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Find luxury hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri Luxury Hotels

Tonight
3 Oct - 4 Oct
Tomorrow
4 Oct - 5 Oct
Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

Our top choices for Southeast Missouri luxury hotels

1. The Riverview

The Riverview
Cape Girardeau
£88
includes taxes & fees
12 Oct - 13 Oct
The Riverview

2. Fall Getaway Cabin Bordering Mark Twain National Forest w/Fire Pit & Trails

Fall Getaway Cabin Bordering Mark Twain National Forest w/Fire Pit & Trails
Mill Spring
£134
includes taxes & fees
5 Oct - 6 Oct
Fall Getaway Cabin Bordering Mark Twain National Forest w/Fire Pit & Trails

3. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
£119
includes taxes & fees
1 Nov - 2 Nov
Drury Plaza Hotel St. Louis Brentwood

4. Club Boulders by Pinemark® Heated Pool+Hot Tub

Club Boulders by Pinemark® Heated Pool+Hot Tub
Bourbon
£481
includes taxes & fees
5 Oct - 6 Oct
Club Boulders by Pinemark® Heated Pool+Hot Tub
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Find out more about Southeast Missouri

Southeast Missouriand its attractions for luxury travelers

Southeast Missouri boasts a compelling blend of natural beauty and cultural richness, perfect for the discerning traveller seeking luxury. Begin your journey in Cape Girardeau, where the historic Riverfront adds charm to your stay; indulge in a gourmet meal at a riverside restaurant followed by a leisurely stroll along the Mississippi River. For a touch of adventure, head to the stunning trails of the Ozark National Scenic Riverways, where you can explore crystal-clear springs and enjoy a private guided canoe tour, immersing yourself in Missouri's breathtaking landscapes. The historic town of Ste. Genevieve, rich in French historic architecture, offers boutique shopping and exquisite dining experiences that cater to refined tastes. The region’s acclaimed wineries, such as the nearby Chaumette Vineyards, provide exclusive tastings and vineyard tours, perfect for an afternoon of indulgence. For a luxurious stay, consider the upscale options in Cape Girardeau, where hotels offer stunning views of the river along with top amenities and personalised services, ensuring that you feel pampered throughout your visit.

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Terrific base accommodation. Clean, efficient. I use this place whenever I’m in the area. I’m"
Herman 1-night trip
Posted 2 days ago
Motel 6 Poplar Bluff, MO
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"EVERYONE was EXTREMELY FRIENDLY even maintenance all FRIENDLY"
Rex 1-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"Difficult to communicate with person setting up and maintaining breakfast area as they did not speak English"
Terry 1-night trip
Posted 6 days ago
Comfort Inn Festus - St Louis South
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 12 days ago
Days Inn and Suites by Wyndham Sikeston

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