Title: The 10 Best 5 Star Hotels in Esquilino - 2025 Updated Prices | Expedia.co.uk [Esquilino Travel Guide](https://expedia.co.uk/Rome-Esquilino.dx6170957)[Holiday Rentals in Rome](https://expedia.co.uk/Rome-Holiday-Rentals.d179899.Travel-Guide-HolidayRentals)[Flights to Rome](https://expedia.co.uk/Cheap-Flights-To-Rome.d179899.Travel-Guide-Flights)[Things to do in Rome](https://expedia.co.uk/Things-To-Do-In-Rome.d179899.Travel-Guide-Activities)[Esquilino Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Esquilino.d6170957.Car-Hire-Guide)[Esquilino Holidays](https://expedia.co.uk/Esquilino.d6170957.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/545000/545661-esquilino.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Esquilino, Rome ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Esquilino 5 Star Hotels Tonight [9 Oct - 10 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2025-10-09&endDate=2025-10-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Oct - 11 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2025-10-10&endDate=2025-10-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Esquilino 5 Star Hotels ![Exterior](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/e4a6fedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room | Minibar, in-room safe, desk, soundproofing](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/w3839h2559x0y0-0b510f45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/64622daa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/ae094d19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NH Collection Roma Palazzo Cinquecento Rome City Centre 9.0/10 Wonderful (1002) "Good location and much more peaceful than the historic centres. Excellent breakfast buffet. Helpful staff. " £258 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Rome-Hotels-NH-Collection-Roma-Palazzo-Cinquecento.h12741260.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Esquilino-Rome-Hotels.s50-n6170957-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Esquilino-Rome-Hotels.s50-n6170957-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Esquilino. ![Napoleon Hotel](https://images.trvl-media.com/lodging/1000000/10000/6600/6548/9e2b5c71_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Napoleon Hotel Piazza Vittorio Emanuele II 105, Rome, RM [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F10%2F2025&endDate=24%2F10%2F2025&selected=6548&PinnedHotelID=6548&HadPinnedHotel=true®ionId=6170957) 8.2/10 Very Good! (1,005 reviews) [](https://expedia.co.uk/Rome-Hotels-Napoleon-Hotel.h6548.Hotel-Information) ![Hotel Morgana](https://images.trvl-media.com/lodging/1000000/30000/25800/25722/e6ade1c0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Morgana Via Filippo Turati 31 33 35, Rome, RM £133 8 Nov - 9 Nov includes taxes & fees 8.2/10 Very Good! (999 reviews) [](https://expedia.co.uk/Rome-Hotels-Hotel-Morgana.h25722.Hotel-Information) ![Hotel Aphrodite](https://images.trvl-media.com/lodging/1000000/990000/982500/982481/d6f00bdd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Aphrodite Via Marsala 90, Rome, RM [Get rates](https://expedia.co.uk/Hotel-Search?startDate=23%2F10%2F2025&endDate=24%2F10%2F2025&selected=982481&PinnedHotelID=982481&HadPinnedHotel=true®ionId=6170957) 7.6/10 Good! (990 reviews) [](https://expedia.co.uk/Rome-Hotels-Hotel-Aphrodite.h982481.Hotel-Information) Still don't see what you're looking for? [See all properties in Esquilino.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6170957&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6170957&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6170957&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6170957&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6170957&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6170957&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Esquilino Hotel Reviews ![NH Collection Roma Palazzo Cinquecento](//images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/e4a6fedb_y.jpg) ### NH Collection Roma Palazzo Cinquecento 10/10 Excellent "Great experience. Staff were super nice and accommodating and hotel was beautiful and well located next to Termini station. 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[Basilica di Santa Maria Maggiore](https://www.expedia.co.uk/Basilica-Di-Santa-Maria-Maggiore-Rome-City-Centre.d6073994.Attraction) - [Colosseum](https://www.expedia.co.uk/Colosseum-Rome-City-Centre.d6046257.Attraction) - [Golden House of Nero](https://www.expedia.co.uk/Golden-House-Of-Nero-Rome-City-Centre.d6074034.Attraction) - [Monti Holidays](https://www.expedia.co.uk/Monti.d6185346.Holidays-City-Breaks) - [Visit Monti](https://www.expedia.co.uk/Rome-Monti.dx6185346) - [Visit San Lorenzo](https://www.expedia.co.uk/Rome-San-Lorenzo.dx6145024) - [Rome Holidays](https://www.expedia.co.uk/Rome.d179899.Holidays-City-Breaks) - [Studio d'Arte Contemporanea di Pino Casagrande](https://www.expedia.co.uk/Studio-DArte-Contemporanea-Di-Pino-Casagrande-Tiburtino.d553248621532500732.Attraction) - [Triclinium Leoninum](https://www.expedia.co.uk/Triclinium-Leoninum-Rome-Historic-Centre.d553248621533001840.Attraction) - [Villa Giustiniani Massimo](https://www.expedia.co.uk/Villa-Giustiniani-Massimo-Rome-City-Centre.d553248621532501679.Attraction) - [Car hire near Colosseum](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Colosseum.d6046257.Car-Hire-Guide) - [Car hire near Golden House of Nero](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Golden-House-Of-Nero.d6074034.Car-Hire-Guide) - [Car hire near San Lorenzo](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-San-Lorenzo.d6145024.Car-Hire-Guide) - [Economy Car Hire near Golden House of Nero](https://www.expedia.co.uk/Economy-Car-Rentals-In-Golden-House-Of-Nero.d6074034-tEconomy.Car-Rental-Guide-Class) - [Full-Size Car Hire near Colosseum](https://www.expedia.co.uk/Fullsize-Car-Rentals-In-Colosseum.d6046257-tFullsize.Car-Rental-Guide-Class) - [Luxury Car Hire near Colosseum](https://www.expedia.co.uk/Luxury-Car-Rentals-In-Colosseum.d6046257-tLuxury.Car-Rental-Guide-Class) - [Sports Car Car Hire near Colosseum](https://www.expedia.co.uk/Sportscar-Car-Rentals-In-Colosseum.d6046257-tSportscar.Car-Rental-Guide-Class) - [Sports Car Car Hire near Golden House of Nero](https://www.expedia.co.uk/Sportscar-Car-Rentals-In-Golden-House-Of-Nero.d6074034-tSportscar.Car-Rental-Guide-Class) - [Standard Car Hire near Colosseum](https://www.expedia.co.uk/Standard-Car-Rentals-In-Colosseum.d6046257-tStandard.Car-Rental-Guide-Class) - [People Carrier Car Hire near Golden House of Nero](https://www.expedia.co.uk/Van-Car-Rentals-In-Golden-House-Of-Nero.d6074034-tVan.Car-Rental-Guide-Class) - [Things to do in Rome](https://www.expedia.co.uk/Things-To-Do-In-Rome.d179899.Travel-Guide-Activities) - [Book Hotels in Esquilino on Expedia.it](https://www.expedia.it/5Stelle-Esquilino-Roma-Hotel.s50-n6170957-0.Guida-Viaggi-Filtro-Hotel)