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Top 10 Southeast Missouri hotels and places to stay

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (23)
"Had a wonderful time"
The price is £100
includes taxes & fees
3 Aug - 4 Aug
Postcard Cabins St. Francois

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (396)
"Great stay!"
The price is £64
includes taxes & fees
4 Aug - 5 Aug
The Farmstead Hotel

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very good, (569)
"Loved it and will be back again. "
The price is £51
includes taxes & fees
14 Aug - 15 Aug
Super 8 by Wyndham Farmington

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
"We had a last minute reservation here. The staff was very pleasant, helpful and wonderful overall!!"
The price is £72
includes taxes & fees
14 Aug - 15 Aug
Drury Inn & Suites Jackson MO

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (493)
"Super nice staff. Our room smelled so nice and clean. Breakfast was very good too! "
The price is £95
includes taxes & fees
23 Aug - 24 Aug
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
9.4 out of 10, Exceptional, (659)
"Valid to stay at "
The price is £102
includes taxes & fees
10 Aug - 11 Aug
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Super 8 by Wyndham Perryville

2.0 star property
8.4 out of 10, Very good, (885)
"Very clean and rooms might have been renovated last year. "
The price is £61
includes taxes & fees
17 Aug - 18 Aug
Super 8 by Wyndham Perryville

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1001)
"We enjoyed the quick check in and how quiet the property was. "
The price is £59
includes taxes & fees
14 Aug - 15 Aug
Pear Tree Inn Cape Girardeau West

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great stay!"
The price is £81
includes taxes & fees
28 Aug - 29 Aug
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (965)
"Love the property. Staff is always amazing."
The price is £76
includes taxes & fees
14 Aug - 15 Aug
Drury Inn & Suites Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
8.8 out of 10, Excellent, (586)
"This was a great hotel at a great price!"
The price is £64
includes taxes & fees
1 Sept - 2 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1002)
"Excellent place to stay "
The price is £59
includes taxes & fees
7 Aug - 8 Aug
Pear Tree Inn Cape Girardeau Near the Medical Center

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very good, (1006)
"Fair prices and nice staff well taken care ofby the Baymont family "
The price is £48
includes taxes & fees
14 Aug - 15 Aug
Baymont Inn and Suites by Wyndham Farmington, MO

Festus Inn

2.0 star property
5.0 out of 10, (18)
"Quiet property and near plenty of restaurants. Would definitely stay here again. "
The price is £78
includes taxes & fees
13 Aug - 14 Aug
Festus Inn

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1004)
"Great place to stay. "
The price is £88
includes taxes & fees
17 Aug - 18 Aug
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Comfort Inn Festus - St Louis South

2.5 star property
8.0 out of 10, Very good, (846)
"Great Front Desk and easy check in "
The price is £68
includes taxes & fees
1 Sept - 2 Sept
Comfort Inn Festus - St Louis South

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (369)
"A very cool destination!"
The price is £90
includes taxes & fees
3 Aug - 4 Aug
The Riverview

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1003)
"The staff was very friendly and the hotel was very clean!"
The price is £87
includes taxes & fees
14 Aug - 15 Aug
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Will stay again"
The price is £78
includes taxes & fees
1 Sept - 2 Sept
Drury Inn & Suites Sikeston, MO

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3.0 star property
8.0 out of 10, Very good, (826)
"I was very pleased with our stay here. "
The price is £94
includes taxes & fees
31 Aug - 1 Sept
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:15 Aug - 17 Aug
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Accommodation near Southeast Missouri attractions

Southeast Missouri State University

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

Century Casino Caruthersville

Century Casino Caruthersville

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews

Frequently asked questions

Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Southeast Missouri hotel for you.
How can I save on a Southeast Missouri hotel booking with Expedia?
Members always get our best prices. Find our best Southeast Missouri hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Southeast Missouri hotel?
Prices for hotels in Southeast Missouri often vary, but you can find a great deal from £48 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.