Title: TOP Hotels with Air Conditioning in Southeast Missouri, MO for 2025 | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard # Search Hotels with Air Conditioning in Southeast Missouri - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri Hotels with Air Conditioning Tonight [11 Nov - 12 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-11&endDate=2025-11-12&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Nov - 13 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-12&endDate=2025-11-13&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [14 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [21 Nov - 23 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-11-21&endDate=2025-11-23&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Missouri Hotels with Air Conditioning ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Refrigerator & Microwave (Sofabed, 2 Rooms, Tub) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/83931306.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Poplar Bluff Poplar Bluff 9.2/10 Wonderful (943) "Very clean and comfortable!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy £81 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/2d914387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center Cape Girardeau 9.6/10 Exceptional (1000) "Clean room and amenities were great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Crystal £77 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/4071c448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/db5aadc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children’s play area – outdoor](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/104061b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/136440e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Echo Bluff State Park Eminence 9.4/10 Exceptional (213) "Great staff and beautiful lodge! Pictures on Expedia are just the cabins. This is a little misleading because my reservation was actually in the lodge." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alisa £119 includes taxes & fees 12 Nov - 13 Nov [](https://www.expedia.co.uk/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/08371d9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f737107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO Sikeston 9.4/10 Exceptional (1008) "Clean room, great location and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark £82 includes taxes & fees 19 Nov - 20 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/a8b491ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/686f0126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston Sikeston 8.8/10 Excellent (423) "Nice property and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy £82 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/2df4267b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/4ea3df4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/ee6292b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau Near the Medical Center Cape Girardeau 9.0/10 Wonderful (1005) "Always enjoy our stay. Staff is very friendly, especially at breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul £60 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/874a4e6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/0a692e3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room | Hypo-allergenic bedding, in-room safe, desk, soundproofing](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/4ea0b11e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Poplar Bluff by IHG Poplar Bluff 8.8/10 Excellent (685) "I appreciated the quiet room, friendly staff and the included breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ray £87 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds | Room amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/d42a6e3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG Perryville 9.2/10 Wonderful (527) "Clean room and pleasant staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David £83 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/5904f90a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/e921a7b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/f6482ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Poplar Bluff Poplar Bluff 9.4/10 Exceptional (785) "Excellent property, great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina £83 includes taxes & fees 1 Dec - 2 Dec [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/35f08a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Farmstead Hotel Caruthersville 8.8/10 Excellent (442) "Excellent hotel. Very clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Don £74 includes taxes & fees 12 Nov - 13 Nov [](https://www.expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-25&endDate=2025-11-26®ionId=6058763&adults=2&amenities=AIR_CONDITIONING&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Missouri Hotel Reviews ![Pear Tree Inn Cape Girardeau West](//images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Everything!" [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Clean room very nice staff. Breakfast was good too." [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](//images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Yes" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Baymont Inn and Suites by Wyndham Farmington, MO](//images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 10/10 Excellent "Ok" [](https://expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "The room was clean and comfy. The staf was friendly, courteous and efficient. Many thanks!" