In the heart of Cape Girardeau Historic District, this beautifully renovated duplex offers a cozy living room and large dining room perfect for relaxation. Explore downtown's local restaurants, antique shops, and boutiques within walking distance or unwind on the balcony overlooking the shared yard.
Reviews
1010 out of 10
Exceptional
Entire home
3 bedrooms2 bathroomsSleeps 51600 sq ft
Popular amenities
Kitchen
Outdoor space
Parking available
Fireplace
The current price is £186
£186
includes taxes & fees
1 Apr - 2 Apr
Add dates for prices
About this property
Entire place
You'll have the entire home to yourself and will only share it with other guests in your party.
Serenity South -- Gardens, River-Views, and Refreshing Space
Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions.
Property amenities
Internet
Available in the house: WiFi
Parking and transport
Car not required
Parking on site
Kitchen
Coffee grinder
Coffee/tea maker
Cookware, dishware, and utensils
Dishwasher
Hob
Ice maker
Microwave
Oven
Paper towels
Refrigerator
Spices
Toaster
Bedrooms
3 bedrooms
Bedsheets provided
Bathroom
1.5 bathrooms
Bathtub or shower
Hair dryer
Shampoo
Soap
Toilet paper
Towels provided
Living spaces
Fireplace
Living room
Separate dining area
Entertainment
Books
DVD player
Games
TV
Outdoor areas
Balcony
Garden
Outdoor furniture
Laundry
Laundromat nearby
Comfort
Air conditioning
Heating
Pets
No pets allowed
Suitability/Accessibility
Smoke-free property
Services and conveniences
Iron/ironing board
Location highlights
Near a health/beauty spa
Near a hospital
Near an outlet shopping centre
On a river
Things to do
Basketball nearby
Casino nearby
Cycling nearby
Fishing nearby
Golfing nearby
Hiking/biking trails nearby
Horseback riding nearby
Motor boating nearby
Swimming nearby
Wildlife walks nearby
Winery tours nearby
Safety features
Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property)
Smoke detector (host has indicated there is a smoke detector on the property)
You will receive an email from the host with check-in and check-out instructions
Information provided by the property may be translated using automated translation tools
Rules
Back yard is shared with the other side of the duplex. Please respect their use of the common space.
Pets
Pets not allowed
Children and extra beds
Children are welcome
Note from host: Excellent fenced back yard.
Events
Events allowed: family gatherings, birthday parties, weddings
Parties or events must okayed before arrival.
Smoking
Smoking is not permitted
Important information
You need to know
This property is managed by a professional host. The provision of housing is linked to their trade, business or profession.
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Parties and events (including family gatherings, birthday parties and weddings) are allowed on site. Maximum attendees: 50
Note from host: Parties or events must okayed before arrival.
Host has indicated that there is a carbon monoxide detector on the property
Host has indicated that there is a smoke detector on the property
Safety features at this property include a deadlock
This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation
If you cancel your booking, you'll be subject to the host's cancellation policy. In accordance with UK consumer law, property booking services are not subject to the right of withdrawal.
We should mention
A car is not required for transport to and from this property
About the area
Located in Cape Girardeau, this holiday home is near a water park and on a river. The area's natural beauty can be seen at Shawnee National Forest and Mississippi River. Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are also worth visiting. Discover the area's water adventures with power boating and fishing nearby, or enjoy the great outdoors with cycling and horse riding. Visit our Cape Girardeau travel guide
Is Serenity South -- Gardens, River-Views, and Refreshing Space pet-friendly?
No, pets are not allowed at this property.
How much does it cost to stay at Serenity South -- Gardens, River-Views, and Refreshing Space?
As of 29 Mar 2026, prices found for a 1-night stay for 2 adults at Serenity South -- Gardens, River-Views, and Refreshing Space on 1 Apr 2026 start from £186, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.
How much is parking at Serenity South -- Gardens, River-Views, and Refreshing Space?
On-site parking is available at the property.
What time is check-in at Serenity South -- Gardens, River-Views, and Refreshing Space?
Check-in begins at 4:00 PM.
What time is check-out at Serenity South -- Gardens, River-Views, and Refreshing Space?
Checkout is at 11:00 AM.
Where is Serenity South -- Gardens, River-Views, and Refreshing Space located?
Situated on a river, this holiday home is steps away from eDen Spa & Salon, Shawnee National Forest and Mississippi River. Riverfront Park and The Glenn House are also within 5 minutes.
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Serenity South -- Gardens, River-Views, and Refreshing Space Reviews
Reviews
Exceptional
All reviews shown are from real guest experiences. Only travellers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.
Moving our daughter in to the dorm at SEMO for yr 2. Been coming to this location since our trip here during her senior year of HS when she visited SEMO to audition for the musical theatre program. It is a great place to stay when you have more than 2 people.
Serenity south was welcoming comfortable and very clean. Impeccably maintained historic home. Comfortable beds, great water pressure and shower head, easy to maintain consistent temperature. Good vibes throughout. Not haunted. Beautiful outdoor space but it was too hot to use it much while we were there. Recommend stopping by the olive oil store William and Water across the street.
Great Location short walking distance to the Downtown Area with lots do do, Restaurants, Water Park, Shopping. This is the 2nd time I have stayed and it is a true delight. Very spacious and comfortable. Easy to communicate with the Owner/Manager. I will be staying there again in the future. I recommend it with 5 Stars!
Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay.
When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay.
The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area.
We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!
Here for a volleyball tournament. Had 3 short days to enjoy this beautiful home. Just not long enough. Has everything u need and more. Jo is a lovely host. So quiet and peaceful.. most of all in a safe area. I plan to go back by summers end just so I can enjoy the home and walk to coffee shop and tour the old part of town. Just wonderful!
This is an older home (1920’s?) with so much charm. It’s exceptionally well cared for - the floors are clean and in excellent condition, the walls are clean, paint job is beautiful, etc. The air is clean (no smell of mold) bathroom fans work, etc! In short, one of the best maintained rentals we’ve stayed in. The beds are comfy. Oh - and the landscaping is also beautiful! It is winter - would love to see the gardens in the spring. Jo was easy to contact, check in was easy. The trains do run 1 or 2 times per night and are close and on Friday night there were some people having fun running their loud cars through town but otherwise it is quiet and peaceful. The walk to town is only a few blocks. We would definitely stay here again!
This was the second year in a row that we have stayed here. This is a beautiful home to stay in. I love the charm and detail of the house. We stay here after a Christmas party and walk downtown so it’s definitely located in a convenient spot. I will be booking again for next year Great communication with Jo and if there’s any questions I need, Jo is very quick to respond. Thank you for making our stay good!