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It's an area of Northeast Missouri that around 320,000 people live in.
Jefferson City, the state capital, is roughly 110 miles to the west of St. Louis, and Smithton is 20 miles to the southeast.
One of your guidebook's top tips will certainly be the Gateway Arch. Make sure you allow some time to visit this renowned sight.
Get active with the kids at Grants Farm and Six Flags St. Louis. If you're on the lookout for even more family fun, head on to the Magic House - St. Louis Children's Museum and Alligator Creek Aquatic Center.
From aquatic schools of fish to mysterious underwater flora, you just never know what you might discover at St. Louis Children's Aquarium.
You and the kids will have a blast checking out the rare and exotic animals at the St. Louis Zoo. If you can't spare too much time, be sure to collect a map so you can quickly find the zoo highlights.
Do you enjoy a beer or three? If so, take the time to stop in at the Anheuser-Busch Brewery, a very educational place to spend an afternoon. Discover how each beer is made, and afterwards, be sure to put this knowledge to good use by sampling the end product!
Enjoy a fantastic day out with your friends at the Chandler Hill Vineyards, the Yellow Farmhouse Winery or the Sugar Creek Winery. Wander through vine rows, sample their best blends and maybe even buy a few bottles to take with you.
Whether you want to put on your poker face or just take in the lively sights and sounds, the Hollywood Casino and the Ameristar Casino St. Charles are not to be missed. On another day, you could also pull up a chair at the Lumiere Place Casino and the River City Casino.
Passionate plant lovers can get their horticultural fix at the Missouri Botanical Gardens and Arboretum and the Sophia M. Sachs Butterfly House.
On a fine day, pack some lunch and head out to one of the scenic green spaces, such as Laumeier Sculpture Park or the Faust Park. August A. Busch Memorial Conservation Area and O'Fallon Park are two more pleasant spots to while away a lazy day over a good book.
Find out more about St. Louis by picking up some maps and chatting with the staff at Weldon Spring Site Interpretive Center and Dennis and Judith Jones Visitor and Education Center.
Need some time away from the hustle and bustle of the modern world? Make your way over to Lone Elk Park and Babler State Park. Route 66 State Park and Myron and Sonya Glassberg Family Conservation Area are also appreciated by nature enthusiasts.
Grab a buddy or two and explore some of the popular exhibition spaces in the area. The City Museum and the St. Louis Art Museum offer a range of collections that are sure to capture your attention. The Missouri History Museum and the Museum of Transportation are also worth considering.
See intriguing gadgets and learn about scientific advances at the St. Louis Science Center.
A haven for art lovers, this area is home to numerous spaces in which amateurs and professionals regularly exhibit their work. Revel in the creative atmosphere at the Pulitzer Foundation for the Arts and the Componere Gallery. If you have time afterwards, the Contemporary Art Museum St. Louis and the Mildred Lane Kemper Art Museum are also well worth your time.
Make your way through the peaceful hallways and view the artifacts displayed at the Arnold Historical Society & Museum.
The 9-11 Memorial and the Lindenwood University are certainly worth looking into, even if you aren't a history buff. More tales from the days of yore await at the Millikin University and Old Courthouse.
Eads Bridge and Old Chain of Rocks Bridge are time-worn examples of engineering ingenuity that will stand strong for years to come.
Whether you consider yourself spiritual or not, you'll be sure enjoy an afternoon at Cathedral Basilica of St. Louis and Shrine of St. Joseph. Old Cathedral of St. Louis of France and St. Alphonsus Liguori Catholic Church are two more intriguing religious sites.
St. Louis' most celebrated sights often overshadow its less visited, yet equally fascinating activities. Some worthwhile options are Westport Plaza and the Central Public Library. If you've got more time to spare, also think about visiting the Center of Creative Arts or the St. Louis Walk of Fame.
Booking a welcoming place to stay is important if you're after a wonderful trip. You can browse the best St. Louis hotel prices on Expedia's hotels guide.
Four Seasons Hotel St Louis at 999 North Second Street, and The Chase Park Plaza, at 212 N Kingshighway are two excellent examples of the more stylish accommodations in St. Louis. Alternatively, the Days Inn Downtown St. Louis, at 2810 N 9th St, and the Americas Best Value Inn St. Louis/Downtown, at 1100 N 3rd St, are two more budget-friendly choices worth looking into.
Another great option is to stay just a short stroll away from Gateway Arch by booking a room at the Embassy Suites St. Louis - Downtown, which is just 0.5 miles away. Equally popular is the Hilton St. Louis at the Ballpark, 0.4 miles from Gateway Arch.
Located in Downtown St. Louis, this hotel is within a 10-minute walk of Old Courthouse and Gateway Arch. Busch Stadium and Dome at America’s Center are also within 15 minutes.
Situated in Grover, this hotel is within 9 miles (15 km) of Dr. Edmund A. Babler Memorial State Park, Hidden Valley Ski Resort and Babler State Park. Westfield Chesterfield Mall and Castlewood State Park are also within 9 miles (15 km).
Located in Downtown St. Louis, this hotel is within a 10-minute walk of Kiener Plaza, Busch Stadium and Dome at America’s Center. Gateway Arch and City Museum are also within 1 mile (2 km).
Located in Downtown St. Louis, this romantic hotel is within a 5-minute walk of America's Center Convention Complex and Dome at America’s Center. Busch Stadium and City Museum are also within 15 minutes.
This family-friendly Richmond Heights hotel is located in the historical district, within 1 mi (2 km) of Mildred Lane Kemper Art Museum and St. Louis Zoo. St. Louis Art Museum is 1.3 mi (2.1 km) away.
Located in Clayton, this hotel is within 3 miles (5 km) of Washington University, St. Louis Art Museum and St. Louis Zoo. Center of Creative Arts and Mildred Lane Kemper Art Museum are also within 3 miles (5 km).
Located in Downtown St. Louis, this romantic hotel is within a 10-minute walk of Security Building and Dome at America’s Center. Gateway Arch and Busch Stadium are also within 15 minutes.
Situated on the riverwalk, this hotel is 2.6 mi (4.1 km) from Missouri Civil War Museum and 3.1 mi (4.9 km) from Bellerive Park. Sylvan Springs County Park and Willmore Park are also within 6 miles (10 km).