Title: Panama Safari Hotels, Mexico and Central America: Panama Hotel Guide | Expedia.co.uk [Panama Travel Guide](https://expedia.co.uk/Panama.dx142)[Panama Hotels](https://expedia.co.uk/Destinations-In-Panama.d142.Hotel-Destinations)[Holiday Rentals in Panama](https://expedia.co.uk/Destinations-In-Panama.d142.Holiday-Rental-Destinations)[Panama Flights](https://expedia.co.uk/Destinations-In-Panama.d142.Flight-Destinations)[Panama Car Hire](https://expedia.co.uk/Destinations-In-Panama.d142.Car-Hire-Destinations)[Panama Holidays](https://expedia.co.uk/Panama.d142.Holidays-City-Breaks) ![Panama showing island views, landscape views and tropical scenes](https://images.trvl-media.com/place/142/329febe6-4cd6-48f7-a9e8-71ea862bef81.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by PhotoJoy # Search Safari Hotels in Panama - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Panama Accommodation: Most Popular Cities to Stay ![](https://mediaim.expedia.com/destination/1/1916fc53ea2cb142bbaeb7b9e6efaf16.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Panama City [](https://expedia.co.uk/Panama-City-Hotels-Safari-Hotel.0-0-d2897-tsafarihotel.Travel-Guide-Filter-Hotels) ## Check availability on Panama Safari Hotels Tonight [15 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=142&startDate=2025-11-15&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [16 Nov - 17 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=142&startDate=2025-11-16&endDate=2025-11-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [21 Nov - 23 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=142&startDate=2025-11-21&endDate=2025-11-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=142&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Panama Safari Hotels ![On the beach, white sand](https://images.trvl-media.com/lodging/17000000/16010000/16006800/16006774/1094ce19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16010000/16006800/16006774/19a1546a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/17000000/16010000/16006800/16006774/527a916b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/17000000/16010000/16006800/16006774/ca7dc21b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Playa Bluff Hotel Bocas del Toro 8.0/10 Very good (33) "Booked and paid for an ocean view room with a balcony but only garden view rooms were available so instead of the waves crashing I heard the property next door doing Los construction all day long …. Other than that the place was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendy £81 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/Bocas-Del-Toro-Hotels-Playa-Bluff-Lodge.h16006774.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/1000000/440000/438200/438135/0d6dbc5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/440000/438200/438135/daf15c9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/440000/438200/438135/c7eb2b99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/440000/438200/438135/be207e74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gamboa Rainforest Reserve Colon 7.8/10 Good (654) "Great customer service. Food delicious" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephanie Lezcano £84 includes taxes & fees 9 Dec - 10 Dec [](https://www.expedia.co.uk/Gamboa-Hotels-Gamboa-Rainforest-Reserve.h438135.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-29&endDate=2025-11-30®ionId=142&adults=2&recreation_group_explore=safari_on_site&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Panama-Safari-Hotel.0-0-d142-tsafarihotel.Hotel-Filter-Destinations)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Panama-Safari-Hotel.0-0-d142-tsafarihotel.Hotel-Filter-Destinations) ## Top Panama Hotel Reviews ### Hotel Riu Plaza Panama 10/10 Excellent "Food variety and freshness " [](https://expedia.co.uk/Panama-City-Hotels-Hotel-Riu-Plaza-Panama.h3900395.Hotel-Information) ### Megapolis Hotel Panamá 10/10 Excellent "The room was spotless and the staff was courteous " [](https://expedia.co.uk/Panama-City-Hotels-Megapolis-Hotel-Panama.h91995575.Hotel-Information) ### Arcadia Condo Suites 10/10 Excellent "Excellent appartement " [](https://expedia.co.uk/Panama-City-Hotels-Arcadia-Condo-Suites.h104456900.Hotel-Information) ### Las Americas Golden Tower Panama 10/10 Excellent "Yes" [](https://expedia.co.uk/Panama-City-Hotels-Las-Americas-Golden-Tower-Panama.h9675263.Hotel-Information) ### Crowne Plaza Panama Airport by IHG 10/10 Excellent "Rapidez del proceso" [](https://expedia.co.uk/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) ### Waldorf Astoria Panama 10/10 Excellent "Great stay. Staff was excellent. Location is great too" [](https://expedia.co.uk/Panama-City-Hotels-Waldorf-Astoria-Panama.h4952056.Hotel-Information) ### Novotel Panama City 10/10 Excellent "My stay was nothing short of amazing, room was superb, the staff was friendly, the hotel was located in the ideal spot and I want to thank the front desk clerk Javier he really made our stay so much more awesome; he was helpful, accommodating, knowledgeable and all with a smile his service (11/10), Also our server Jeny was splendid she truly made our dining experiences memorable. Overall Novotel is a 10/10 for me and definitely will recommend to others." [](https://expedia.co.uk/Panama-City-Hotels-Novotel-Panama-City.h7050512.Hotel-Information) ![Principe Hotel and Suites](//images.trvl-media.com/lodging/8000000/7460000/7451800/7451703/2baee2b4_y.jpg) ### Principe Hotel and Suites 10/10 Excellent "lugar muy agradable, tiene tienda de conveniencia al lado, el. metro está cerca para ir al aeropuerto, el personal fue muy amable, el check in fue flexible. " [](https://expedia.co.uk/Panama-City-Hotels-Principe-Hotel-And-Suites.h7451703.Hotel-Information) ### The Westin Playa Bonita Panama 10/10 Excellent "Rooms were great! A/C felt AMAZING! Staff SUPER NICE AND FRIENDLY! FOOD AMAZING! There was literally nothing we ate that we did not love! We added the Premium all inclusive package when we arrived for a great price! We ate at all the restaurants, buffets and had top shelf liquor ! I would for sure stay here again! " [](https://expedia.co.uk/Panama-City-Hotels-The-Westin-Playa-Bonita-Panama.h4668643.Hotel-Information)