Photo by Bill Dillard
Find hotels in Southeast Missouri, MO from £42
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Our top choices for Southeast Missouri hotels
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,003 reviews)
"Nice place to stay"
Lance
The price is £94
includes taxes & fees
5 May - 6 May
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (893 reviews)
"Staff is Great , Room very clean and well stocked ."
joan
The price is £91
includes taxes & fees
4 May - 5 May
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (177 reviews)
"Nice room, good breakfast "
KENNETH
The price is £77
includes taxes & fees
28 May - 29 May
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,003 reviews)
"Hotel was nice and staff was quite helpful!"
Linda
The price is £83
includes taxes & fees
21 May - 22 May
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,004 reviews)
"Hotel is in a convenient central area. Was clean and staff was friendly."
Michael
The price is £87
includes taxes & fees
17 May - 18 May
Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (829 reviews)
"The breakfast was great."
Carolyn
The price is £77
includes taxes & fees
31 May - 1 Jun
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (755 reviews)
"Property was easily accessible and very clean!!"
Denise
The price is £78
includes taxes & fees
3 May - 4 May
Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (552 reviews)
"Perfect nights stay!! "
Amanda
The price is £85
includes taxes & fees
17 May - 18 May
Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (989 reviews)
"Enjoyed our stay "
Cynthia
The price is £59
includes taxes & fees
19 May - 20 May
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (348 reviews)
"Room was clean and near the handicap ramp. Staff was very helpful. "
Kandy
The price is £76
includes taxes & fees
3 May - 4 May
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,000 reviews)
"Most catering to people staying there than any other properties we have stayed on our trip."
Ruth
The price is £68
includes taxes & fees
21 May - 22 May
The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (561 reviews)
"I ALWAYS stay here when I come to Cape! Wonderful, great place!"
Audra
The price is £99
includes taxes & fees
28 May - 29 May
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (74 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
Angela
The price is £92
includes taxes & fees
14 May - 15 May
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very good, (972 reviews)
"Staff was super nice! "
Youpeng
The price is £78
includes taxes & fees
6 May - 7 May
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHGFestus
9.4 out of 10, Exceptional, (724 reviews)
"Clean, friendly and breakfast was well stocked "
Jason
The price is £108
includes taxes & fees
3 May - 4 May
The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (543 reviews)
"Such a wonderful hotel! I highly recommend staying here. I’ve been there multiple times and I’ve never once been disappointed. "
Alexus
The price is £79
includes taxes & fees
3 May - 4 May
Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (122 reviews)
"This is a clean, quiet, well designed hotel."
Kendra
The price is £82
includes taxes & fees
13 May - 14 May
EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
9.6 out of 10, Exceptional, (89 reviews)
"Great place to stay! Nostalgic dining connected to hotel is pretty cool. If nearby, for sure stay with them."
Jacob
The price is £68
includes taxes & fees
12 May - 13 May
Super 8 by Wyndham Farmington
Super 8 by Wyndham FarmingtonFarmington
8.0 out of 10, Very good, (639 reviews)
"Friendly staff"
Faith
The price is £49
includes taxes & fees
10 May - 11 May
Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (612 reviews)
"Excellent staff and location was nice and quiet
"
Colleen
The price is £88
includes taxes & fees
24 May - 25 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Southeast Missouri
Cabin
10.0 out of 10, Exceptional, (2 reviews)
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Stay near popular Southeast Missouri attractions
Learn more about Southeast Missouri
Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Drury Inn & Suites Cape Girardeau
10/10 Excellent
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is £50 per night from 31 May to 1 Jun
£50
31 May - 1 Jun
includes taxes & fees
8/10 Very Good! (1,005 reviews)
Hotels in Southeast Missouri with star rating
4 Star Hotels
2 properties
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- Allenville Hotels
- Annapolis Hotels
- Arcadia Hotels
- Belleview Hotels
- Bismarck Hotels
- B&B in Black
- Black Hotels
- Caledonia Hotels
- Centerville Hotels
- Desloge Hotels
- Doe Run Hotels
- Ellington Hotels
- Farmington Hotels
- Flat River Hotels
- Fredericktown Hotels
- Friedheim Hotels
- Glen Allen Hotels
- Ironton Hotels
- Hotels near Johnson's Shut-ins State Park
- Junction City Hotels
- Leadwood Hotels
- Gay-Friendly Hotels in Lesterville
- Lesterville Hotels
- Marble Hill Hotels
- Marquand Hotels
- Middle Brook Hotels
- Park Hills Hotels
- Piedmont Hotels
- Pilot Knob Hotels
- Gay-Friendly Hotels in Poplar Bluff
- Sedgewickville Hotels
- Wappapello Hotels
- Williamsville Hotels
- Flights to Bonne Terre
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