Title: Hotels in Lithium, MO - Best Lithium Hotels from £53 - Fully Refundable Options - Expedia.co.uk [Holiday Rentals in Lithium](https://expedia.co.uk/Lithium-Holiday-Rentals.d553248634983113033.Travel-Guide-HolidayRentals)[Lithium Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Lithium.d553248634983113033.Car-Hire-Guide)[Lithium Holidays](https://expedia.co.uk/Lithium.d553248634983113033.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Lithium, MO from £53 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Lithium Pool [](https://www.expedia.co.uk/Hotel-Search?destination=Lithium%2C+Missouri%2C+United+States+of+America®ionId=553248634983113033&latLong=37.832898%2C-89.885105&adults=2&startDate=2026-01-25&d1=2026-01-25&endDate=2026-01-27&d2=2026-01-27&amenities=POOL) Apart­ment [](https://www.expedia.co.uk/Hotel-Search?destination=Lithium%2C+Missouri%2C+United+States+of+America®ionId=553248634983113033&latLong=37.832898%2C-89.885105&adults=2&startDate=2026-01-25&d1=2026-01-25&endDate=2026-01-27&d2=2026-01-27&lodging=APARTMENT) Family friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Lithium%2C+Missouri%2C+United+States+of+America®ionId=553248634983113033&latLong=37.832898%2C-89.885105&adults=2&startDate=2026-01-25&d1=2026-01-25&endDate=2026-01-27&d2=2026-01-27&travelerType=family_friendly) Hot tub [](https://www.expedia.co.uk/Hotel-Search?destination=Lithium%2C+Missouri%2C+United+States+of+America®ionId=553248634983113033&latLong=37.832898%2C-89.885105&adults=2&startDate=2026-01-25&d1=2026-01-25&endDate=2026-01-27&d2=2026-01-27&amenities=HOT_TUB) Pet friendly [](https://www.expedia.co.uk/Hotel-Search?destination=Lithium%2C+Missouri%2C+United+States+of+America®ionId=553248634983113033&latLong=37.832898%2C-89.885105&adults=2&startDate=2026-01-25&d1=2026-01-25&endDate=2026-01-27&d2=2026-01-27&amenities=PETS) Waterpark [](https://www.expedia.co.uk/Hotel-Search?destination=Lithium%2C+Missouri%2C+United+States+of+America®ionId=553248634983113033&latLong=37.832898%2C-89.885105&adults=2&startDate=2026-01-25&d1=2026-01-25&endDate=2026-01-27&d2=2026-01-27&amenities=WATER_PARK) ## Check prices for these dates Tonight [11 Jan - 12 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983113033&startDate=2026-01-11&endDate=2026-01-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Jan - 13 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983113033&startDate=2026-01-12&endDate=2026-01-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983113033&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248634983113033&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Lithium hotels ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/469821a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/2b5bb07a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, soundproofing](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/ab22ad5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG [](https://www.expedia.co.uk/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) Perryville 9.2/10 Wonderful (551 reviews) "lean, updated rooms, friendly staff and great breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda £78 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Deluxe Studio Suite, 1 King Bed, Non Smoking | Jetted bathtub](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/19091438.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/ddade665.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/333ae023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/50566fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Chester IL [](https://www.expedia.co.uk/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) Chester 8.6/10 Excellent (352 reviews) "The room was clean and the staff were friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) RODNEY £57 includes taxes & fees 16 Jan - 17 Jan [](https://www.expedia.co.uk/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) ![Suite, 1 King Bed, Non Smoking (1 Bedroom) | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/e270ba08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/504b77a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible) | In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/ef8850d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/807f3a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Perryville [](https://www.expedia.co.uk/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) Perryville 8.4/10 Very good (945 reviews) "Great beds Temperature control " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alan £56 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Premium bedding, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/96e79bac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/7601c384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/475e9554.