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Drury Inn & Suites Hayti Caruthersville](//images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031_y.jpg) ### Drury Inn & Suites Hayti Caruthersville 10/10 Excellent "Great stay. Clean room, and Drury Inns always seem to have the most comfortable beds." [](https://expedia.co.uk/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information) ![Pear Tree Inn Cape Girardeau Near the Medical Center](//images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg) ### Pear Tree Inn Cape Girardeau Near the Medical Center 10/10 Excellent "Always great service and awesome accomodations." [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Motel 6 Poplar Bluff, MO](//images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Everything we needed" [](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ## Frequently asked questions ### How much do hotels with air conditioning in Southeast Missouri cost? > Hotels with air conditioning in Southeast Missouri range between and per night. These stays provide the comfort you need at a price that'll make your bank balance smile. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best hotels with air conditioning in Southeast Missouri? > Jump straight into holiday mode and take it easy in one of Southeast Missouri's multiple hotels with air conditioning. With a total average guest review rating of , there's something here for every taste and budget. Many visitors to Cape Girardeau prefer a stay at [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information), a highly rated 2.5-stars option with a dining venue, a swimming pool and air conditioning. Another traveller favourite in this popular city is [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information). This 3-stars escape offers a swimming pool and complimentary breakfast. ### How many hotels with air conditioning are there in Southeast Missouri? > Browse our hotels with AC in Southeast Missouri and then select your favourite. Whether you're organising a holiday with all the fam or kicking it with friends, with Expedia, your perfect stay is just a few clicks away. ### What are the best cheap hotels with air conditioning in Southeast Missouri? > Save on your Southeast Missouri adventure by choosing hotels with air conditioning from only per night. Planning to explore the must-visit attractions of Cape Girardeau? Unpack your bags at [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information), a money-saving option with in-room AC, a dining venue and a terrace. If you're travelling to Sikeston, [Pear Tree Inn Sikeston](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) is a popular pick. It offers the air-conditioned comfort you need along with a swimming pool and complimentary breakfast. Explore Southeast Missouri on a shoestring by filling your itinerary with fantastic free attractions. [Isle Casino Cape Girardeau](https://www.expedia.co.uk/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Attraction) in Cape Girardeau is a highlight. If you're heading to Sikeston, you won't have to touch your wallet when you visit [Sikeston Depot Museum](https://www.expedia.co.uk/Sikeston-Depot-Museum-Sikeston.d6305602.Attraction). This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the top motels with air conditioning in Southeast Missouri? > Offering convenience and comfort, motels with air conditioning in Southeast Missouri are a low-cost way to holiday with the whole family. If you're stopping over in Cape Girardeau, check out [Town House Inn](https://www.expedia.co.uk/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information). It's 9 mi northwest of downtown and has amenities such as an oven and free WiFi. Another top option that has air conditioning is [Town House Inn Cape Giradreau](https://www.expedia.co.uk/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information). It also comes with front desk services and free WiFi and is located about 2 mi west of the centre of Cape Girardeau.Cape Girardeau is bursting with fascinating things to see and do. Be sure to stop by [Cape Splash Family Aquatic Centre](https://www.expedia.co.uk/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Vacation-Attraction) and [Hunter Valley Winery](https://www.expedia.co.uk/Hunter-Valley-Winery-Cape-Girardeau.d553248621532655783.Vacation-Attraction) when you're ready to