Beginning of main content

Business Hotel in San Francisco, California

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

San Francisco Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Top San Francisco Neighborhoods for Business Hotel

Featured San Francisco Business Hotel

See all 493 Hotels in San Francisco
Serrano Hotel

Serrano Hotel

405 Taylor St, San Francisco
4.0 out of 5.0
3.9 out of 5 (1,509 reviews)
Nice hotel Stayed overnight. Very nice lady at front desk. Easy check in and out. The room was ok but they had really comfortable bed. Bathroom very small but clean.
  26 Jun 2017

£140

£140
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
3.5 out of 5.0
3.1 out of 5 (3,041 reviews)
Reasonable price for SF hotelOlder hotel in decent condition. Room size was small but comfortable. Wireless service is not good due to hotel construction and the apparent lack of repeaters. There is a great diner across the street that serves breakfast, lunch and dinner. Neighborhood not great with homeless/panhandlers, but ...
  25 Jun 2017

£127

£127
Parc 55 San Francisco - A Hilton Hotel

Parc 55 San Francisco - A Hilton Hotel

55 Cyril Magnin St, San Francisco
4.0 out of 5.0
4.2 out of 5 (4,243 reviews)
Great stay! Rooms were clean and staff was friendly. We felt safe and comfortable. Easy access to the BART and cable cars right around the corner. Great restaurants nearby and extremely close to Union Square. My only complaint is that the breakfast at the hotel was extremely expensive and it's hard ...
  3 Jun 2017

£170

£170
Hotel Nikko San Francisco

Hotel Nikko San Francisco

222 Mason St, San Francisco
4.0 out of 5.0
4.3 out of 5 (2,700 reviews)
Beautiful view. Beautiful service. Wonderful experience. Love the location. Staff very helpful. Will be back.
  26 Jun 2017

£172

£172
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

424 Clay St, San Francisco
4.0 out of 5.0
4.1 out of 5 (1,354 reviews)
Modern and comfortableSmall room with new furniture, comfortable bed, empty mini fridge and microwave. Right next to a Starbucks. I'd definitely stay here again. It was perfect for me.
  4 Jun 2017

£114

£114
Larkspur Landing South San Francisco - An All-Suite Hotel

Larkspur Landing South San Francisco - An All-Suite Hotel

690 Gateway Blvd, South San Francisco
3.0 out of 5.0
4.3 out of 5 (772 reviews)
This is one of the firsts hotel me and my wife stayed 3 days for and loved ever second of it. It was a nice experience and if we plan on going back for another San Francisco trip we know that this is the place we are going to stay at. Thank you it was a awesome trip!
  8 Jun 2017

£119

£119
The Mosser

The Mosser

54 4th Street, San Francisco
2.5 out of 5.0
3.9 out of 5 (1,737 reviews)
Cute HotelGood location close to everything. Room was small but it worked.
  26 Jun 2017

£90

£90
San Francisco Marriott Marquis

San Francisco Marriott Marquis

780 Mission Street, San Francisco
4.0 out of 5.0
4.4 out of 5 (1,567 reviews)
Nice hotel with good locationPros: Good location, near to Metro Station, near Powell Street. Staff are very nice. When I got to the hotel , it was just morning but the staff are quite helpful that they let me check in at that time without need waiting till 3pm. Cons: The facility in the hotel is a bit old.
  14 Jun 2017

£173

£173
Pullman San Francisco Bay

Pullman San Francisco Bay

223 Twin Dolphin Dr, Redwood City
4.0 out of 5.0
4.3 out of 5 (1,166 reviews)
Loved the view! Wonderful staff! It's my second time staying here in a month. I enjoyed my time here. Clean hotel, friendly staff! Will definitely stay here in September.
  26 Jun 2017

£86

£86
The Marker San Francisco, a Joie de Vivre Hotel

The Marker San Francisco, a Joie de Vivre Hotel

501 Geary St, San Francisco
4.0 out of 5.0
4.4 out of 5 (929 reviews)
Lovely Stay I had a very comfortable stay at The Marker. My hotel was clean and pretty, the staff was pleasant and I could walk to all areas of interest.
  24 Jun 2017

£163

£163
Map

Recently booked San Francisco hotels

Calista Organic Hotel
3.0 out of 5.0
Last booking: 1 minute ago
Travelodge Mill Valley/Sausalito
2.0 out of 5.0
Last booking: 2 minutes ago
Atherton Park Inn & Suites
2.5 out of 5.0
Last booking: 3 minutes ago
Hotel Fusion, a C-Two Hotel
3.0 out of 5.0
Last booking: 4 minutes ago
The Pickwick Hotel
3.0 out of 5.0
Last booking: 5 minutes ago
Cavallo Point
4.5 out of 5.0
Last booking: 6 minutes ago
Handlery Union Square Hotel
3.5 out of 5.0
Last booking: 6 minutes ago
Days Inn San Francisco Downtown/Civic Center Area
2.0 out of 5.0
Last booking: 8 minutes ago
InterContinental San Francisco
4.5 out of 5.0
Last booking: 8 minutes ago

Pocket Guide: Business Hotel Hotels in San Francisco

Search for hotels in San Francisco on Expedia.co.uk. You can easily find your hotels in San Francisco using one of the methods below:

  • View our selection of featured hotels in San Francisco
  • Use the map to find hotels in the San Francisco neighborhood you prefer
  • Use the filters to see hotels in a specific area of San Francisco, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in San Francisco
  • Enter your travel dates to view the best deals on hotels in San Francisco - while they last