Compare and book 5 Star hotels in St. Louis, Missouri
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30 Oct - 1 NovOur top choices for St. Louis 5-star hotels
£329
includes taxes & fees
28 Oct - 29 Oct
£508
includes taxes & fees
1 Nov - 2 Nov
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Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in St. Louis.
Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
£98
20 Nov - 21 Nov
includes taxes & fees
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
£119
30 Oct - 31 Oct
includes taxes & fees
8.6/10 Excellent! (4,375 reviews)
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
£130
17 Nov - 18 Nov
includes taxes & fees
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
St. Louis and related destinations
The Gateway Arch towers 630 feet above the Mississippi, with a tram that takes you to spectacular views at the top. Explore Forest Park's free museums, catch a Cardinals game at Busch Stadium, and don't miss Ted Drewes' frozen custard that locals swear by.
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Frequently asked questions
What are the best 5-star hotels in St. Louis?
Treat yourself to a luxurious stay at Four Seasons Hotel St Louis. This is among the top 5-star hotels in St. Louis based on Expedia customer reviews. From its guest services to its well-appointed rooms and prime location, you can rely on the highest standard of excellence.
How much does it cost to stay in a 5-star hotel in St. Louis?
You'll find many different pricing options for a 5-star hotel in St. Louis on Expedia. The amount you pay will depend on your travel dates, trip length and other factors. Compare available accommodation for your desired dates and use our pricing and other filters to lock in the ideal high-end stay.
- Search for the lowest price per night from £98
What makes a hotel 5 stars in St. Louis?
From gourmet dining venues and 24/7 fitness centres to pools and the finest bedding, the 5-star experience in St. Louis is all about indulgence and comfort. But it takes more than just upscale perks to earn a 5-star rating. Accommodation must also deliver remarkable guest-focused services like in-room massage treatments, on-site dry cleaning and laundry and a nightly turn-down service.
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