explore. ### Are there any family-friendly hotels with air conditioning in Southeast Missouri? > There sure are, so gather the family and get busy planning your Southeast Missouri escape! If Cape Girardeau is your preferred destination, make a reservation at [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information). This 3-stars option is a favourite family-friendly hotel with air conditioning. It also features complimentary breakfast and WiFi. Another superb choice is [Pear Tree Inn Cape Girardeau West](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information). Also in Cape Girardeau, it has a 2.5-stars rating and has complimentary breakfast, a laundry service and air conditioning. Cape Girardeau offers loads of family-friendly attractions when it's time to go sightseeing. [Cape Splash Family Aquatic Centre](https://www.expedia.co.uk/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Attraction) and [Riverfront Park](https://www.expedia.co.uk/Riverfront-Park-Cape-Girardeau.d740677735274594304.Attraction) promise fun for the entire crew. ### Why book your hotel with air conditioning in Southeast Missouri with Expedia? > Expedia has irresistible deals on hotels with air conditioning in Southeast Missouri. If you have a certain budget, choose how much you're willing to spend and the preferred star rating of your hotel. Then use our handy filters to search for air-conditioned digs with perks like a kitchen or a pool. We'll help you find the perfect fit whatever your holiday looks like. ### How can I find cheap hotels with air conditioning in Southeast Missouri? > Expedia can help you narrow down your search for cheap hotels with air conditioning in Southeast Missouri. Just click "air conditioned" below the amenities filter to view accommodation with this feature. Next, pick your hotel star rating (lower-rated stays are generally cheaper) and your budget per night to find a suitable spot with air conditioning at the most affordable price. ### What is there to do in Southeast Missouri near my hotel with air conditioning? > You'll find many things to do in Southeast Missouri. If you're bound for Cape Girardeau, be sure to look around [Isle Casino Cape Girardeau](https://www.expedia.co.uk/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction), [Cape Rock Park](https://www.expedia.co.uk/Cape-Rock-Park-Cape-Girardeau.d553248621532655781.Vacation-Attraction) and [Fort D Historic Site](https://www.expedia.co.uk/Fort-D-Historic-Site-Cape-Girardeau.d553248621532655775.Vacation-Attraction). Packing your bags for Ste Genevieve? [Sainte Genevieve Winery](https://www.expedia.co.uk/Sainte-Genevieve-Winery-Ste-Genevieve.d553248621532648574.Vacation-Attraction), [Bolduc House Museum](https://www.expedia.co.uk/Bolduc-House-Museum-Ste-Genevieve.d553248621532648575.Vacation-Attraction) and [Felix Valle House State Historic Site](https://www.expedia.co.uk/Felix-Valle-House-State-Historic-Site-Ste-Genevieve.d553248621532648573.Vacation-Attraction) are popular sights here. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Allenville Hotels](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Annapolis Hotels](https://www.expedia.co.uk/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Arcadia Hotels](https://www.expedia.co.uk/Arcadia-Hotels.d6346857.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Arnold](https://www.expedia.co.uk/Arnold-Hotels-Gay-Friendly-Hotel.0-0-d177608-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Pool in Arnold](https://www.expedia.co.uk/Arnold-Hotels-Hotels-With-Pool.0-0-d177608-tHotelswithPool.Travel-Guide-Filter-Hotels) - [Spa Hotels in Arnold](https://www.expedia.co.uk/Arnold-Hotels-Spa-Hotels.0-0-d177608-tSpaHotels.Travel-Guide-Filter-Hotels) - [Belleview Hotels](https://www.expedia.co.uk/Belleview-Hotels.d3000444413.Travel-Guide-Hotels) - [Bismarck Hotels](https://www.expedia.co.uk/Bismarck-Hotels.d553248634983538264.Travel-Guide-Hotels) - [B&B in Black](https://www.expedia.co.uk/Black-Bed-And-Breakfasts.d3000444470-aaBedAndBreakfasts.Travel-Guide-Accommodation) - [Black Hotels](https://www.expedia.co.uk/Black-Hotels.d3000444470.Travel-Guide-Hotels) - [Bonne Terre Hotels](https://www.expedia.co.uk/Bonne-Terre-Hotels.d55598.Travel-Guide-Hotels) - [Caledonia Hotels](https://www.expedia.co.uk/Caledonia-Hotels.d6359344.Travel-Guide-Hotels) - [Adults Only Resorts & in Cape Girardeau](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Adults-Only-Resorts.0-0-d820-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Historic Hotels in Cape Girardeau](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Historic-Hotel.0-0-d820-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Centerville Hotels](https://www.expedia.co.uk/Centerville-Hotels.d553248634983078632.