29 Sept
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Big Spring
9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forests and riverfront while you're in the area.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
What to do in Southeast Missouri
Night Ghost Tour of Pythian Castle in Springfield Missouri
£15
per adult
96% of travellers recommend
Frequently asked questions
How much does a Southeast Missouri travel package cost?
Create unforgettable memories with our Southeast Missouri travel packages, which start from a low £938. Choose the hotels and flights that suit your travel plans. Then, add on some tours or activities to round off your unique getaway.
If I'm not able to travel, can I cancel my Southeast Missouri travel package?
We get it — life can throw you the odd curveball. If you've booked a Southeast Missouri travel package and have to amend or cancel it, we're here to help. We recommend looking up our Customer Service Portal first for information. But generally speaking, if you've booked your package in the last 24 hours, you may be able to change your itinerary free of charge. If it's been more than 24 hours, your hotel, airline or car rental company may charge a fee.
How do I get a cheap travel package to Southeast Missouri?
It's easy. Just bundle. Flights, hotels and rental cars — combine whatever you need into a Southeast Missouri travel package to save tons of cash. Score even more deals when you add extras such as experiences or tours to your booking. But that's not the only impressive part. You have the freedom to customize your trip your own way. We offer over 550 air carriers and 1,000,000 hotels across the globe, so that everyone has a chance to travel and fulfil those holiday fantasies.
Does Expedia offer Book Now, Pay Later Southeast Missouri holidays?
Good news! We do. Expedia has teamed up with online lender Klarna to help you conveniently pay for your holiday in manageable instalments. Simply pick the payment plan that works for you during the checkout process and take the stress out of budgeting for your trip. Remember to bundle your flights, accommodation and activities with Expedia to get the biggest bang for your buck. Take a look at our flexible payment options below:
- Pay monthly holidays: Escape on that dream holiday sooner with Klarna's manageable monthly instalment plans. If paying just a small amount each month works for you, choose this option at checkout.
- Pay in instalments holidays: Into the idea of paying for your holiday in multiple transactions? Then check out this Book Now, Pay Later option with Klarna.
- Low deposit holidays: When you want to jump on an unbeatable deal but your budget doesn't quite cover it yet, Klarna's low deposit holiday plan will help you lock it in.
How far in advance should I book my Southeast Missouri holiday?
It can be difficult to know exactly when is the perfect time to book your Southeast Missouri holiday. But generally the earlier you book, the better the prices. Sometimes, you can lock in your flights and hotels up to 12 months before your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are fantastic deals featured on Expedia every day.
What does an Expedia Southeast Missouri travel package include?
Flights, rental cars and hotels, or any combination of them — it's up to you! Whether you're visiting Southeast Missouri with the whole family or travelling with your friends, there's a package to suit every style and budget. Once you've made your booking, why not add on one or two activities?
What should I know before booking a Southeast Missouri travel package?
Whether it's relaxation or adventure you're seeking, a Southeast Missouri travel package lets you organise your escape your way. Plus, you'll get access to great discounts when you combine your hotel with your rental car and flights. The more you bundle, the bigger the savings!
Can I choose my airline with a Southeast Missouri Expedia travel package?
Expedia has access to more than 550 partner airlines globally, so you certainly can. Just choose the carrier you want and put together your ideal Southeast Missouri trip.
Explore a world of travel with Expedia
- Rustic River Cabin Getaway
- B&B in Black
- Bloomsdale Suite at Baetje Farms
- Adults Only Resorts & in Cape Girardeau
- “Brickyard”
- The Riverview
- Tru By Hilton Cape Girardeau
- Doe Run Hotels
- Current River Cottage
- Doniphan Hotels
- Ellington Hotels
- Hogan’s Hideout Bonnie Manor
- Crown Pointe Lodge
- High Hope Tree House #1 @Spring Lake Ranch
- ❤️ THE MAGIC TIPI RETREAT
- Farmington Hotels
- Fredericktown Hotels
- Postcard Cabins St Francois
- Glen Allen Hotels
- Hotels near Johnson's Shut-ins State Park
- Junction City Hotels
- Black River Motel and Restaurant
- Gay-Friendly Hotels in Lesterville
- Wilderness Lodge
- Lithium Hotels
- Middle Brook Hotels
- New Offenburg Hotels
- Urban Lofts
- Dancing Under Red Skies Tree House @Spring Lake
- Potosi Hotels
- Dexter Inn
- Drury Plaza Hotel Cape Girardeau Conference Center
- Fairfield Inn & Suites by Marriott Sikeston
- Hampton Inn Sikeston
- The cabin in Eden
- Towneplace Suites by Marriott Sikeston
- Travel Inn & Suites
- Sikeston Hotels
- Hotels with Connecting Rooms in Southeast Missouri
- Pet-Friendly Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Hotels near Southeast Missouri State University
- Peaceful 4BR ranch w/ hot tub
- Silo Farm Haus
- 1/4 Mile To The Boat Launch & Beach 2 miles the Camp! Free WiFi
- Winona Hotels
- Flights to Bonne Terre
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- Flights to Desloge
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- Flights to Wappapello
- Flights from Cape Girardeau Municipal
- Flights from Ste Genevieve
- Flights from Black
- Flights from Lesterville
- Flights from Dexter
- Flights from Viburnum
- Flights from Bonne Terre
- Flights from Arcadia
- Flights from London (LHR) to Cape Girardeau (CGI)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
