Title: Holiday Rentals Southeast Missouri from £79: Find Short-Term Rentals & Holiday Accommodations | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Holiday Rentals in Southeast Missouri ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [11 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-11&endDate=2025-10-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-12&endDate=2025-10-13&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-17&endDate=2025-10-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-24&endDate=2025-10-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Holiday Rentals in Southeast Missouri ![Exterior](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/94cc7abb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/4e65fabc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/77123b3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1860000/1858600/1858536/e3a8a6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG De Soto 9.4/10 Exceptional (153) "Enjoyed our short stay, will definitely be back. " [](https://www.expedia.co.uk/Farmington-Hotels-Holiday-Inn-Club-Vacations-Timber-Creek-Resort.h1858536.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/c5548b67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/f7c063b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/1360d6ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/96000000/95130000/95124200/95124119/315251e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Treehouse and Hot Tub on 10acres - Pet Friendly! Dittmer 9.2/10 Wonderful (11) "It is a good place to spend a pleasant time in peace and with a lot of tranquility. " [](https://www.expedia.co.uk/Treehouse-And-Hot-Tub-On-10acres-Pet-Friendly.h95124119.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/c347e331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/5869d4ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/5cb6ee33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119320000/119310900/119310813/358bd3b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 2 bedroom cabin on a beautiful private lake. Ironton 10/10 Exceptional (10) £148 includes taxes & fees 15 Oct - 16 Oct [](https://www.expedia.co.uk/Arcadia-Hotels-Charming-2-Bedroom-Cabin-On-A-Beautiful-Private-Lake.h119310813.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/w1525h2000x0y0-3cce06ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/b1b7b87a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/9c2435e1_edited_6d62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111500000/111491800/111491747/d4816ff1_edited_0721.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Springside Cottage in beautiful Eminence. Great outdoor space - NEW Hot tub! Eminence 9.8/10 Exceptional (12) "My family (kids 17, 16, and 7 years old plus husband and I) stayed at Springside Cottage Monday through Friday and had a wonderful little vacation. The location is perfect and the cottage was very comfortable. The host was super responsive and kind. Would stay again!" £181 includes taxes & fees 13 Oct - 14 Oct [](https://www.expedia.co.uk/Eminence-Hotels-Springside-Cottage-In-Pleasant-Eminence-Great-Outdoor-Space-Large-Yard.h111491747.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/97025525.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/b308ae25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/3eecb893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91610000/91606600/91606513/33230034.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kings Cabin on the edge of town only 1/2 mile from Current River ! Van Buren 9.6/10 Exceptional (24) "Very nice cabin! Better than staying at a hotel, at near the same price." [](https://www.expedia.co.uk/Van-Buren-Hotels-Cozy-Cabin-On-The-Edge-Of-Town-Only-12-Mile-From-Current-River.h91606513.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/2fc67c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/1c2b5527.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, computer monitors](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/54de2de2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/74000000/73470000/73470000/73469992/b5064413.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin 1 at the Pallet Factory Leadwood 9.6/10 Exceptional (33) "Excellent will stay again!" £133 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/Park-Hills-Hotels-Relax-And-Enjoy-The-Privacy.h73469992.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/ed5a3737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Twisted Sassafras Treehouse Cape Girardeau 10/10 Exceptional (24) "Charming little treehouse. We wanted a private little getaway that was still semi close and it was perfect. The hot tub, the outdoor set up, the two person shower. Would highly recommend. " £251 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/b82525ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/3ab0bd80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/42ba85f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/90000000/89990000/89989800/89989748/12b9dbcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Secluded cabin on private property De Soto 10/10 Exceptional (58) "Beautiful quiet setting nice property " [](https://www.expedia.co.uk/De-Soto-Hotels-Secluded-Cabin-On-Private-Property.h89989748.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/07947c99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/a0e3b3dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/7ff68b98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/73000000/72660000/72655300/72655210/1cdd6e88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fox Pen Cabins Cabin #2 Not friendly for street bikes… Pet-Friendly Eminence 10/10 Exceptional (7) "Great little cabin, roads to cabin not the best but worth it!" [](https://www.expedia.co.uk/Eminence-Hotels-Fox-Pen-CabinsLitl-RedCabin-2Not-Friendly-For-Street-BikesPet-Friendly.h72655210.