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Compare and book 4 Star hotels in Southeast Missouri, Missouri

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Check availability on Southeast Missouri 4 Star Hotels

Tonight
11 Sept - 12 Sept
Tomorrow
12 Sept - 13 Sept
This weekend
11 Sept - 13 Sept
Next weekend
18 Sept - 20 Sept

Our top choices for Southeast Missouri 4-star hotels

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

1. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
£88
includes taxes & fees
16 Sept - 17 Sept
The Riverview
A wooden staircase with a metal handrail against a brick wall.

2. Urban Lofts

Urban Lofts
Perryville
Urban Lofts
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Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

The Riverview

The Riverview

10/10 Excellent
"Very clean They need a fitness center !"
John 1-night trip
Posted 2 days ago
The Riverview

Find out more about Southeast Missouri

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Southeast Missouri?
To book a 4-star hotel in Southeast Missouri that matches your budget, take advantage of Expedia's handy search filters. Browse the available options during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest stay first.
  • Search for the lowest price from £88
What's the difference between 5-star and 4-star hotels in Southeast Missouri?
Treat yourself to refined living during your Southeast Missouri holiday by choosing a 4-star hotel. As well as featuring upmarket surroundings, these retreats are typically packed with amenities, including complimentary bathrobes, large beds and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and memorable one. 24-hour front desk, on-site spas and gourmet dining are a few of the superior services and conveniences you'll likely have access to.
Does Southeast Missouri have any 4-star all-inclusive resorts?
Enjoy a stress-free holiday experience where everything is included in the upfront price by using our "All inclusive" filter. Budgeting is easy when your room, meals and many activities are already taken care of. Eager for more ideas? Check out the amazing deals on Expedia's standard 4-star hotels in and around Southeast Missouri too.

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