Title: Holiday Rentals Southeast Missouri from £80: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard # Search Holiday Rentals in Southeast Missouri - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-12&endDate=2025-12-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-01-23&endDate=2026-01-25&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-02-20&endDate=2026-02-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [20 Mar - 22 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Holiday Rentals in Southeast Missouri ![Exterior](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/54dccacb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/1072ccd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/16fef5e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/79000000/78390000/78382600/78382544/f713c817.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Leadwood 9.6/10 Exceptional (21) "it was a nice cozy stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alvaro £122 includes taxes & fees 26 Nov - 27 Nov [](https://www.expedia.co.uk/Park-Hills-Hotels-Couples-Retreat-With-Hot-Tub.h78382544.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113880000/113879200/113879109/df663fcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/114000000/113880000/113879200/113879109/f41c0202.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/114000000/113880000/113879200/113879109/7b3fcea3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/114000000/113880000/113879200/113879109/e64cef9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in New Offenburg 10/10 Exceptional (4) "Relaxing setting between Farmington and St Genevieve. Both towns are rich in history and have small town charm. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim M. £234 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Peaceful-3-Bedroom-House-With-WiFi-And-AC-In-Lovely-New-Offenburg.h113879109.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/ed5a3737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/725f800a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Cape Girardeau 10/10 Exceptional (26) "The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary C. £235 includes taxes & fees 8 Dec - 9 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/67000000/66890000/66883200/66883194/283ae672.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/67000000/66890000/66883200/66883194/c213727d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/67000000/66890000/66883200/66883194/8cdda898.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/67000000/66890000/66883200/66883194/59b1b1e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Fredericktown 10/10 Exceptional (76) "This was my second visit and am planning to return again someday. Very quiet and cozy. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) eric y. [](https://www.expedia.co.uk/Fredericktown-Hotels-Micro-House-Cabin-Located-Near-Silver-Mines-Recreation-Area.h66883194.Hotel-Information) ![1 bedroom, iron/ironing board, bed sheets](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/86d734a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/08a1bdfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/81907571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/f03e39eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Ste. Genevieve 10/10 Exceptional (270) "Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elsie H. £140 includes taxes & fees 28 Nov - 29 Nov [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Beautiful-Modern-Loft-In-Wine-Country.h23139432.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/9f1b48ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/5aaf2aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/w1170h1560x0y486-7708b776.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/w1170h1560x0y486-717b3c8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Ste. Genevieve 10/10 Exceptional (54) "Great place. Close to everything you need for a great stay in St. Genevieve. Easy check and great host." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Justin S. £209 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Doves-Nest-Guest-Housebr-Tranquil-Relaxing.h67135817.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/570788ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/b46c570c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/eed3215e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/60000000/59960000/59955800/59955709/831297c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Summersville 10/10 Exceptional (70) "Wanted an escape before starting back to school for the fall and this was exactly what we got. Easy communication with owner and got quick response. Beautiful and quiet property! Great spot on the river!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erin A. £265 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Contemplationcabin-On-The-Jacks-Fork-River.h59955709.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/93328db2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/07bdf180_edited_b214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/w525h683x259y0-930fe938.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, Hulu, streaming services](https://images.trvl-media.com/lodging/89000000/89000000/88996300/88996203/w507h683x259y0-c8068718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Ste. Genevieve 10/10 Exceptional (62) "Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lettitia B. £124 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Little-Brick-House.h88996203.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/0fce9903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin | 1 bedroom, desk](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Williamsville 10/10 Exceptional (1) "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dyann £111 includes taxes & fees 27 Nov - 28 Nov [](https://www.expedia.co.uk/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/w1525h2000x0y0-3cce06ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/b1b7b87a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/9c2435e1_edited_6d62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/d4816ff1_edited_0721.