Title: TOP Hotels with Air Conditioning in Southeast Missouri, MO for 2025 | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Hotels with Air Conditioning in Southeast Missouri ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri Hotels with Air Conditioning Tonight [27 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-09-27&endDate=2025-09-28&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [28 Sept - 29 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-09-28&endDate=2025-09-29&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-03&endDate=2025-10-05&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [10 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-10&endDate=2025-10-12&adults=2&amenities=AIR_CONDITIONING&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Missouri Hotels with Air Conditioning ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/49c875c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/f46408d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/a5281c8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Hayti Caruthersville Hayti 9.4/10 Exceptional (1007) "Nice place for a over night stay would recamend." £80 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Premium bedding, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/96e79bac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/46991f0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 Queen Bed, Non Smoking | Room amenity](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/ca717d37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/d63c0a0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Sainte Genevieve Ste Genevieve 8.8/10 Excellent (595) "Clean, friendly, and safe." £64 includes taxes & fees 12 Oct - 13 Oct [](https://www.expedia.co.uk/Ste-Genevieve-Hotels-Microtel-Inn-Suites-By-Wyndham-Sainte-Genevieve.h425932.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/e3fbcab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily breakfast ](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8df39481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/3c8c0a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Sikeston Sikeston 9.4/10 Exceptional (1007) "I love this hotel! Have stayed several times and will definitely stay again. The rooms are always very clean and the staff is so friendly and helpful. I highly recommend this hotel!" £66 includes taxes & fees 3 Oct - 4 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/66c21f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO Jackson 9.6/10 Exceptional (1018) "Was a clean room, nice staff, good parking " £71 includes taxes & fees 2 Oct - 3 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/08371d9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds, Accessible, Refrigerator & Microwave (Tub) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/0941dc05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO Sikeston 9.4/10 Exceptional (1013) "Everything was extremely nice" £77 includes taxes & fees 2 Oct - 3 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Refrigerator & Microwave (Sofabed, 2 Rooms, Tub) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/83931306.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b2d719b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Poplar Bluff Poplar Bluff 9.2/10 Wonderful (915) "Always a good stay" £84 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/c6e7fccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG Perryville 9.4/10 Exceptional (510) "Have stayed here the past 3 years during the Laid Back on I-55 Truck Show! Great place to stay! The breakfast is fantastic!! The staff does not disappoint!! " £73 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/57db158c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite, 1 Queen Bed with Sofa bed, Kitchen | In-room dining](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/a091ce3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/091dc4e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Double Room, 2 Queen Beds, Kitchenette | Bathroom | Combined shower/bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/99d2e456.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Shepherd Mountain Inn Ironton 9.4/10 Exceptional (300) " Nice room, nice bed, convenient location" [](https://www.expedia.co.uk/Farmington-Hotels-Shepherd-Mountain-Inn.h12582009.Hotel-Information) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/633eb669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/5aa6a52b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/c1fba8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau Cape Girardeau 9.6/10 Exceptional (68) "Property is new and very modern - great breakfast" £86 includes taxes & fees 20 Oct - 21 Oct [](https://www.expedia.co.uk/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/3b6f469d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Cabin, 1 Queen Bed | 1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/de973d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/3ec0c384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/d9c54765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins St. Francois French Village 9.8/10 Exceptional (36) "Peaceful, beautiful stay. " £100 includes