Title: TOP Boutique Hotels in Greenville, SC for 2025 | Expedia.co.uk [Greenville Travel Guide](https://expedia.co.uk/Greenville.dx1388)[Hotels in Greenville](https://expedia.co.uk/Greenville-Hotels.d1388.Travel-Guide-Hotels)[Holiday Rentals in Greenville](https://expedia.co.uk/Greenville-Holiday-Rentals.d1388.Travel-Guide-HolidayRentals)[Flights to Greenville](https://expedia.co.uk/Cheap-Flights-To-Greenville.d1388.Travel-Guide-Flights)[Things to do in Greenville](https://expedia.co.uk/Things-To-Do-In-Greenville.d1388.Travel-Guide-Activities)[Greenville Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Greenville.d1388.Car-Hire-Guide)[Greenville Holidays](https://expedia.co.uk/Greenville.d1388.Holidays-City-Breaks) ![Greenville showing a marina, general coastal views and a river or creek](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63749-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Boutique Hotels in Greenville ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Greenville Boutique Hotels Tonight [24 Oct - 25 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-24&endDate=2025-10-25&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [25 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-25&endDate=2025-10-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [31 Oct - 2 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Greenville Boutique Hotels ![Bar (on property)](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/1f0407e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/53680281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/4694c80e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/598f5b2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Domestique Travelers Rest 9.6/10 Exceptional (30) "Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chuck £338 includes taxes & fees 23 Nov - 24 Nov [](https://www.expedia.co.uk/Travelers-Rest-Hotels-Hotel-Domestique.h9704647.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-07&endDate=2025-11-08®ionId=1388&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Greenville Hotel Reviews ## Frequently asked questions ### What's there to see and do in Greenville? > The shopping, waterfalls and sporting events are just some of the things to enjoy while you're in the area. Activities and attractions to experience around Greenville include The Peace Center, Greenville County Museum of Art and Bob Jones University Museum and Gallery. For even more to see and do, make a stop at The Children's Museum of the Upstate, Bon Secours Wellness Arena and Greenville Zoo. ### What kind of weather should I plan for when I travel to Greenville? > Having a good idea of the weather in Greenville is important when planning your trip. The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 8°C. Average annual precipitation for Greenville is 1399 mm. ### What's the best way to get to my boutique hotel in Greenville? > You have a few options for getting to Greenville. The nearest major airport is Greenville, SC (GSP-Greenville-Spartanburg Intl.), which is located 10.7 mi (17.2 km) from the heart of the city. 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