Southeast Missouri Holidays from £1,183

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Your Southeast Missouri Holiday

Make putting together your next travel adventure simple with a holiday package to Southeast Missouri. If it's family-friendly attractions, history and culture you're searching for, the city of Cape Girardeau is waiting for you. With so much to see and do on a trip to Southeast Missouri, it can be tricky to know where to begin. Kick off your travels in Cape Girardeau at Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre — two leading attractions here. Another city to add to your itinerary is Sikeston. Be sure not to miss The Book Bug and Central Park. Whether you're planning to travel on a budget or in the lap of luxury, Expedia are here to help you tailor-make your next dream Southeast Missouri holiday.

Top Southeast Missouri Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
per person
18 Oct - 24 Oct
found 3 hours ago
Return flight included
Manchester (MAN) to St. Louis (STL)
8.2/10 Very Good! (756 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on 26 Jul 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
per person
18 Oct - 24 Oct
found 3 hours ago
Return flight included
Manchester (MAN) to St. Louis (STL)
9/10 Wonderful! (1,549 reviews)
Did like the softness of the beds but thats just a personal preference. It wouldnt bother me but they felt just to soft. Like they just folded up.

Reviewed on 28 Jul 2025

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
per person
18 Oct - 24 Oct
found 3 hours ago
Return flight included
Manchester (MAN) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
The hotel room was comfortable and well-kept - it’s a good spot for a weekend getaway or a night before flying out from the airport. Good mix of slots and tables.

Reviewed on 24 Jul 2025

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
per person
18 Oct - 24 Oct
found 3 hours ago
Return flight included
Manchester (MAN) to St. Louis (STL)
9.4/10 Exceptional! (337 reviews)
Property was well kept and great location

Reviewed on 29 Jul 2025

Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
per person
18 Oct - 24 Oct
found 3 hours ago
Return flight included
Manchester (MAN) to St. Louis (STL)
9/10 Wonderful! (1,783 reviews)
Nice visual look and fun encased collectibles to look at.

Reviewed on 29 Jul 2025

Southeast Missouri Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

Top hotels in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is £48 per night from 14 Aug to 15 Aug
£48
14 Aug - 15 Aug
includes taxes & fees
8/10 Very Good! (1,022 reviews)
"I was very impressed with this motel. Very clean and the staff was very friendly and helpful. The breakfast was delicious!!!"

Reviewed on 28 Jul 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is £89 per night from 31 Jul to 1 Aug
£89
31 Jul - 1 Aug
includes taxes & fees
9.2/10 Wonderful! (364 reviews)
"Beautiful spacious room."

Reviewed on 27 Jul 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is £76 per night from 3 Aug to 4 Aug
£76
3 Aug - 4 Aug
includes taxes & fees
9.4/10 Exceptional! (1,016 reviews)
5 stars
"Hotel was extremely nice and comfortable. Unfortunately my family was unable to take advantage of the drinks and snacks in the lobby due to several youth volleyball teams also staying at the hotel. They took over the lobby and pool area and were so loud we couldn’t hear the hotel staff checking us ..."

Reviewed on 24 Jul 2025

Drury Plaza Hotel Cape Girardeau Conference Center
See all 586 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Southeast Missouri travel package cost?
Create unforgettable memories with our Southeast Missouri travel packages, which start from a low £1,183. Choose the hotels and flights that suit your travel plans. Then, add on some tours or activities to round off your unique getaway.
If I'm not able to travel, can I cancel my Southeast Missouri travel package?
We get it — life can throw you the odd curveball. If you've booked a Southeast Missouri travel package and have to amend or cancel it, we're here to help. We recommend looking up our Customer Service Portal first for information. But generally speaking, if you've booked your package in the last 24 hours, you may be able to change your itinerary free of charge. If it's been more than 24 hours, your hotel, airline or car rental company may charge a fee.
How do I get a cheap travel package to Southeast Missouri?
It's easy. Just bundle. Flights, hotels and rental cars — combine whatever you need into a Southeast Missouri travel package to save tons of cash. Score even more deals when you add extras such as experiences or tours to your booking. But that's not the only impressive part. You have the freedom to customize your trip your own way. We offer over 550 air carriers and 1,000,000 hotels across the globe, so that everyone has a chance to travel and fulfil those holiday fantasies.
Does Expedia offer Book Now, Pay Later Southeast Missouri holidays?
Good news! We do. Expedia has teamed up with online lender Klarna to help you conveniently pay for your holiday in manageable instalments. Simply pick the payment plan that works for you during the checkout process and take the stress out of budgeting for your trip. Remember to bundle your flights, accommodation and activities with Expedia to get the biggest bang for your buck. Take a look at our flexible payment options below:

  • Pay monthly holidays: Escape on that dream holiday sooner with Klarna's manageable monthly instalment plans. If paying just a small amount each month works for you, choose this option at checkout.
  • Pay in instalments holidays: Into the idea of paying for your holiday in multiple transactions? Then check out this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: When you want to jump on an unbeatable deal but your budget doesn't quite cover it yet, Klarna's low deposit holiday plan will help you lock it in.

How far in advance should I book my Southeast Missouri holiday?
It can be difficult to know exactly when is the perfect time to book your Southeast Missouri holiday. But generally the earlier you book, the better the prices. Sometimes, you can lock in your flights and hotels up to 12 months before your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are fantastic deals featured on Expedia every day.
What does an Expedia Southeast Missouri travel package include?
Flights, rental cars and hotels, or any combination of them — it's up to you! Whether you're visiting Southeast Missouri with the whole family or travelling with your friends, there's a package to suit every style and budget. Once you've made your booking, why not add on one or two activities?
What should I know before booking a Southeast Missouri travel package?
Whether it's relaxation or adventure you're seeking, a Southeast Missouri travel package lets you organise your escape your way. Plus, you'll get access to great discounts when you combine your hotel with your rental car and flights. The more you bundle, the bigger the savings!
Can I choose my airline with a Southeast Missouri Expedia travel package?
Expedia has access to more than 550 partner airlines globally, so you certainly can. Just choose the carrier you want and put together your ideal Southeast Missouri trip.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.