Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama City 5 Star Hotels

See all 152 Hotels in Panama City
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,100 reviews)
Best timeThe best room, food, pool , location. Stayed two time now and it was the best , except for the staff, it wasnt friendly, too slow , and asking too many questions
  20 Feb 2018

£119

£119
Hard Rock Hotel Panama Megapolis

Hard Rock Hotel Panama Megapolis

Ave. Balboa al lado de Multicentro, Panama City
5.0 out of 5.0
4.3 out of 5 (2,244 reviews)
shower water pressure is like Manhattan Caio restaurant was a real treat
  18 Feb 2018

£106

£106
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (430 reviews)
Nice hotel Very clean, comfortable room, comfortable bed and helpful staff. Very good breakfast with a large selection in the hot and cold counters; attentive staff. There is also a restaurant that serves lunch and dinner. Good food
  17 Feb 2018

£125

£125
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (433 reviews)
Best hotel in Panama CityExcellent service, comfortable rooms, in a district with a lot of restaurants and nightlife.
  10 Feb 2018

£104

£104
Hilton Panama

Hilton Panama

Balboa Ave. and Aquilino De La Guardia, Panama City
5.0 out of 5.0
4.5 out of 5 (267 reviews)
Busy hotel in main thoroughfare This hotel was always very busy. There is a casino downstairs. The decor was very contemporary but the carpet in the rooms looked like they needed to be vacuumed. The staff was friendly and helpful couldn’t ask for better staff. The location of hotel was exactly where we wanted it. It is in center ...
  30 Jan 2018

£99

£99
Sortis Hotel, Spa & Casino, Autograph Collection

Sortis Hotel, Spa & Casino, Autograph Collection

56 y 57 East Street, Obarrio, Panama City
5.0 out of 5.0
4.4 out of 5 (246 reviews)
modern hotel, bit busy an noisy at times when coming in and out of the lobby
  27 Jan 2018

£112

£112
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street, Panama City
5.0 out of 5.0
4.2 out of 5 (261 reviews)
Very nice hotel Very clean, just as expected. A lot of parkings. And valet parking is included. It has stores inside if you need anything and a couple a bank cash dispensers. The restaurant is also really good.
  28 Jan 2018

£83

£83
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.2 out of 5 (302 reviews)
Our vacation at Westin Playa BonitaOf course the beach is a non-factor on this side of Panama. We stayed off the beach. Having an ocean front room was great but the ocean water was very murky and filled with quite a few large oil tankers in a distance. The hotel grounds and rooms were 5 stars, but the amenities were limited due to ...
  19 Feb 2018

£129

£129
Manrey Boutique Hotel

Manrey Boutique Hotel

Calle Uruguay y Calle 48, Panama City
5.0 out of 5.0
3.8 out of 5 (252 reviews)
Service is goodGreat location for night life. Several Discos and nice restruant walking distance.
  19 Oct 2015
W Panama

W Panama

Calle Aquilino de la Guardia & Calle 50, Panama City
5.0 out of 5.0

£104

£104

Pocket Guide: 5 Star Hotels in Panama City

Search for hotels in Panama City on Expedia.co.uk. You can easily find your hotels in Panama City using one of the methods below:

  • View our selection of featured hotels in Panama City
  • Use the map to find hotels in the Panama City neighborhood you prefer
  • Use the filters to see hotels in a specific area of Panama City, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Panama City
  • Enter your travel dates to view the best deals on hotels in Panama City - while they last

Recently booked Panama City hotels

Wyndham Garden Panama City
4.0 out of 5.0
Last booking: 1 minute ago
Hilton Garden Inn Panama
4.0 out of 5.0
Last booking: 24 minutes ago
Wyndham Panama Albrook Mall
4.5 out of 5.0
Last booking: 57 minutes ago
Country Inn & Suites by Radisson, Panama City, Panama
3.5 out of 5.0
Last booking: 1 hour ago
Hampton by Hilton Panama
3.5 out of 5.0
Last booking: 1 hour ago
Tantalo Hotel / Kitchen / Roofbar
3.5 out of 5.0
Last booking: 1 hour ago
Ramada Plaza Panama Punta Pacifica
4.5 out of 5.0
Last booking: 1 hour ago
TRYP by Wyndham Panamá Centro
4.0 out of 5.0
Last booking: 2 hours ago
Hotel El Parador
3.5 out of 5.0
Last booking: 2 hours ago