Title: The 10 Best 2 Star Hotels in Southeast Missouri - 2025 Updated Prices | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 2 Star hotels in Southeast Missouri, Missouri - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri 2 Star Hotels Tonight [8 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-08&endDate=2025-11-09&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [9 Nov - 10 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-09&endDate=2025-11-10&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [14 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-14&endDate=2025-11-16&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [21 Nov - 23 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-21&endDate=2025-11-23&adults=2&star=20&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Missouri 2 Star Hotels ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/7e9b49ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | 1 bedroom, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/23ae42af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Building design](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/f4d876e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont Inn and Suites by Wyndham Farmington, MO Farmington 8.0/10 Very good (1001) "The room was clean and the staff, as always were very courteous!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven £47 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![1 bedroom, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/5e8a3e29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn and Suites by Wyndham Sikeston Sikeston 7.2/10 Good (1003) "A great stay in every aspect. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gertrude £54 includes taxes & fees 11 Nov - 12 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchenette](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/476a2a56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/58027ab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Poplar Bluff, MO Poplar Bluff 8.0/10 Very good (1001) "Check in was smooth and facilities are excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hector £63 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/35f08a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Farmstead Hotel Caruthersville 8.8/10 Excellent (441) "Excellent hotel. Very clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Don £74 includes taxes & fees 18 Nov - 19 Nov [](https://www.expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/99ef8265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/d71a605c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Poplar Bluff Poplar Bluff 9.4/10 Exceptional (833) "The staff was so friendly and professional. The hotel is very nice, the room was wxcellwnt, with comfortable beds. The breakfast was excellent. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alex £91 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/3ea7ebcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/70be7941.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/705e1bff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/fc42ec39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Festus - St Louis South Festus 7.8/10 Good (898) "Good stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charlotte £71 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/4ea3df4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/2df4267b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/da4fe5e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau Near the Medical Center Cape Girardeau 9.0/10 Wonderful (1001) "Always enjoy our stay. Staff is very friendly, especially at breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul £60 includes taxes & fees 13 Nov - 14 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/a8b491ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/686f0126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston Sikeston 9.0/10 Wonderful (419) "Nice property and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy £82 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/f6482ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/5904f90a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed, Non Smoking, Kitchenette | Hypo-allergenic bedding, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/25677988.