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cottage in Eminence 9.2/10 Wonderful (15) "Amazing cottage! Great location for a float trip or to explore the Ozark sites. Check-in was easy, host was very accommodating, house was clean and cozy. We will definitely be back for a peaceful getaway! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Betsy S. [](https://www.expedia.co.uk/Eminence-Hotels-Springside-Cottage-In-Pleasant-Eminence-Great-Outdoor-Space-Large-Yard.h111491747.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1020h683x4y0-fa4cb879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/67a4ab9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1024h480x0y101-641c723e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, DVD player, books, video library](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1024h455x0y114-14a42b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Birch Tree 9.6/10 Exceptional (25) "Really awesome!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melinda R. [](https://www.expedia.co.uk/Birch-Tree-Hotels-Collier-Cabin-In-Pine-Hollow-Eminence.h104123411.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/17fd79b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/89b52c31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/d8535e58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/e90509fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apartment in Cape Girardeau 9.6/10 Exceptional (44) "This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jordan S. £109 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/1e8bea93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau 8.6/10 Excellent (48) "Some issues with check-in. Very nice area. Lot of history." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey M. £80 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/b002a425.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/1e923d10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/66471bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/c93cba87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Cape Girardeau 10/10 Exceptional (27) "Great property and a super host! He was super helpful and always willing to help with any questions we had. Would definitely rent here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark M. [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Remodeled-1920s-Dutch-Colonial-Revival-In-Downtown-Cape-Girardeau.h76544096.Hotel-Information) ![Beach](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/0cb5c163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/w1024h570x0y57-17016e83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/w1024h570x0y56-1ec5791d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/101000000/100470000/100465300/100465272/w1024h570x0y57-36b84305.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Home in Farmington 10/10 Exceptional (36) "Beautiful piece of property. Would stay here again and again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary N. [](https://www.expedia.co.uk/Farmington-Hotels-Your-Home-Away-From-Home-In-Downtown.h100465272.Hotel-Information) ![Cabin | 5 bedrooms](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin | 5 bedrooms](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/8921c844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin | 5 bedrooms](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c7addad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Patterson 9.2/10 Wonderful (5) "Pet friendly, great staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlie £101 includes taxes & fees 3 Dec - 4 Dec [](https://www.expedia.co.uk/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/07947c99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/7ff68b98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/1cdd6e88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/2ef177bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Eminence 9.2/10 Wonderful (10) "Great little cabin, roads to cabin not the best but worth it!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pam [](https://www.expedia.co.uk/Eminence-Hotels-Fox-Pen-CabinsLitl-RedCabin-2Not-Friendly-For-Street-BikesPet-Friendly.h72655210.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/92000000/91610000/91604100/91604045/92213a4a_edited_27e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/92000000/91610000/91604100/91604045/a2104458.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/92000000/91610000/91604100/91604045/b26f87a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/92000000/91610000/91604100/91604045/988779b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Van Buren 9.4/10 Exceptional (8) "We stay here a couple times a year. In the summer to float the river and in the winter to be near relatives for the holidays. Great experience in both seasons. Very close to the river, gas, and grocery. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelie L. [](https://www.expedia.co.uk/Van-Buren-Hotels-Cozy-Cabin-On-The-Edge-Of-Town-Only-12-Mile-From-Current-River.h91604045.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/2fc67c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/93347520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/b5064413.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/1c2b5527.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Leadwood 9.6/10 Exceptional (37) "Just what we expected. Very quiet and secluded. Close to towns. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cheyenne F. £122 includes taxes & fees 27 Nov - 28 Nov [](https://www.expedia.co.uk/Park-Hills-Hotels-Relax-And-Enjoy-The-Privacy.h73469992.Hotel-Information) ![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/117000000/116190000/116182100/116182073/71b80ec6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/117000000/116190000/116182100/116182073/0e9bc366.