A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.

Compare and book 5 Star hotels in Panama City, Panamá Province

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Check availability on Panama City 5 Star Hotels

Tonight
12 Oct - 13 Oct
Tomorrow
13 Oct - 14 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Panama City 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A modern hotel room with a dining area, a TV, and a city view.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Caroline
£110
includes taxes & fees
21 Oct - 22 Oct
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.
A modern building with a rooftop lounge area, large windows, and a balcony overlooking a cityscape.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
£218
includes taxes & fees
31 Oct - 1 Nov
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.
A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
£292
includes taxes & fees
3 Nov - 4 Nov
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
A modern hotel entrance with a prominent 'Renaissance Hotel' sign, a well-lit outdoor area with a wooden structure, and a staircase leading to the upper floors.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
£112
includes taxes & fees
31 Oct - 1 Nov
Renaissance Panama City Hotel
A poolside area with lounge chairs and a view of the ocean.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.
A terrace with seating and a view of the ocean.

5. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Detra Dorsey
£232
includes taxes & fees
7 Nov - 8 Nov
JW Marriott Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A modern interior with a central seating area, potted plants, and a staircase.
A modern building with a sign reading 'HYATT REGENCY.'
A spacious hotel lobby with modern furniture, large windows, and a city view.

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Mariah
£155
includes taxes & fees
24 Oct - 25 Oct
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
A pool with a central water feature, surrounded by seating areas and potted plants.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.
The entrance of The Santa Maria with a covered walkway and a view of the interior.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Carmen
£230
includes taxes & fees
1 Nov - 2 Nov
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.

8. W Panama

W Panama
Bella Vista
United States
Naomi
£192
includes taxes & fees
1 Nov - 2 Nov
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A modern bar area with seating and a view of the city.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Simon
£204
includes taxes & fees
6 Nov - 7 Nov
Hilton Panama
A hotel with a pool, beach, and palm trees.
A beachfront hotel with a large building, a beach, and a clear sky.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Anna
£171
includes taxes & fees
25 Oct - 26 Oct
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.
A person performing a yoga pose in a living room with a large window and a sofa.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
£207
includes taxes & fees
17 Oct - 18 Oct
Bristol Panama, a Registry Collection Hotel
Lobby
Outdoor pool
Bar (on property)
Breakfast area

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
£85
includes taxes & fees
7 Nov - 8 Nov
Waymore Hotel Spa and Casino
Terrace/patio
Outdoor spa tub
Room
Casino

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
£218
includes taxes & fees
3 Nov - 4 Nov
Megapolis Hotel Panamá
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama City.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
£116
10 Nov - 11 Nov
includes taxes & fees
8.6/10 Excellent! (2,759 reviews)
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
£185
9 Nov - 10 Nov
includes taxes & fees
9/10 Wonderful! (1,014 reviews)
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
£113
31 Oct - 1 Nov
includes taxes & fees
Megapolis Hotel Panamá
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

See all hotels in Panama City
A city skyline with high-rise buildings, a calm waterfront, and a sunset sky.

Top Panama City Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"The breakfast buffet was a welcome bonus"
Nicole A 4-night trip
Posted 7 hours ago
Hotel Riu Plaza Panama
Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"Exactly what you would expect from hyatt resort"
Nehemiah 3-night trip
Posted 19 hours ago
Hyatt Regency Panama City
JW Marriott Panama

JW Marriott Panama

10/10 Excellent
"N/A"
Rhonda 3-night trip
Posted 19 hours ago
JW Marriott Panama

Find out more about Panama City

Frequently asked questions

What are the best 5-star hotels in Panama City?
According to Expedia guest reviews, Bristol Panama, a Registry Collection Hotel, W Panama and Waldorf Astoria Panama are among the top 5-star hotels in Panama City. Providing top-quality amenities and unmatchable service, you'll enjoy a luxurious and memorable stay.
How much does it cost to stay in a 5-star hotel in Panama City?
How much you pay for a 5-star hotel in Panama City can vary according to when you prefer to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to find the best deal on a luxurious getaway.
  • Search for the lowest price per night from £113
What makes a hotel 5 stars in Panama City?
From fine dining restaurants and 24-hour gyms to swimming pools and the finest bedding, the 5-star experience in Panama City is all about comfort and luxury. But it takes more than just top-notch amenities to receive a 5-star rating. Hotels also have to offer remarkable guest-centric services like in-room beauty treatments, on-site laundry and dry cleaning and room service any time day or night.

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