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Poplar Bluff Poplar Bluff 9.4/10 Exceptional (782) "Excellent property, great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina £83 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/c6e7fccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG Perryville 9.2/10 Wonderful (526) "Clean room and pleasant staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David £83 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily English breakfast ](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/e034ecf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/dc836bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking | Egyptian cotton sheets, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/9a57fa49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cape Girardeau 7.2/10 Good (664) "nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandon £54 includes taxes & fees 9 Dec - 10 Dec [](https://www.expedia.co.uk/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/a085469e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/284f2de7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/032aa313.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West Cape Girardeau 9.0/10 Wonderful (1004) "Staff were great and courteous! Room was clean and comfy. Would stay again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronda £60 includes taxes & fees 13 Nov - 14 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, pool loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast ](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Cape Girardeau 9.4/10 Exceptional (1003) "Clean and welcoming. Tyler at the front desk for check in was engaging and friendly. He’s a gem!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Penny £85 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/b92f19d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/8874e729.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Sikeston Sikeston 8.4/10 Very good (1019) "Very convenient and great breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Duwaine £73 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/4de18ac4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/cc0ef67f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-sized fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/e322869e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Cape Girardeau by IHG Cape Girardeau 8.0/10 Very good (867) "Great staff and convenient location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greg £70 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/1db8fd06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, rollaway beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/bac18eb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/774fe752.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/80000/79500/79403/68b10c10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Poplar Bluff North Poplar Bluff 7.8/10 Good (395) "Comfortable beds, very clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) mary £76 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Comfort-Inn-Poplar-Bluff-North.h79403.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/4bc8c9bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/2099c0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout curtains, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/2794fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/49192655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Bonne Terre Bonne Terre 7.0/10 Good (527) "Very nice facility. Room was clean and quiet." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey K. £47 includes taxes & fees 3 Dec - 4 Dec [](https://www.expedia.co.uk/Farmington-Hotels-Super-8-By-Wyndham-Bonne-Terre.h856283.Hotel-Information) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/c1fba8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/633eb669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/627d4131.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau Cape Girardeau 9.6/10 Exceptional (85) "The staff was very kind and welcoming!