Title: TOP Adults Only Resorts & Hotels in Panama City for 2025 | Expedia.co.uk [Panama City Travel Guide](https://expedia.co.uk/Panama-City.dx2897)[Hotels in Panama City](https://expedia.co.uk/Panama-City-Hotels.d2897.Travel-Guide-Hotels)[Holiday Rentals in Panama City](https://expedia.co.uk/Panama-City-Holiday-Rentals.d2897.Travel-Guide-HolidayRentals)[Flights to Panama City](https://expedia.co.uk/Cheap-Flights-To-Panama-City.d2897.Travel-Guide-Flights)[Things to do in Panama City](https://expedia.co.uk/Things-To-Do-In-Panama-City.d2897.Travel-Guide-Activities)[Panama City Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Panama-City.d2897.Car-Hire-Guide)[Panama City Holidays](https://expedia.co.uk/Panama-City.d2897.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/1/1916fc53ea2cb142bbaeb7b9e6efaf16.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Adults Only Resorts & Hotels in Panama City ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Panama City Adults Only Resorts & Hotels Tonight [16 Oct - 17 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=2897&startDate=2025-10-16&endDate=2025-10-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Tomorrow [17 Oct - 18 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=2897&startDate=2025-10-17&endDate=2025-10-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) This weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=2897&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Next weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=2897&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) ## Top Panama City Adults Only Resorts & Hotels ![Breakfast, lunch, dinner served; Fusion cuisine ](https://images.trvl-media.com/lodging/5000000/4890000/4880500/4880470/255ee499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Double by Cris Allende | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/5000000/4890000/4880500/4880470/3c62c55c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Double by Cris Allende | Premium bedding, down duvets, minibar, in-room safe](https://images.trvl-media.com/lodging/5000000/4890000/4880500/4880470/db6dac9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/5000000/4890000/4880500/4880470/c1c9d6fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tantalo Hotel Casco Viejo 8.8/10 Excellent (273) "My favorite place in Casco Viejo. " [](https://www.expedia.co.uk/Panama-City-Hotels-Tantalo-Hotel-Kitchen-Roofbar.h4880470.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-31&endDate=2025-11-01®ionId=2897&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Panama City ### Discover top Panama City attractions Panama City boasts a vibrant fusion of history and modernity, making it a thrilling destination for adventurous families. Start your journey at the Panama Canal, where you can witness the impressive Miraflores Locks in action and learn about the engineering marvel that connects the Atlantic and Pacific Oceans. Next, explore the colourful streets of Casco Viejo, a UNESCO World Heritage site, where you can enjoy charming historic architecture, lively plazas, and delightful local eateries. For a dose of nature, visit the Metropolitan Natural Park, an urban rainforest filled with wildlife, offering scenic trails that are perfect for family hikes. Don’t miss the Biomuseo, designed by Frank Gehry, where engaging exhibits will captivate both children and adults alike. Finally, unwind at the Amador Causeway, providing stunning views of the skyline and a breezy promenade ideal for cycling or leisurely strolls. For a comfortable stay, consider the hotels in the bustling Causeway area, where you’ll find luxurious accommodations with ocean views and easy access to these attractions. Here, your family can enjoy gourmet dining and attentive service, ensuring a perfect blend of relaxation and adventure. ### Find the best adults only resorts & hotels in Panama City For those seeking a tranquil escape in Panama City, these top hotels cater exclusively to adult guests, ensuring a serene and sophisticated atmosphere. [Tantalo Hotel](https://www.expedia.co.uk/Panama-City-Hotels-Tantalo-Hotel-Kitchen-Roofbar.h4880470.Hotel-Information) - **Why it's great for an adults only getaway:** The Tantalo Hotel stands out as a premier destination for adult travellers, an excellent review rating of 8.8. This adults-only hotel in the charming Casco Viejo neighbourhood offers a chic atmosphere with a rooftop terrace where guests can unwind and enjoy