Title: TOP Casino Hotels in Southeast Missouri, MO for 2026 | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri Casino Hotels Tonight [5 Mar - 6 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-05&endDate=2026-03-06&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [6 Mar - 7 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-06&endDate=2026-03-07&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-06&endDate=2026-03-08&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-13&endDate=2026-03-15&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeast Missouri hotels with a casino ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Jackpot Suite | Living area | LED TV, Netflix, Hulu, first-run films](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (516 reviews) "The room was clean and I was able to check in a bit early." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara £76 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Casino](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/95f299eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/589b05b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Farmstead Hotel [](https://www.expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) Caruthersville 8.6/10 Excellent (502 reviews) "Clean room, very nice staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mack £58 includes taxes & fees 6 Mar - 7 Mar [](https://www.expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/dc7dee1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/ccad2677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) Jackson 9.0/10 Wonderful (718 reviews) "Conveniently located, clean, friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Philip £68 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Standard Double Room, 2 Queen Beds, Transfer Shower | Desk, laptop workspace, free WiFi](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/690c1aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/16ab8462.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, free WiFi](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/884d70e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/c98026e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Century Casino & Hotel Caruthersville [](https://www.expedia.co.uk/Caruthersville-Hotels-Century-Casino-Hotel-Caruthersville.h111402094.Hotel-Information) Caruthersville 8.6/10 Excellent (125 reviews) "Really nice place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brett £95 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Caruthersville-Hotels-Century-Casino-Hotel-Caruthersville.h111402094.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/c7d69739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/20bc712d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Cape Girardeau Downtown [](https://www.expedia.co.uk/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (490 reviews) "Very nice hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angie £106 includes taxes & fees 14 Mar - 15 Mar [](https://www.expedia.co.uk/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/5950187f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/a236a8e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/7794c781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/9f324b7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rockwood Inn [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Rockwood-Inn.h105486893.Hotel-Information) Cape Girardeau 10/10 Exceptional (20 reviews) "My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim £118 includes taxes & fees 17 Mar - 18 Mar [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Rockwood-Inn.h105486893.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/b5436bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Festus [](https://www.expedia.co.uk/Festus-Hotels-Baymont-By-Wyndham-Festus.h5523.Hotel-Information) Festus 6.8/10 (940 reviews) "Room was good and staff was helpful and friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £69 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Festus-Hotels-Baymont-By-Wyndham-Festus.h5523.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/564d6e43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serenity South -- Gardens, River-Views, and Refreshing Space [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) Cape Girardeau 10/10 Exceptional (151 reviews) "Such a great place and location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy H. £184 includes taxes & fees 7 Mar - 8 Mar [](https://www.expedia.co.uk/Sikeston-Hotels-Serenity-South-Gardens.h38940154.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, table football](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/a7fa16a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Games room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/f1c736a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, table football](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (8 reviews) "Nice place, great times" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jace W. £323 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information) ![Casino](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/427242cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/30a89ffb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/71580e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/4addfd67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### River City Casino & Hotel [](https://www.expedia.co.uk/St-Louis-Hotels-River-City-Casino-Hotel.h6456459.Hotel-Information) St. Louis 9.0/10 Wonderful (1,493 reviews) "Clean and comfy great food " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Theresa A £89 includes taxes & fees 17 Mar - 18 Mar [](https://www.expedia.co.uk/St-Louis-Hotels-River-City-Casino-Hotel.h6456459.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-19&endDate=2026-03-20®ionId=6058763&adults=2&amenities=CASINO&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_6058763) ## Top Southeast Missouri Hotel Reviews ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 10/10 Excellent "Everything was excellent. Staff was very friendly and helpful." [](https://expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Great as all Drury’s" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg) ### Candlewood Suites Cape Girardeau by IHG 6/10 Okay "Excessive fee for dogs was $75.00\. No breakfast. Very loud room next to freeway. Old coil bed could feel every move my husband made. Will not be coming back. " [](https://expedia.co.uk/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Yes to all the above." 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