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/117000000/116190000/116182100/116182073/edf8f0ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/117000000/116190000/116182100/116182073/bf250f0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villa in Eminence 9.6/10 Exceptional (5) "The space was exactly as described. We were there for a few days. The host was great. Just a few miles from town, and super quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandon J. [](https://www.expedia.co.uk/Eminence-Hotels-Charming-Bunk-House-Suite-In-Eminence-With-ACHeat.h116182073.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-09&endDate=2025-12-10®ionId=6058763&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=VR_BF_PROMO_6058763) ## Find holiday rentals that suit your style Cabins [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-02-23&d1=2026-02-23&endDate=2026-02-26&d2=2026-02-26&lodging=CABIN) Cottages [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-02-23&d1=2026-02-23&endDate=2026-02-26&d2=2026-02-26&lodging=COTTAGE) Aparthotels [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-02-23&d1=2026-02-23&endDate=2026-02-26&d2=2026-02-26&lodging=APART_HOTEL) Apartments [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-02-23&d1=2026-02-23&endDate=2026-02-26&d2=2026-02-26&lodging=APARTMENT) Condos [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-02-23&d1=2026-02-23&endDate=2026-02-26&d2=2026-02-26&lodging=CONDO) Private holiday homes [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-02-23&d1=2026-02-23&endDate=2026-02-26&d2=2026-02-26&lodging=VACATION_HOME) Villas [](https://www.expedia.co.uk/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-02-23&d1=2026-02-23&endDate=2026-02-26&d2=2026-02-26&lodging=VILLA) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals) ## Top Southeast Missouri Hotel Reviews ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Modern up to date facilities " [](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Breakfast and super Kickoff was AWESOME? love this hotel!!!" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "I did not stay for breakfast, but I did have a hot dinner that was excellent. I will recommend and stay at Drury Inn's the next time I travel." [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg) ### Fairfield Inn & Suites by Marriott Poplar Bluff 10/10 Excellent "Everything was extremely clean, staff were very helpful and courteous, and the price was good. I would definitely recommend this motel." [](https://expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg) ### The Farmstead Hotel 10/10 Excellent "No issues" [](https://expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "Great staff. Great prices. Beautiful specious rooms. Great all round loved it" [](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Everything was great. " [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "Great room, close to downtown, awesome food options in the venue as well. Really nice views of the river." [](https://expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Holiday Inn Poplar Bluff by IHG](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7_y.jpg) ### Holiday Inn Poplar Bluff by IHG 10/10 Excellent "Very spacious suite, awesome staff! " [](https://expedia.co.uk/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ## Find out more about Southeast Missouri **Everything you need to know about** **Southeast Missouri** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.  **Southeast Missouri holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in .  Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southeast Missouri holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Southeast Missouri holiday rentals we have selected for you start as low as £80 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Southeast Missouri rentals** At Expedia, we put the best Southeast Missouri holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.  To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.  ## Explore a world of travel with Expedia - Trending destinations on Expedia.co.uk - All accommodation types in Southeast Missouri ### Trending destinations on Expedia.co.uk - [Holiday Rentals in the Cotswold](https://www.expedia.co.uk/lp/b/vr/cotswold) - [Holiday Rentals in Lake District](https://www.expedia.co.uk/lp/b/vr/lake-district) - [Devon Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Devon.d6046196.Holiday-Rental-Destinations) - [Norfolk Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Norfolk.d6046223.Holiday-Rental-Destinations) - [Bedfordshire Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Bedfordshire.d6046189.Holiday-Rental-Destinations) - [Dorset Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Dorset.d6046198.Holiday-Rental-Destinations) - [Northumberland Holiday Rentals](https://www.expedia.com/Destinations-In-Northumberland.d6046225.Vacation-Rental-Destinations) - 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[Outer Banks Holidays](https://expedia.co.uk/Outer-Banks.d602135.Holidays-City-Breaks) - [Anna Maria Island Holidays](https://expedia.co.uk/Anna-Maria-Island.d553248622847118534.Holidays-City-Breaks) - [Cape Cod Holidays](https://expedia.co.uk/Cape-Cod.d180061.Holidays-City-Breaks) - [Magic House - St. Louis Children's Museum](https://expedia.co.uk/Magic-House-St-Louis-Childrens-Museum-St-Louis.d6191631.Attraction) - [Maui Holidays](https://expedia.co.uk/Maui.d180073.Holidays-City-Breaks) - [Hamptons Holidays](https://expedia.co.uk/Hamptons.d6056452.Holidays-City-Breaks) - [Niagara Falls - Western New York Holidays](https://expedia.co.uk/Niagara-Falls-Western-New-York.d6056506.Holidays-City-Breaks) General - [Visit Southeast Florida](https://expedia.co.uk/Southeast-Florida.dx6047949) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)