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Search Business Hotels in Southeast Missouri

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Check availability on Southeast Missouri Business Hotels

Tonight
29 Sept - 30 Sept
Tomorrow
30 Sept - 1 Oct
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

Our top choices for Southeast Missouri business-friendly hotels

A motel with a covered entrance, a flag, and a phone number.
A hotel room with two beds, a desk, a chair, a TV, and a bathroom.
A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.
A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

1. Madison Inn Lodge

Madison Inn Lodge
Fredericktown
United States
Bawan
£72
includes taxes & fees
8 Oct - 9 Oct
Madison Inn Lodge
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.
A hotel room with two beds, a lamp, and a painting on the wall.
A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

2. Shepherd Mountain Inn

Shepherd Mountain Inn
Ironton
United States
Michael
£102
includes taxes & fees
30 Sept - 1 Oct
Shepherd Mountain Inn
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A hotel room with two beds, a brick wall, and a wooden headboard.

3. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
£67
includes taxes & fees
11 Oct - 12 Oct
Drury Inn & Suites Jackson MO
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A gym with cardio equipment, a bench press, and a squat rack.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.
A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

4. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
Joseph
£47
includes taxes & fees
25 Oct - 26 Oct
Baymont Inn and Suites by Wyndham Farmington, MO
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.
Pool
Exterior
Terrace/patio

5. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
Poplar Bluff
United States
Rhonda
£74
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
£85
includes taxes & fees
4 Oct - 5 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

7. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
£69
includes taxes & fees
1 Oct - 2 Oct
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a bed, a sofa, a desk, and a chair.
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.

8. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
£97
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express & Suites Farmington by IHG
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.
A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.
A spacious hotel lobby with a dining area, kitchen, and large windows.

9. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
Susan
£90
includes taxes & fees
29 Oct - 30 Oct
Crown Pointe Lodge, BW Signature Collection
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

10. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
£90
includes taxes & fees
29 Oct - 30 Oct
The Riverview
View all properties

Top Southeast Missouri Hotel Reviews

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

10/10 Excellent
"Every thing was great but I do have one complete the beds are to high it was very hard getting into the bed they need step stills to get in the beds"
Denise 2-night trip
Posted 2 hours ago
Baymont Inn and Suites by Wyndham Farmington, MO
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"The room was very clean and the bed was very comfortable. The parking around the hotel was ample and the amenities were great. So many stores and restaurants within walking distance. The breakfast was the best with home cooked eggs and gravy."
Sharon 1-night trip
Posted 2 hours ago
Pear Tree Inn Cape Girardeau West
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

10/10 Excellent
"Difficult to communicate with person setting up and maintaining breakfast area as they did not speak English"
Terry 1-night trip
Posted 1 day ago
Comfort Inn Festus - St Louis South
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Great experience. Staff was welcoming. Rooms were clean."
yolanda 2-night trip
Posted 1 day ago
Drury Inn & Suites Hayti Caruthersville
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"Debbie at the desk was super nice and helpful."
Nancy 1-night trip
Posted 2 days ago
Holiday Inn Poplar Bluff by IHG
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

8/10 Good
"Definitely worth it, clean"
Joy 1-night trip
Posted 3 days ago
Motel 6 Poplar Bluff, MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 6 days ago
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Clean room, staff"
Lavonne 2-night trip
Posted 6 days ago
Drury Inn & Suites Poplar Bluff
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 7 days ago
Days Inn and Suites by Wyndham Sikeston

Frequently asked questions

How much do business hotels in Southeast Missouri cost?
Business hotels in Southeast Missouri range between £47 and £102 per night. This means you can lock in a property with conveniences like conference rooms and WiFi at a price that's within your budget. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business hotels are there in Southeast Missouri?
When your next meeting or conference takes you someplace in Southeast Missouri, there are 50 business hotels to choose from.
Why book your business hotel in Southeast Missouri with Expedia?
We're here to help you find the ideal business hotel when work takes you on the road. From meeting rooms and conference spaces to gyms and spas, our stays come with all you'll need to get the job done.
How can I find cheap business hotels in Southeast Missouri?
Expedia can help you narrow down your search for cheap business hotels in Southeast Missouri. Head to the "traveller experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work effectively and comfortably, like free WiFi and included breakfast. You can also choose your hotel star rating and budget to keep costs within range.

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