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/46991f0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Sainte Genevieve [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Microtel-Inn-Suites-By-Wyndham-Sainte-Genevieve.h425932.Hotel-Information) Ste Genevieve 8.8/10 Excellent (614 reviews) "Excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £62 includes taxes & fees 15 Jan - 16 Jan [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Microtel-Inn-Suites-By-Wyndham-Sainte-Genevieve.h425932.Hotel-Information) ![Standard Room, 2 Double Beds | Blackout curtains, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/416a5c39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Blackout curtains, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/3b572bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/41fbb4bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Blackout curtains, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/72d26ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Triangle Inn Motel [](https://www.expedia.co.uk/Perryville-Hotels-Triangle-Inn-Motel.h29373308.Hotel-Information) Ste Genevieve 8.0/10 Very good (42 reviews) "The staff was very accommodating." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Herbert [](https://www.expedia.co.uk/Perryville-Hotels-Triangle-Inn-Motel.h29373308.Hotel-Information) ![Room, 1 King Bed | Jetted bathtub](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/6caf4858.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/19d8e2e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/0ac21fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/f6ab26a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Perryville [](https://www.expedia.co.uk/Perryville-Hotels-Days-Inn-By-Wyndham-Perryville.h10352.Hotel-Information) Perryville 6.8/10 (417 reviews) "Was a nice place." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lesliee £53 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Perryville-Hotels-Days-Inn-By-Wyndham-Perryville.h10352.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/bf2aa006.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/26f852d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/01a032b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily breakfast ](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/6b56391d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Perryville I-55 [](https://www.expedia.co.uk/Perryville-Hotels-Quality-Inn.h84949.Hotel-Information) Perryville 6.6/10 (124 reviews) "Nice place would recommend Mary Jane’s if you’re looking for good food " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew £64 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Perryville-Hotels-Quality-Inn.h84949.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-25&endDate=2026-01-26®ionId=553248634983113033&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLithium-Hotels.d553248634983113033.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLithium-Hotels.d553248634983113033.Travel-Guide-Hotels) ## Top Lithium Hotel Reviews ![Hot Tub & Creek Views: Secluded Perryville Cabin](https://images.trvl-media.com/lodging/116000000/115020000/115013900/115013833/762b23c1_y.jpg) ### Hot Tub & Creek Views: Secluded Perryville Cabin 10/10 Excellent "Host was super helpful and the stay was top notch. What a unique old home to get to stay in!" [](https://expedia.co.uk/Perryville-Hotels-Hot-Tub-Creek-Views-Secluded-Perryville-Cabin.h115013833.Hotel-Information) ![Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.](https://images.trvl-media.com/lodging/114000000/113880000/113879200/113879109/df663fcf_y.jpg) ### Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten. 10/10 Excellent "The view is amazing. The entry, kitchen, and living room are an open concept and feel very spacious. The bedrooms are neat and clean with comfortable beds. The location is a little off the beaten path, but worth the view. The host left the porch light on due to our late arrival and the directions worked perfectly." [](https://expedia.co.uk/Ste-Genevieve-Hotels-Peaceful-3-Bedroom-House-With-WiFi-And-AC-In-Lovely-New-Offenburg.h113879109.Hotel-Information) ![Days Inn by Wyndham Perryville](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/f6ab26a4_y.jpg) ### Days Inn by Wyndham Perryville 10/10 Excellent "No" [](https://expedia.co.uk/Perryville-Hotels-Days-Inn-By-Wyndham-Perryville.h10352.Hotel-Information) ![Silo Farm Haus- located in the heart of wine country!](https://images.trvl-media.com/lodging/40000000/39500000/39493900/39493801/bc6052c1_y.jpg) ### Silo Farm Haus- located in the heart of wine country! 