Compare and book 4 Star hotels in Southeast Missouri, Missouri

    price find illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri 4 Star Hotels

Top Southeast Missouri 4 Star Hotels

Urban Lofts
Street view

Urban Lofts

4.0 star property
Urban Lofts
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
To book a 4-star hotel in Southeast Missouri that matches your budget, take advantage of Expedia's handy search filters. Browse the available options during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest stay first.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Treat yourself to refined living during your Southeast Missouri holiday by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities, including complimentary bathrobes, large beds and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and memorable one. 24-hour front desk, on-site spas and gourmet dining are a few of the superior services and conveniences you'll likely have access to.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Enjoy a stress-free holiday experience where everything is included in the upfront price by using our "All inclusive" filter. Budgeting is easy when your room, meals and many activities are already taken care of. Eager for more ideas? Check out the amazing deals on Expedia's standard 4-star hotels in and around Southeast Missouri too.