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Natalie £75 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/e3fbcab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8fe6deab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily breakfast ](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8df39481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Sikeston Sikeston 9.4/10 Exceptional (1002) "Friendly staff and clean rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LENA M £67 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/4329af11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/c7be0f94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) Sikeston 8.4/10 Very good (703) "Very quiet and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lana £49 includes taxes & fees 10 Nov - 11 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels) ## Explore similar 3-star hotels Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Southeast Missouri. ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive, Cape Girardeau, MO £81 14 Nov - 15 Nov includes taxes & fees 9.4/10 Exceptional! (1,002 reviews) [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 3003 SOUTH OLD ORCHARD ROAD, Jackson, MO £69 11 Nov - 12 Nov includes taxes & fees 8.8/10 Excellent! (647 reviews) [](https://expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner, Sikeston, MO £82 23 Nov - 24 Nov includes taxes & fees 9.4/10 Exceptional! (1,002 reviews) [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Still don't see what you're looking for? [See all properties in Southeast Missouri.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=09%2F11%2F2025&endDate=10%2F11%2F2025®ionId=6058763&star=20) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=09%2F11%2F2025&endDate=10%2F11%2F2025®ionId=6058763&star=20&star=20&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=09%2F11%2F2025&endDate=10%2F11%2F2025®ionId=6058763&star=20&star=20&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=09%2F11%2F2025&endDate=10%2F11%2F2025®ionId=6058763&star=20&star=20&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=09%2F11%2F2025&endDate=10%2F11%2F2025®ionId=6058763&star=20&star=20&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=09%2F11%2F2025&endDate=10%2F11%2F2025®ionId=6058763&star=20&star=20&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Southeast Missouri Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area. [See all hotels in Southeast Missouri](https://www.expedia.co.uk/Hotel-Search?startDate=2025-11-22&endDate=2025-11-23&adults=2®ionId=6058763) ![150th anniversary of the historic French fort. ](https://images.trvl-media.com/place/148078/1ef720df-0786-4e45-8a4f-890d982b757b.jpg?impolicy=fcrop&w=900&h=598&p=1&q=high) Photo by JG Morris ## Top Southeast Missouri Hotel Reviews ![Motel 6 Poplar Bluff, MO](//images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Everything we needed" [](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ## Find out more about Southeast Missouri ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [5 Star Hotels in Central West End](https://www.expedia.co.uk/5Star-Central-West-End-St-Louis-Hotels.s50-n6175135-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Chesterfield](https://www.expedia.co.uk/5Star-Chesterfield-Hotels.s50-0-d9530.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Kirkwood](https://www.expedia.co.uk/5Star-Kirkwood-Hotels.s50-0-d8470.Travel-Guide-Filter-Hotels) - [5 Star Hotels in St. Louis](https://www.expedia.co.uk/5Star-St-Louis-Hotels.s50-0-d178309.Travel-Guide-Filter-Hotels) - [Allenville Hotels](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Annapolis Hotels](https://www.expedia.co.uk/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Arcadia Hotels](https://www.expedia.co.uk/Arcadia-Hotels.d6346857.Travel-Guide-Hotels) - [Belleview Hotels](https://www.expedia.co.uk/Belleview-Hotels.d3000444413.Travel-Guide-Hotels) - [Bismarck Hotels](https://www.expedia.co.uk/Bismarck-Hotels.d553248634983538264.Travel-Guide-Hotels) - [B&B in Black](https://www.expedia.co.uk/Black-Bed-And-Breakfasts.d3000444470-aaBedAndBreakfasts.Travel-Guide-Accommodation) - [Black Hotels](https://www.expedia.co.uk/Black-Hotels.d3000444470.Travel-Guide-Hotels) - [Bloomfield Hotels](https://www.expedia.co.uk/Bloomfield-Hotels.d6351829.Travel-Guide-Hotels) - [Bonne Terre Hotels](https://www.expedia.co.uk/Bonne-Terre-Hotels.d55598.Travel-Guide-Hotels) - [Bunker Hotels](https://www.expedia.co.uk/Bunker-Hotels.d553248634983305544.Travel-Guide-Hotels) - [Cadet Hotels](https://www.expedia.co.uk/Cadet-Hotels.d3000349308.Travel-Guide-Hotels) - [Caledonia Hotels](https://www.expedia.co.uk/Caledonia-Hotels.d6359344.Travel-Guide-Hotels) - [Centerville