Title: Hotels in Southeast Missouri - Best Southeast Missouri Hotels from £45 - Fully Refundable Options - Expedia.co.uk

[Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks)

![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Bill Dillard

# Find hotels in Southeast Missouri, MO from £45

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## Go beyond your typical stay in Southeast Missouri

Cabin

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&lodging=CABIN)

Apart­ment

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&lodging=APARTMENT)

Farm

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&lodging=AGRITOURISM)

Hot tub

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&amenities=HOT_TUB)

Pool

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&amenities=POOL)

Family friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&travelerType=family_friendly)

Pet friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&amenities=PETS)

Cottage

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&lodging=COTTAGE)

Waterpark

[](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-31&d1=2025-12-31&endDate=2026-01-02&d2=2026-01-02&amenities=WATER_PARK)

## Check prices for these dates

Tonight

[17 Dec - 18 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[18 Dec - 19 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-18&endDate=2025-12-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Southeast Missouri hotels

![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/35f08a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Farmstead Hotel

[](https://www.expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

Caruthersville

8.8/10

Excellent

(463)

"Nice place "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debbie

£72

includes taxes & fees

18 Dec - 19 Dec

[](https://www.expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/08371d9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f737107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1003)

"Clean room, great location and friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

£77

includes taxes & fees

5 Jan - 6 Jan 2026

[](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchenette](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/476a2a56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/58027ab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Motel 6 Poplar Bluff, MO

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

Poplar Bluff

7.8/10

Good

(1002)

"Love the updated rooms and the vending area."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathi

£60

includes taxes & fees

18 Dec - 19 Dec

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/d71a605c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/99ef8265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Poplar Bluff

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(855)

"Very clean, great check in"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Teresa

£87

includes taxes & fees

4 Jan - 5 Jan 2026

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

![Free daily full breakfast ](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/8874e729.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laptop workspace, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/ed042ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Sikeston

[](https://www.expedia.co.uk/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

Sikeston

8.4/10

Very good

(1003)

"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

joseph

£64

includes taxes & fees

22 Dec - 23 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars) | Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

[](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

Jackson

8.8/10

Excellent

(669)

"Great place "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

GUY

£68

includes taxes & fees

7 Jan - 8 Jan 2026

[](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/c7be0f94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/e7b8b662.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/4329af11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

[](https://www.expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

Sikeston

8.4/10

Very good

(719)

"Stayed one night. Good rate for the Hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul

£47

includes taxes & fees

5 Jan - 6 Jan 2026

[](https://www.expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free breakfast ](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 8 AM to 11 PM, pool loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

[](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(1000)

"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brian

£80

includes taxes & fees

24 Dec - 25 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/5904f90a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/f6482ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/e921a7b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Poplar Bluff

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(796)

"Staff was kind and provided a lot of information during check out."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shea

£93

includes taxes & fees

10 Jan - 11 Jan 2026

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/a8b491ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/686f0126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

[](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

Sikeston

9.0/10

Wonderful

(444)

"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Doncheial

£83

includes taxes & fees

28 Dec - 29 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Children’s play area – outdoor](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/e8909449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hiking](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/f1b1e4d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Single Room | Individually decorated, individually furnished, desk, blackout curtains](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/868bcfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast ](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/603f552a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Honeysuckle Inn - Mountain View

[](https://www.expedia.co.uk/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

Mountain View

8.6/10

Excellent

(331)

"Staff was very friendly."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joyce

£77

includes taxes & fees

19 Dec - 20 Dec

[](https://www.expedia.co.uk/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room, 1 Bedroom, Non Smoking | Bathroom | Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/06367e7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### New Orleans Inn Portageville 

[](https://www.expedia.co.uk/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

Portageville

8.0/10

Very good

(726)

"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Roger

[](https://www.expedia.co.uk/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/2d914387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

[](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(1004)

"Great place and staff, very accommodating!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Megan

£76

includes taxes & fees

24 Dec - 25 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/66c21f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Jackson MO

[](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

Jackson

9.6/10

Exceptional

(1004)

"Breakfast was great- staff was welcoming. Will stay there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura

£65

includes taxes & fees

22 Dec - 23 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Accessible, Refrigerator & Microwave (Sofabed, 2 Rooms, Tub) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/83931306.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Poplar Bluff

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

Poplar Bluff

9.2/10

Wonderful

(964)

"Nice room helpful staff. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Deborah

£79

includes taxes & fees

21 Dec - 22 Dec

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/57db158c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/091dc4e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Suite, 1 Queen Bed with Sofa bed, Kitchen | In-room dining](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/a091ce3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Signature Double Room, 2 Queen Beds, Kitchenette | Bathroom | Combined shower/bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/99d2e456.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Shepherd Mountain Inn

[](https://www.expedia.co.uk/Farmington-Hotels-Shepherd-Mountain-Inn.h12582009.Hotel-Information)

