Title: TOP Hotels Suites in Southeast Missouri, MO for 2026 |  Expedia.co.uk

[Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks)

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## Check availability on Southeast Missouri Hotels Suites

Tonight

[6 Apr - 7 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-04-06&endDate=2026-04-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[7 Apr - 8 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[17 Apr - 19 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Southeast Missouri Hotel Reviews

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Clean room. "

[](https://expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

8/10 Good

"It would be nice to have bacon sometime."

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

4/10 Poor

"I’ve stayed at this hotel twice now while visiting family in the area. The property itself is very nice—clean, well‑maintained, and in a great location right off the interstate. The staff has also been friendly during both of my stays. However, both times my mom and I were placed in the exact same room directly above the atrium, and that unfortunately made the stay much less restful. The noise from the lobby carries straight up into the room. Late at night you can clearly hear people talking and laughing in the dining area, chairs scraping across the floor, and every sound seems amplified. Then very early in the morning, you’re woken up again by staff setting up breakfast and guests eating downstairs. I’m honestly frustrated with myself for not thinking to request a room away from the lobby this time, because I didn’t expect to be put in the same noisy room again. The hotel is great in many ways, but I would strongly recommend requesting a room far from the atrium if you’re a light sleeper or want a quiet stay."

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Wonderful. I will definitely stay here again. "

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

## Frequently asked questions

### How much do hotels with suites in Southeast Missouri cost?

### What are the best hotels with suites in Southeast Missouri?

### How many hotels with suites are there in Southeast Missouri?

### What are the best cheap hotels with suites in Southeast Missouri?

### Are there any family-friendly hotels with suites in Southeast Missouri?

### Why book your hotel with suites in Southeast Missouri with Expedia?

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- [Book Hotels Suites in Southeast Missouri on Expedia.com ](https://www.expedia.com/Southeast-Missouri-Hotels-Hotel-Suites.0-0-d6058763-tHotelSuites.Travel-Guide-Filter-Hotels)