TOP Winery Hotels in Southeast Missouri, MO for 2026

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Our top choices for Southeast Missouri hotels with winery

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

An outdoor pool area with lounge chairs and an umbrella.

1. Fort Davidson Hotel

Ironton

richard

£101

includes taxes & fees

13 Sept - 14 Sept

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A hotel room with two beds, a nightstand, a lamp, and a chair.

An outdoor patio with tables and chairs, a stone wall, and large windows.

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Andrew

£74

includes taxes & fees

15 Sept - 16 Sept

A modern kitchen with grey cabinets, a black refrigerator, and a microwave.

A dining area with a wooden table and chairs, a ceiling fan, a window with a valance, and a framed picture on the wall.

A two-story house with a gravel driveway and a small garden area.

A single-story house with a grey siding exterior, two windows, a small porch, and a planter with plants.

3. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

Farmington

Ben C.

£180

includes taxes & fees

14 Sept - 15 Sept

A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

A cozy living room with a dark-colored sofa, a patterned armchair, and a built-in bench with storage shelves.

Two Adirondack chairs facing a pond with a view of a green field and hills in the background.

A bay window with a view of green hills, white cabinetry, and a television on the right.

4. Beautiful Modern Loft In Wine Country!

Ste. Genevieve

Shayna P.

£152

includes taxes & fees

15 Sept - 16 Sept

A laundry room with two washing machines, a change machine, and a chair.

A hotel room with two beds, a desk with a TV, a chair, and a window with curtains.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and a potted plant.

A hotel with a brick facade, multiple windows, and a parking lot.

5. Baymont by Wyndham Festus

Festus

Linda

£57

additional charges may apply

27 Sept - 28 Sept

A person sitting on rocks by a flowing river surrounded by greenery.

A modern kitchen with a marble countertop, a coffee table, a television, and a sliding glass door leading to an outdoor area.

A modern kitchen with white cabinets, a marble countertop, and a built-in oven.

A deck with a table and chairs, a trash can, and a large umbrella.

6. Your home away from home in downtown, historic Farmington!

Farmington

Emily N.

£189

includes taxes & fees

15 Sept - 16 Sept

A red barn with a sloped roof, surrounded by a grassy field and trees.

A kitchen with a white stove, wooden cabinets, a clock, and a coffee maker.

A fire pit with four Adirondack chairs in red and blue colors, surrounded by a grassy area with trees and a building in the background.

A large tree in front of a row of mobile homes.

7. The Weber Farm - Enjoy a beautiful 100 acre farm!

Frohna

Alison C.

£124

includes taxes & fees

14 Sept - 15 Sept

A two-story cylindrical building with a covered porch and a welcoming sign.

A kitchen with wooden cabinets, a coffee station, and a rustic barrel.

A rustic interior with a wooden barrel table, stools, a decorative wreath, and a sliding barn door.

A cozy living room with a gray sofa, a wooden coffee table, and a kitchen area featuring white cabinets, a stove, and a microwave.

8. Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve

Anthony S.

£278

includes taxes & fees

14 Sept - 15 Sept

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Top Southeast Missouri Hotel Reviews

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Room 1

Change your mind

Treat yourself

Be picky

Check availability on Southeast Missouri Winery Hotels

Our top choices for Southeast Missouri hotels with winery

1. Fort Davidson Hotel

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

4. Beautiful Modern Loft In Wine Country!

5. Baymont by Wyndham Festus

6. Your home away from home in downtown, historic Farmington!

7. The Weber Farm - Enjoy a beautiful 100 acre farm!

8. Silo Farm Haus- located in the heart of wine country!

9. Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC w/ room for your horses

10. #ContemplationCabin on the Jacks Fork River!

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia

Search Winery Hotels in Southeast Missouri

Change your mind

Treat yourself

Be picky

Check availability on Southeast Missouri Winery Hotels

Our top choices for Southeast Missouri hotels with winery

1. Fort Davidson Hotel

2. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3. "The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

4. Beautiful Modern Loft In Wine Country!

5. Baymont by Wyndham Festus

6. Your home away from home in downtown, historic Farmington!

7. The Weber Farm - Enjoy a beautiful 100 acre farm!

8. Silo Farm Haus- located in the heart of wine country!

9. Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC w/ room for your horses

10. #ContemplationCabin on the Jacks Fork River!

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia