Title: TOP Adults Only Resorts & Hotels in Upstate South Carolina, SC for 2026 | Expedia.co.uk [Upstate South Carolina Travel Guide](https://expedia.co.uk/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Holiday Rentals in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Holiday-Rentals.d6057939.Travel-Guide-HolidayRentals)[Flights to Upstate South Carolina](https://expedia.co.uk/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.co.uk/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Upstate-South-Carolina.d6057939.Car-Hire-Guide)[Upstate South Carolina Holidays](https://expedia.co.uk/Upstate-South-Carolina.d6057939.Holidays-City-Breaks) ![Greenville - Spartanburg](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Visit Greenville, South Carolina ![](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina Adults Only Resorts & Hotels Tonight [23 Mar - 24 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-03-23&endDate=2026-03-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Tomorrow [24 Mar - 25 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-03-24&endDate=2026-03-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) This weekend [27 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Next weekend [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) ## Our top choices for Upstate South Carolina adults-only hotels ![Property grounds](https://images.trvl-media.com/lodging/54000000/53160000/53157700/53157625/47340e8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/54000000/53160000/53157700/53157625/09b09840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom](https://images.trvl-media.com/lodging/54000000/53160000/53157700/53157625/083a7faf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/54000000/53160000/53157700/53157625/6f8a898a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### CLIFFSIDE CABIN - Breathtaking Cliffside Gem Off Grid-Cabin Adventure! [](https://www.expedia.co.uk/Fletcher-Hotels-OFF-GRID-CABIN-W-SOLAR-CAVERNCAVE-15-Min-To-ASHEVILLE.h53157625.Hotel-Information) Fletcher 10/10 Exceptional (3 reviews) "My husband and I took a last minute little getaway from Valentine's day. To say this is the absolute most amazing place we've ever stayed is an understatement. We wish we could have stayed longer but it was so short notice we only stayed one night.We will absolutely be back. There is not a single thing I would change. Doug and Jen are the sweetest!!!! They are so helpful and responsive!We cant wait to go back!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katie W. £151 includes taxes & fees 26 Mar - 27 Mar [](https://www.expedia.co.uk/Fletcher-Hotels-OFF-GRID-CABIN-W-SOLAR-CAVERNCAVE-15-Min-To-ASHEVILLE.h53157625.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-06&endDate=2026-04-07®ionId=6057939&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true) ## Top Upstate South Carolina Hotel Reviews ## Frequently asked questions ### How can I find cheap adults-only hotels in Upstate South Carolina? ### From what age can you stay in an adult-only hotel in Upstate South Carolina? ### Are all adult-only resorts all-inclusive in Upstate South Carolina? ### Why book your adults-only hotel in Upstate South Carolina with Expedia? ### When is the best time to stay at an adult-only all-inclusive resort in Upstate South Carolina? ### Can I cancel or change my adult-only resort booking? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Hotels with a View in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-A-View.0-0-d242-thotelwithaview.Hotel-Filter-Destinations) - 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[Flights from Greenville ](https://www.expedia.co.uk/lp/flights/1388/flights-from-greenville) - [Flights from Dunean ](https://www.expedia.co.uk/lp/flights/553248634999354841/flights-from-dunean) - [Flights from Simpsonville ](https://www.expedia.co.uk/lp/flights/6239/flights-from-simpsonville) - [Flights from Augusta (AGS) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/ags/gmu/augusta-to-greenville) - [Flights from Anderson (AND) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/and/gmu/anderson-to-greenville) - [Flights from Atlanta (ATL) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/atl/gmu/atlanta-to-greenville) - [Flights from Clemson (CEU) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/ceu/gdc/clemson-to-greenville) - [Flights from Washington (DCA) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/dca/gdc/washington-to-greenville) - [Flights from Detroit (DTW) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/dtw/gmu/detroit-to-greenville) - 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Airport (EWR) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/ewr/gmu/newark-liberty-intl-airport-to-greenville) - [Flights from Gaithersburg (GAI) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/gai/gmu/gaithersburg-to-greenville) - [Flights from Greenwood (GRD) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/grd/gmu/greenwood-to-greenville) - [Flights from Hagerstown (HGR) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/hgr/gmu/hagerstown-to-greenville) - [Flights from Hong Kong (HKG) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/hkg/gdc/hong-kong-to-greenville) - [Flights from Islip (ISP) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/isp/gmu/islip-to-greenville) - [Flights from Jacksonville (JAX) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/jax/gmu/jacksonville-to-greenville) - [Flights from Las Vegas (LAS) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/las/gmu/las-vegas-to-greenville) - [Flights from Los Angeles (LAX) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/lax/gmu/los-angeles-to-greenville) - [Flights from Pickens (LQK) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/lqk/gdc/pickens-to-greenville) - [Flights from Morgantown (MGW) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/mgw/gmu/morgantown-to-greenville) - [Flights from Dayton (MGY) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/mgy/gmu/dayton-to-greenville) - [Flights from Madison (MSN) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/msn/gdc/madison-to-greenville) - [Flights from New Orleans (MSY) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/msy/gmu/new-orleans-to-greenville) - [Flights from Paris (PAR) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/par/gdc/paris-to-greenville) - [Flights from Rocky Mount (RWI) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/rwi/gmu/rocky-mount-to-greenville) - [Flights from Louisville (SDF) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/sdf/gmu/louisville-to-greenville) - [Flights from St. Louis (STL) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/stl/gmu/st-louis-to-greenville) - [Flights from Taipei (TPE) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/tpe/gdc/taipei-to-greenville) - [Discovery Island Water Park ](https://www.expedia.co.uk/Discovery-Island-Water-Park-Greenville.d553248621532656705.Attraction) - [Frankie's Fun Park ](https://www.expedia.co.uk/Frankies-Fun-Park-Greenville.d553248621532656780.Attraction) - [Greenville Holidays ](https://www.expedia.co.uk/Greenville.d1388.Holidays-City-Breaks) - [Visit Greenville ](https://www.expedia.co.uk/Greenville.dx1388) - [Patewood Memorial Hospital ](https://www.expedia.co.uk/Patewood-Memorial-Hospital-Greenville.d6130783.Attraction) - [Simpsonville Holidays ](https://www.expedia.co.uk/Simpsonville.d6239.Holidays-City-Breaks) - [Warehouse Theatre ](https://www.expedia.co.uk/Warehouse-Theatre-Greenville-Downtown.d553248621532656721.Attraction) - [Car hire Greenville ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Greenville.d1388.Car-Hire-Guide) - [Car hire Simpsonville ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Simpsonville.d6239.Car-Hire-Guide) - [Gantt Holiday Rentals ](https://www.expedia.co.uk/Gantt-Holiday-Rentals.d553248634999376437.Travel-Guide-HolidayRentals) - [Greenville Holiday Rentals ](https://www.expedia.co.uk/Greenville-Holiday-Rentals.d1388.Travel-Guide-HolidayRentals) - [Mauldin Holiday Rentals ](https://www.expedia.co.uk/Mauldin-Holiday-Rentals.d183944.Travel-Guide-HolidayRentals) - [Things to do in Greenville ](https://www.expedia.co.uk/Things-To-Do-In-Greenville.d1388.Travel-Guide-Activities) - [Things to do in Simpsonville ](https://www.expedia.co.uk/Things-To-Do-In-Simpsonville.d6239.Travel-Guide-Activities) - [Book Adults Only Resorts & Hotels in Upstate South Carolina on Expedia.com ](https://www.expedia.com/Upstate-South-Carolina-Hotels-Adults-Only-Resorts.0-0-d6057939-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)