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/1e8bea93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Little Blue Cottage on Spanish Cape Girardeau 8.6/10 Excellent (43) "We enjoy every time we stay here . We have stayed her many times. There is some repairs that need to be done . Also I think there needs to be a better way to cook besides a microwave. " £79 includes taxes & fees 15 Oct - 16 Oct [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/88708082.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/c7ba1671.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/cb3420c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/115000000/114610000/114607400/114607335/9ea8abbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### “The Cabin”@ Serenity Ranch. Centrally located to all the wonders of Shannon co. Winona 10/10 Exceptional (12) "Had a great time. Loved the privacy and all the stocked kitchen amenities. AC was cold. That shower was amazing. Quiet retreat in proximity to Rocky Falls and our float trip on Jack's Fork! " [](https://www.expedia.co.uk/Winona-Hotels-Charming-3-Bedroom-Cabin-With-Wi-Fi.h114607335.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/29617056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/ec557893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/c59bcf0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serenity South -- Gardens, River-Views, and Refreshing Space Cape Girardeau 10/10 Exceptional (142) "Beautiful house. Great stay. Would definitely stay again!" £188 includes taxes & fees 15 Oct - 16 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/b0450c68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/dc4e06f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, travel cot, WiFi](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/be9ee859.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace](https://images.trvl-media.com/lodging/107000000/106850000/106848100/106848020/555e828a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clifford's Country Cottage Bonne Terre 10/10 Exceptional (21) "Great place to stayLove the interiorPerfect set up for what we needed" £117 includes taxes & fees 15 Oct - 16 Oct [](https://www.expedia.co.uk/Bonne-Terre-Hotels-Cliffords-Country-Cottage.h106848020.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1020h683x4y0-fa4cb879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1014h683x5y0-c3534739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, DVD player, books, video library](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/w1024h455x0y114-14a42b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104130000/104123500/104123411/67a4ab9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Collier Cabin in Pine Hollow ~ Eminence, MO Birch Tree 9.8/10 Exceptional (20) "Best host’s around and a very private peaceful cabin. Everything about this place is great. Second time staying there and I will definitely be back!" [](https://www.expedia.co.uk/Birch-Tree-Hotels-Collier-Cabin-In-Pine-Hollow-Eminence.h104123411.Hotel-Information) ![Smart TV, fireplace, video library](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/f948f069.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/e2783694.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/a5241d57_edited_a6c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/115000000/114970000/114966400/114966382/d70c1885_edited_c93b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful 3-bedrm , 3.5 ba Log/Stone in Eminence MO. Will sleep up to 16 guests. Eminence 9.8/10 Exceptional (7) "Great place to gather family for float trips" [](https://www.expedia.co.uk/Eminence-Hotels-Beautiful-3-Bedrm.h114966382.Hotel-Information) ![Cabin | 5 bedrooms](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c09183cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin | 5 bedrooms](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ec7dbabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin | 5 bedrooms](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin | 5 bedrooms](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/8921c844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sam A Baker State Park Patterson 9.2/10 Wonderful (5) "Pet friendly, great staff. " £99 includes taxes & fees 20 Oct - 21 Oct [](https://www.expedia.co.uk/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin | 1 bedroom, desk](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/a0649327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/4b3fbea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Wappapello Williamsville 10/10 Exceptional (1) "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." £109 includes taxes & fees 24 Oct - 25 Oct [](https://www.expedia.co.uk/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/a741342a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/d7c38180.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/bd987570.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/113000000/112720000/112715000/112714993/bbdc94ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Linkin: a cozy mountain cabin w/ king bed Ironton 10/10 Exceptional (8) "Stayed two nights and me and the fiance couldn't have been happier. Plenty of things to do in a small area, with just as many good places to eat. Everything was spot on at the cabin. A previous night guest did bust the top of the bottom side hot plate but we wanted to eat out as much as we could do it didn't effect our stay. " £226 includes taxes & fees 14 Oct - 15 Oct [](https://www.expedia.co.uk/Ironton-Hotels-The-Linkin-A-Cozy-Mountain-Cabin-W-King-Bed.h112714993.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/15c37025.