Drury Inn & Suites Hotels in Southeast Missouri
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A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Search Hotels by Drury Inn & Suites in Southeast Missouri from £63

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Our top choices for Southeast Missouri Drury Inn & Suites

A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a modern design, featuring a reception desk, seating area, and a large chandelier.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

1. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property

Sikeston

9.6 out of 10, Exceptional, (1,002 reviews)

9.6/10

Exceptional

(1,002 reviews)

"Great place to stay!"

Tiffany

The price is £82

£82

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Sikeston, MO

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

A hotel room with a large bed, a desk, a chair, a television, and a brick accent wall.

Two grey armchairs with green cushions, a small side table with a white lamp, and wall-mounted sconces.

An indoor swimming pool with multiple lanes, surrounded by seating areas and tables.

2. Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3.0 star property

Hayti

9.2 out of 10, Wonderful, (1,000 reviews)

9.2/10

Wonderful

(1,000 reviews)

"Food and drinks were very good."

Philip

The price is £84

£84

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Hayti Caruthersville

An indoor swimming pool with a clear view of the outside through large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

A spacious lobby with a reception desk, seating area, and large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

3. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3.0 star property

Poplar Bluff

9.4 out of 10, Exceptional, (1,002 reviews)

9.4/10

Exceptional

(1,002 reviews)

"I like how clean they were, and the food was excellent and the hot tub was great"

Alan

The price is £80

£80

includes taxes & fees

19 Nov - 20 Nov

Drury Inn & Suites Poplar Bluff

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

4. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property

Cape Girardeau

9.4 out of 10, Exceptional, (1,000 reviews)

9.4/10

Exceptional

(1,000 reviews)

"Clean, spacious suite, enjoyable kick back and breakfast!"

Mary

The price is £77

£77

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Cape Girardeau

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A lobby with a reception desk, a purple sofa, and two patterned chairs.

5. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property

Jackson

9.6 out of 10, Exceptional, (1,001 reviews)

9.6/10

Exceptional

(1,001 reviews)

"The hotel was clean, comfortable and the breakfast was good."

Leonardo

The price is £64

£64

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Jackson MO

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Hotels recommended for families in Southeast Missouri

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with a large bed, a chair, a nightstand with a lamp, and a telephone.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

Shepherd Mountain Inn

2.5 star property

Ironton

9.2 out of 10, Wonderful, (339)

9.2/10

Wonderful

(339)

The price is £102

£102

includes taxes & fees

16 Nov - 17 Nov

Shepherd Mountain Inn

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A hotel entrance with a covered driveway, large windows, and a sign indicating the address.

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property

Farmington

8.0 out of 10, Very good, (1,004)

8.0/10

Very good

(1,004)

The price is £47

£47

includes taxes & fees

22 Nov - 23 Nov

Baymont Inn and Suites by Wyndham Farmington, MO

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A two-story motel with a signboard for 'Madison Inn Lodge' and a 'New Management' sign.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A hotel room with a bed, a dresser, a television, a bathroom with a sink and mirror, and a painting on the wall.

Madison Inn Lodge

2.5 star property

Fredericktown

7.6 out of 10, Good, (314)

7.6/10

Good

(314)

The price is £72

£72

includes taxes & fees

15 Nov - 16 Nov

Madison Inn Lodge

A hotel room with two beds, a large wall-mounted picture of a waterfall, a bedside table with a lamp, and a door.

A long, narrow hallway with patterned carpet, grey walls, and doors on both sides.

A modern kitchen with a refrigerator, coffee machine, and a juice dispenser.

A building entrance with a covered area marked '930,' brick walls, and a parking lot.

Super 8 by Wyndham Farmington

2.0 star property

Farmington

8.0 out of 10, Very good, (691)

8.0/10

Very good

(691)

The price is £51

£51

includes taxes & fees

20 Nov - 21 Nov

Super 8 by Wyndham Farmington

Drury Inn & Suites Poplar Bluff

3.0 star property

Poplar Bluff

9.4 out of 10, Exceptional, (1,002)

9.4/10

Exceptional

(1,002)

The price is £80

£80

includes taxes & fees

19 Nov - 20 Nov

Drury Inn & Suites Poplar Bluff

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a large bed, a chair, two bedside tables with lamps, and a telephone.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

Fort Davidson Hotel

2.5 star property

Ironton

9.2 out of 10, Wonderful, (190)

9.2/10

Wonderful

(190)

The price is £103

£103

includes taxes & fees

15 Nov - 16 Nov

Fort Davidson Hotel

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

A buffet with various food items, including omelets and other dishes, displayed in metal serving trays.

A hotel room with a bed, a sofa, a desk, and a chair.

A reception area with a modern abstract wall art, two potted plants, and a wooden console table with a decorative bowl.

Holiday Inn Express & Suites Farmington by IHG

2.5 star property

Farmington

8.6 out of 10, Excellent, (445)

8.6/10

Excellent

(445)

The price is £96

£96

includes taxes & fees

13 Dec - 14 Dec

Holiday Inn Express & Suites Farmington by IHG

A modern hotel lobby with a reception desk, seating area, and a large rug.

A hotel room with a bed, desk, chair, and a small refrigerator.

An indoor swimming pool with clear lane markings, a lifeguard chair, and a no diving sign.

A Hampton Inn hotel with a clear entrance, American flag, and well-lit signage.

Hampton Inn Farmington

2.5 star property

Farmington

8.8 out of 10, Excellent, (584)

8.8/10

Excellent

(584)

The price is £90

£90

includes taxes & fees

4 Dec - 5 Dec

Hampton Inn Farmington

Top Southeast Missouri Hotel Reviews

A Drury Inn & Suites hotel with a modern facade, multiple floors, and a parking lot.

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

An indoor swimming pool area with a hot tub, a table with chairs, and a sign warning of no lifeguard on duty.

A spacious dining area with multiple tables and chairs, large windows, and recessed ceiling lights.

Drury Inn & Suites St. Louis Arnold

Arnold

10/10 Excellent

Lovely hotel all good

ivan

Reviewed August 1, 2018Reviewed August 1, 2018

Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites Poplar Bluff

Poplar Bluff

10/10 Excellent

Just one night, but CeeCee left a lasting impression on us. Lovely lady!

Gary

Reviewed August 26, 2017Reviewed August 26, 2017

Drury Inn & Suites Poplar Bluff

A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

A compact kitchen with a microwave, a coffee maker, a sink, and a small refrigerator.

A reception desk with a 'Welcome to Hampton' sign, a 'Hampton Guarantee' badge, and a 'Hilton Honors' sign.

Hampton Inn Poplar Bluff

Poplar Bluff

10/10 Excellent

Very clean Good breakfast Very helpful staff

heather

Reviewed May 22, 2026Reviewed May 22, 2026

Hampton Inn Poplar Bluff

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A multi-story hotel with a modern facade, a covered entrance, and a parking lot with handicapped-accessible spaces.

A modern conference room with a large table, wooden chairs, and a colorful striped carpet.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

10/10 Excellent

It was wonderful stay and very comfortable sleep

Sarmad

Reviewed September 9, 2023Reviewed September 9, 2023

Fairfield Inn & Suites by Marriott Poplar Bluff

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Search Hotels by Drury Inn & Suites in Southeast Missouri from £63

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Missouri Drury Inn & Suites

1. Drury Inn & Suites Sikeston, MO

2. Drury Inn & Suites Hayti Caruthersville

3. Drury Inn & Suites Poplar Bluff

4. Drury Inn & Suites Cape Girardeau

5. Drury Inn & Suites Jackson MO

Hotels recommended for families in Southeast Missouri

Shepherd Mountain Inn

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites St. Louis Arnold

10/10 Excellent

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