stunning views of the historic district. The hotel's exclusive guest policy ensures a peaceful retreat for all visitors seeking relaxation and sophistication. - **Other amenities:** Guests will appreciate various conveniences including 24-hour airport shuttle service and valet parking for easy arrivals and departures. The hotel features daily housekeeping, air conditioning for comfort, and a concierge service that can assist with local attractions. With its Art Deco design and premium bedding, Tantalo Hotel promises a stylish and comfortable stay, complemented by onsite shopping options and free bicycles for exploring the vibrant surroundings. - **Neighborhood:** Casco Viejo - **Nearby attractions:** Avenida Balboa - 0.7 km, Metropolitan Cathedral of Panama - 0.4 km, National Theater - 1 km ## Top Panama City Hotel Reviews ## Frequently asked questions ### How much do adults-only hotels in Panama City cost? > The price for adults-only hotels in Panama City may vary due to, among other things, the star rating and amenities included with your stay. Whatever your budget, you'll discover a grown-up getaway where you'll be able to unwind in peace and quiet with Expedia. ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - [Hotels near Albrook Shopping Mall](https://www.expedia.co.uk/Albrook-Shopping-Mall-Hotels.0-l6159851-0.Travel-Guide-Filter-Hotels) - [Hotels with Gym in Amador](https://www.expedia.co.uk/Amador-Panama-City-Hotels-Hotel-With-Gym.0-n553248635933392377-0-thotelwithgym.Travel-Guide-Filter-Hotels) - [Hotels near Ancon Hill](https://www.expedia.co.uk/Ancon-Hill-Hotels.0-l6286129-0.Travel-Guide-Filter-Hotels) - [Barrio Chino Hotels](https://www.expedia.co.uk/Barrio-Chino-Panama-City-Hotels.0-n714749931894550528-0.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Bella Vista](https://www.expedia.co.uk/Bella-Vista-Panama-City-Hotels-Gay-Friendly-Hotel.0-n3000663485-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Laundry Service in Bella Vista](https://www.expedia.co.uk/Bella-Vista-Panama-City-Hotels-Hotel-With-Laundry-Service.0-n3000663485-0-thotelwithlaundryservice.Travel-Guide-Filter-Hotels) - [Bella Vista Hotels](https://www.expedia.co.uk/Bella-Vista-Panama-City-Hotels.0-n3000663485-0.Travel-Guide-Filter-Hotels) - [Calidonia Hotels](https://www.expedia.co.uk/Calidonia-Panama-City-Hotels.0-n3000663488-0.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Campo Alegre](https://www.expedia.co.uk/Campo-Alegre-Panama-City-Hotels-Gay-Friendly-Hotel.0-n553248635976397615-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Campo Alegre Hotels](https://www.expedia.co.uk/Campo-Alegre-Panama-City-Hotels.0-n553248635976397615-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Casco Viejo](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Boutique-Hotel.0-n6285189-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Casco Viejo](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Hilton-Hotels.0-n6285189-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Casco Viejo](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Historic-Hotel.0-n6285189-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Wedding Hotels in Casco Viejo](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Wedding-Hotel.0-n6285189-0-tWeddingHotel.Travel-Guide-Filter-Hotels) - [Casco Viejo Hotels](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels.0-n6285189-0.Travel-Guide-Filter-Hotels) - [Beach Resorts & in Causeway Islands](https://www.expedia.co.uk/Causeway-Islands-Hotels-Beach-Hotels.0-0-d6336377-tBeachHotels.Travel-Guide-Filter-Hotels) - [Hotels near Cinta Costera](https://www.expedia.co.uk/Cinta-Costera-Hotels.0-l6245970-0.Travel-Guide-Filter-Hotels) - [Curundu Hotels](https://www.expedia.co.uk/Curundu-Panama-City-Hotels.0-n553248623199107736-0.Travel-Guide-Filter-Hotels) - [All-Inclusive Hotels in Panamá Province](https://www.expedia.co.uk/Destinations-In-Panama-Province-All-Inclusive-Hotel.0-0-d6246281-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Gay-Friendly Hotels in Panamá Province](https://www.expedia.co.uk/Destinations-In-Panama-Province-Gay-Friendly-Hotel.0-0-d6246281-tGayFriendlyHotel.Hotel-Filter-Destinations) - [Panamá Province Hotels](https://www.expedia.co.uk/Destinations-In-Panama-Province.d6246281.Hotel-Destinations) - [El Cangrejo Hotels](https://www.expedia.co.uk/El-Cangrejo-Panama-City-Hotels.0-n6285972-0.Travel-Guide-Filter-Hotels) - [Hotels near Estación Lotería](https://www.expedia.co.uk/Estacion-Loteria-Hotels.d553248635125946139.