10/10 Excellent "This house was immaculate. The attention to every detail in the decor was amazing and adorable. Hosts were great. A fantastic place to stay. " [](https://expedia.co.uk/Ste-Genevieve-Hotels-Silo-Farm-Haus-Located-In-The-Heart-Of-Wine-Country.h39493801.Hotel-Information) ![ ⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4](https://images.trvl-media.com/lodging/107000000/106060000/106052600/106052541/e186477c_y.jpg) ### ⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4 10/10 Excellent "Property was lovely, and full of history. Amenities were nice, hosts were very gracious. Will definitely return." [](https://expedia.co.uk/Ste-Genevieve-Hotels-Rivertown-Retreat-Historic-Dufour-House-Circa-1800Downtown-District-Sleeps-4.h106052541.Hotel-Information) ![Baymont by Wyndham Chester IL](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/19091438_y.jpg) ### Baymont by Wyndham Chester IL 10/10 Excellent "The hotel has been declining in recent years but the new management is working to make things better and they are doing a great job. Our room was very comfortable and clean. The staff were very friendly and helpful. It was an enjoyable experience and we will stay here again. " [](https://expedia.co.uk/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) ![Super 8 by Wyndham Perryville](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9_y.jpg) ### Super 8 by Wyndham Perryville 10/10 Excellent "The room and common area was very clean and attractive. But breakfast was a big disapp ointment. Maybe they ran out of bacon or sausage but it wasn't refilled so all of this left and 8:30 was waffles cereal and scrambled eggs." [](https://expedia.co.uk/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Triangle Inn Motel](https://images.trvl-media.com/lodging/30000000/29380000/29373400/29373308/a0b4cb43_y.jpg) ### Triangle Inn Motel 10/10 Excellent "Dee was the most gracious owner and manager of the motel. Said to call her if we needed anything and was very helpful overall. Bed was clean and comfortable. Even though the rooms could use an updating, it was clean and served the purpose of a good sleep. " [](https://expedia.co.uk/Perryville-Hotels-Triangle-Inn-Motel.h29373308.Hotel-Information) ![Beautiful Modern Loft In Wine Country!](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/86d734a8_y.jpg) ### Beautiful Modern Loft In Wine Country! 10/10 Excellent "It was the perfect spot for a weekend getaway!" [](https://expedia.co.uk/Ste-Genevieve-Hotels-Beautiful-Modern-Loft-In-Wine-Country.h23139432.Hotel-Information) ## More cheap stays in Lithium ![Days Inn by Wyndham Perryville](https://images.trvl-media.com/lodging/1000000/20000/10400/10352/f6ab26a4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Perryville 1500 Liberty Street Perryville MO £53 13 Jan - 14 Jan includes taxes & fees 6.8/10 (417 reviews) [](https://expedia.co.uk/Perryville-Hotels-Days-Inn-By-Wyndham-Perryville.h10352.Hotel-Information) ![Super 8 by Wyndham Perryville](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Super 8 by Wyndham Perryville 1119 Vincent Dr Perryville MO £56 1 Feb - 2 Feb includes taxes & fees 8.4/10 Very Good! (945 reviews) [](https://expedia.co.uk/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Baymont by Wyndham Chester IL](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/19091438_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont by Wyndham Chester IL 2150 State Street Chester IL £57 16 Jan - 17 Jan includes taxes & fees 8.4/10 Very Good! (352 reviews) [](https://expedia.co.uk/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) ![Microtel Inn & Suites by Wyndham Sainte Genevieve](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/96e79bac_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Microtel Inn & Suites by Wyndham Sainte Genevieve 21958 Hwy 32 Ste Genevieve MO £62 15 Jan - 16 Jan includes taxes & fees 8.6/10 Excellent! (614 reviews) [](https://expedia.co.uk/Ste-Genevieve-Hotels-Microtel-Inn-Suites-By-Wyndham-Sainte-Genevieve.h425932.Hotel-Information) ![Quality Inn Perryville I-55](https://images.trvl-media.com/lodging/1000000/90000/85000/84949/bf2aa006_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Perryville I-55 1517 S. Perryville Blvd. Perryville MO £64 18 Jan - 19 Jan includes taxes & fees 6.6/10 (124 reviews) [](https://expedia.co.uk/Perryville-Hotels-Quality-Inn.h84949.Hotel-Information) ![Holiday Inn Express & Suites Perryville by IHG](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Perryville by IHG 2020 Jefferson St Perryville MO £78 18 Jan - 19 Jan includes taxes & fees 9.2/10 Wonderful! (550 reviews) [](https://expedia.co.uk/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ## Frequently asked questions ### What's the best place for a stay in Lithium? ### What are some of the best holiday rentals that Lithium has to offer? ### If I need to cancel my hotel reservation in Lithium, will I receive a refund? ### What is staying in Lithium like? ### What should I see while I'm in Lithium? ### What's the weather like in Lithium? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Bismarck Hotels ](https://www.expedia.co.uk/Bismarck-Hotels.d553248634983538264.Travel-Guide-Hotels) - [Bloomsdale Hotels ](https://www.expedia.co.uk/Bloomsdale-Hotels.d3000444549.Travel-Guide-Hotels) - [Bonne Terre Hotels ](https://www.expedia.co.uk/Bonne-Terre-Hotels.d55598.Travel-Guide-Hotels) - [Adults Only Resorts & in Cape Girardeau ](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Adults-Only-Resorts.0-0-d820-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - 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