Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Panama City 5 Star Hotels

See all 152 Hotels in Panama City
Trump International Hotel and Tower Panama

Trump International Hotel and Tower Panama

Calle Punta Colon, Punta Pacifica, Panama City
5.0 out of 5.0
4.4 out of 5 (1,024 reviews)
Good hotelRequested ocean view but did not get and had to change rooms
  8 Nov 2017

£112

£112
Waldorf Astoria Panama

Waldorf Astoria Panama

47th St. & Uruguay Street, Panama City
5.0 out of 5.0
4.4 out of 5 (404 reviews)
City center, very centrally located. Great hotel. Very luxurious. Makes you feel like royalty!
  16 Nov 2017

£93

£93
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Panama City
5.0 out of 5.0
4.2 out of 5 (282 reviews)
Westin is the way to go.The hotel and the room were clean. The staff was very friendly and we were able to get by with our limited Spanish speaking skills.
  2 Nov 2017

£130

£130
Bristol Panama

Bristol Panama

Avenida Aquilino de La Guardia, Panama City
5.0 out of 5.0
4.6 out of 5 (389 reviews)
Always good and will always recommend.This hotel with out a doubt is a hidden jewel. It's close to everything the staff is so friendly. I've been coming here very often and cannot think of staying anywhere else.
  6 Nov 2017

£119

£119
Map

Pocket Guide: 5 Star Hotels in Panama City

Search for hotels in Panama City on Expedia.co.uk. You can easily find your hotels in Panama City using one of the methods below:

  • View our selection of featured hotels in Panama City
  • Use the map to find hotels in the Panama City neighborhood you prefer
  • Use the filters to see hotels in a specific area of Panama City, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Panama City
  • Enter your travel dates to view the best deals on hotels in Panama City - while they last

Recently booked Panama City hotels

Trump Ocean Club International Hotel and Tower Panama
5.0 out of 5.0
Last booking: 6 hours ago