Find hotels in Southeast Missouri, MO from £46
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Check prices for these dates
Tonight
14 Sept - 15 SeptTomorrow
15 Sept - 16 SeptThis weekend
18 Sept - 20 SeptNext weekend
25 Sept - 27 SeptOur top choices for Southeast Missouri hotels
1. Madison Inn Lodge
Madison Inn LodgeFredericktown
Bawan
£71
includes taxes & fees
22 Sept - 23 Sept
2. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
Ronrecus
£111
includes taxes & fees
21 Sept - 22 Sept
3. Shepherd Mountain Inn
Shepherd Mountain InnIronton
Ryan
£100
includes taxes & fees
15 Sept - 16 Sept
4. Fort Davidson Hotel
Fort Davidson HotelIronton
richard
£101
includes taxes & fees
15 Sept - 16 Sept
5. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
JANEEN
£62
includes taxes & fees
17 Sept - 18 Sept
6. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
William
£63
includes taxes & fees
21 Sept - 22 Sept
7. Echo Bluff State Park
Echo Bluff State ParkEminence
Penny
£156
includes taxes & fees
15 Oct - 16 Oct
8. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
ILUNGA
£46
includes taxes & fees
28 Sept - 29 Sept
9. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Theresa
£77
includes taxes & fees
4 Oct - 5 Oct
10. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Sandra
£83
includes taxes & fees
20 Sept - 21 Sept
11. The Riverview
The RiverviewCape Girardeau
Alyssa
£86
includes taxes & fees
24 Sept - 25 Sept
12. Sam A Baker State Park
Sam A Baker State ParkPatterson
Charlie
£138
includes taxes & fees
15 Sept - 16 Sept
13. Hampton Inn & Suites By Hilton Festus
Hampton Inn & Suites By Hilton FestusFestus
Abram
£80
includes taxes & fees
8 Oct - 9 Oct
14. Black River Motel and Restaurant
Black River Motel and RestaurantLesterville
Douglas
£91
includes taxes & fees
15 Sept - 16 Sept
15. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Allen
£85
includes taxes & fees
20 Sept - 21 Sept
16. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Scott Andrew
£87
includes taxes & fees
18 Sept - 19 Sept
17. Quality Inn Farmington
Quality Inn FarmingtonFarmington
Desiree
£50
includes taxes & fees
11 Oct - 12 Oct
18. Holiday Inn Express & Suites Farmington by IHG
Holiday Inn Express & Suites Farmington by IHGFarmington
Shawn
£89
includes taxes & fees
20 Sept - 21 Sept
19. Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
Darlene
£75
includes taxes & fees
21 Sept - 22 Sept
20. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
Arsenia
£84
includes taxes & fees
4 Oct - 5 Oct
Holiday Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Holiday Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Cottage
Walk to Dtwn: Ironton Home in Historic District
Walk to Dtwn: Ironton Home in Historic DistrictIronton
"Clean and comfortable "
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
Cottage
Cottage w/ Yard, Walk to Historic Attractions
Cottage w/ Yard, Walk to Historic AttractionsSte Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Big Spring
9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forests and riverfront while you're in the area.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your time in Cape Girardeau? While in this family-friendly area, you can savour the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Very nice hotel we enjoyed everything"
Comfort Inn Festus - St Louis South
10/10 Excellent
"Check in was easy, the room was clean, price was good, and the breakfast was good."
Days Inn and Suites by Wyndham Sikeston
8/10 Good
"The room did not have an extra roll of toilet paper and also the hairdryer did not work. That was the only two things that was not. I was not happy with."
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"Great experience- food, cleanliness, friendly staff"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"This was the perfect stress free getaway. 10 minutes from a gas station and some fast food. 20 minutes from at least 2 cute towns and 3 wineries. It felt quiet without feeling isolated. The cabin was perfectly appointed with everything we needed, including firewood, starters, and lighters. We hope to go back!"
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"Excellent breakfast,friendly staff and clean rooms"
Fairfield Inn & Suites by Marriott Cape Girardeau
10/10 Excellent
"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."
Motel 6 Poplar Bluff, MO
10/10 Excellent
"Nice"
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
£46
28 Sept - 29 Sept
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
£56
16 Sept - 17 Sept
includes taxes & fees
7.2/10 Good! (1,002 reviews)
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
£60
20 Sept - 21 Sept
includes taxes & fees
9.2/10 Wonderful! (1,006 reviews)
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
£66
11 Oct - 12 Oct
includes taxes & fees
The Farmstead Hotel
778 E 3rd St Caruthersville MO
£72
28 Sept - 29 Sept
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
£85
20 Sept - 21 Sept
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Hotels in Southeast Missouri with star rating
4 Star Hotels
2 properties
3 Star Hotels
68 properties
2 Star Hotels
88 properties
Explore a world of travel with Expedia
- Rustic River Cabin Getaway
- B&B in Black
- Bloomsdale Suite at Baetje Farms
- Adults Only Resorts & in Cape Girardeau
- “Brickyard”
- The Riverview
- Tru By Hilton Cape Girardeau
- Doe Run Hotels
- Current River Cottage
- Doniphan Hotels
- Ellington Hotels
- Hogan’s Hideout Bonnie Manor
- Crown Pointe Lodge
- High Hope Tree House #1 @Spring Lake Ranch
- ❤️ THE MAGIC TIPI RETREAT
- Farmington Hotels
- Fredericktown Hotels
- Postcard Cabins St Francois
- Glen Allen Hotels
- Hotels near Johnson's Shut-ins State Park
- Junction City Hotels
- Black River Motel and Restaurant
- Gay-Friendly Hotels in Lesterville
- Wilderness Lodge
- Lithium Hotels
- Middle Brook Hotels
- New Offenburg Hotels
- Urban Lofts
- Dancing Under Red Skies Tree House @Spring Lake
- Potosi Hotels
- Dexter Inn
- Drury Plaza Hotel Cape Girardeau Conference Center
- Fairfield Inn & Suites by Marriott Sikeston
- Hampton Inn Sikeston
- The cabin in Eden
- Towneplace Suites by Marriott Sikeston
- Travel Inn & Suites
- Sikeston Hotels
- Hotels with Connecting Rooms in Southeast Missouri
- Pet-Friendly Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Hotels near Southeast Missouri State University
- Peaceful 4BR ranch w/ hot tub
- Silo Farm Haus
- 1/4 Mile To The Boat Launch & Beach 2 miles the Camp! Free WiFi
- Winona Hotels
- Flights to Bonne Terre
- Flights to Cape Girardeau
- Flights to Desloge
- Flights to Park Hills
- Flights to Wappapello
- Flights from Cape Girardeau Municipal
- Flights from Ste Genevieve
- Flights from Black
- Flights from Lesterville
- Flights from Dexter
- Flights from Viburnum
- Flights from Bonne Terre
- Flights from Arcadia
- Flights from London (LHR) to Cape Girardeau (CGI)
