Title: TOP Adults Only Resorts & Hotels in Cape Girardeau, MO for 2026 | Expedia.co.uk [Hotels in Cape Girardeau](https://expedia.co.uk/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Holiday Rentals in Cape Girardeau](https://expedia.co.uk/Cape-Girardeau-Holiday-Rentals.d820.Travel-Guide-HolidayRentals)[Flights to Cape Girardeau](https://expedia.co.uk/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Cape-Girardeau.d820.Car-Hire-Guide)[Cape Girardeau Holidays](https://expedia.co.uk/Cape-Girardeau.d820.Holidays-City-Breaks) ![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Alice Burghart # Search Adults Only Resorts & Hotels in Cape Girardeau - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cape Girardeau Adults Only Resorts & Hotels Tonight [9 Jan - 10 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=820&startDate=2026-01-09&endDate=2026-01-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Tomorrow [10 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=820&startDate=2026-01-10&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) This weekend [9 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=820&startDate=2026-01-09&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=820&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) No exact matches found, but these alternatives could be just right ## Recommended hotels in Cape Girardeau ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Jackson 9.6/10 Exceptional (1,002 reviews) "Breakfast was great- staff was welcoming. Will stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura £65 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/db8c9491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,005 reviews) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly £76 includes taxes & fees 19 Jan - 20 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/ccad2677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-service breakfast ](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8447c54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) Jackson 9.0/10 Wonderful (685 reviews) "Conveniently located, clean, friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Philip £68 includes taxes & fees 12 Jan - 13 Jan [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (148 reviews) "Lovely staff clean hotel comfortable beds " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kastriot £74 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/59c49f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/a085469e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/05842f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/f32a343b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) Cape Girardeau 9.0/10 Wonderful (1,001 reviews) "Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colleen £59 includes taxes & fees 14 Jan - 15 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/dc836bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Egyptian cotton sheets, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/4ac4ba46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/44b66206.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cape Girardeau North [](https://www.expedia.co.uk/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) Cape Girardeau 7.2/10 Good (690 reviews) "The room was clean and nice. The breakfast was really good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kalani £50 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/006e0795.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/2df4267b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/4ea3df4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau Near the Medical Center [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) Cape Girardeau 9.0/10 Wonderful (1,002 reviews) "Staff great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy £59 includes taxes & fees 14 Jan - 15 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/182edc95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom (Feature) | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/40930878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast ](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG [](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (1,002 reviews) "Breakfast was very good and staff was extremely friendly and rooms were very clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rex £80 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (487 reviews) " Excellent stay. Will come again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joydeep £75 includes taxes & fees 12 Jan - 13 Jan [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2f374258.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2e166a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/0aa802d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/5aa6a52b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (104 reviews) "It was a nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Douglas £76 includes taxes & fees 28 Jan - 29 Jan [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-24&endDate=2026-01-25®ionId=820&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Cape Girardeau ### Discover top Cape Girardeau attractions Cape Girardeau, Missouri, offers a delightful blend of culture, history, and outdoor adventure perfect for discerning travellers. Start your exploration at the Cape Riverfront, where you can stroll along the scenic riverwalk, enjoy local art installations, and soak in stunning views of the Mississippi River. Just a short distance away, the Cape Girardeau Conservation Nature Center invites families to connect with nature through interactive exhibits and beautiful trails, making it a fantastic spot for both children and adults to enjoy the great outdoors. For history enthusiasts, the Southeast Missouri Museum showcases the region's rich heritage with engaging displays and collections that are sure to captivate visitors. Don't miss the opportunity to experience the vibrant arts scene at the Arts Council of Southeast Missouri, which frequently hosts exhibits and events featuring local artists. Finally, for a dose of family fun, the Discovery Playhouse offers an engaging, hands-on environment for younger children to explore and learn. When it comes to accommodation, consider staying near the bustling downtown area, where charming hotels provide convenient access to these attractions, ensuring a relaxing base from which to explore. Many hotels in this area boast modern amenities and attentive service, creating an inviting atmosphere for families seeking both comfort and value. ## Top Cape Girardeau Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Allenville Hotels ](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Arnold ](https://www.expedia.co.uk/Arnold-Hotels-Gay-Friendly-Hotel.0-0-d177608-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Pool in Arnold ](https://www.expedia.co.uk/Arnold-Hotels-Hotels-With-Pool.0-0-d177608-tHotelswithPool.Travel-Guide-Filter-Hotels) - [Spa Hotels in Arnold ](https://www.expedia.co.uk/Arnold-Hotels-Spa-Hotels.0-0-d177608-tSpaHotels.Travel-Guide-Filter-Hotels) - [Benton Hotels ](https://www.expedia.co.uk/Benton-Hotels.d553248634983369680.Travel-Guide-Hotels) - [Bernie Hotels ](https://www.expedia.co.uk/Bernie-Hotels.d3000349284.Travel-Guide-Hotels) - 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