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/8e499cec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/1f8cdae2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/67000000/66200000/66199100/66199066/7f2cfbe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Secluded Ozarks Bunk House Cabin at Old Desperado Ranch Eminence 10/10 Exceptional (54) "Property was beautiful, very secluded and relaxing. Property owners were very friendly hand helpful. Would definitely visit again. " [](https://www.expedia.co.uk/Eminence-Hotels-Secluded-Ozarks-Bunk-House-Cabin-At-Old-Desperado-Ranch.h66199066.Hotel-Information) ![1 bedroom, iron/ironing board, bed sheets](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/86d734a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/f03e39eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/81907571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, DVD player, video library](https://images.trvl-media.com/lodging/24000000/23140000/23139500/23139432/17e1434d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful Modern Loft In Wine Country! Ste. Genevieve 10/10 Exceptional (265) "Beautiful loft on beautiful property!" £137 includes taxes & fees 21 Oct - 22 Oct [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Beautiful-Modern-Loft-In-Wine-Country.h23139432.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=6058763&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals) ## Top Southeast Missouri Hotel Reviews ![Courtyard by Marriott Cape Girardeau Downtown](//images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da_y.jpg) ### Courtyard by Marriott Cape Girardeau Downtown 10/10 Excellent "Clean room. " [](https://expedia.co.uk/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](//images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Close to the interstate so easy to get to when traveling. Nice property - plus that Outback Steakhouse is right next door for dining. We have stayed here numerous times over the years and always pleased. " [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Best Western Plus Sikeston](//images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Room was clean and relaxing." [](https://expedia.co.uk/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Motel 6 Poplar Bluff, MO](//images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Property was very clean, staff wa very friendly. And room was perfect!" [](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Baymont Inn and Suites by Wyndham Farmington, MO](//images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 10/10 Excellent "It was very nice. There was a problem with me being charge 2 times but that was fix right away" [](https://expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Clean, well maintained." [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![The Riverview](//images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "The rooms are always amazing! When we go in its always so nice and cool. Loved having a k-cup in my room again. This is my favorite place in cape. My only complaint would be no microwave in the room for snacks and things. " [](https://expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "The lady that checked me in was amazing!" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Drury Inn & Suites Jackson MO](//images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "Love to stay at any Drury. They do things right. Most friendly guest service staff around." [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ## Find out more about Southeast Missouri **Everything you need to know about** **Southeast Missouri** **holiday rentals** Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Southeast Missouri holiday rental for you. At Expedia, you can take your pick from private holiday homes, [apartments](https://www.expedia.co.uk/aa/Apartments), cottages, [apart-hotels](https://www.expedia.co.uk/aa/ApartHotels), cabins, [villas](https://www.expedia.co.uk/aa/Villas)... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southeast Missouri holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.  **Southeast Missouri holiday rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Southeast Missouri. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in .  Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southeast Missouri holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Southeast Missouri holiday rentals we have selected for you start as low as £79 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on Southeast Missouri rentals** At Expedia, we put the best Southeast Missouri holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.  To find some top Southeast Missouri rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southeast Missouri holiday. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southeast Missouri. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.  ## Explore a world of travel with Expedia - Trending destinations on Expedia.co.uk - All accommodation types in Southeast Missouri ### Trending destinations on Expedia.co.uk - [Holiday Rentals in the Cotswold](https://www.expedia.co.uk/lp/b/vr/cotswold) - [Holiday Rentals in Lake District](https://www.expedia.co.uk/lp/b/vr/lake-district) - [Devon Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Devon.d6046196.Holiday-Rental-Destinations) - [Norfolk Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Norfolk.d6046223.Holiday-Rental-Destinations) - [Bedfordshire Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Bedfordshire.d6046189.Holiday-Rental-Destinations) - [Dorset Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Dorset.d6046198.Holiday-Rental-Destinations) - [Northumberland Holiday