Title: TOP Cheap Hotels in Southeast Missouri, MO for 2026 | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri Cheap Hotels Tonight [27 Feb - 28 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-02-27&endDate=2026-02-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=budget_property) Tomorrow [28 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-02-28&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=budget_property) This weekend [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=budget_property) Next weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=budget_property) ## Our top choices for Southeast Missouri cheap hotels ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1,001 reviews) "As always it was a perfect visit" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John £80 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/dc7dee1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-service breakfast ](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8447c54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) Jackson 9.0/10 Wonderful (711 reviews) "Conveniently located, clean, friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Philip £67 includes taxes & fees 5 Mar - 6 Mar [](https://www.expedia.co.uk/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout curtains, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/15d55416.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchenette](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/8d2b66d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/a07fa840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Poplar Bluff, MO [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) Poplar Bluff 8.0/10 Very good (1,000 reviews) "Very clean and staff was very friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherry £51 includes taxes & fees 3 Mar - 4 Mar [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/4bc8c9bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/2099c0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/9d3ff163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout curtains, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/860000/856300/856283/2794fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Bonne Terre [](https://www.expedia.co.uk/Farmington-Hotels-Super-8-By-Wyndham-Bonne-Terre.h856283.Hotel-Information) Bonne Terre 7.0/10 Good (549 reviews) "Rooms were clean, staff was very friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy £45 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Farmington-Hotels-Super-8-By-Wyndham-Bonne-Terre.h856283.Hotel-Information) ![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 Bedroom, Non Smoking | Bathroom | Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New Orleans Inn Portageville [](https://www.expedia.co.uk/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) Portageville 8.0/10 Very good (746 reviews) "Parking was good, staff was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Corey [](https://www.expedia.co.uk/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/8b122520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Poplar Bluff [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (874 reviews) "Very clean and well maintained hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £87 includes taxes & fees 20 Mar - 21 Mar [](https://www.expedia.co.uk/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down duvets, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, pool loungers](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/65f9cbe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Sikeston Southwest by IHG [](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) Sikeston 8.6/10 Excellent (447 reviews) "Stay was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kourtney £73 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily English breakfast ](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/c66d7d11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Egyptian cotton sheets, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/4ac4ba46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/dc836bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cape Girardeau North [](https://www.expedia.co.uk/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) Cape Girardeau 7.2/10 Good (701 reviews) "The room was clean and nice. The breakfast was really good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kalani £50 includes taxes & fees 5 Mar - 6 Mar [](https://www.expedia.co.uk/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston [](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) Sikeston 9.0/10 Wonderful (486 reviews) "Very Clean room, friendly staff, breakfast in the morning. Will be staying again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Affinity £80 includes taxes & fees 7 Mar - 8 Mar [](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,002 reviews) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly £83 includes taxes & fees 4 Mar - 5 Mar [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-13&endDate=2026-03-14®ionId=6058763&adults=2&sort=BUDGET&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_6058763) ## Find out more about Southeast Missouri ## How to get cheap hotels in Southeast Missouri? ✅ The **length of stay** in Southeast Missouri often varies depending on the nature of the trip, but many travellers opt to stay for several days or up to a week to take in Southeast Missouri's notable landmarks and points of interest. ✅ If you're looking for **cheap hotels in Southeast Missouri** in 2026, book your hotel well in advance. Reserving your stay at least a few weeks or months ahead of time can help you take advantage of amazing rates on cheap hotels in Southeast Missouri, and if your plans change you can find many options of **[hotels with free cancelation](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&rfrr=Editorial.Tips&paymentType=FREE_CANCELLATION&sort=PRICE_RELEVANT).** ✅ To find affordable hotels in Southeast Missouri on Expedia, start by entering your travel dates and the number of individuals in your group. Once you've provided this information, you can refine your search results by filtering for **[budget hotels in Southeast Missouri](https://expedia.co.uk/Hotel-Search?regionId=6058763&sort=PRICE_LOW_TO_HIGH&rfrr=Editorial.Tips).** ✅ Use the **filtering tools** offered by Expedia to refine your search results by location, **price limits, amenities such as [breakfast included](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&rfrr=Editorial.Tips&sort=PRICE_RELEVANT&mealPlan=FREE_BREAKFAST),** and other factors that matter to you. This will help you quickly locate the ideal budget-friendly hotel that fits your specific requirements. ✅ If you're looking to save money on a **cheap hotel in Southeast Missouri,** the ideal time to go is usually during the off-season in Southeast Missouri. On Expedia, you can find hotels **from £45\*.** ✅ Southeast Missouri offers numerous **budget-friendly attractions and activities** for travellers, such as art and exhibits at free museums and galleries or exploring Southeast Missouri on foot. ✅ One of the best ways to find **cheap hotels in Southeast Missouri** is to search Expedia for properties that provide [**family-friendly**](https://expedia.co.uk/Hotel-Search?regionId=6058763&rfrr=Editorial.Tips&sort=RECOMMENDED&travelerType=FAMILY) accommodations and features such as activities and complimentary meals, and then **[sort these by price.](https://expedia.co.uk/Hotel-Search?regionId=6058763&rfrr=Editorial.Tips&sort=PRICE_LOW_TO_HIGH&travelerType=FAMILY)** \*Prices and availability are subject to change. Additional terms may apply. ## Top Southeast Missouri Hotel Reviews ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Staff was excellent " [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 10/10 Excellent "Room was clean, breakfast was nice." [](https://expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 10/10 Excellent "Loved it. Super clean. Lots of places to eat close by." [](https://expedia.co.uk/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 10/10 Excellent "Great staff and nice accommodations " [](https://expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Allenville Hotels ](https://www.expedia.co.uk/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Annapolis Hotels ](https://www.expedia.co.uk/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Arcadia Hotels ](https://www.expedia.co.uk/Arcadia-Hotels.d6346857.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Arnold ](https://www.expedia.co.uk/Arnold-Hotels-Gay-Friendly-Hotel.0-0-d177608-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - 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