Hotels](https://www.expedia.co.uk/Centerville-Hotels.d553248634983078632.Travel-Guide-Hotels) - [Desloge Hotels](https://www.expedia.co.uk/Desloge-Hotels.d55671.Travel-Guide-Hotels) - [Dexter Hotels](https://www.expedia.co.uk/Dexter-Hotels.d55097.Travel-Guide-Hotels) - [Doe Run Hotels](https://www.expedia.co.uk/Doe-Run-Hotels.d3000349343.Travel-Guide-Hotels) - [Ellington Hotels](https://www.expedia.co.uk/Ellington-Hotels.d3000444859.Travel-Guide-Hotels) - [Farmington Hotels](https://www.expedia.co.uk/Farmington-Hotels.d6058764.Travel-Guide-Hotels) - [Fisk Hotels](https://www.expedia.co.uk/Fisk-Hotels.d553248634983120615.Travel-Guide-Hotels) - [Flat River Hotels](https://www.expedia.co.uk/Flat-River-Hotels.d183474.Travel-Guide-Hotels) - [Fredericktown Hotels](https://www.expedia.co.uk/Fredericktown-Hotels.d55114.Travel-Guide-Hotels) - [French Village Hotels](https://www.expedia.co.uk/French-Village-Hotels.d553248635975849064.Travel-Guide-Hotels) - [Friedheim Hotels](https://www.expedia.co.uk/Friedheim-Hotels.d3000349372.Travel-Guide-Hotels) - [Glen Allen Hotels](https://www.expedia.co.uk/Glen-Allen-Hotels.d553248634983455025.Travel-Guide-Hotels) - [Ironton Hotels](https://www.expedia.co.uk/Ironton-Hotels.d6053585.Travel-Guide-Hotels) - [Jackson Hotels](https://www.expedia.co.uk/Jackson-Hotels.d55765.Travel-Guide-Hotels) - [Hotels near Johnson's Shut-ins State Park](https://www.expedia.co.uk/Johnsons-Shut-Ins-State-Park-Hotels.0-l553248621555612544-0.Travel-Guide-Filter-Hotels) - [Junction City Hotels](https://www.expedia.co.uk/Junction-City-Hotels.d553248634983410095.Travel-Guide-Hotels) - [Leadwood Hotels](https://www.expedia.co.uk/Leadwood-Hotels.d3000349432.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Lesterville](https://www.expedia.co.uk/Lesterville-Hotels-Gay-Friendly-Hotel.0-0-d3000445174-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Lesterville Hotels](https://www.expedia.co.uk/Lesterville-Hotels.d3000445174.Travel-Guide-Hotels) - [Marble Hill Hotels](https://www.expedia.co.uk/Marble-Hill-Hotels.d3000445212.Travel-Guide-Hotels) - [Marquand Hotels](https://www.expedia.co.uk/Marquand-Hotels.d553248634983260789.Travel-Guide-Hotels) - [Middle Brook Hotels](https://www.expedia.co.uk/Middle-Brook-Hotels.d3000445241.Travel-Guide-Hotels) - [New Offenburg Hotels](https://www.expedia.co.uk/New-Offenburg-Hotels.d3000349478.Travel-Guide-Hotels) - [Park Hills Hotels](https://www.expedia.co.uk/Park-Hills-Hotels.d183485.Travel-Guide-Hotels) - [Perryville Hotels](https://www.expedia.co.uk/Perryville-Hotels.d6134448.Travel-Guide-Hotels) - [Piedmont Hotels](https://www.expedia.co.uk/Piedmont-Hotels.d3000445413.Travel-Guide-Hotels) - [Pilot Knob Hotels](https://www.expedia.co.uk/Pilot-Knob-Hotels.d3000008143.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Poplar Bluff](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Gay-Friendly-Hotel.0-0-d9449-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Poplar Bluff Hotels](https://www.expedia.co.uk/Poplar-Bluff-Hotels.d9449.Travel-Guide-Hotels) - [Potosi Hotels](https://www.expedia.co.uk/Potosi-Hotels.d181478.Travel-Guide-Hotels) - [Sedgewickville Hotels](https://www.expedia.co.uk/Sedgewickville-Hotels.d3000349537.Travel-Guide-Hotels) - [St Mary Hotels](https://www.expedia.co.uk/St-Mary-Hotels.d3000445480.Travel-Guide-Hotels) - [Valles Mines Hotels](https://www.expedia.co.uk/Valles-Mines-Hotels.d3000349575.Travel-Guide-Hotels) - [Van Buren Hotels](https://www.expedia.co.uk/Van-Buren-Hotels.d183504.Travel-Guide-Hotels) - [Wappapello Hotels](https://www.expedia.co.uk/Wappapello-Hotels.d183505.Travel-Guide-Hotels) - [Weingarten Hotels](https://www.expedia.co.uk/Weingarten-Hotels.d553248635975847364.Travel-Guide-Hotels) - [Williamsville Hotels](https://www.expedia.co.uk/Williamsville-Hotels.d553248634983506457.Travel-Guide-Hotels) - [Flights to Bonne Terre](https://www.expedia.co.uk/Cheap-Flights-To-Bonne-Terre.d55598.Travel-Guide-Flights) - [Flights to Desloge](https://www.expedia.co.uk/Cheap-Flights-To-Desloge.d55671.Travel-Guide-Flights) - [Flights to Dexter](https://www.expedia.co.uk/Cheap-Flights-To-Dexter.d55097.Travel-Guide-Flights) - [Flights to Park Hills](https://www.expedia.co.uk/Cheap-Flights-To-Park-Hills.d183485.Travel-Guide-Flights) - [Flights to Wappapello](https://www.expedia.co.uk/Cheap-Flights-To-Wappapello.d183505.Travel-Guide-Flights) - [Flights