Title: Cheap Car Hire in Southeast Missouri, USA - Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/148078/1ef720df-0786-4e45-8a4f-890d982b757b.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Southeast Missouri, USA ## Search and Compare from Car Companies in Southeast Missouri Photo by JG Morris ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Southeast Missouri \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people Southeast Missouri, Missouri, USA ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Southeast%20Missouri,%20Missouri,%20United%20States%20of%20America&dpln=6058763&date1=04/01/2026&date2=06/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people Southeast Missouri, Missouri, USA ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Southeast%20Missouri,%20Missouri,%20United%20States%20of%20America&dpln=6058763&date1=04/01/2026&date2=06/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people Southeast Missouri, Missouri, USA ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Southeast%20Missouri,%20Missouri,%20United%20States%20of%20America&dpln=6058763&date1=04/01/2026&date2=06/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people Southeast Missouri, Missouri, USA ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Southeast%20Missouri,%20Missouri,%20United%20States%20of%20America&dpln=6058763&date1=04/01/2026&date2=06/01/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car hire in Southeast Missouri [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Southeast%20Missouri,%20Missouri,%20United%20States%20of%20America&dpln=6058763&date1=04/01/2026&date2=06/01/2026&crfrr=defaultFlex&SearchType=Place) ## Frequently asked questions ### What happens if I need to cancel my Southeast Missouri car reservation? ### What types of cars can I rent in Southeast Missouri? ### How do I find the best car hire deals in Southeast Missouri with Expedia? ### How old do you have to be to rent a car in Southeast Missouri? ### What do you need to rent a car in Southeast Missouri? ### Can I hire a car for a month or longer in Southeast Missouri? ### Where can I find a Southeast Missouri hire car if I am younger than 25? ### Why should I rent a Southeast Missouri car with Expedia? ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) | ## Explore a world of travel with Expedia - 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[Williamsville Hotels ](https://www.expedia.co.uk/Williamsville-Hotels.d553248634983506457.Travel-Guide-Hotels) - [Flights to Bonne Terre ](https://www.expedia.co.uk/Cheap-Flights-To-Bonne-Terre.d55598.Travel-Guide-Flights) - [Flights to Desloge ](https://www.expedia.co.uk/Cheap-Flights-To-Desloge.d55671.Travel-Guide-Flights) - [Flights to Park Hills ](https://www.expedia.co.uk/Cheap-Flights-To-Park-Hills.d183485.Travel-Guide-Flights) - [Flights to Wappapello ](https://www.expedia.co.uk/Cheap-Flights-To-Wappapello.d183505.Travel-Guide-Flights) - [Flights from Park Hills ](https://www.expedia.co.uk/lp/flights/183485/flights-from-park-hills) - [Flights from Pilot Knob ](https://www.expedia.co.uk/lp/flights/3000008143/flights-from-pilot-knob) - [Flights from Doe Run ](https://www.expedia.co.uk/lp/flights/3000349343/flights-from-doe-run) - [Flights from Black ](https://www.expedia.co.uk/lp/flights/3000444470/flights-from-black) - [Flights from Lesterville ](https://www.expedia.co.uk/lp/flights/3000445174/flights-from-lesterville) - 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[Doe Run Holiday Rentals ](https://www.expedia.co.uk/Doe-Run-Holiday-Rentals.d3000349343.Travel-Guide-HolidayRentals) - [Lesterville Holiday Rentals ](https://www.expedia.co.uk/Lesterville-Holiday-Rentals.d3000445174.Travel-Guide-HolidayRentals) - [Pilot Knob Holiday Rentals ](https://www.expedia.co.uk/Pilot-Knob-Holiday-Rentals.d3000008143.Travel-Guide-HolidayRentals) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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