Title: All Hotels by Drury Inn & Suites in Southeast Missouri - 2026 Updated Prices | Expedia.co.uk [Southeast Missouri Travel Guide](https://expedia.co.uk/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Holiday Rentals in Southeast Missouri](https://expedia.co.uk/Southeast-Missouri-Holiday-Rentals.d6058763.Travel-Guide-HolidayRentals)[Flights to Southeast Missouri](https://expedia.co.uk/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.co.uk/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southeast-Missouri.d6058763.Car-Hire-Guide)[Southeast Missouri Holidays](https://expedia.co.uk/Southeast-Missouri.d6058763.Holidays-City-Breaks) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard # Search Hotels by Drury Inn & Suites in Southeast Missouri from £65 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [22 Dec - 23 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-22&endDate=2025-12-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [23 Dec - 24 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-23&endDate=2025-12-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6058763&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeast Missouri Drury Inn & Suites ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1009) "This our favorite place to stop for a good night sleep. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eileen £77 includes taxes & fees 27 Dec - 28 Dec [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/15afcc22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/49c875c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/f46408d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Hayti Caruthersville [](https://www.expedia.co.uk/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information) Hayti 9.4/10 Exceptional (1000) "Staff is very friendly. Breakfast was good. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha £80 includes taxes & fees 16 Jan - 17 Jan 2026 [](https://www.expedia.co.uk/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Jackson 9.6/10 Exceptional (1007) "Breakfast was great- staff was welcoming. Will stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura £65 includes taxes & fees 6 Jan - 7 Jan 2026 [](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-06&endDate=2026-01-07®ionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels-Drury-Inn-Suites.0-0-d6058763--bDruryInnSuites.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels-Drury-Inn-Suites.0-0-d6058763--bDruryInnSuites.Travel-Guide-Filter-Hotels) ## Top Southeast Missouri Hotel Reviews ![Drury Inn & Suites Poplar Bluff](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164_y.jpg) ### Drury Inn & Suites Poplar Bluff 10/10 Excellent "The breakfast was excellent. The food was hot and tastey! There are excellent choices!" [](https://expedia.co.uk/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "The room was great. Very clean and the bed was comfortable. " [](https://expedia.co.uk/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 10/10 Excellent "Yes " [](https://expedia.co.uk/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Festus - St. Louis South](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70_y.jpg) ### La Quinta Inn & Suites by Wyndham Festus - St. Louis South 10/10 Excellent "Breakfast was great! Location right off interstate was perfect. The property is a little old." [](https://expedia.co.uk/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Everything was well done" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Friendly staff clean rooms " [](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Econo Lodge](https://images.trvl-media.com/lodging/1000000/50000/40200/40136/1fd839ba_y.jpg) ### Econo Lodge 10/10 Excellent "Staff was very accommodating " [](https://expedia.co.uk/Kennett-Hotels-Econo-Lodge.h40136.Hotel-Information) ![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg) ### The Farmstead Hotel 10/10 Excellent "Nice place " [](https://expedia.co.uk/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "The room was clean and the mattress was extremely comfortable " [](https://expedia.co.uk/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ## Explore a world of travel with Expedia - 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