Title: TOP Hotels Suites in Southeast Missouri, MO for 2025 | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Hotels Suites in Southeast Missouri ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri Hotels Suites Tonight [21 Oct - 22 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-21&endDate=2025-10-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [22 Oct - 23 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-22&endDate=2025-10-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [31 Oct - 2 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Missouri Hotels Suites ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds, Accessible, Refrigerator & Microwave (Tub) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/0941dc05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/08371d9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO Sikeston 9.4/10 Exceptional (1012) "Very nice and quiet " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lana £77 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/2d914387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center Cape Girardeau 9.6/10 Exceptional (1000) "Great place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric £76 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/4071c448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/db5aadc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/0c1d1e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/136440e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Echo Bluff State Park Eminence 9.4/10 Exceptional (210) "Beautiful location…excellent service and facilities / grounds were clean and well kept." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William £112 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/2df4267b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/ee6292b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/4ea3df4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau Near the Medical Center Cape Girardeau 9.0/10 Wonderful (1012) "Staff was very friendly and helpful would stay again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Keith £59 includes taxes & fees 23 Oct - 24 Oct [](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b2d719b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Refrigerator & Microwave (Sofabed, 2 Rooms, Tub) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/83931306.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Poplar Bluff Poplar Bluff 9.2/10 Wonderful (927) "Delicious, well-ran breakfast and quiet peaceful hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janene £79 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/59050052.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/0a692e3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/874a4e6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Poplar Bluff by IHG Poplar Bluff 8.8/10 Excellent (680) "Staff was friendly and accommodating. Room was quiet and clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lynda £82 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/35f08a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Farmstead Hotel Caruthersville 8.8/10 Excellent (431) "Very nice place to stay at." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Edina £70 includes taxes & fees 23 Oct - 24 Oct [](https://www.expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/d71a605c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Poplar Bluff Poplar Bluff 9.4/10 Exceptional (825) "Very friendly staff and clean rooms. My go to hotel!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara £86 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Children’s play area – outdoor](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/e8909449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/603f552a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Single Room | Individually decorated, individually furnished, desk, blackout curtains](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/868bcfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/5013cbb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Honeysuckle Inn - Mountain View Mountain View 8.6/10 Excellent (321) "Staff was very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joyce £77 includes taxes & fees 22 Oct - 23 Oct [](https://www.expedia.co.uk/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars) | Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8571b84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson 8.8/10 Excellent (640) "We had a restful stay very safe & clean! Friendly staff:)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rachel £68 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-04&endDate=2025-11-05®ionId=6058763&adults=2&nearby_group=suites&sort=RECOMMENDED&openPlayBack=true) ## Top Southeast Missouri Hotel Reviews ![Drury Inn & Suites Jackson MO](//images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "This place is everything you would want for the price. " [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Very clean, fantastic staff meals are great" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](//images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "The staff was very professional, kind and accommodating. " [](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ## Frequently asked questions ### How much do hotels with suites in Southeast Missouri cost? > You'll pay between and per night for hotels with suites in Southeast Missouri. Whatever your plans or budget, Expedia will help you find a home away from home with the spaciousness you're after. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### What are the best hotels with suites in Southeast Missouri? > Relax in one of the multiple hotels with suites in Southeast Missouri. With a total average guest review rating of , there's something here for everyone's budget and style. Cape Girardeau has plenty of properties with suites, including [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information). It holds a 2.5-star rating and amenities such as a terrace and a swimming pool. Another popular pick in this city is [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information). As well as spacious rooms, this 3-star escape features a swimming pool and a spa tub. ### How many hotels with suites are there in Southeast Missouri? > Southeast Missouri has hotels with suites to choose from. Enter your destination and travel dates and get a start on planning your perfect getaway today. ### What are the best cheap hotels with suites in Southeast Missouri? > It all depends on which corner of Southeast Missouri you'd like to explore. If you're travelling to Cape Girardeau, [Hampton Inn Cape Girardeau I 55 East](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) is an excellent choice. In addition to suites, this low-priced property features pool sun loungers and a terrace. Making a stop in Sikeston? [Pear Tree Inn Sikeston](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) is an affordable choice with suite rooms in this city. A swimming pool and a spa tub are among the amenities at this stay. Hotels with suites start from just per night, which means your trip doesn't have to hurt your hip pocket! Discover Southeast Missouri on a budget by filling your sightseeing itinerary with fantastic free attractions. [Isle Casino Cape Girardeau](https://www.expedia.co.uk/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Attraction) in Cape Girardeau is a must-see. If you're planning a trip to Sikeston, you won't have to touch your wallet when visiting [Sikeston Depot Museum](https://www.expedia.co.uk/Sikeston-Depot-Museum-Sikeston.d6305602.Attraction). This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### Are there any family-friendly hotels with suites in Southeast Missouri? > You'll discover some excellent family-friendly hotels that offer this type of accommodation in Southeast Missouri. If you're travelling to Cape Girardeau, look up [Drury Plaza Hotel Cape Girardeau Conference Centre](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information). With suites and handy amenities such as complimentary breakfast and housekeeping services, your group will enjoy kicking back at this 3-star stay. [Drury Inn & Suites Cape Girardeau](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) is another great pick for families in Cape Girardeau. This 3-star option features complimentary breakfast, housekeeping services and spacious suite rooms. Once you've checked in to your room, start sightseeing around Cape Girardeau. Make memories together at family-friendly attractions such as [Cape Splash Family Aquatic Centre](https://www.expedia.co.uk/Cape-Splash-Family-Aquatic-Center-Cape-Girardeau.d553248621532655772.Attraction) and [Riverfront Park](https://www.expedia.co.uk/Riverfront-Park-Cape-Girardeau.d740677735274594304.Attraction). ### Why book your hotel with suites in Southeast Missouri with Expedia? > Booking a hotel with suites in Southeast Missouri is as simple as deciding on your travel dates and selecting an option that suits you best. Seeking something low cost or luxurious, or a property that also has a particular amenity like a pool or spa? Expedia's filters make it a breeze to narrow down your search results and find your perfect match. ### How can I find cheap hotels with suites in Southeast Missouri? > Finding an affordable hotel with suites in Southeast Missouri is easy with Expedia. Just use our convenient filter tool to choose the hotel star rating you prefer, then decide on your nightly budget. Opting for fewer amenities can also help you land bigger savings. ### What is there to do in Southeast Missouri near my hotel with suites? > No matter your interests, there are so many things to put on your to-do list in Southeast Missouri. If you're holidaying in Cape Girardeau, check out [Isle Casino Cape Girardeau](https://www.expedia.co.uk/Isle-Casino-Cape-Girardeau-Cape-Girardeau.d553248621532655780.Vacation-Attraction), [Cape Rock Park](https://www.expedia.co.uk/Cape-Rock-Park-Cape-Girardeau.d553248621532655781.Vacation-Attraction) and [Fort D Historic Site](https://www.expedia.co.uk/Fort-D-Historic-Site-Cape-Girardeau.d553248621532655775.Vacation-Attraction). Basing yourself in Ste Genevieve? [Sainte Genevieve Winery](https://www.expedia.co.uk/Sainte-Genevieve-Winery-Ste-Genevieve.d553248621532648574.Vacation-Attraction), [Bolduc House Museum](https://www.expedia.co.uk/Bolduc-House-Museum-Ste-Genevieve.d553248621532648575.Vacation-Attraction) and [Felix Valle House State Historic Site](https://www.expedia.co.uk/Felix-Valle-House-State-Historic-Site-Ste-Genevieve.d553248621532648573.Vacation-Attraction) are among the best sights in this city. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Allenville Hotels](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Annapolis Hotels](https://www.expedia.co.uk/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Arcadia Hotels](https://www.expedia.co.uk/Arcadia-Hotels.d6346857.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Arnold](https://www.expedia.co.uk/Arnold-Hotels-Gay-Friendly-Hotel.0-0-d177608-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - 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