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Las Cumbres](https://www.expedia.co.uk/Las-Cumbres-Hotels-Gay-Friendly-Hotel.0-0-d6246011-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Marbella Hotels](https://www.expedia.co.uk/Marbella-Panama-City-Hotels.0-n3000663483-0.Travel-Guide-Filter-Hotels) - [Hotels near Marcos A. 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Gelabert Intl.](https://www.expedia.co.uk/Cheap-Flights-To-Marcos-A-Gelabert-Intl.d4407632.Travel-Guide-Flights) - [Flights from Marcos A. Gelabert Intl.](https://www.expedia.co.uk/lp/airports/pac/flights-from-marcos-a-gelabert-intl-airport) - [Hahn Air Technologies Bocas del Toro (BOC) to Panama City (PAC) flights](https://www.expedia.co.uk/lp/flight-routes/hahn-air-technologies-from-bocas-del-toro-intl-to-marcos-a-gelabert-intl/x1/boc/pac) - [Flights from Bilbao (BIO) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/bio/pac/bilbao-to-panama-city) - [Flights from Bocas del Toro (BOC) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/boc/pac/bocas-del-toro-to-panama-city) - [Flights from Baltimore (BWI) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/bwi/pac/baltimore-to-panama-city) - [Flights from Belize City (BZE) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/bze/pac/belize-city-to-panama-city) - [Flights from Columbia (CAE) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/cae/pac/columbia-to-panama-city) - [Flights from Waco Kungo (CEO) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/ceo/pac/waco-kungo-to-panama-city) - 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[Flights from San José (SJO) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/sjo/pac/san-jose-to-panama-city) - [Flights from Springfield (SPI) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/spi/pac/springfield-to-panama-city) - [Flights from Syracuse (SYR) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/syr/pac/syracuse-to-panama-city) - [Flights from Trinidad (TAD) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/tad/pac/trinidad-to-panama-city) - [Flights from Tapachula (TAP) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/tap/pac/tapachula-to-panama-city) - [Flights from Tampa (TPA) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/tpa/pac/tampa-to-panama-city) - [Flights from Tulcan (TUA) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/tua/pac/tulcan-to-panama-city) - [Flights from Uberlandia (UDI) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/udi/pac/uberlandia-to-panama-city) - [Flights from Owen Sound (YOS) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/yos/pac/owen-sound-to-panama-city) - [Flights from Zürich (ZRH) to Panama City (PAC)](https://www.expedia.co.uk/lp/flights/zrh/pac/zurich-to-panama-city) - [Albrook Shopping Mall](https://www.expedia.co.uk/Albrook-Shopping-Mall-Panama-City.d6159851.Attraction) - [Calidonia Holidays](https://www.expedia.co.uk/Calidonia.d3000663488.Holidays-City-Breaks) - [Cinta Costera](https://www.expedia.co.uk/Cinta-Costera-Calidonia.d6245970.Attraction) - [Metropolitan Cathedral of Panama](https://www.expedia.co.uk/Metropolitan-Cathedral-Of-Panama-Casco-Viejo.d6078477.Attraction) - [Metropolitan Nature Park](https://www.expedia.co.uk/Metropolitan-Nature-Park-Panama-City.d6078485.Attraction) - [Pacific Center](https://www.expedia.co.uk/Pacific-Center-San-Francisco.d633625826652135424.Attraction) - [Palacio Bolivar](https://www.expedia.co.uk/Palacio-Bolivar-Casco-Viejo.d553248621562725897.Attraction) - [Visit Bella Vista](https://www.expedia.co.uk/Panama-City-Bella-Vista.dx3000663485) - [Visit Bethania](https://www.expedia.co.uk/Panama-City-Bethania.dx553248623199112069) - [Visit Calidonia](https://www.expedia.co.uk/Panama-City-Calidonia.dx3000663488) - [Visit Campo Alegre](https://www.expedia.co.uk/Panama-City-Campo-Alegre.dx553248635976397615) - [Visit Curundu](https://www.expedia.co.uk/Panama-City-Curundu.dx553248623199107736) - [Visit El Cangrejo](https://www.expedia.co.uk/Panama-City-El-Cangrejo.dx6285972) - [Visit Marbella](https://www.expedia.co.uk/Panama-City-Marbella.dx3000663483) - [Visit Obarrio](https://www.expedia.co.uk/Panama-City-Obarrio.dx3000663487) - [Visit Punta Pacifica](https://www.expedia.co.uk/Panama-City-Punta-Pacifica.dx3000663482) - [Visit Punta Paitilla](https://www.expedia.co.uk/Panama-City-Punta-Paitilla.dx6285983) - [Visit Santa Ana](https://www.expedia.co.uk/Panama-City-Santa-Ana.dx553248623199107606)