
Los Santos Holidays
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Your Los Santos Holiday
Unlock the door to adventure with a holiday package to Los Santos. Get your journey underway in Guarare, where its festivals will be among the things that make this city stand out. Why not plan your trip to Los Santos around its most well-known cities? Las Escobas del Venado, Pedasi and Las Tablas are all fantastic places to start. Expedia has everything you need when it comes to planning your Los Santos holiday. From hotels and flights, to activities and more, we're here to help you create a travel experience like no other.
Top destinations in Los Santos

Punta Mala
Top Los Santos Flight + Hotel Deals

MARINN Tropical Vibes Hotel
Reviewed on 24 Jul 2025

Central Hotel Panama Casco Viejo
Reviewed on 25 Jul 2025


Hotel Riu Plaza Panama
Reviewed on 29 Jul 2025

Hotel Plaza Herrera
Reviewed on 5 May 2025
Los Santos Essential Information
Language | Spanish |
---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Closest Airport | Tocumen Intl. Airport (PTY) |
Top Sights | Venao Beach, El Uverito Beach and Playa Las Comadres |
Top hotels in Los Santos

Playa Venao Hotel Resort
Reviewed on 28 May 2025

Hotel Posada Destiladeros
Reviewed on 17 Jul 2025

Villa Marina Lodge & Condos
Reviewed on 14 Jul 2025
Frequently asked questions
Popular places to visit
Guanico Abajo Beach
If a restful holiday is part of your travel plans, Guanico Abajo Beach might be the perfect place to visit during your trip to Guanico Abajo.
What to do in Los Santos
More trip options
Expedia's Latest Trends
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.