Name: Hampton Inn Sikeston
Price range: £81
Rating: 9

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

1. Shepherd Mountain Inn

Ironton

Jonathan

includes taxes & fees

2 Nov - 3 Nov

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

2. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

includes taxes & fees

9 Nov - 10 Nov

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

3. Super 8 by Wyndham Farmington

Farmington

Marisa

includes taxes & fees

9 Nov - 10 Nov

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

4. Fort Davidson Hotel

Ironton

richard

includes taxes & fees

31 Oct - 1 Nov

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

5. Hampton Inn & Suites By Hilton Festus

Festus

Misty

includes taxes & fees

15 Nov - 16 Nov

A motel with a covered entrance, a flag, and a phone number.

6. Madison Inn Lodge

Fredericktown

Bawan

includes taxes & fees

2 Nov - 3 Nov

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

7. Hampton Inn Farmington

Farmington

Charlie

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a reception desk, seating area, and large windows.

8. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

includes taxes & fees

13 Nov - 14 Nov

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

9. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

includes taxes & fees

31 Oct - 1 Nov

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

10. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

includes taxes & fees

29 Nov - 30 Nov

A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

11. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

Jose

includes taxes & fees

30 Nov - 1 Dec

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

12. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Chris

includes taxes & fees

1 Nov - 2 Nov

A living room with a blue wall, a fireplace, a sofa, and a chair.

13. EC Reed's Mercantile and Hotel

Marble Hill

Jan

includes taxes & fees

30 Nov - 1 Dec

A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

14. Motel 6 Poplar Bluff, MO

Poplar Bluff

Jim

includes taxes & fees

13 Nov - 14 Nov

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

15. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, two bedside tables, a nightstand, and a framed picture on the wall.

16. Quality Inn Farmington

Farmington

Tracy

includes taxes & fees

9 Nov - 10 Nov

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

17. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

18. Drury Inn & Suites Jackson MO

Jackson

Lyn

includes taxes & fees

15 Nov - 16 Nov

A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

19. Super 8 By Wyndham Marston

Marston

Wendy

includes taxes & fees

1 Nov - 2 Nov

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

20. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Terry

includes taxes & fees

15 Nov - 16 Nov

View all properties

Holiday Rentals in Southeast Missouri

Cabin

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Holiday Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A log cabin with a glass door leading to an outdoor patio, a grill, and a table with chairs.

Peaceful 2-cabin Property: 1 Mi to Current River!

Van Buren

"We had the best time. We had plenty of room for our families that were in town for a wedding. The rental had everything we needed."

Cottage

A bedroom with a bed, nightstand, lamp, and curtains.

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Hampton Inn Poplar Bluff

10/10 Excellent

"Clean room; comfortable bed Staff was helpful & we got a bagged breakfast when we left - we missed the breakfast time"

Silo Farm Haus- located in the heart of wine country!

10/10 Excellent

"The photos don't do this place justice, it's absolutely stunning inside and out. It was so peaceful, with such beautiful scenery. I got to enjoy my morning coffee on the porch swing and watch the sun rise over the hills. Inside was very clean, and I absolutely LOVED all of the decor! It was the perfect weekend getaway for just the two of us. 10/10 will be back again!!"