Southeast Missouri Holidays from £874

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Your Southeast Missouri Holiday

Make putting together your next travel adventure simple with a holiday package to Southeast Missouri. If it's family-friendly attractions, history and culture you're searching for, the city of Cape Girardeau is waiting for you. With so much to see and do on a trip to Southeast Missouri, it can be tricky to know where to begin. Kick off your travels in Cape Girardeau at Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre — two leading attractions here. Another city to add to your itinerary is Sikeston. Be sure not to miss The Book Bug and Central Park. Whether you're planning to travel on a budget or in the lap of luxury, Expedia are here to help you tailor-make your next dream Southeast Missouri holiday.

Top Southeast Missouri Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was £1,385, price is now £874 per person
£874
per person
2 Sept - 9 Sept
found 15 hours ago
Return direct flight included
London (LON) to St. Louis (STL)
9.2/10 Wonderful! (1,657 reviews)
Everything was good, except the air conditioning was so loud,we couldn't sleep at all.

Reviewed on 11 Jun 2026

The Cheshire

The Cheshire

4 out of 5
Price was £1,196, price is now £962 per person
£962
per person
2 Sept - 9 Sept
found 15 hours ago
Return direct flight included
London (LON) to St. Louis (STL)
8.8/10 Excellent! (1,007 reviews)
Hi-Point best neighborhood, near the park

Reviewed on 16 Jun 2026

Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
Price was £1,180, price is now £952 per person
£952
per person
2 Sept - 9 Sept
found 15 hours ago
Return direct flight included
London (LON) to St. Louis (STL)
9/10 Wonderful! (1,957 reviews)
Super convenient location, friendly staff, cool decor! Will definitely stay here again.

Reviewed on 15 Jun 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Price was £1,135, price is now £921 per person
£921
per person
2 Sept - 9 Sept
found 15 hours ago
Return direct flight included
London (LON) to St. Louis (STL)
9.4/10 Exceptional! (569 reviews)
A hidden gem in the Forest Park area of St. Louis. Had no idea it was there. Close to zoo, art museum, the U.City Loop and other attractions. Easy Metro ride to see a Cards game if you catch the U.City Loop train. Great small pub just off the lobby with excellent fish n' chips, toasted ravioli and a delicious and hearty breakfast buffet that is way better than a typical chain hotel. You have to pay a bit for it, but it's worth it. Highly recommend.

Reviewed on 10 Jun 2026

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Price was £1,280, price is now £1,054 per person
£1,054
per person
2 Sept - 9 Sept
found 15 hours ago
Return direct flight included
London (LON) to St. Louis (STL)
8.6/10 Excellent! (1,008 reviews)
The beds are super comfortable and the rooms are nicely laid out. However, for the price it is not worth it. You cannot get breakfast until 8 am, there is no shuttle service anywhere and no formal parking format. For the price you pay and the "resort fee" you would expect a valet or some sort of structured parking arrangement.

Reviewed on 14 Jun 2026

Southeast Missouri Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

Top hotels in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is £86 per night from 6 Jul to 7 Jul
£86
6 Jul - 7 Jul
includes taxes & fees
9.6/10 Exceptional! (1,015 reviews)
"Best stay of our vacation."

Reviewed on 15 Jun 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is £95 per night from 20 Jun to 21 Jun
£95
20 Jun - 21 Jun
includes taxes & fees
9.6/10 Exceptional! (1,019 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on 15 Jun 2026

Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is £49 per night from 28 Jun to 29 Jun
£49
28 Jun - 29 Jun
includes taxes & fees
8/10 Very Good! (1,018 reviews)
"Amazing"

Reviewed on 14 Jun 2026

Baymont Inn and Suites by Wyndham Farmington, MO
See all 655 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Southeast Missouri attractions

Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/5 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Frequently asked questions

Can I cancel my flight booking to Southeast Missouri due to COVID-19?
Many airlines now offer greater flexibility due to COVID-19. Our handy Customer Service Portal will help you answer most queries about which policies apply to your Southeast Missouri flight. It's also wise to check the terms and conditions of your fare — preferably before locking in your tickets!
What's the best way to find cheap flights to Southeast Missouri that have flexible change policies?
It's as easy as counting to three with Expedia. Step 1: Enter your travel details and click on the "Search" button. Step 2? Check "No change fee" directly underneath the "Flexible change policies" filter to the left of your screen. Step 3. Book your flexible and cheap ticket to Southeast Missouri.
What are some of the general tips for travellers to Southeast Missouri during the COVID-19 outbreak?
With new rules, restrictions and safety measures to adhere to, travel looks a little different right now. Here's what you should know before you hop on that plane to Southeast Missouri:
  • Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight.
  • When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry.
  • Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning.
  • Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Southeast Missouri?
Contour Aviation is a major airline servicing Southeast Missouri. Search for a fare to Waynesville Regional Airport (TBN) and you'll have 56 Contour Aviation flights a month to pick from.
How can I find cheap tickets to Southeast Missouri?
You'll always score an unbeatable deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred flight date, then tick the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Southeast Missouri in the last seven days.
How much is a flight to Southeast Missouri?
If you were jetting one way from (), you could've snapped up a cheap fare for just in the last seven days. Return flights to Southeast Missouri ranged from to over the same period.
What are the most popular airports to fly into in Southeast Missouri?
Southeast Missouri's main entryway is Waynesville Regional Airport (TBN). Get your next big journey underway by reserving a ticket on one of the 56 flights a month to this destination.
When is the cheapest time to fly to Southeast Missouri?
If you'd rather spend your holiday savings enjoying the best of Southeast Missouri rather than on your flight there, depart earlier in the week. The most cost-effective day to travel is normally Tuesday, with Monday a close second. With many folks travelling on the weekend, Saturday often has the highest airfares.
How much is a plane ticket to Southeast Missouri?
In the last seven days, plane tickets varied between and . Browse through our fantastic deals to Southeast Missouri, make a booking and then start packing your things!
Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented new rules and standards to help their passengers fly with extra peace of mind. Check out what these carriers are doing:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.