Title: Holiday Rentals Southeast Missouri from £87: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [24 Apr - 26 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [22 May - 24 May](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [19 Jun - 21 Jun](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeast Missouri holiday rentals ![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/d4a93b47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/ebca14b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/61c8f623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/72fc0b4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.co.uk/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) French Village 9.8/10 Exceptional (54 reviews) "I had a great time with my mom there!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lily £87 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/7a5cb69e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/a7c4cf22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/51a8f2fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room dining](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/ba998441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Johnson's Shut-ins State Park [](https://www.expedia.co.uk/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information) Middle Brook 10/10 Exceptional (1 review) "These newer cabins are clean and have everything you need. Highly recommend! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelly £197 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/8557dc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/cbaecd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 1 bedroom](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/e3c698b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tiny Houses of French Village [](https://www.expedia.co.uk/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information) French Village 10/10 Exceptional (3 reviews) "Charming property with a space for everything and everything in its place. Would not hesitate to recommend or stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Norma [](https://www.expedia.co.uk/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information) ![Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/8010cd32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/2ec33dcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/586044dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urban Lofts [](https://www.expedia.co.uk/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information) Perryville 9.2/10 Wonderful (17 reviews) "Great place to stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric [](https://www.expedia.co.uk/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/1c1368ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/0b3aaea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/b8327ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Twisted Sassafras Treehouse [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) Cape Girardeau 10/10 Exceptional (31 reviews) "This is the perfect private romantic getaway! We had such a blast here. Definitely recommend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric S. £231 includes taxes & fees 9 Mar - 10 Mar [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/5c70b8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/1467ce2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/55281df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/74000000/73280000/73274700/73274691/a85f19dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 82 Acre Hobby Farm with Lincoln Log Cabin [](https://www.expedia.co.uk/De-Soto-Hotels-82-Acre-Hobby-Farm-With-Lincoln-Log-Cabin.h73274691.Hotel-Information) De Soto 10/10 Exceptional (41 reviews) "The cabin was wonderful with many extras like snacks and coffee." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janna B. £205 includes taxes & fees 7 Mar - 8 Mar [](https://www.expedia.co.uk/De-Soto-Hotels-82-Acre-Hobby-Farm-With-Lincoln-Log-Cabin.h73274691.Hotel-Information) ![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/0053b39a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ec7dbabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ce5a77d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sam A Baker State Park [](https://www.expedia.co.uk/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) Patterson 9.0/10 Wonderful (6 reviews) "Pet friendly, great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlie £106 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) ![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/2c8cc497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/3619a392.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/bb974ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gorgeous 1856 Log Cabin, Completely Renovated [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information) Jackson 10/10 Exceptional (3 reviews) "incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chandler G. £227 includes taxes & fees 11 Mar - 12 Mar [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/a97a55c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/d33a9d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/6a739ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information) Cape Girardeau 8.8/10 Excellent (39 reviews) "Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Emily D. £161 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/049919f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/eed3215e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/831297c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/6a3fe9ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### #ContemplationCabin on the Jacks Fork River! [](https://www.expedia.co.uk/Contemplationcabin-On-The-Jacks-Fork-River.h59955709.Hotel-Information) Summersville 10/10 Exceptional (76 reviews) "The cabin was beautiful and perfectly maintained. Our weekend stay was relaxing and memorable — everything was clean, comfortable, and thoughtfully managed. We’re already looking forward to returning in every season!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathia L. £254 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Contemplationcabin-On-The-Jacks-Fork-River.h59955709.