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Clayton-Tamm](https://www.expedia.co.uk/Clayton-Tamm-St-Louis-Hotels-Gay-Friendly-Hotel.0-n553248635976473263-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Sports Hotels in Cuba](https://www.expedia.co.uk/Cuba-Hotels-Adventure-Sport-Hotel.0-0-d6499-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Cuba](https://www.expedia.co.uk/Cuba-Hotels-Hotels-With-Hot-Tubs.0-0-d6499-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Cuba](https://www.expedia.co.uk/Cuba-Hotels-Luxury-Hotel.0-0-d6499-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Desloge Hotels](https://www.expedia.co.uk/Desloge-Hotels.d55671.Travel-Guide-Hotels) - [Doe Run Hotels](https://www.expedia.co.uk/Doe-Run-Hotels.d3000349343.Travel-Guide-Hotels) - [Ellington Hotels](https://www.expedia.co.uk/Ellington-Hotels.d3000444859.Travel-Guide-Hotels) - [Farmington Hotels](https://www.expedia.co.uk/Farmington-Hotels.d6058764.Travel-Guide-Hotels) - [Wedding Hotels in Fenton](https://www.expedia.co.uk/Fenton-Hotels-Wedding-Hotel.0-0-d7150-tWeddingHotel.Travel-Guide-Filter-Hotels) - [Flat River Hotels](https://www.expedia.co.uk/Flat-River-Hotels.d183474.Travel-Guide-Hotels) - [Fredericktown Hotels](https://www.expedia.co.uk/Fredericktown-Hotels.d55114.Travel-Guide-Hotels) - [Friedheim Hotels](https://www.expedia.co.uk/Friedheim-Hotels.d3000349372.Travel-Guide-Hotels) - [Glen Allen Hotels](https://www.expedia.co.uk/Glen-Allen-Hotels.d553248634983455025.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Hayti](https://www.expedia.co.uk/Hayti-Hotels-Gay-Friendly-Hotel.0-0-d6058765-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Ironton Hotels](https://www.expedia.co.uk/Ironton-Hotels.d6053585.Travel-Guide-Hotels) - [Hotels near Johnson's Shut-ins State Park](https://www.expedia.co.uk/Johnsons-Shut-Ins-State-Park-Hotels.0-l553248621555612544-0.Travel-Guide-Filter-Hotels) - [Junction City Hotels](https://www.expedia.co.uk/Junction-City-Hotels.d553248634983410095.Travel-Guide-Hotels) - [Leadwood Hotels](https://www.expedia.co.uk/Leadwood-Hotels.d3000349432.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Lemay](https://www.expedia.co.uk/Lemay-Hotels-Gay-Friendly-Hotel.0-0-d3000008297-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Lesterville](https://www.expedia.co.uk/Lesterville-Hotels-Gay-Friendly-Hotel.0-0-d3000445174-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Lesterville Hotels](https://www.expedia.co.uk/Lesterville-Hotels.d3000445174.Travel-Guide-Hotels) - [Marble Hill Hotels](https://www.expedia.co.uk/Marble-Hill-Hotels.d3000445212.Travel-Guide-Hotels) - [Marquand Hotels](https://www.expedia.co.uk/Marquand-Hotels.d553248634983260789.Travel-Guide-Hotels) - [Hotels with Restaurant in Marston](https://www.expedia.co.uk/Marston-Hotels-Hotel-With-Restaurant.0-0-d55824-thotelwithrestaurant.Travel-Guide-Filter-Hotels) - [Middle Brook Hotels](https://www.expedia.co.uk/Middle-Brook-Hotels.d3000445241.Travel-Guide-Hotels) - [New Offenburg Hotels](https://www.expedia.co.uk/New-Offenburg-Hotels.d3000349478.Travel-Guide-Hotels) - [Park Hills Hotels](https://www.expedia.co.uk/Park-Hills-Hotels.d183485.Travel-Guide-Hotels) - [Perryville Hotels](https://www.expedia.co.uk/Perryville-Hotels.d6134448.Travel-Guide-Hotels) - [Piedmont Hotels](https://www.expedia.co.uk/Piedmont-Hotels.d3000445413.Travel-Guide-Hotels) - [Pilot Knob Hotels](https://www.expedia.co.uk/Pilot-Knob-Hotels.d3000008143.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Poplar Bluff](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Gay-Friendly-Hotel.0-0-d9449-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Rolla](https://www.expedia.co.uk/Rolla-Hotels-Gay-Friendly-Hotel.0-0-d6058783-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Room Service in Rolla](https://www.expedia.co.uk/Rolla-Hotels-Hotel-With-Room-Service.0-0-d6058783-thotelwithroomservice.Travel-Guide-Filter-Hotels) - [Hotels with Indoor Pools in Rolla](https://www.expedia.co.uk/Rolla-Hotels-Hotels-With-Indoor-Pools.0-0-d6058783-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Rolla](https://www.expedia.co.uk/Rolla-Hotels-Pet-Friendly-Hotel.0-0-d6058783-tPetFriendlyHotel.Travel-Guide-Filter-Hotels) - [Sedgewickville Hotels](https://www.expedia.co.uk/Sedgewickville-Hotels.d3000349537.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Sikeston](https://www.expedia.co.uk/Sikeston-Hotels-Gay-Friendly-Hotel.0-0-d6058766-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Indoor Pools in Sikeston](https://www.expedia.co.uk/Sikeston-Hotels-Hotels-With-Indoor-Pools.0-0-d6058766-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels) - [Cheap Hotels in St. James](https://www.expedia.co.uk/St-James-Hotels-Budget-Hotels.0-0-d7592-tBudgetHotels.Travel-Guide-Filter-Hotels) - [Business Hotels in St. James](https://www.expedia.co.uk/St-James-Hotels-Business-Hotel.0-0-d7592-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels with Entertainment in St. James](https://www.expedia.co.uk/St-James-Hotels-Hotel-With-Entertainment.0-0-d7592-thotelwithentertainment.