Hotels near Museums in Southeast Missouri
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Hotels near Museums
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A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

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your current months are November, 2026 and December, 2026.

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Our top choices for Southeast Missouri hotels with museums nearby

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

1. Madison Inn Lodge

Madison Inn Lodge

2.5 star property

Fredericktown

7.6 out of 10, Good, (314 reviews)

7.6/10

Good

(314 reviews)

"Nice and clean friendly staff"

Bawan

The price is £70

£70

includes taxes & fees

10 Nov - 11 Nov

Madison Inn Lodge

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A building with a red awning labeled "Shepherd Mountain Inn."

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

2. Shepherd Mountain Inn

Shepherd Mountain Inn

2.5 star property

Ironton

9.2 out of 10, Wonderful, (338 reviews)

9.2/10

Wonderful

(338 reviews)

"Clean room, wifi easy to connect to, parking right in front."

Jonathan

The price is £101

£101

includes taxes & fees

10 Nov - 11 Nov

Shepherd Mountain Inn

A bathroom with a large bathtub, a chair, and a small shelf with plants.

A rooftop patio with outdoor seating, a pool, and a sunset view.

An outdoor seating area with a fire pit, chairs, and two evergreen trees.

3. Pinemark Inn & Suites

Pinemark Inn & Suites

2.0 star property

St. Clair

9.6 out of 10, Exceptional, (1,006 reviews)

9.6/10

Exceptional

(1,006 reviews)

"Very clean and good breakfast...I'd stay here again."

Michael

The price is £107

£107

includes taxes & fees

10 Nov - 11 Nov

Pinemark Inn & Suites

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

4. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus

Festus

9.4 out of 10, Exceptional, (25 reviews)

9.4/10

Exceptional

(25 reviews)

"This was a wonderful hotel and had a wonderful stay. Room was clean and staff was wonderful."

Misty

The price is £96

£96

includes taxes & fees

15 Nov - 16 Nov

Hampton Inn & Suites By Hilton Festus

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

A reception area with a modern abstract wall art, two potted plants, and a wooden console table with a decorative bowl.

A Holiday Inn Express & Suites hotel with a prominent entrance, large columns, and a clear view of the sky.

A hotel room with a bed, a sofa, a desk, and a chair.

5. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG

2.5 star property

Farmington

8.6 out of 10, Excellent, (445 reviews)

8.6/10

Excellent

(445 reviews)

"We stayed one night and it was great! Breakfast was delicious."

January

The price is £99

£99

includes taxes & fees

22 Nov - 23 Nov

Holiday Inn Express & Suites Farmington by IHG

A hotel lobby with a reception desk, seating area, and a patterned carpet.

A hotel lobby with a seating area, a reception desk, and a bar.

A Holiday Inn Express & Suites building with a covered entrance and multiple windows.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and a ceiling with recessed lighting.

6. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property

Perryville

9.2 out of 10, Wonderful, (645 reviews)

9.2/10

Wonderful

(645 reviews)

"Excellent stay , couldn't believe the property was 10 years old , it looks like it was just built , great place , highly recommend ."

allan p.

The price is £87

£87

includes taxes & fees

15 Nov - 16 Nov

Holiday Inn Express & Suites Perryville by IHG

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property

Farmington

8.0 out of 10, Very good, (1,003 reviews)

8.0/10

Very good

(1,003 reviews)

"Our room was spacious, clean and the bed was super comfortable!"

Kim

The price is £47

£47

includes taxes & fees

15 Nov - 16 Nov

Baymont Inn and Suites by Wyndham Farmington, MO

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

8. Fort Davidson Hotel

Fort Davidson Hotel

2.5 star property

Ironton

9.2 out of 10, Wonderful, (190 reviews)

9.2/10

Wonderful

(190 reviews)

"Clean rooms , nice pool."

richard

The price is £98

£98

includes taxes & fees

17 Nov - 18 Nov

Fort Davidson Hotel

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

9. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

2.0 star property

Farmington

8.0 out of 10, Very good, (690 reviews)

8.0/10

Very good

(690 reviews)

"Clean nice staff are great"

Marisa

The price is £51

£51

includes taxes & fees

15 Nov - 16 Nov

Super 8 by Wyndham Farmington

A modern kitchen with a central island, built-in appliances, and a view into the dining area.

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

A hotel room with a bed, a desk, a microwave, a coffee maker, and a TV mounted on the wall.

A reception desk with a modern design, a digital screen, and a sign indicating 'IHG' branding.

10. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property

Festus

9.4 out of 10, Exceptional, (790 reviews)

9.4/10

Exceptional

(790 reviews)

"Hotel was very clean and comfortable to stay"

Megnauth

The price is £86

£86

includes taxes & fees

22 Nov - 23 Nov

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Southeast Missouri Hotel Reviews

A spacious lobby with a reception desk, seating area, and large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

An indoor swimming pool with a clear view of the outside through large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

Drury Inn & Suites Poplar Bluff

Poplar Bluff

10/10 Excellent

Just one night, but CeeCee left a lasting impression on us. Lovely lady!

Gary

Reviewed August 26, 2017Reviewed August 26, 2017

Drury Inn & Suites Poplar Bluff

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

Hampton Inn Poplar Bluff

Poplar Bluff

10/10 Excellent

Very clean Good breakfast Very helpful staff

heather

Reviewed May 22, 2026Reviewed May 22, 2026

Hampton Inn Poplar Bluff

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

10/10 Excellent

It was wonderful stay and very comfortable sleep

Sarmad

Reviewed September 9, 2023Reviewed September 9, 2023

Fairfield Inn & Suites by Marriott Poplar Bluff

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Drury Plaza Hotel Cape Girardeau Conference Center
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Fairfield Inn & Suites by Marriott Sikeston
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Hampton Inn Sikeston
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Travel Inn & Suites
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Hotels with Connecting Rooms in Southeast Missouri
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Silo Farm Haus
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1/4 Mile To The Boat Launch & Beach 2 miles the Camp! Free WiFi
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Visit Sikeston
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Ste Genevieve Holidays
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Search Hotels near Museums in Southeast Missouri

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Missouri hotels with museums nearby

1. Madison Inn Lodge

2. Shepherd Mountain Inn

3. Pinemark Inn & Suites

4. Hampton Inn & Suites By Hilton Festus

5. Holiday Inn Express & Suites Farmington by IHG

6. Holiday Inn Express & Suites Perryville by IHG

7. Baymont Inn and Suites by Wyndham Farmington, MO

8. Fort Davidson Hotel

9. Super 8 by Wyndham Farmington

10. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Poplar Bluff

10/10 Excellent

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