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/0e13dd89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serenity South -- Gardens, River-Views, and Refreshing Space [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) Cape Girardeau 10/10 Exceptional (151 reviews) "Such a great place and location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy H. £184 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/a08b65d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/w907h683x60y0-f986d826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/w695h683x165y0-d0f50453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/w507h683x259y0-84bc4b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### "Little Brick House on Main (1865)” [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Little-Brick-House.h88996203.Hotel-Information) Ste. Genevieve 10/10 Exceptional (67 reviews) "Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lettitia B. £121 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Little-Brick-House.h88996203.Hotel-Information) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/125000000/124440000/124436100/124436034/7dd99b60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/125000000/124440000/124436100/124436034/ea9019ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/125000000/124440000/124436100/124436034/ff6283e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/125000000/124440000/124436100/124436034/4dcb58df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walk to Current River: Ozarks Adventure Home! [](https://www.expedia.co.uk/Van-Buren-Hotels-Walk-To-Current-River-Ozarks-Adventure-Home.h124436034.Hotel-Information) Van Buren £261 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Van-Buren-Hotels-Walk-To-Current-River-Ozarks-Adventure-Home.h124436034.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/d2b33581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Games room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/f1c736a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, table football](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (8 reviews) "Nice place, great times" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jace W. £321 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/40000000/39180000/39172700/39172650/28a74f04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/40000000/39180000/39172700/39172650/6bcb8110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/40000000/39180000/39172700/39172650/b30aa081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, travel cot, WiFi](https://images.trvl-media.com/lodging/40000000/39180000/39172700/39172650/9def0a49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Upstairs 2 bedroom Private Apt Off I- 55 in Pevely [](https://www.expedia.co.uk/Pevely-Hotels-Cozy-Beautiful-View-Upstairs-2-Bedrm-1-Bath-Apartment-Off-I-55-In-Gobbler-Hollow.h39172650.Hotel-Information) Pevely 9.6/10 Exceptional (11 reviews) "We had a peaceful, quiet stay while visiting family in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Caren L. £195 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Pevely-Hotels-Cozy-Beautiful-View-Upstairs-2-Bedrm-1-Bath-Apartment-Off-I-55-In-Gobbler-Hollow.h39172650.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/109000000/108070000/108062000/108061955/6d6d2646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108070000/108062000/108061955/64bfbb18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/109000000/108070000/108062000/108061955/68b3043d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/109000000/108070000/108062000/108061955/96e452f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Living Waters Estates, Elegant 3 BR Home with kids area, hot tub, sleeps 12 [](https://www.expedia.co.uk/Van-Buren-Hotels-Living-Waters-Estates.h108061955.Hotel-Information) Van Buren 10/10 Exceptional (12 reviews) "Wonderful stay. Good location. Very enjoyable experience." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas H. £415 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Van-Buren-Hotels-Living-Waters-Estates.h108061955.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/d086ec00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/be129fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/473f1a90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/107000000/106410000/106408100/106408017/8e6dee64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### "The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC [](https://www.expedia.co.uk/Farmington-Hotels-The-Hideaway-2-Charming-2-Bedroom-House-In-Delightful-Farmington-With-WiFi.h106408017.Hotel-Information) Farmington 10/10 Exceptional (8 reviews) "It is a very nice place and very comfortable has everything you could possibly need for homeaway from home." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott £175 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Farmington-Hotels-The-Hideaway-2-Charming-2-Bedroom-House-In-Delightful-Farmington-With-WiFi.h106408017.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/fab7488b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player, video library](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/17e1434d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/17bc755f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/81907571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful Modern Loft In Wine Country! [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Beautiful-Modern-Loft-In-Wine-Country.h23139432.Hotel-Information) Ste. Genevieve 10/10 Exceptional (272 reviews) "It was the perfect spot for a weekend getaway!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brittany P. £136 includes taxes & fees 27 Feb - 28 Feb [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Beautiful-Modern-Loft-In-Wine-Country.h23139432.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/96000000/95900000/95897400/95897321/927547da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/96000000/95900000/95897400/95897321/cd1d16c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95900000/95897400/95897321/6f52d18e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95900000/95897400/95897321/f98bd05c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gorgeous large rental home in Lesterville MO just minutes from Blackwater River. [](https://www.expedia.co.uk/Lesterville-Hotels-Gorgeous-Large-Rental-Home-In-Lesterville-MO-Just-Minutes-From-Blackwater-River.h95897321.Hotel-Information) Lesterville 9.2/10 Wonderful (17 reviews) "Great house and location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas M. £367 includes taxes & fees 26 Feb - 27 Feb [](https://www.expedia.co.uk/Lesterville-Hotels-Gorgeous-Large-Rental-Home-In-Lesterville-MO-Just-Minutes-From-Blackwater-River.h95897321.