taxes & fees 28 Sept - 29 Sept [](https://www.expedia.co.uk/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=6058763&adults=2&amenities=AIR_CONDITIONING&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Missouri Hotel Reviews ![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Very, Very nice. Always, first think I look at is landscaping. It foretells that attitude of the hotel. Drury of the Cape was nicely done, well maintained and fresh. Ok, good start. Start check in and Travelocity computer was not up to speed with Drury's. Desk person got manager, sorted it in just a few short minutes, with a smile the whole time, and up to my room. Room was immaculate, well appointed, nicely decorated, and just plain comfortable. Relaxed a few minutes in the comfortable chair and went down for complimentary dinner. No gigantic spread but, way more than I expected and very tasty. Eveything about my stay was over the top for the price I paid. Everyone working there seemed happy and smiling genuinely.Absolutely one of the nicest hotels I've ever stayed in. This company has the right idea on providing service while not trying to rob you at the same time. Thank You!" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Baymont Inn and Suites by Wyndham Farmington, MO](//images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 10/10 Excellent "I loved everything about you keep up the great work" [](https://expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Pear Tree Inn Cape Girardeau Near the Medical Center](//images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg) ### Pear Tree Inn Cape Girardeau Near the Medical Center 10/10 Excellent "Staff was friendly, room was clean, good location, good rate." [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Drury Inn & Suites Jackson MO](//images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "this place is awesome! evening snacks and drinks (a meal really!) and very nice breakfast comfortable bed and beautiful grounds-quite rural, but Dairy Queen across the road. easy and safe seeming parking " [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](//images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Very clean, sincerely friendly staff and very helpful. Pillows and bed comfy. Great location. " [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Motel 6 Poplar Bluff, MO](//images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Everything was great. I was traveling with 2 dogs. Everyone was great. I would only question the choice of the bathroom sink. Very unhandy. Otherwise a great value. " [](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Comfort Inn Festus - St Louis South](//images.trvl-media.com/lodging/1000000/50000/40200/40138/3ea7ebcc_y.jpg) ### Comfort Inn Festus - St Louis South 10/10 Excellent "This hotel was a good place to stay and will be coming back. The staff were really friendly and polite. Convenient to restaurants and other stores. The only thing that we didn’t like was how there is no pool. What happened to every hotel having a pool lol. " [](https://expedia.co.uk/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Festus - St. Louis South](//images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70_y.jpg) ### La Quinta Inn & Suites by Wyndham Festus - St. Louis South 10/10 Excellent "Great easy place to stay. Good location." [](https://expedia.co.uk/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Always a nice place to stay!" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ## Frequently asked questions ### How much do hotels with air conditioning in Southeast Missouri cost? > Hotels with air conditioning in Southeast Missouri range between and per night. These stays provide the comfort you need at a price that'll make your bank balance smile. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best hotels with air conditioning in Southeast Missouri? > Jump straight into holiday mode and take it easy in one of Southeast Missouri's multiple hotels with air conditioning. With a total average guest review rating of , there's something here for every taste and budget. Many visitors to Cape Girardeau prefer a stay at [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information), a highly rated 2.5-stars option with a dining venue, a swimming pool and air conditioning. Another traveller favourite in this popular city is [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information). This 3-stars escape offers a swimming pool and complimentary breakfast. ### How many hotels with air conditioning are there in Southeast Missouri? > Browse our hotels with AC in Southeast Missouri and then select your favourite. Whether you're organising a holiday with all the fam or kicking it with friends, with Expedia, your perfect stay is just a few clicks away. ### What are the best cheap hotels with air conditioning in Southeast Missouri? > Save on your Southeast Missouri adventure by choosing hotels with air conditioning from only per night. Planning to explore the must-visit attractions of Cape Girardeau? Unpack your bags at [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information), a money-saving option with in-room AC, a dining venue and a terrace. If you're travelling to Sikeston, [Pear Tree Inn