A calm body of water, a sandy beach, and a forested area in the distance.

Search Holiday Homes in Cape Girardeau

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
16 Oct - 18 Oct
In two months
27 Nov - 29 Nov
In three months
25 Dec - 27 Dec
In four months
22 Jan - 24 Jan

Our top choices for Cape Girardeau holiday homes

A living room with a TV, a fireplace, a sofa, and wall art.

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (58 reviews)
"Great cute place. "
United States
Jeremy W.
The price is £85
includes taxes & fees
29 Sept - 30 Sept
Little Blue Cottage on Spanish
A kitchen with a wooden countertop, coffee machine, and wall decorations including coffee cup illustrations and a welcome sign.

2. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is £136
includes taxes & fees
20 Oct - 21 Oct
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

3. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is £175
includes taxes & fees
1 Oct - 2 Oct
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

4. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is £171
includes taxes & fees
11 Oct - 12 Oct
The Little Château | Woodland Escape
A two-story house with a front porch, a small garden, and a white picket fence.

5. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (44 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is £237
includes taxes & fees
29 Sept - 30 Sept
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

6. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
The price is £175
includes taxes & fees
3 Oct - 4 Oct
The Little Cape Lofted Cottage | Creek & Nature
A modern kitchen with a large island, white cabinetry, and a brick accent wall.

7. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
The price is £238
includes taxes & fees
5 Oct - 6 Oct
Beautifully Renovated Farmhouse in Jackson, MO
A house with a backyard swimming pool, outdoor furniture, and a barbecue area.

8. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
The price is £418
includes taxes & fees
29 Sept - 30 Sept
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
A wooden cabinet with a microwave, coffee maker, and plates.

9. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (25 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is £122
includes taxes & fees
4 Oct - 5 Oct
Cozy and Updated Farmhouse with King Suite
A brick building with a sign reading "1898 Guesthouse".

10. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (14 reviews)
"Cool renovated property that keeps that old fashioned charm. Spacious living with all the amenities you need for a vacation stay."
United States
Dylan
The price is £218
includes taxes & fees
29 Sept - 30 Sept
Stunning 2 bedroom in town, close to Shawnee National Forest
A covered porch with a wooden railing, a table with chairs, and a sofa.

11. Beautiful location in the secluded woods

Beautiful location in the secluded woods
Pomona
10.0 out of 10, Exceptional, (82 reviews)
"This rental was very clean, pet friendly, and definitely secluded. We enjoyed our stay here."
United States
Candi M.
The price is £139
includes taxes & fees
6 Oct - 7 Oct
Beautiful location in the secluded woods
A red barn with a sloped roof, surrounded by a grassy field and trees.

12. The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!
Frohna
10.0 out of 10, Exceptional, (34 reviews)
"Wonderful time! "
United States
Alison C.
The price is £127
includes taxes & fees
6 Oct - 7 Oct
The Weber Farm - Enjoy a beautiful 100 acre farm!
A kitchen with wooden cabinets, a countertop, and a window with blinds.

13. Crossview Cottage - Direct view of Bald Knob Cross

Crossview Cottage - Direct view of Bald Knob Cross
Alto Pass
The price is £96
includes taxes & fees
29 Sept - 30 Sept
Crossview Cottage - Direct view of Bald Knob Cross
A spacious living room with a brown leather sofa, a dining area with a wooden table and chairs, a kitchen with white cabinets and a central island, and large windows with blinds.

14. Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.

Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
Anna
10.0 out of 10, Exceptional, (10 reviews)
"Clean, attentive host, shops near by, family friendly "
United States
Molly J.
The price is £211
includes taxes & fees
12 Oct - 13 Oct
Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
A wooden deck with two white Adirondack chairs and a small round table.

15. Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
Alto Pass
10.0 out of 10, Exceptional, (5 reviews)
"The house was very welcoming and clean. Very inviting for our short stay. "
United States
brian O.
The price is £198
includes taxes & fees
29 Sept - 30 Sept
Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
A kitchen with a refrigerator, cabinets, and a dining area with chairs and a table.

16. Vulture's Roost

Vulture's Roost
Makanda
10.0 out of 10, Exceptional, (1 review)
"Wonderful place! Everything you need! Love the eclectic decor. Hostesses were easy to communicate with. Very close to Giant City State Park for hiking etc. also antiquing in nearby towns."
United States
cris g.
The price is £152
includes taxes & fees
29 Sept - 30 Sept
Vulture's Roost
A large, two-story house with a wrap-around porch, surrounded by a well-maintained garden with various flowering plants.

17. Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
9.8 out of 10, Exceptional, (19 reviews)
"Everything was beautiful, and although we weren’t there for a long time, enjoyed an Incredible sleep in the most comfortable beds!"
United States
Rachel H.
The price is £295
includes taxes & fees
6 Oct - 7 Oct
Magical Victorian near hiking / wine trail

18. Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda

Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda
Makanda
The price is £120
includes taxes & fees
29 Sept - 30 Sept
Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda
A spacious living area with a kitchen, a dining table, and comfortable seating.

19. Whole Inn Rental! 5 King Beds, 2 Hot Tubs

Whole Inn Rental! 5 King Beds, 2 Hot Tubs
Cobden
The price is £555
includes taxes & fees
29 Sept - 30 Sept
Whole Inn Rental! 5 King Beds, 2 Hot Tubs
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Upgraded to a 2 room suite. Rey nice room lots of storage. Would definitely stay here again."
Christy 2-night trip
Posted 13 hours ago
Drury Inn & Suites Cape Girardeau

Find out more about Cape Girardeau

Cape Girardeau Holiday Homes information

Number of reviews
229
Accommodation
61 Holiday Homes
Lowest Price
£85
Highest Price
£555