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90321800/90321706/96030d4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/91000000/90330000/90321800/90321706/537b4e3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90330000/90321800/90321706/14c66769.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90330000/90321800/90321706/685cd7dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rustic cabin on 80 acres with access to hiking and ATV trails. [](https://www.expedia.co.uk/Potosi-Hotels-Rustic-Cabin-On-80-Acres-With-Access-To-Hiking-And-ATV-Trails.h90321706.Hotel-Information) Potosi 10/10 Exceptional (8 reviews) "Our second stay at this house, that should speak for itself. This is a quiet area and the house offers a great place to stay in a rural area yet close to a small town. Owner is helpful with great communication." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martin B. £267 includes taxes & fees 27 Feb - 28 Feb [](https://www.expedia.co.uk/Potosi-Hotels-Rustic-Cabin-On-80-Acres-With-Access-To-Hiking-And-ATV-Trails.h90321706.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12®ionId=6058763&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=VR_SPRING_PROMO_6058763) ## Find holiday rentals that suit your style Cabins [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=CABIN) Cottages [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=COTTAGE) Aparthotels [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=APART_HOTEL) Apartments [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=APARTMENT) Condos [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=CONDO) Villas [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=VILLA) Private holiday homes [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=VACATION_HOME) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals) ## Top Southeast Missouri Hotel Reviews ## Find out more about Southeast Missouri **Everything you need to know about** **Southeast Missouri** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Southeast Missouri holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in . Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southeast Missouri holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in. The selection of Southeast Missouri holiday rentals we have selected for you start as low as £87 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Southeast Missouri rentals** At Expedia, we put the best Southeast Missouri holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.co.uk - All accommodation types in Southeast Missouri ### Trending destinations on Expedia.co.uk - [Holiday Rentals in the Cotswold ](https://www.expedia.co.uk/lp/b/vr/cotswold) - [Holiday Rentals in Lake District ](https://www.expedia.co.uk/lp/b/vr/lake-district) - [Devon Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Devon.d6046196.Holiday-Rental-Destinations) - [Norfolk Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Norfolk.d6046223.Holiday-Rental-Destinations) - [Bedfordshire Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Bedfordshire.d6046189.Holiday-Rental-Destinations) - [Dorset Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Dorset.d6046198.Holiday-Rental-Destinations) - [Northumberland Holiday Rentals ](https://www.expedia.com/Destinations-In-Northumberland.d6046225.Vacation-Rental-Destinations) - 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[Northern Ireland Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Northern-Ireland.d11221.Holiday-Rental-Destinations) - [Holiday Homes in Southeast Missouri ](https://expedia.co.uk/Southeast-Missouri-Private-Holiday-Homes.d6058763-aaPrivateHolidayHomes.Travel-Guide-Accommodation) - [Cabin Rentals in Southeast Missouri ](https://expedia.co.uk/Southeast-Missouri-Cabins.d6058763-aaCabins.Travel-Guide-Accommodation) - [Cottages in Southeast Missouri ](https://expedia.co.uk/Southeast-Missouri-Cottages.d6058763-aaCottages.Travel-Guide-Accommodation) - [Apartments in Southeast Missouri ](https://expedia.co.uk/Southeast-Missouri-Apartments.d6058763-aaApartments.Travel-Guide-Accommodation) - [Motels in Southeast Missouri ](https://expedia.co.uk/Southeast-Missouri-Motels.d6058763-aaMotels.Travel-Guide-Accommodation) - [Farmstay in Southeast Missouri ](https://expedia.co.uk/Southeast-Missouri-Agritourism.d6058763-aaAgritourism.Travel-Guide-Accommodation) - [Lodges in Southeast Missouri ](https://expedia.co.uk/Southeast-Missouri-Lodges.d6058763-aaLodges.Travel-Guide-Accommodation) - 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[Flights to ACK](https://expedia.co.uk/Cheap-Flights-To-Marthas-Vineyard.d6047691.Travel-Guide-Flights) - [Flights to ORF](https://expedia.co.uk/Cheap-Flights-To-Outer-Banks.d602135.Travel-Guide-Flights) - [Flights to ACK](https://expedia.co.uk/Cheap-Flights-To-Nantucket-Island.d6047676.Travel-Guide-Flights) - [Flights to KOA](https://expedia.co.uk/Cheap-Flights-To-Hawaii-Island.d180074.Travel-Guide-Flights) - [Flights to NYC](https://expedia.co.uk/Cheap-Flights-To-Long-Island.d602887.Travel-Guide-Flights) Cars - [convertible Car Hire near Route 66 State Park](https://expedia.co.uk/Convertible-Car-Rentals-In-Route-66-State-Park.d6292976-tConvertible.Car-Rental-Guide-Class) - [Car rental in Kansas City](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Kansas-City-Intl.d4801357.Car-Hire-Guide) Activities - [Things to do in South Florida](https://expedia.co.uk/Things-To-Do-In-South-Florida.d6233792.Travel-Guide-Activities) - [Things to do in Long Island](https://expedia.co.uk/Things-To-Do-In-Long-Island.d602887.Travel-Guide-Activities) Packages - [Aspen Snowmass City Breaks](https://expedia.co.uk/Aspen-Snowmass.d553248621593965848.Holidays-City-Breaks) - [Cape Cod City Breaks](https://expedia.co.uk/Cape-Cod.d180061.Holidays-City-Breaks) - [Magic House - St. Louis Children's Museum](https://expedia.co.uk/Magic-House-St-Louis-Childrens-Museum-St-Louis.d6191631.Attraction) - [Maui City Breaks](https://expedia.co.uk/Maui.d180073.Holidays-City-Breaks) - [St. Charles City Breaks](https://expedia.co.uk/St-Charles.d9786.Holidays-City-Breaks) - [Silver Dollar City](https://expedia.co.uk/Silver-Dollar-City-Branson-West.d6064111.Attraction) - [Vaile Mansion](https://expedia.co.uk/Vaile-Mansion-Kansas-City.d6323538.Attraction) - [Hamptons City Breaks](https://expedia.co.uk/Hamptons.d6056452.Holidays-City-Breaks) General - [Visit Downtown Kansas City](https://expedia.co.uk/Kansas-City-Downtown-Kansas-City.dx6058828) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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