Find hotels in Southeast Missouri, MO from £42

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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,003 reviews)
"Nice place to stay"
United States
Lance
The price is £94
includes taxes & fees
5 May - 6 May
Drury Inn & Suites Sikeston, MO

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (893 reviews)
"Staff is Great , Room very clean and well stocked ."
United States
joan
The price is £91
includes taxes & fees
4 May - 5 May
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (177 reviews)
"Nice room, good breakfast "
United States
KENNETH
The price is £77
includes taxes & fees
28 May - 29 May
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,003 reviews)
"Hotel was nice and staff was quite helpful!"
United States
Linda
The price is £83
includes taxes & fees
21 May - 22 May
Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,004 reviews)
"Hotel is in a convenient central area. Was clean and staff was friendly."
United States
Michael
The price is £87
includes taxes & fees
17 May - 18 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (829 reviews)
"The breakfast was great."
United States
Carolyn
The price is £77
includes taxes & fees
31 May - 1 Jun
Hampton Inn Poplar Bluff

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (755 reviews)
"Property was easily accessible and very clean!!"
United States
Denise
The price is £78
includes taxes & fees
3 May - 4 May
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (552 reviews)
"Perfect nights stay!! "
United States
Amanda
The price is £85
includes taxes & fees
17 May - 18 May
Hampton Inn Sikeston

Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.4 out of 10, Very good, (989 reviews)
"Enjoyed our stay "
United States
Cynthia
The price is £59
includes taxes & fees
19 May - 20 May
Super 8 by Wyndham Perryville

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (348 reviews)
"Room was clean and near the handicap ramp. Staff was very helpful. "
United States
Kandy
The price is £76
includes taxes & fees
3 May - 4 May
Honeysuckle Inn - Mountain View

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,000 reviews)
"Most catering to people staying there than any other properties we have stayed on our trip."
United States
Ruth
The price is £68
includes taxes & fees
21 May - 22 May
Drury Inn & Suites Jackson MO

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (561 reviews)
"I ALWAYS stay here when I come to Cape! Wonderful, great place!"
United States
Audra
The price is £99
includes taxes & fees
28 May - 29 May
The Riverview

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (74 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
The price is £92
includes taxes & fees
14 May - 15 May
Fairfield Inn & Suites by Marriott Sikeston

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very good, (972 reviews)
"Staff was super nice! "
United States
Youpeng
The price is £78
includes taxes & fees
6 May - 7 May
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
Festus
9.4 out of 10, Exceptional, (724 reviews)
"Clean, friendly and breakfast was well stocked "
United States
Jason
The price is £108
includes taxes & fees
3 May - 4 May
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (543 reviews)
"Such a wonderful hotel! I highly recommend staying here. I’ve been there multiple times and I’ve never once been disappointed. "
United States
Alexus
The price is £79
includes taxes & fees
3 May - 4 May
The Farmstead Hotel

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (122 reviews)
"This is a clean, quiet, well designed hotel."
United States
Kendra
The price is £82
includes taxes & fees
13 May - 14 May
Tru By Hilton Cape Girardeau

EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.6 out of 10, Exceptional, (89 reviews)
"Great place to stay! Nostalgic dining connected to hotel is pretty cool. If nearby, for sure stay with them."
United States
Jacob
The price is £68
includes taxes & fees
12 May - 13 May
EC Reed's Mercantile and Hotel

Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very good, (639 reviews)
"Friendly staff"
United States
Faith
The price is £49
includes taxes & fees
10 May - 11 May
Super 8 by Wyndham Farmington

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (612 reviews)
"Excellent staff and location was nice and quiet "
United States
Colleen
The price is £88
includes taxes & fees
24 May - 25 May
Crown Pointe Lodge, BW Signature Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Holiday Rentals in Southeast Missouri

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Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

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Open Photo by Bill Dillard

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