Rentals](https://www.expedia.com/Destinations-In-Northumberland.d6046225.Vacation-Rental-Destinations) - [Herefordshire Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Herefordshire.d6046203.Holiday-Rental-Destinations) - [Essex Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Essex.d6046201.Holiday-Rental-Destinations) - [Cumbria Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Cumbria.d6046194.Holiday-Rental-Destinations) - [Yorkshire Holiday Rentals](https://www.expedia.co.uk/Yorkshire-Holiday-Rentals.d6342462.Travel-Guide-HolidayRentals) - [South Wales Holiday Rentals](https://www.expedia.co.uk/South-Wales-Holiday-Rentals.d6054274.Travel-Guide-HolidayRentals) - [North Wales Holiday Rentals](https://www.expedia.co.uk/North-Wales-Holiday-Rentals.d6054276.Travel-Guide-HolidayRentals) - [London Holiday Rentals](https://www.expedia.co.uk/London-Holiday-Rentals.d178279.Travel-Guide-HolidayRentals) - [York Holiday Rentals](https://www.expedia.co.uk/York-Holiday-Rentals.d5489.Travel-Guide-HolidayRentals) - [Blackpool Holiday Rentals](https://www.expedia.co.uk/Blackpool-Holiday-Rentals.d619.Travel-Guide-HolidayRentals) - 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[Northern Ireland Holiday Rentals](https://www.expedia.co.uk/Destinations-In-Northern-Ireland.d11221.Holiday-Rental-Destinations) - [Holiday Homes in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Private-Holiday-Homes.d6058763-aaPrivateHolidayHomes.Travel-Guide-Accommodation) - [Cabin Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Cabins.d6058763-aaCabins.Travel-Guide-Accommodation) - [Cottages in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Cottages.d6058763-aaCottages.Travel-Guide-Accommodation) - [Apartments in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Apartments.d6058763-aaApartments.Travel-Guide-Accommodation) - [Motels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Motels.d6058763-aaMotels.Travel-Guide-Accommodation) - [Farmstay in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Agritourism.d6058763-aaAgritourism.Travel-Guide-Accommodation) - [Caravan Parks in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Caravan-Parks.d6058763-aaCaravanParks.Travel-Guide-Accommodation) - [Lodges in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Lodges.d6058763-aaLodges.Travel-Guide-Accommodation) - [Serviced Apartments in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Apart-Hotels.d6058763-aaApartHotels.Travel-Guide-Accommodation) - [Condo Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Condos.d6058763-aaCondos.Travel-Guide-Accommodation) - [B&B in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Bed-And-Breakfasts.d6058763-aaBedAndBreakfasts.Travel-Guide-Accommodation) - [Villas in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Villas.d6058763-aaVillas.Travel-Guide-Accommodation) ### Expedia's Latest Trends Hotels - [Anna Maria Island Accommodation](https://expedia.co.uk/Anna-Maria-Island-Hotels.d553248622847118534.Travel-Guide-Hotels) - [Maui Accommodation](https://expedia.co.uk/Maui-Hotels.d180073.Travel-Guide-Hotels) - [Cape Cod Accommodation](https://expedia.co.uk/Cape-Cod-Hotels.d180061.Travel-Guide-Hotels) - [Martha's Vineyard Accommodation](https://expedia.co.uk/Marthas-Vineyard-Hotels.d6047691.Travel-Guide-Hotels) - [Hamptons Accommodation](https://expedia.co.uk/Hamptons-Hotels.d6056452.Travel-Guide-Hotels) Flights - [Flights to PHF](https://expedia.co.uk/Cheap-Flights-To-Norfolk-Virginia-Beach.d602904.Travel-Guide-Flights) - [Flights to VPS](https://expedia.co.uk/Cheap-Flights-To-Fort-Walton-Beach-Destin.d6023392.Travel-Guide-Flights) - [Flights to LIH](https://expedia.co.uk/Cheap-Flights-To-Kauai.d180075.Travel-Guide-Flights) - [Flights to OGG](https://expedia.co.uk/Cheap-Flights-To-Maui.d180073.Travel-Guide-Flights) - [Flights to ACK](https://expedia.co.uk/Cheap-Flights-To-Marthas-Vineyard.d6047691.Travel-Guide-Flights) - [Flights to ORF](https://expedia.co.uk/Cheap-Flights-To-Outer-Banks.d602135.Travel-Guide-Flights) - [Flights to ACK](https://expedia.co.uk/Cheap-Flights-To-Nantucket-Island.d6047676.Travel-Guide-Flights) - [Flights to PVC](https://expedia.co.uk/Cheap-Flights-To-Cape-Cod.d180061.Travel-Guide-Flights) - [Flights to AVX](https://expedia.co.uk/Cheap-Flights-To-Catalina-Island.d6192.Travel-Guide-Flights) - [Flights to KOA](https://expedia.co.uk/Cheap-Flights-To-Hawaii-Island.d180074.Travel-Guide-Flights) - [Flights to NYC](https://expedia.co.uk/Cheap-Flights-To-Long-Island.d602887.Travel-Guide-Flights) Cars - [Car rental in Maui](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Maui.d180073.Car-Hire-Guide) - [Car rental in Oahu](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Oahu.d180077.Car-Hire-Guide) - [Car rental in Kauai](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Kauai.d180075.Car-Hire-Guide) Activities - [Things to do in South Florida](https://expedia.co.uk/Things-To-Do-In-South-Florida.d6233792.Travel-Guide-Activities) Packages - [Aspen Snowmass City Breaks](https://expedia.co.uk/Aspen-Snowmass.d553248621593965848.Holidays-City-Breaks) - [Martha's Vineyard City Breaks](https://expedia.co.uk/Marthas-Vineyard.d6047691.Holidays-City-Breaks) - [Outer Banks City Breaks](https://expedia.co.uk/Outer-Banks.d602135.Holidays-City-Breaks) - [Anna Maria Island City Breaks](https://expedia.co.uk/Anna-Maria-Island.d553248622847118534.Holidays-City-Breaks) - [Cape Cod City Breaks](https://expedia.co.uk/Cape-Cod.d180061.Holidays-City-Breaks) - [Magic House - St. Louis Children's Museum](https://expedia.co.uk/Magic-House-St-Louis-Childrens-Museum-St-Louis.d6191631.Attraction) - [Maui City Breaks](https://expedia.co.uk/Maui.d180073.Holidays-City-Breaks) - [Hamptons City Breaks](https://expedia.co.uk/Hamptons.d6056452.Holidays-City-Breaks) - [Niagara Falls - Western New York City Breaks](https://expedia.co.uk/Niagara-Falls-Western-New-York.d6056506.Holidays-City-Breaks) General - [Visit Southeast Florida](https://expedia.co.uk/Southeast-Florida.dx6047949) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)