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in St. James](https://www.expedia.co.uk/St-James-Hotels-Hotels-With-Hot-Tubs.0-0-d7592-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotels with Indoor Pools in St. James](https://www.expedia.co.uk/St-James-Hotels-Hotels-With-Indoor-Pools.0-0-d7592-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in St. James](https://www.expedia.co.uk/St-James-Hotels-Pet-Friendly-Hotel.0-0-d7592-tPetFriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in St. James](https://www.expedia.co.uk/St-James-Hotels-Romantic-Hotel.0-0-d7592-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Town and Country](https://www.expedia.co.uk/Town-And-Country-Hotels-Gay-Friendly-Hotel.0-0-d6252549-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Van Buren Hotels](https://www.expedia.co.uk/Van-Buren-Hotels.d183504.Travel-Guide-Hotels) - [Wappapello Hotels](https://www.expedia.co.uk/Wappapello-Hotels.d183505.Travel-Guide-Hotels) - [Weingarten Hotels](https://www.expedia.co.uk/Weingarten-Hotels.d553248635975847364.Travel-Guide-Hotels) - [Gay-Friendly Hotels in West Plains](https://www.expedia.co.uk/West-Plains-Hotels-Gay-Friendly-Hotel.0-0-d6134031-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Williamsville Hotels](https://www.expedia.co.uk/Williamsville-Hotels.d553248634983506457.Travel-Guide-Hotels) - [Flights to Bonne Terre](https://www.expedia.co.uk/Cheap-Flights-To-Bonne-Terre.d55598.Travel-Guide-Flights) - [Flights to Desloge](https://www.expedia.co.uk/Cheap-Flights-To-Desloge.d55671.Travel-Guide-Flights) - [Flights to Park Hills](https://www.expedia.co.uk/Cheap-Flights-To-Park-Hills.d183485.Travel-Guide-Flights) - [Flights to Wappapello](https://www.expedia.co.uk/Cheap-Flights-To-Wappapello.d183505.Travel-Guide-Flights) - [Flights from Park Hills](https://www.expedia.co.uk/lp/flights/183485/flights-from-park-hills) - [Flights from Pilot Knob](https://www.expedia.co.uk/lp/flights/3000008143/flights-from-pilot-knob) - [Flights from Doe Run](https://www.expedia.co.uk/lp/flights/3000349343/flights-from-doe-run) - [Flights from Black](https://www.expedia.co.uk/lp/flights/3000444470/flights-from-black) - [Flights from Lesterville](https://www.expedia.co.uk/lp/flights/3000445174/flights-from-lesterville) - [Flights from Fredericktown](https://www.expedia.co.uk/lp/flights/55114/flights-from-fredericktown) - [Flights from Marquand](https://www.expedia.co.uk/lp/flights/553248634983260789/flights-from-marquand) - [Flights from Zalma](https://www.expedia.co.uk/lp/flights/553248634983373716/flights-from-zalma) - [Flights from Ellsinore](https://www.expedia.co.uk/lp/flights/553248634983439149/flights-from-ellsinore) - [Flights from Bonne Terre](https://www.expedia.co.uk/lp/flights/55598/flights-from-bonne-terre) - [Flights from Farmington](https://www.expedia.co.uk/lp/flights/6058764/flights-from-farmington) - [Flights from Annapolis](https://www.expedia.co.uk/lp/flights/6282465/flights-from-annapolis) - [Flights from Arcadia](https://www.expedia.co.uk/lp/flights/6346857/flights-from-arcadia) - [Flights from Los Angeles (LAX) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/lax/pof/los-angeles-to-poplar-bluff) - [Flights from Carbondale (MDH) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/mdh/pof/carbondale-to-poplar-bluff) - [Flights from Pittsburgh (PIT) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/pit/pof/pittsburgh-to-poplar-bluff) - [Visit Bonne Terre](https://www.expedia.co.uk/Bonne-Terre.dx55598) - [Caledonia Holidays](https://www.expedia.co.uk/Caledonia.d6359344.Holidays-City-Breaks) - [Visit Farmington](https://www.expedia.co.uk/Farmington.dx6058764) - [Visit Fredericktown](https://www.expedia.co.uk/Fredericktown.dx55114) - [Leadwood Holidays](https://www.expedia.co.uk/Leadwood.d3000349432.Holidays-City-Breaks) - [Visit Lesterville](https://www.expedia.co.uk/Lesterville.dx3000445174) - [Van Buren Holidays](https://www.expedia.co.uk/Van-Buren.d183504.Holidays-City-Breaks) - [Car hire Black](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Black.d3000444470.Car-Hire-Guide) - [Hertz Rental Cars in Centerville](https://www.expedia.co.uk/Hertz-Car-Rentals-In-Centerville.d553248634983078632-c40.Car-Rental-Guide-Suppliers) - [Island Car Rentals Rental Cars in Cobalt](https://www.expedia.co.uk/Island-Car-Rentals-Car-Rentals-In-Cobalt.d553248634983153223-c1132.Car-Rental-Guide-Suppliers) - [Thrifty Car Rental Rental Cars in Belgrade](https://www.expedia.co.uk/Thrifty-Car-Rental-Car-Rentals-In-Belgrade.d553248635975850450-c45.Car-Rental-Guide-Suppliers) - [Doe Run Holiday Rentals](https://www.expedia.co.uk/Doe-Run-Holiday-Rentals.d3000349343.Travel-Guide-HolidayRentals) - [Lesterville Holiday Rentals](https://www.expedia.co.uk/Lesterville-Holiday-Rentals.d3000445174.Travel-Guide-HolidayRentals) - [Pilot Knob Holiday Rentals](https://www.expedia.co.uk/Pilot-Knob-Holiday-Rentals.d3000008143.Travel-Guide-HolidayRentals) - [Book Hotels with Air Conditioning in Southeast Missouri on Expedia.com](https://www.expedia.com/Southeast-Missouri-Hotels-Hotels-With-Air-Conditioning.0-0-d6058763-tHotelswithAirConditioning.Travel-Guide-Filter-Hotels)