from Potosi](https://www.expedia.co.uk/lp/flights/181478/flights-from-potosi) - [Flights from Park Hills](https://www.expedia.co.uk/lp/flights/183485/flights-from-park-hills) - [Flights from Pilot Knob](https://www.expedia.co.uk/lp/flights/3000008143/flights-from-pilot-knob) - [Flights from Doe Run](https://www.expedia.co.uk/lp/flights/3000349343/flights-from-doe-run) - [Flights from Black](https://www.expedia.co.uk/lp/flights/3000444470/flights-from-black) - [Flights from Lesterville](https://www.expedia.co.uk/lp/flights/3000445174/flights-from-lesterville) - [Flights from Dexter](https://www.expedia.co.uk/lp/flights/55097/flights-from-dexter) - [Flights from Fredericktown](https://www.expedia.co.uk/lp/flights/55114/flights-from-fredericktown) - [Flights from Marquand](https://www.expedia.co.uk/lp/flights/553248634983260789/flights-from-marquand) - [Flights from Zalma](https://www.expedia.co.uk/lp/flights/553248634983373716/flights-from-zalma) - [Flights from Ellsinore](https://www.expedia.co.uk/lp/flights/553248634983439149/flights-from-ellsinore) - [Flights from Viburnum](https://www.expedia.co.uk/lp/flights/553248634983489800/flights-from-viburnum) - [Flights from Bonne Terre](https://www.expedia.co.uk/lp/flights/55598/flights-from-bonne-terre) - [Flights from Jackson](https://www.expedia.co.uk/lp/flights/55765/flights-from-jackson) - [Flights from Farmington](https://www.expedia.co.uk/lp/flights/6058764/flights-from-farmington) - [Flights from Annapolis](https://www.expedia.co.uk/lp/flights/6282465/flights-from-annapolis) - [Flights from Arcadia](https://www.expedia.co.uk/lp/flights/6346857/flights-from-arcadia) - [Flights from Poplar Bluff](https://www.expedia.co.uk/lp/flights/9449/flights-from-poplar-bluff) - [Flights from Los Angeles (LAX) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/lax/pof/los-angeles-to-poplar-bluff) - [Flights from Carbondale (MDH) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/mdh/pof/carbondale-to-poplar-bluff) - [Flights from Pittsburgh (PIT) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/pit/pof/pittsburgh-to-poplar-bluff) - [Flights from San Antonio (SAT) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/sat/pof/san-antonio-to-poplar-bluff) - [Visit Bonne Terre](https://www.expedia.co.uk/Bonne-Terre.dx55598) - [Cadet Holidays](https://www.expedia.co.uk/Cadet.d3000349308.Holidays-City-Breaks) - [Caledonia Holidays](https://www.expedia.co.uk/Caledonia.d6359344.Holidays-City-Breaks) - [Dexter Holidays](https://www.expedia.co.uk/Dexter.d55097.Holidays-City-Breaks) - [Visit Farmington](https://www.expedia.co.uk/Farmington.dx6058764) - [Fourche Valley Golf Club](https://www.expedia.co.uk/Fourche-Valley-Golf-Club-Potosi.d553248621561876443.Attraction) - [Visit Fredericktown](https://www.expedia.co.uk/Fredericktown.dx55114) - [Leadwood Holidays](https://www.expedia.co.uk/Leadwood.d3000349432.Holidays-City-Breaks) - [Visit Lesterville](https://www.expedia.co.uk/Lesterville.dx3000445174) - [Visit Poplar Bluff](https://www.expedia.co.uk/Poplar-Bluff.dx9449) - [Visit Potosi](https://www.expedia.co.uk/Potosi.dx181478) - [Powder Mill Cave Natural Area](https://www.expedia.co.uk/Powder-Mill-Cave-Natural-Area-Ellington.d553248622784732009.Attraction) - [Van Buren Holidays](https://www.expedia.co.uk/Van-Buren.d183504.Holidays-City-Breaks) - [Car hire Black](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Black.d3000444470.Car-Hire-Guide) - [Hertz Rental Cars in Centerville](https://www.expedia.co.uk/Hertz-Car-Rentals-In-Centerville.d553248634983078632-c40.Car-Rental-Guide-Suppliers) - [Island Car Rentals Rental Cars in Cobalt](https://www.expedia.co.uk/Island-Car-Rentals-Car-Rentals-In-Cobalt.d553248634983153223-c1132.Car-Rental-Guide-Suppliers) - [Thrifty Car Rental Rental Cars in Belgrade](https://www.expedia.co.uk/Thrifty-Car-Rental-Car-Rentals-In-Belgrade.d553248635975850450-c45.Car-Rental-Guide-Suppliers) - [Doe Run Holiday Rentals](https://www.expedia.co.uk/Doe-Run-Holiday-Rentals.d3000349343.Travel-Guide-HolidayRentals) - [Lesterville Holiday Rentals](https://www.expedia.co.uk/Lesterville-Holiday-Rentals.d3000445174.Travel-Guide-HolidayRentals) - [Pilot Knob Holiday Rentals](https://www.expedia.co.uk/Pilot-Knob-Holiday-Rentals.d3000008143.Travel-Guide-HolidayRentals) - [Book 2 Star Hotels in Southeast Missouri on Expedia.com](https://www.expedia.com/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels)