Drury Inn & Suites Hotels in Southeast Missouri
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A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Search Hotels by Drury Inn & Suites in Southeast Missouri from £63

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Our top choices for Southeast Missouri Drury Inn & Suites

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

1. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property

Sikeston

9.6 out of 10, Exceptional, (1,002 reviews)

9.6/10

Exceptional

(1,002 reviews)

"Great place to stay!"

Tiffany

The price is £82

£82

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Sikeston, MO

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

A hotel room with a brick wall, two beds, a desk with a TV, and a patterned carpet.

An indoor swimming pool with multiple lanes, surrounded by seating areas and tables.

A gym with treadmills, elliptical machines, and a mirrored wall.

2. Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3.0 star property

Hayti

9.2 out of 10, Wonderful, (1,000 reviews)

9.2/10

Wonderful

(1,000 reviews)

"Food and drinks were very good."

Philip

The price is £84

£84

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Hayti Caruthersville

A spacious lobby with a reception desk, seating area, and large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

An indoor swimming pool with a clear view of the outside through large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

3. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3.0 star property

Poplar Bluff

9.4 out of 10, Exceptional, (1,002 reviews)

9.4/10

Exceptional

(1,002 reviews)

"I like how clean they were, and the food was excellent and the hot tub was great"

Alan

The price is £80

£80

includes taxes & fees

19 Nov - 20 Nov

Drury Inn & Suites Poplar Bluff

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

4. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property

Cape Girardeau

9.4 out of 10, Exceptional, (1,000 reviews)

9.4/10

Exceptional

(1,000 reviews)

"Clean, spacious suite, enjoyable kick back and breakfast!"

Mary

The price is £77

£77

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Cape Girardeau

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

5. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property

Jackson

9.6 out of 10, Exceptional, (1,001 reviews)

9.6/10

Exceptional

(1,001 reviews)

"The hotel was clean, comfortable and the breakfast was good."

Leonardo

The price is £64

£64

includes taxes & fees

22 Nov - 23 Nov

Drury Inn & Suites Jackson MO

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Hotels recommended for families in Southeast Missouri

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

Shepherd Mountain Inn

2.5 star property

Ironton

9.2 out of 10, Wonderful, (339)

9.2/10

Wonderful

(339)

The price is £102

£102

includes taxes & fees

16 Nov - 17 Nov

Shepherd Mountain Inn

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property

Farmington

8.0 out of 10, Very good, (1,004)

8.0/10

Very good

(1,004)

The price is £47

£47

includes taxes & fees

22 Nov - 23 Nov

Baymont Inn and Suites by Wyndham Farmington, MO

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

Madison Inn Lodge

2.5 star property

Fredericktown

7.6 out of 10, Good, (314)

7.6/10

Good

(314)

The price is £72

£72

includes taxes & fees

15 Nov - 16 Nov

Madison Inn Lodge

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

Super 8 by Wyndham Farmington

2.0 star property

Farmington

8.0 out of 10, Very good, (691)

8.0/10

Very good

(691)

The price is £51

£51

includes taxes & fees

20 Nov - 21 Nov

Super 8 by Wyndham Farmington

Drury Inn & Suites Poplar Bluff

3.0 star property

Poplar Bluff

9.4 out of 10, Exceptional, (1,002)

9.4/10

Exceptional

(1,002)

The price is £80

£80

includes taxes & fees

19 Nov - 20 Nov

Drury Inn & Suites Poplar Bluff

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

Fort Davidson Hotel

2.5 star property

Ironton

9.2 out of 10, Wonderful, (190)

9.2/10

Wonderful

(190)

The price is £103

£103

includes taxes & fees

15 Nov - 16 Nov

Fort Davidson Hotel

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

A reception area with a modern abstract wall art, two potted plants, and a wooden console table with a decorative bowl.

A Holiday Inn Express & Suites hotel with a prominent entrance, large columns, and a clear view of the sky.

A hotel room with a bed, a sofa, a desk, and a chair.

Holiday Inn Express & Suites Farmington by IHG

2.5 star property

Farmington

8.6 out of 10, Excellent, (445)

8.6/10

Excellent

(445)

The price is £96

£96

includes taxes & fees

13 Dec - 14 Dec

Holiday Inn Express & Suites Farmington by IHG

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.

A reception desk with a wooden panel design, a bicycle mounted on the wall, and a sign reading "Hilton Honors".

A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.

Hampton Inn Farmington

2.5 star property

Farmington

8.8 out of 10, Excellent, (584)

8.8/10

Excellent

(584)

The price is £90

£90

includes taxes & fees

20 Nov - 21 Nov

Hampton Inn Farmington

Top Southeast Missouri Hotel Reviews

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

An indoor swimming pool area with a hot tub, a table with chairs, and a sign warning of no lifeguard on duty.

A hotel room with a desk, two beds, a television, a lamp, and a cityscape painting on the wall.

A spacious dining area with multiple tables and chairs, large windows, and ceiling lights.

Drury Inn & Suites St. Louis Arnold

Arnold

10/10 Excellent

Lovely hotel all good

ivan

Reviewed August 1, 2018Reviewed August 1, 2018

Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites Poplar Bluff

Poplar Bluff

10/10 Excellent

Just one night, but CeeCee left a lasting impression on us. Lovely lady!

Gary

Reviewed August 26, 2017Reviewed August 26, 2017

Drury Inn & Suites Poplar Bluff

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

A grocery store aisle with various snack and food items.

An outdoor patio with yellow metal chairs and tables, a white umbrella, and a backdrop of evergreen trees.

Hampton Inn Poplar Bluff

Poplar Bluff

10/10 Excellent

Very clean Good breakfast Very helpful staff

heather

Reviewed May 22, 2026Reviewed May 22, 2026

Hampton Inn Poplar Bluff

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

10/10 Excellent

It was wonderful stay and very comfortable sleep

Sarmad

Reviewed September 9, 2023Reviewed September 9, 2023

Fairfield Inn & Suites by Marriott Poplar Bluff

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Search Hotels by Drury Inn & Suites in Southeast Missouri from £63

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southeast Missouri Drury Inn & Suites

1. Drury Inn & Suites Sikeston, MO

2. Drury Inn & Suites Hayti Caruthersville

3. Drury Inn & Suites Poplar Bluff

4. Drury Inn & Suites Cape Girardeau

5. Drury Inn & Suites Jackson MO

Hotels recommended for families in Southeast Missouri

Shepherd Mountain Inn

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites St. Louis Arnold

10/10 Excellent

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