A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Find Family-Friendly Hotels in Southeast Missouri, MO

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
  • Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Family-Friendly Hotels

Tonight
10 Sept - 11 Sept
Tomorrow
11 Sept - 12 Sept
This weekend
11 Sept - 13 Sept
Next weekend
18 Sept - 20 Sept

Our top choices for Southeast Missouri family-friendly hotels

1. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
  • Year-round family fun with inviting pools and free activities makes this Poplar Bluff inn perfect for kids of all ages.
£88
includes taxes & fees
27 Sept - 28 Sept
Drury Inn & Suites Poplar Bluff

2. Black River Motel and Restaurant

Black River Motel and Restaurant
Lesterville
£91
includes taxes & fees
15 Sept - 16 Sept
Black River Motel and Restaurant

3. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
  • Seasonal outdoor pool and family-friendly perks create magical memories at this Farmington retreat just minutes from adventure.
£44
includes taxes & fees
20 Sept - 21 Sept
Baymont Inn and Suites by Wyndham Farmington, MO

4. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
  • Family fun destination with an indoor pool and fitness centre, plus a delicious free breakfast every morning.
£88
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express & Suites Farmington by IHG

5. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
  • A family paradise with splash-worthy fun awaits, where complimentary breakfast and an indoor pool create lasting memories for all ages.
£83
includes taxes & fees
27 Sept - 28 Sept
Drury Plaza Hotel Cape Girardeau Conference Center

6. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
£48
includes taxes & fees
20 Sept - 21 Sept
Super 8 by Wyndham Farmington

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
£84
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau

8. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
  • Family getaway with indoor pool and kid-friendly perks near Cape Splash Family Aquatic Centre.
£74
includes taxes & fees
15 Sept - 16 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

9. Quality Inn Farmington

Quality Inn Farmington
Farmington
  • Adventure awaits with a family-friendly indoor pool and free extras just minutes from St. Joe State Park.
£50
includes taxes & fees
4 Oct - 5 Oct
Quality Inn Farmington

10. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
  • Family-friendly adventures await with free breakfast, cots, and easy access to Cape Splash Aquatic Centre, just minutes away.
£60
includes taxes & fees
27 Sept - 28 Sept
Pear Tree Inn Cape Girardeau West
View all properties

Choose what matters most at family-friendly hotels in Southeast Missouri

Breakfast included
Pool
All-inclusive
4 stars
5 stars

Family-friendly hotels with free breakfast in Southeast Missouri

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
£80
includes taxes & fees
14 Sept - 15 Sept
Drury Inn & Suites Sikeston, MO

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
£83
includes taxes & fees
27 Sept - 28 Sept
Drury Plaza Hotel Cape Girardeau Conference Center

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
£44
includes taxes & fees
20 Sept - 21 Sept
Baymont Inn and Suites by Wyndham Farmington, MO

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
Perryville
£82
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express & Suites Perryville by IHG

Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
£48
includes taxes & fees
20 Sept - 21 Sept
Super 8 by Wyndham Farmington

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
£84
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
£74
includes taxes & fees
15 Sept - 16 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
£60
includes taxes & fees
27 Sept - 28 Sept
Pear Tree Inn Cape Girardeau West

Hampton Inn Farmington

Hampton Inn Farmington
Farmington
£85
includes taxes & fees
20 Sept - 21 Sept
Hampton Inn Farmington

Quality Inn Farmington

Quality Inn Farmington
Farmington
£50
includes taxes & fees
4 Oct - 5 Oct
Quality Inn Farmington
View all properties

Family-friendly hotels with pools in Southeast Missouri

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
Poplar Bluff
£88
includes taxes & fees
27 Sept - 28 Sept
Drury Inn & Suites Poplar Bluff

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
£83
includes taxes & fees
27 Sept - 28 Sept
Drury Plaza Hotel Cape Girardeau Conference Center

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
£44
includes taxes & fees
20 Sept - 21 Sept
Baymont Inn and Suites by Wyndham Farmington, MO

Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
£88
includes taxes & fees
20 Sept - 21 Sept
Holiday Inn Express & Suites Farmington by IHG

Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
Farmington
£48
includes taxes & fees
20 Sept - 21 Sept
Super 8 by Wyndham Farmington

Quality Inn Farmington

Quality Inn Farmington
Farmington
£50
includes taxes & fees
4 Oct - 5 Oct
Quality Inn Farmington

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
£74
includes taxes & fees
15 Sept - 16 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
£84
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau

Hampton Inn Farmington

Hampton Inn Farmington
Farmington
£85
includes taxes & fees
20 Sept - 21 Sept
Hampton Inn Farmington

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
£54
includes taxes & fees
16 Sept - 17 Sept
The Riverstone Hotel Charleston-Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Find out more about Southeast Missouri

Family friendly things to do in Southeast Missouri

Southeast Missouri is a paradise of family-friendly adventures, perfect for those seeking both excitement and quality accommodation. Begin your journey at the stunning Lake of the Ozarks, where you can enjoy a wealth of water activities, from jet skiing to serene boat rides, all while soaking up the sun on sandy beaches. For a taste of nature, the stunning Elephant Rocks State Park invites families to hike among gigantic boulders that seem to defy gravity, providing a unique playground for kids and adults alike. A visit to the Discovery Playhouse in Cape Girardeau offers an interactive experience designed to spark curiosity and creativity in younger travellers, featuring hands-on exhibits that make learning fun. If your family is keen on history, the Missouri Civil War Museum in Cape Girardeau provides an engaging way to explore the region's rich past, with exhibits that captivate all ages. After a day of exploration, consider staying in the charming town of Cape Girardeau, where family-friendly hotels offer convenient access to these attractions and more. Many hotels here pride themselves on attentive service, providing amenities like spacious rooms and complimentary breakfasts, ensuring your family feels pampered during your stay. With easy access to both the natural beauty and cultural heritage of Southeast Missouri, you’ll create lasting memories while enjoying the comforts and quality service that meet your family's high expectations.

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"All good, staff friendly and helpful! Breakfast was great and kick back dinner was good!"
Randy 1-night trip
Posted 1 hour ago
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"The hot tub was cold and the pool was cold sadly"
Kandi 1-night trip
Posted 17 hours ago
Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"All was good. Will stay here again."
Henry 1-night trip
Posted 18 hours ago
Pear Tree Inn Cape Girardeau West
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"The room was very clean. The king sized bed was extremely comfortable. The outdoor pool was maintained well. The staff were efficient with the check in. I’ve paid far more for lodging properties that weren’t nearly as nice."
William 1-night trip
Posted 1 day ago
Baymont Inn and Suites by Wyndham Farmington, MO
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"."
Floyd 1-night trip
Posted 2 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Nice"
Carol 3-night trip
Posted 2 days ago
Motel 6 Poplar Bluff, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

8/10 Good
"Great location, nice, clean and well maintained, Hotel employees were very helpful great customer service,"
Bernice 2-night trip
Posted 3 days ago
Best Western Plus Sikeston I-55
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

8/10 Good
"room was clean and the front staff was nice. place served it's purpose (stayed for only 2 nights). Not much amenitites."
johnny 2-night trip
Posted 7 days ago
Comfort Inn Festus - St Louis South

Explore a world of travel with Expedia