A tropical island with palm trees and a clear blue sky.

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Panama Accommodation: Most Popular Cities to Stay

A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.
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Panama City

Panama City
A waterfront area with buildings, boats, and a dock.
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Bocas del Toro

Bocas del Toro

Check availability on Panama Luxury Hotels

This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

Our top choices for Panama luxury hotels

A poolside area with lounge chairs and a view of the ocean.

1. JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.2 out of 10, Wonderful, (1,004 reviews)
  • cleanliness
    Unwind in opulent waterfront luxury with 4 pristine pools and ocean-view dining in Panama City.
The price is £275
includes taxes & fees
27 Nov - 28 Nov
JW Marriott Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.

2. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
5.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Art deco elegance meets modern luxury in this Panama City hotel featuring 2 bars, a full-service spa, and an outdoor pool.
The price is £174
includes taxes & fees
14 Nov - 15 Nov
Bristol Panama, a Registry Collection Hotel
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.

3. Waldorf Astoria Panama

Waldorf Astoria Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1,001 reviews)
  • cleanliness
    Panama City elegance at this Waldorf Astoria hotel with a full-service spa, outdoor pool, and refined dining in two upscale restaurants.
The price is £227
includes taxes & fees
7 Nov - 8 Nov
Waldorf Astoria Panama
A spacious indoor area with high ceilings, large windows, and multiple dining tables.

4. American Trade Hotel

American Trade Hotel
4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (825 reviews)
  • cleanliness
    A colonial gem in Panama City offering luxurious comfort, exquisite dining, and personalised service in a historic district.
The price is £176
includes taxes & fees
15 Nov - 16 Nov
American Trade Hotel
A poolside area with covered seating and palm trees.

5. Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
4.5 star property
Bella Vista
8.8 out of 10, Excellent, (1,000 reviews)
  • cleanliness
    Indulge in Panama City luxury with an outdoor pool, full-service spa, and casino at this stylish hotel near Via Espana.
The price is £201
includes taxes & fees
4 Dec - 5 Dec
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
A modern hotel pool area with lounge chairs and a clear view of the ocean.

6. Hilton Panama

Hilton Panama
5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1,002 reviews)
  • cleanliness
    Panama City sophistication meets relaxation with an attached winery, poolside dining, and a full-service spa offering couples' treatments.
The price is £205
includes taxes & fees
4 Dec - 5 Dec
Hilton Panama
Terrace/patio

7. Megapolis Hotel Panamá

Megapolis Hotel Panamá
5.0 star property
San Francisco
8.4 out of 10, Very good, (1,000 reviews)
  • cleanliness
    Indulgent pampering awaits at this Beaux Arts Panama City gem with spa, casino, and rooftop bar.
The price is £216
includes taxes & fees
25 Nov - 26 Nov
Megapolis Hotel Panamá
A poolside lounge area with two white cushioned chairs and a lantern, surrounded by palm trees and a view of the ocean at sunset.

8. The Buenaventura Golf & Beach Resort Panama, Autograph Collection

The Buenaventura Golf & Beach Resort Panama, Autograph Collection
5.0 star property
El Chiru
9.2 out of 10, Wonderful, (785 reviews)
  • cleanliness
    Immerse in beachfront opulence with 12 stunning pools, a full-service spa, and private beach access at this Panama golf resort.
The price is £190
includes taxes & fees
26 Nov - 27 Nov
The Buenaventura Golf & Beach Resort Panama, Autograph Collection
A modern lobby with a glass railing, a central staircase, and a view of the cityscape through large windows.

9. Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1,135 reviews)
  • cleanliness
    Panama City hotel offers upscale comfort with spa, indoor pool, and pillowtop beds in San Francisco district.
The price is £123
includes taxes & fees
8 Nov - 9 Nov
Las Americas Golden Tower Panama
A rooftop pool area with lounge chairs and a bar, overlooking a city skyline at sunset.

10. Marriott Panama Hotel

Marriott Panama Hotel
4.0 star property
Panama City
9.2 out of 10, Wonderful, (1,003 reviews)
  • cleanliness
    Luxury redefined in Panama City with rooftop pool, premium dining, and concierge services to elevate your urban escape.
The price is £146
includes taxes & fees
4 Dec - 5 Dec
Marriott Panama Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panama Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Had a great week’s stay at the hotel and it was great, very clean and helpful staff. Will definitely recommend and return."
Lance 7-night trip
Posted less than an hour ago
Hotel Riu Plaza Panama

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