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Top 10 Southeast Missouri hotels and places to stay

Our top choices for Southeast Missouri hotels

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (29)
"Sweet cabin"
The price is £99
includes taxes & fees
26 Aug - 27 Aug
Postcard Cabins St. Francois

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1003)
"The pool the happy hour was really nice very relaxed nice activities front desk was very helpful at all times"
The price is £76
includes taxes & fees
1 Sept - 2 Sept
Drury Inn & Suites Sikeston, MO

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1005)
"Very nice property Friendly helpful staff"
The price is £65
includes taxes & fees
4 Sept - 5 Sept
Pear Tree Inn Sikeston

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1004)
"We had a last minute reservation here. The staff was very pleasant, helpful and wonderful overall!!"
The price is £70
includes taxes & fees
31 Aug - 1 Sept
Drury Inn & Suites Jackson MO

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1002)
"We enjoyed our stay."
The price is £79
includes taxes & fees
31 Aug - 1 Sept
Drury Inn & Suites Hayti Caruthersville

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Excellent place to stay "
The price is £58
includes taxes & fees
26 Aug - 27 Aug
Pear Tree Inn Cape Girardeau Near the Medical Center

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (405)
"Great place. "
The price is £99
includes taxes & fees
27 Aug - 28 Aug
The Farmstead Hotel

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (588)
"It was a great stay. Only thimg maybe more variety or hot breakfast."
The price is £70
includes taxes & fees
7 Sept - 8 Sept
Microtel Inn & Suites by Wyndham Sainte Genevieve

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very good, (669)
"Everything was nice"
The price is £42
includes taxes & fees
27 Aug - 28 Aug
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (499)
"Have stayed here the past 3 years during the Laid Back on I-55 Truck Show! Great place to stay! The breakfast is fantastic!! The staff does not disappoint!! "
The price is £80
includes taxes & fees
28 Aug - 29 Aug
Holiday Inn Express & Suites Perryville by IHG

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very good, (579)
"Very friendly staff who make sure guests are taken care of! Clean, great location, and safe place to stay. "
The price is £47
includes taxes & fees
8 Sept - 9 Sept
Super 8 by Wyndham Farmington

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very good, (1004)
"Nice stay for the price!"
The price is £46
includes taxes & fees
1 Sept - 2 Sept
Baymont Inn and Suites by Wyndham Farmington, MO

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (799)
"Hotel was very clean and the staff was friendly! I would stay again. "
The price is £83
includes taxes & fees
4 Sept - 5 Sept
Fairfield Inn & Suites by Marriott Poplar Bluff

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (291)
"Wonderful small town motel in a beautiful & quiet location."
Shepherd Mountain Inn

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1561)
"Great place to stay."
The Wildwood Hotel

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (396)
"Nice place to stay! everything was fun and clean."
The price is £88
includes taxes & fees
26 Aug - 27 Aug
The Riverview

Super 8 by Wyndham Perryville

2.0 star property
8.4 out of 10, Very good, (899)
" Love the stay and staff was great "
The price is £54
includes taxes & fees
1 Sept - 2 Sept
Super 8 by Wyndham Perryville

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (985)
"Easy access and parking"
The price is £75
includes taxes & fees
31 Aug - 1 Sept
Drury Inn & Suites Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (125)
"The hotel was very clean and updated and the staff was super friendly and very informative!"
The price is £78
includes taxes & fees
4 Sept - 5 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1011)
"Very nice hotel and nice staff "
The price is £75
includes taxes & fees
31 Aug - 1 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

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Check out hotels with free breakfast in Southeast Missouri

Farmstays in Southeast Missouri you'll enjoy

These pet-friendly hotels in Southeast Missouri may fit your trip

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Accommodation near Southeast Missouri attractions

Southeast Missouri State University

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.

Century Casino Caruthersville

Century Casino Caruthersville

Why not try your luck with a visit to Century Casino Caruthersville during your visit to Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Learn more about Southeast Missouri

Discover the family-friendly area of Southeast Missouri—wineries, a scenic riverfront and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews

Frequently asked questions

Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Southeast Missouri hotel for you.
How can I save on a Southeast Missouri hotel booking with Expedia?
Members always get our best prices. Find our best Southeast Missouri hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Southeast Missouri hotel?
Prices for hotels in Southeast Missouri often vary, but you can find a great deal from £46 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.