Title: The 10 Best 5 Star Hotels in Esquilino - 2026 Updated Prices | Expedia.co.uk [Esquilino Travel Guide](https://expedia.co.uk/Rome-Esquilino.dx6170957)[Holiday Rentals in Rome](https://expedia.co.uk/Rome-Holiday-Rentals.d179899.Travel-Guide-HolidayRentals)[Flights to Rome](https://expedia.co.uk/Cheap-Flights-To-Rome.d179899.Travel-Guide-Flights)[Things to do in Rome](https://expedia.co.uk/Things-To-Do-In-Rome.d179899.Travel-Guide-Activities)[Esquilino Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Esquilino.d6170957.Car-Hire-Guide)[Esquilino Holidays](https://expedia.co.uk/Esquilino.d6170957.Holidays-City-Breaks) ![Esquilino which includes interior views, heritage architecture and heritage elements](https://images.trvl-media.com/place/6170957/31a26e9b-dedb-4f38-b57a-30c09f5e4a83.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6170957/31a26e9b-dedb-4f38-b57a-30c09f5e4a83.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Esquilino 5 Star Hotels Tonight [15 Jan - 16 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2026-01-15&endDate=2026-01-16&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [16 Jan - 17 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2026-01-16&endDate=2026-01-17&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2026-01-16&endDate=2026-01-18&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6170957&startDate=2026-01-23&endDate=2026-01-25&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Esquilino 5-star hotels ![Daily buffet breakfast for a fee](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/08478e2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/ae094d19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/e9e1e7d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/7c35417f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NH Collection Roma Palazzo Cinquecento [](https://www.expedia.co.uk/Rome-Hotels-NH-Collection-Roma-Palazzo-Cinquecento.h12741260.Hotel-Information) Rome City Centre 9.0/10 Wonderful (1,000 reviews) "Excellent location and very clean the staff were very polite and helpful. We had a very pleasant stay and will visit again" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Jason £266 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Rome-Hotels-NH-Collection-Roma-Palazzo-Cinquecento.h12741260.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Esquilino-Rome-Hotels.s50-n6170957-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Esquilino-Rome-Hotels.s50-n6170957-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Esquilino. ![Napoleon Hotel](https://images.trvl-media.com/lodging/1000000/10000/6600/6548/9e2b5c71_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Napoleon Hotel Piazza Vittorio Emanuele II 105 Rome RM £90 18 Jan - 19 Jan includes taxes & fees 8.4/10 Very Good! (1,001 reviews) [](https://expedia.co.uk/Rome-Hotels-Napoleon-Hotel.h6548.Hotel-Information) ![Hotel Palladium Palace](https://images.trvl-media.com/lodging/1000000/10000/3300/3252/7e47b71b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Palladium Palace Via Gioberti 36 Rome RM [Get rates](https://expedia.co.uk/Hotel-Search?startDate=29%2F01%2F2026&endDate=30%2F01%2F2026&selected=3252&PinnedHotelID=3252&HadPinnedHotel=true®ionId=6170957) 8/10 Very Good! (919 reviews) [](https://expedia.co.uk/Rome-Hotels-Hotel-Palladium-Palace.h3252.Hotel-Information) ![Hotel Aphrodite](https://images.trvl-media.com/lodging/1000000/990000/982500/982481/d6f00bdd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Aphrodite Via Marsala 90 Rome RM £82 29 Jan - 30 Jan includes taxes & fees 7.6/10 Good! (991 reviews) [](https://expedia.co.uk/Rome-Hotels-Hotel-Aphrodite.h982481.Hotel-Information) Still don't see what you're looking for? [See all properties in Esquilino.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=16%2F01%2F2026&endDate=17%2F01%2F2026®ionId=6170957&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=16%2F01%2F2026&endDate=17%2F01%2F2026®ionId=6170957&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=16%2F01%2F2026&endDate=17%2F01%2F2026®ionId=6170957&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=16%2F01%2F2026&endDate=17%2F01%2F2026®ionId=6170957&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=16%2F01%2F2026&endDate=17%2F01%2F2026®ionId=6170957&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=16%2F01%2F2026&endDate=17%2F01%2F2026®ionId=6170957&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Esquilino Hotel Reviews ![NH Collection Roma Palazzo Cinquecento](https://images.trvl-media.com/lodging/13000000/12750000/12741300/12741260/e4a6fedb_y.jpg) ### NH Collection Roma Palazzo Cinquecento 10/10 Excellent "The position of the hotel was exceptional. The service was good and the breakfast outstanding" [](https://expedia.co.uk/Rome-Hotels-NH-Collection-Roma-Palazzo-Cinquecento.h12741260.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Other - More ways to book - [1 Star Hotels in Rome ](https://www.expedia.co.uk/1Star-Rome-Hotels.s10-0-d179899.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Cinecitta ](https://www.expedia.co.uk/2Star-Cinecitta-Rome-Hotels.s20-n6185671-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Rome ](https://www.expedia.co.uk/2Star-Rome-Hotels.s20-0-d179899.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Monti ](https://www.expedia.co.uk/3Star-Monti-Rome-Hotels.s30-n6185346-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Northern Rome ](https://www.expedia.co.uk/3Star-Northern-Rome-Hotels.s30-0-d6051852.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Rome City Centre ](https://www.expedia.co.uk/3Star-Rome-City-Centre-Rome-Hotels.s30-n553248633938945217-0.Travel-Guide-Filter-Hotels) - 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