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Top 10 Hotels in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Free cancellationReserve now, pay when you stay
£85
per night
17 Dec-18 Dec
4.8/5Exceptional! (376 reviews)

"Hotel was noisy..could hear the people in the room next door"…"

Reviewed on 29 Nov 2019

Drury Plaza Hotel Cape Girardeau Conference Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
Free cancellationReserve now, pay when you stay
£54
per night
17 Dec-18 Dec
4.2/5Excellent! (855 reviews)

"The staff was very friendly.. the room was very nice and clean.. it was close to the hospital that my grandpa was in.. it is a great location close to lots of restaurants and shopping.."…"

Reviewed on 9 Dec 2019

Pear Tree Inn Cape Girardeau Near the Medical Center
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Sikeston, MO
Free cancellationReserve now, pay when you stay
£73
per night
3 Jan-4 Jan
4.6/5Exceptional! (690 reviews)

"We were received so kindly by the receptionist, she was very helpful and welcoming!"…"

Reviewed on 6 Dec 2019

Drury Inn & Suites Sikeston, MO
Pear Tree Inn - Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Free cancellationReserve now, pay when you stay
£61
per night
18 Dec-19 Dec
4.5/5Wonderful! (765 reviews)

"Exceptionally clean rooms and common areas. Excellent breakfast, free drinks and snacks in the evening."…"

Reviewed on 2 Dec 2019

Pear Tree Inn - Sikeston
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Free cancellationReserve now, pay when you stay
£54
per night
17 Dec-18 Dec
4.3/5Excellent! (551 reviews)

"Nice place to stay. We stay here often. Great staff."…"

Reviewed on 4 Dec 2019

Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Free cancellationReserve now, pay when you stay
£73
per night
29 Dec-30 Dec
4.6/5Exceptional! (335 reviews)

"Close to great shopping. Staff is always very friendly. We have stayed here multiple times. Best breakfast of any hotel."…"

Reviewed on 25 Nov 2019

Drury Inn & Suites Cape Girardeau
Courtyard by Marriott Cape Girardeau Downtown
3 out of 5
400 Broadway St., Cape Girardeau, MO
Free cancellationReserve now, pay when you stay
£79
per night
5 Jan-6 Jan
4.7/5Exceptional! (48 reviews)

"Hotel is an historic downtown treasure. The Cape is one of the USAs best kept secrets."…"

Reviewed on 12 Oct 2019

Courtyard by Marriott Cape Girardeau Downtown
Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 out of 5
3109 Oak Grove, Poplar Bluff, MO
Free cancellationReserve now, pay when you stay
£72
per night
26 Dec-27 Dec
4.7/5Exceptional! (88 reviews)

"Clean. Friendly. Beds were comfortable. Location was great."…"

Reviewed on 2 Dec 2019

Fairfield Inn & Suites by Marriott Poplar Bluff
Drury Inn & Suites Jackson MO
3 out of 5
225 Drury Lane, Jackson, MO
Free cancellationReserve now, pay when you stay
£65
per night
17 Dec-18 Dec
4.7/5Exceptional! (488 reviews)

"We always love Drury hotels with their kickback service and breakfast. The pool was really nice as well. The only thing off was a small insignificant thing. The fabric shower curtain liner smelled a bit sour like it hadnt been left open to dry. Not a big deal."…"

Reviewed on 18 Nov 2019

Drury Inn & Suites Jackson MO
Hampton Inn Poplar Bluff Mo
2.5 out of 5
2420 Crestwood Dr, Poplar Bluff, MO
Free cancellationReserve now, pay when you stay
£77
per night
19 Dec-20 Dec
4.6/5Exceptional! (243 reviews)

"Great location and a very quiet place rest. Will be back again."…"

Reviewed on 2 Dec 2019

Hampton Inn Poplar Bluff Mo
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Visiting Southeast Missouri

Families will find kid-friendly activities in Southeast Missouri, and visitors give high marks for the top-notch restaurants. Tourists who journey to this welcoming city can discover its wineries, riverfront and university setting. Top sights in the city include Isle Casino Cape Girardeau, Ozark National Scenic Riverways and Lady Luck Casino.

  • There are 139 hotels and other accommodation options in Southeast Missouri
  • The closest major airport is in Cape Girardeau, MO (CGI-Cape Girardeau Municipal), 47.4 mi (76.3 km) from the city centre

Sightseeing and Staying in Southeast Missouri

Cultural venues in the city include Sikeston Depot Museum, Margaret Harwell Art Museum and Mo-Ark Regional Railroad Museum. Families come for attractions such as Lazy L Safari Park, Cape Girardeau Conservation Nature Center and Cape Splash Family Aquatic Center. The city is notable for landmarks like Fort Davidson State Historic Site, The Heritage House and National Shrine of Our Lady of the Miraculous Medal.

In Poplar Bluff, you'll find 139 hotels and other accommodation choices so you can easily organise your perfect retreat at an affordable rate. Here are top ones based on Expedia user reviews:

Other favourite sights in Southeast Missouri include Isle Casino Cape Girardeau, Ozark National Scenic Riverways and Lady Luck Casino.

Getting around Southeast Missouri

To venture out into the surrounding area, ride one of the trains from Arcadia Valley Station or Poplar Bluff Station. Southeast Missouri might not have many public transport choices so consider renting a car to explore the city.

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Southeast Missouri Hotel Reviews

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