Title: TOP Hotels near Museums in Southeast Missouri, MO for 2026 | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri Hotels near Museums Tonight [27 Mar - 28 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-27&endDate=2026-03-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [28 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-28&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [27 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in Southeast Missouri ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Jackson 9.6/10 Exceptional (1,000 reviews) "Great food and pool. Clean and cozy. We will be back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leora £63 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/8cca20e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/5fc6e860.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/e2a51dca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont Inn and Suites by Wyndham Farmington, MO [](https://www.expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) Farmington 8.0/10 Very good (1,009 reviews) "Great staff and nice accommodations " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa £50 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/412c9f32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/a07fa840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchenette](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/8d2b66d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Poplar Bluff, MO [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) Poplar Bluff 8.0/10 Very good (1,003 reviews) "This was our third stay at this Motel 6\. It’s a great hotel with friendly staff, clean rooms and good location. Pets stay free!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy £58 includes taxes & fees 30 Mar - 31 Mar [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/e565804d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/32ba7ac0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/3343007d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/e188e0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Farmington [](https://www.expedia.co.uk/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information) Farmington 8.0/10 Very good (630 reviews) "Friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Faith £51 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-service breakfast ](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8447c54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/dc7dee1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) Jackson 9.0/10 Wonderful (736 reviews) "Very clean and staff was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nastassia £72 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Individually decorated, individually furnished, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/bf40a512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) [](https://www.expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) Sikeston 8.4/10 Very good (754 reviews) "Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark £53 includes taxes & fees 9 Apr - 10 Apr [](https://www.expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston [](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) Sikeston 9.0/10 Wonderful (515 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) grant £86 includes taxes & fees 9 Apr - 10 Apr [](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/ef46b494.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/e6403655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 By Wyndham Marston [](https://www.expedia.co.uk/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) Marston 8.2/10 Very good (53 reviews) "The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sue £56 includes taxes & fees 4 Apr - 5 Apr [](https://www.expedia.co.uk/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,002 reviews) "Great room, staff and breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth £85 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/a77daa89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New Orleans Inn Portageville [](https://www.expedia.co.uk/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) Portageville 8.0/10 Very good (754 reviews) "The staff was great very helpful and friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Javier £42 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-11&endDate=2026-04-12®ionId=6058763&adults=2&location_highlights_explore=museums&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Missouri Hotel Reviews ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg) ### Drury Inn & Suites Sikeston, MO 8/10 Good "Bedding needs to be updated. Pillows smelled and carpet could be cleaned. Bathroom was clean. Staff was friendly and helpful. " [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg) ### Drury Inn & Suites Poplar Bluff 10/10 Excellent "Was a nice place" [](https://expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - [Allenville Hotels ](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Annapolis Hotels ](https://www.expedia.co.uk/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Arcadia Hotels ](https://www.expedia.co.uk/Arcadia-Hotels.d6346857.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Arnold ](https://www.expedia.co.uk/Arnold-Hotels-Gay-Friendly-Hotel.0-0-d177608-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Pool in Arnold ](https://www.expedia.co.uk/Arnold-Hotels-Hotels-With-Pool.0-0-d177608-tHotelswithPool.Travel-Guide-Filter-Hotels) - 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