Ironton

9.4/10

Exceptional

(304)

" Nice room, nice bed, convenient location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Burton

[](https://www.expedia.co.uk/Farmington-Hotels-Shepherd-Mountain-Inn.h12582009.Hotel-Information)

![Standard Room, 1 King Bed | In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/2cf60fb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laundry room](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/b3da6b1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/04ce172c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/79923507.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Potosi

[](https://www.expedia.co.uk/Farmington-Hotels-Super-8-By-Wyndham-Potosi.h158717.Hotel-Information)

Potosi

7.0/10

Good

(379)

"The room was very good for the price."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin

£45

includes taxes & fees

18 Dec - 19 Dec

[](https://www.expedia.co.uk/Farmington-Hotels-Super-8-By-Wyndham-Potosi.h158717.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast ](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, down duvets, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/7dc8a5d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

[](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

Sikeston

8.6/10

Excellent

(443)

"Staff was great. Hotel was clean. Great sleep. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeffrey

£78

includes taxes & fees

11 Jan - 12 Jan 2026

[](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/fd23ac64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout curtains, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/72dcdb56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/a26b8409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout curtains, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/15fecbba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fort Davidson Hotel

[](https://www.expedia.co.uk/Farmington-Hotels-Fort-Davidson-Hotel.h12489555.Hotel-Information)

Ironton

9.2/10

Wonderful

(173)

"Friendly staff, spacious room, nice pool!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

SHARON

£98

includes taxes & fees

18 Dec - 19 Dec

[](https://www.expedia.co.uk/Farmington-Hotels-Fort-Davidson-Hotel.h12489555.Hotel-Information)

![Courtyard](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/cfaba55a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/acc0b9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/4c2e6495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Cape Girardeau I 55 East

[](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(784)

"Excellent stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christina

£85

includes taxes & fees

24 Dec - 25 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01&regionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Holiday Rentals in Southeast Missouri

Holiday Home

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | 1 bedroom](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/e3c698b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/972e20f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Porch](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/e72e4500.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tiny Houses of French Village

[](https://www.expedia.co.uk/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

French Village

10/10

Exceptional

(3)

"Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again."

[](https://www.expedia.co.uk/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information)

Cabin

![Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/71c262d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room dining](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/946846b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laptop workspace, free WiFi](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/w2098h1398x2y0-ee5ff79b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/055f4f65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Johnson's Shut-ins State Park

[](https://www.expedia.co.uk/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information)

Middle Brook

10/10

Exceptional

(1)

"These newer cabins are clean and have everything you need. Highly recommend! "

[](https://www.expedia.co.uk/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information)

Cottage

![House (3 Bedrooms) | Exterior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/a47c37db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/f9f2c035.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/90a48852.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/c6a2f10e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Walk to Dtwn: Ironton Home in Historic District

[](https://www.expedia.co.uk/Ironton-Hotels-Walk-To-Dtwn-Ironton-Home-In-Historic-District.h116687024.Hotel-Information)

Ironton

10/10

Exceptional

(1)

"Clean and comfortable "

[](https://www.expedia.co.uk/Ironton-Hotels-Walk-To-Dtwn-Ironton-Home-In-Historic-District.h116687024.Hotel-Information)

Cabin

![Classic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c7addad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/8921c844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ec7dbabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sam A Baker State Park

[](https://www.expedia.co.uk/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

Patterson

9.2/10

Wonderful

(5)

"Pet friendly, great staff. "

[](https://www.expedia.co.uk/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information)

Cottage

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/a4a2b46f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/13098805.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/e5fcd455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/bcc548cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 'turtle Rock' - Ironton Cabin w/ Furnished Patio!

[](https://www.expedia.co.uk/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information)

Ironton

10/10

Exceptional

(1)

"Stroller, pack n play and high chair. This was amazing "

[](https://www.expedia.co.uk/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information)

Cottage

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/c2de0b90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Living area | Fireplace, DVD player, books](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/6a2519cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/08fa7a40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/f8b751c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 40-acre Poplar Bluff Nature Lovers Paradise!

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information)

Poplar Bluff

10/10

Exceptional

(3)

"Beautiful place enjoyed our stay"

[](https://www.expedia.co.uk/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information)

Cottage

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/4d1e86cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/f9e60430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/f87be0ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/330effe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Belgrade Cottage w/ Wood-burning Stove!

