Southeast Missouri Holidays from £1,058

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Your Southeast Missouri Holiday

Make putting together your next travel adventure simple with a holiday package to Southeast Missouri. If it's family-friendly attractions, history and culture you're searching for, the city of Cape Girardeau is waiting for you. With so much to see and do on a trip to Southeast Missouri, it can be tricky to know where to begin. Kick off your travels in Cape Girardeau at Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre — two leading attractions here. Another city to add to your itinerary is Sikeston. Be sure not to miss The Book Bug and Central Park. Whether you're planning to travel on a budget or in the lap of luxury, Expedia are here to help you tailor-make your next dream Southeast Missouri holiday.

Top Southeast Missouri Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
The Cheshire

The Cheshire

4 out of 5
Price was £1,163, price is now £1,058 per person
£1,058
per person
17 Jun - 20 Jun
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
8.6/10 Excellent! (1,007 reviews)
The bar was the perfect spot for a nightcap! Breakfast was also good, though there wasn't much seating available.

Reviewed on 18 Apr 2026

Spacious 3-Bedroom with King Bed

Spacious 3-Bedroom with King Bed

4 out of 5
Central West End
Price was £1,506, price is now £1,352 per person
£1,352
per person
17 Jun - 20 Jun
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
8.8/10 Excellent! (11 reviews)
Clean room nice area

Reviewed on 1 Feb 2026

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
Clayton
Price was £1,239, price is now £1,145 per person
£1,145
per person
17 Jun - 20 Jun
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
9/10 Wonderful! (968 reviews)
Room was huge. Clean and neat. Pool area was small but nice. Exercise room was small but had several very nice treadmills with extensive options. Parking was in basement garage. Only had a 6 ft 6 inch height opening. Fine for our small car, but would not accomodate oversized pickups. Plenty of parking on street which was in a safe neighborhood. Parking was an additional $20 per night. Regular options for breakfast plus 2 types of waffles, and scones. Nice little bar on site with indoor and outdoor seating. Quiet neighborhood and walkable to other restaurants and bars. Will stay again.

Reviewed on 27 Apr 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Price was £1,147, price is now £1,061 per person
£1,061
per person
17 Jun - 20 Jun
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
9.4/10 Exceptional! (528 reviews)
Clean room, helpful staff, terrific location.

Reviewed on 30 Apr 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was £1,150, price is now £1,064 per person
£1,064
per person
17 Jun - 20 Jun
found 1 day ago
Return direct flight included
London (LON) to St. Louis (STL)
8.8/10 Excellent! (1,061 reviews)
Awesome place. Very unique looking, we slept in the red room. Very roomy and a really nice bathroom. Bed was comfortable. It was located on the same block as the theater where we saw Phantom of the opera. I would go there again.

Reviewed on 1 May 2026

Southeast Missouri Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

Top hotels in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is £83 per night from 17 May to 18 May
£83
17 May - 18 May
includes taxes & fees
9.6/10 Exceptional! (1,002 reviews)
The dinners and drinks were great every night. The breakfast was good too. Rooms are clean. Great place to stay!

Reviewed on 30 Apr 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is £94 per night from 5 May to 6 May
£94
5 May - 6 May
includes taxes & fees
9.6/10 Exceptional! (1,003 reviews)
Staff was friendly, room was clean, breakfast items were good.

Reviewed on 30 Apr 2026

Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is £50 per night from 31 May to 1 Jun
£50
31 May - 1 Jun
includes taxes & fees
8/10 Very Good! (1,005 reviews)
Room was clean but front desk was nonexistent. Not much to the breakfast decided to go elsewhere. Luckily price was right and was only there for one night

Reviewed on 30 Apr 2026

Baymont Inn and Suites by Wyndham Farmington, MO
See all 663 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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What to do in Southeast Missouri

Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

£15
per adult
100% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
See all activities in Southeast Missouri

Frequently asked questions

Can I cancel my flight booking to Southeast Missouri due to COVID-19?
Many airlines now offer greater flexibility due to COVID-19. Our handy Customer Service Portal will help you answer most queries about which policies apply to your Southeast Missouri flight. It's also wise to check the terms and conditions of your fare — preferably before locking in your tickets!
What's the best way to find cheap flights to Southeast Missouri that have flexible change policies?
It's as easy as counting to three with Expedia. Step 1: Enter your travel details and click on the "Search" button. Step 2? Check "No change fee" directly underneath the "Flexible change policies" filter to the left of your screen. Step 3. Book your flexible and cheap ticket to Southeast Missouri.
What are some of the general tips for travellers to Southeast Missouri during the COVID-19 outbreak?
With new rules, restrictions and safety measures to adhere to, travel looks a little different right now. Here's what you should know before you hop on that plane to Southeast Missouri:
  • Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight.
  • When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry.
  • Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning.
  • Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Southeast Missouri?
Contour Aviation is a major airline servicing Southeast Missouri. Search for a fare to Waynesville Regional Airport (TBN) and you'll have 56 Contour Aviation flights a month to pick from.
How can I find cheap tickets to Southeast Missouri?
You'll always score an unbeatable deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred flight date, then tick the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Southeast Missouri in the last seven days.
How much is a flight to Southeast Missouri?
If you were jetting one way from (), you could've snapped up a cheap fare for just in the last seven days. Return flights to Southeast Missouri ranged from to over the same period.
What are the most popular airports to fly into in Southeast Missouri?
Southeast Missouri's main entryway is Waynesville Regional Airport (TBN). Get your next big journey underway by reserving a ticket on one of the 56 flights a month to this destination.
When is the cheapest time to fly to Southeast Missouri?
If you'd rather spend your holiday savings enjoying the best of Southeast Missouri rather than on your flight there, depart earlier in the week. The most cost-effective day to travel is normally Tuesday, with Monday a close second. With many folks travelling on the weekend, Saturday often has the highest airfares.
How much is a plane ticket to Southeast Missouri?
In the last seven days, plane tickets varied between and . Browse through our fantastic deals to Southeast Missouri, make a booking and then start packing your things!
Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented new rules and standards to help their passengers fly with extra peace of mind. Check out what these carriers are doing:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.