Sikeston](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) is a popular pick. It offers the air-conditioned comfort you need along with a swimming pool and complimentary breakfast. Explore Southeast Missouri on a shoestring by filling your itinerary with fantastic free attractions. [Isle Casino Cape Girardeau](https://www.expedia.co.uk/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Attraction) in Cape Girardeau is a highlight. If you're heading to Sikeston, you won't have to touch your wallet when you visit [Sikeston Depot Museum](https://www.expedia.co.uk/Sikeston-Depot-Museum-Sikeston.d6305602.Attraction). This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the top motels with air conditioning in Southeast Missouri? > Offering convenience and comfort, motels with air conditioning in Southeast Missouri are a low-cost way to holiday with the whole family. If you're stopping over in Cape Girardeau, check out [Town House Inn](https://www.expedia.co.uk/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information). It's 9 mi northwest of downtown and has amenities such as an oven and free WiFi. Another top option that has air conditioning is [Town House Inn Cape Giradreau](https://www.expedia.co.uk/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information). It also comes with front desk services and free WiFi and is located about 2 mi west of the centre of Cape Girardeau.Cape Girardeau is bursting with fascinating things to see and do. Be sure to stop by [Cape Splash Family Aquatic Centre](https://www.expedia.co.uk/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Vacation-Attraction) and [Hunter Valley Winery](https://www.expedia.co.uk/Hunter-Valley-Winery-Cape-Girardeau.d553248621532655783.Vacation-Attraction) when you're ready to explore. ### Are there any family-friendly hotels with air conditioning in Southeast Missouri? > There sure are, so gather the family and get busy planning your Southeast Missouri escape! If Cape Girardeau is your preferred destination, make a reservation at [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information). This 3-stars option is a favourite family-friendly hotel with air conditioning. It also features complimentary breakfast and WiFi. Another superb choice is [Pear Tree Inn Cape Girardeau West](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information). Also in Cape Girardeau, it has a 2.5-stars rating and has complimentary breakfast, a laundry service and air conditioning. Cape Girardeau offers loads of family-friendly attractions when it's time to go sightseeing. [Cape Splash Family Aquatic Centre](https://www.expedia.co.uk/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Attraction) and [Riverfront Park](https://www.expedia.co.uk/Riverfront-Park-Cape-Girardeau.d740677735274594304.Attraction) promise fun for the entire crew. ### Why book your hotel with air conditioning in Southeast Missouri with Expedia? > Expedia has irresistible deals on hotels with air conditioning in Southeast Missouri. If you have a certain budget, choose how much you're willing to spend and the preferred star rating of your hotel. Then use our handy filters to search for air-conditioned digs with perks like a kitchen or a pool. We'll help you find the perfect fit whatever your holiday looks like. ### How can I find cheap hotels with air conditioning in Southeast Missouri? > Expedia can help you narrow down your search for cheap hotels with air conditioning in Southeast Missouri. Just click "air conditioned" below the amenities filter to view accommodation with this feature. Next, pick your hotel star rating (lower-rated stays are generally cheaper) and your budget per night to find a suitable spot with air conditioning at the most affordable price. ### What is there to do in Southeast Missouri near my hotel with air conditioning? > You'll find many things to do in Southeast Missouri. If you're bound for Cape Girardeau, be sure to look around [Isle Casino Cape Girardeau](https://www.expedia.co.uk/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction), [Cape Rock Park](https://www.expedia.co.uk/Cape-Rock-Park-Cape-Girardeau.d553248621532655781.Vacation-Attraction) and [Fort D Historic Site](https://www.expedia.co.uk/Fort-D-Historic-Site-Cape-Girardeau.d553248621532655775.Vacation-Attraction). Packing your bags for Ste Genevieve? [Sainte Genevieve Winery](https://www.expedia.co.uk/Sainte-Genevieve-Winery-Ste-Genevieve.d553248621532648574.Vacation-Attraction), [Bolduc House Museum](https://www.expedia.co.uk/Bolduc-House-Museum-Ste-Genevieve.d553248621532648575.Vacation-Attraction) and [Felix Valle House State Historic Site](https://www.expedia.co.uk/Felix-Valle-House-State-Historic-Site-Ste-Genevieve.d553248621532648573.Vacation-Attraction) are popular sights here. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Allenville Hotels](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Annapolis Hotels](https://www.expedia.co.uk/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Arcadia Hotels](https://www.expedia.co.uk/Arcadia-Hotels.d6346857.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Arnold](https://www.expedia.co.uk/Arnold-Hotels-Gay-Friendly-Hotel.0-0-d177608-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - 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