[](https://www.expedia.co.uk/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information)

Belgrade

10/10

Exceptional

(1)

[](https://www.expedia.co.uk/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information)

[See all holiday rentals](https://expedia.co.uk/Hotel-Search?startDate=2026-01-14&endDate=2026-01-17&regionId=6058763&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true)

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## Stay near popular Central United States attractions

![Panorama of Academic Hall, Southeast Missouri State University ](https://images.trvl-media.com/place/553248621554122994/3bc9a5e0-c92b-4ca4-b94a-564376156913.jpg)

### Southeast Missouri State University

4.4/5 (137 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621554122994)

![A huge granite boulder located in Elephant Rocks State Park](https://images.trvl-media.com/place/6058764/b46f1ef8-a151-4a6d-a0ba-117f21235d8d.jpg)

Photo by Pat Long

### Elephant Rocks State Park

4.8/5 (52 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648464)

![Sunrise from the duck blind. ](https://images.trvl-media.com/place/183505/9493e565-66da-46c4-8222-30a8f5da22bb.jpg)

Photo by JG Morris

### Lake Wappapello

4.3/5 (40 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648460)

### Century Casino Caruthersville

3.2/5 (31 reviews)

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655201)

### Isle Casino Cape Girardeau

4.2/5 (104 reviews)

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655780)

### Sainte Genevieve Winery

4.3/5 (10 reviews)

You can enjoy a tasting or tour at Sainte Genevieve Winery during your travels to Ste Genevieve. Take in the entertainment choices while you're in the area. 

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648574)

## Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park. 

[See all hotels in Southeast Missouri](https://www.expedia.co.uk/Hotel-Search?startDate=2025-12-31&endDate=2026-01-01&adults=2&regionId=6058763)

![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high)

Photo by Bill Dillard

## Top Southeast Missouri Hotel Reviews

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"The staff was all friendly clean rooms and really enjoyed our stay"

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"Didn’t eat breakfast "

[](https://expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean room, friendly staff"

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg)

### Motel 6 Poplar Bluff, MO

10/10 Excellent

"Staff was amazing and super nice. Room was very clean. "

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg)

### Drury Inn & Suites Poplar Bluff

10/10 Excellent

"The room was Great!"

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Yes"

[](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"All staff members were outgoing and friendly, rooms very clean, bathrooms. Lean. Their breakfast is better than other hotels I’ve stayed in the past. If Drury is in the area I’m going to, I’ll book Drury. "

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife. "

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg)

### Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent

"The rooms where clean, the water was hot in the showers. The staff was family oriented and friendly felt like my family was safe."

[](https://expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

## More cheap stays in Southeast Missouri

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

£45

23 Dec - 24 Dec

includes taxes & fees

7.8/10 Good! (1,003 reviews)

[](https://expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

£53

5 Jan - 6 Jan 2026

includes taxes & fees

7.2/10 Good! (1,000 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

£59

23 Dec - 24 Dec

includes taxes & fees

9/10 Wonderful! (1,001 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

£60

18 Dec - 19 Dec

includes taxes & fees

7.8/10 Good! (1,005 reviews)

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

£80

24 Dec - 25 Dec

includes taxes & fees

9.4/10 Exceptional! (1,000 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Fairfield Inn & Suites by Marriott Poplar Bluff

3109 Oak Grove Poplar Bluff MO

£87

4 Jan - 5 Jan 2026

includes taxes & fees

9.4/10 Exceptional! (854 reviews)

[](https://expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

## Hotels in Southeast Missouri with star rating

![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg)

4 Star Hotels

2 properties

[](https://expedia.co.uk/4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels)

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

53 properties

[](https://expedia.co.uk/3Star-Southeast-Missouri-Hotels.s30-0-d6058763.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

142 properties

[](https://expedia.co.uk/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels)

## Frequently asked questions

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Southeast Missouri hotel booking with Expedia?

### How much is the nightly rate at a Southeast Missouri hotel?

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- [Flights to Bonne Terre ](https://www.expedia.co.uk/Cheap-Flights-To-Bonne-Terre.d55598.Travel-Guide-Flights)
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- [Flights from Ellsinore ](https://www.expedia.co.uk/lp/flights/553248634983439149/flights-from-ellsinore)
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- [Visit Bonne Terre ](https://www.expedia.co.uk/Bonne-Terre.dx55598)
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- [Visit Lesterville ](https://www.expedia.co.uk/Lesterville.dx3000445174)
- [Visit Poplar Bluff ](https://www.expedia.co.uk/Poplar-Bluff.dx9449)
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- [Car hire Black ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Black.d3000444470.Car-Hire-Guide)
- [Rental cars Cape Girardeau Municipal airport ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Cape-Girardeau-Municipal.d6026978.Car-Hire-Guide)
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- [Car hire Tiff ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Tiff.d3000349564.Car-Hire-Guide)
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- [Doe Run Holiday Rentals ](https://www.expedia.co.uk/Doe-Run-Holiday-Rentals.d3000349343.Travel-Guide-HolidayRentals)
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- [Pilot Knob Holiday Rentals ](https://www.expedia.co.uk/Pilot-Knob-Holiday-Rentals.d3000008143.Travel-Guide-HolidayRentals)

- [Book Hotels in Southeast Missouri on Expedia.com ](https://www.expedia.com/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)

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