Title: South Carolina Boutique Hotels, United States of America: South Carolina Hotel Guide | Expedia.co.uk [South Carolina Travel Guide](https://expedia.co.uk/South-Carolina.dx242)[South Carolina Hotels](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Hotel-Destinations)[Holiday Rentals in South Carolina](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Holiday-Rental-Destinations)[South Carolina Flights](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Flight-Destinations)[South Carolina Car Hire](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Car-Hire-Destinations)[South Carolina Holidays](https://expedia.co.uk/South-Carolina.d242.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/46000/46799-Myrtle-Beach.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Boutique Hotels in South Carolina ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Boutique Hotels Tonight [14 Oct - 15 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2025-10-14&endDate=2025-10-15&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [15 Oct - 16 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2025-10-15&endDate=2025-10-16&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Carolina Boutique Hotels ![Egyptian cotton sheets, premium bedding, pillow-top beds, minibar](https://images.trvl-media.com/lodging/4000000/3300000/3296100/3296061/8dc1af29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two Bedroom Residence | Egyptian cotton sheets, premium bedding, pillow-top beds, minibar](https://images.trvl-media.com/lodging/4000000/3300000/3296100/3296061/909477ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two Bedroom Residence | Egyptian cotton sheets, premium bedding, pillow-top beds, minibar](https://images.trvl-media.com/lodging/4000000/3300000/3296100/3296061/54d98ac5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/4000000/3300000/3296100/3296061/43423cb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Restoration Charleston Historic District 9.6/10 Exceptional (1012) "Great room, awesome restaurant! " £317 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Charleston-Hotels-The-Restoration.h3296061.Hotel-Information) ![Egyptian cotton sheets, premium bedding, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/180000/172500/172457/59c66cc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/180000/172500/172457/e8aeb12a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/180000/172500/172457/27796e82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/1000000/180000/172500/172457/f7ab29bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Vendue Charleston Historic District 9.4/10 Exceptional (697) "Awesome hotel was wonderful location and nice staff" £248 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Charleston-Hotels-The-Vendue.h172457.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/1000000/870000/869100/869045/eaa66f3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee shop](https://images.trvl-media.com/lodging/1000000/870000/869100/869045/1264de92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/1000000/870000/869100/869045/6414d878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/1000000/870000/869100/869045/698fca9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Loft Hotel Historic District 9.6/10 Exceptional (744) "Wonderful boutique hotel in Beaufort,SC, rooms were very clean and comfortable, location was perfect, you could walk to restaurants and shops. " £147 includes taxes & fees 19 Oct - 20 Oct [](https://www.expedia.co.uk/Beaufort-Hotels-City-Loft-Hotel.h869045.Hotel-Information) ![Frette Italian sheets, premium bedding, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/18000000/17570000/17565600/17565555/6f316529.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/18000000/17570000/17565600/17565555/d2ead0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/18000000/17570000/17565600/17565555/51b1d809.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Café](https://images.trvl-media.com/lodging/18000000/17570000/17565600/17565555/fc3c99f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 86 Cannon Charleston - Adults Only Downtown Charleston 10/10 Exceptional (71) "The perfect place to stay if your visiting Charleston " £404 includes taxes & fees 20 Oct - 21 Oct [](https://www.expedia.co.uk/Charleston-Hotels-86-Cannon-Historic-Inn-Adults-Only.h17565555.Hotel-Information) ![1 bedroom, premium bedding, individually decorated](https://images.trvl-media.com/lodging/3000000/2170000/2169500/2169413/1b8cc041.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/3000000/2170000/2169500/2169413/ac852003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, individually decorated](https://images.trvl-media.com/lodging/3000000/2170000/2169500/2169413/10869497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/3000000/2170000/2169500/2169413/267c98cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beaufort Inn Historic District 9.2/10 Wonderful (1004) "The rooms had bet comfortable beds, fabulous location, very clean, and Keurig in the room as well as continental breakfast." £129 includes taxes & fees 3 Nov - 4 Nov [](https://www.expedia.co.uk/Beaufort-Hotels-Beaufort-Inn.h2169413.Hotel-Information) ![Anson Suite | Frette Italian sheets, premium bedding, Tempur-Pedic beds, free minibar](https://images.trvl-media.com/lodging/6000000/5500000/5494400/5494363/08275705.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/6000000/5500000/5494400/5494363/d0eee53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/6000000/5500000/5494400/5494363/be953116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/6000000/5500000/5494400/5494363/ef5b1058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Zero George Street Charleston Historic District 9.8/10 Exceptional (351) "Rooms were well appointed, staff was friendly, nice amenities like the chilled water and cookie bedside each night! Incredible dining experience on site, walkable to much of the shopping and other must see sites of Charleston. A special little place to stay!" £352 includes taxes & fees 29 Oct - 30 Oct [](https://www.expedia.co.uk/Charleston-Hotels-Zero-George-Street.h5494363.Hotel-Information) ![Breakfast, dinner served; American cuisine, garden views ](https://images.trvl-media.com/lodging/1000000/10000/4800/4769/c138e1de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/4800/4769/78bcf752.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite | 1 bedroom, Frette Italian sheets, premium bedding, pillow-top beds](https://images.trvl-media.com/lodging/1000000/10000/4800/4769/143a3024.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/4800/4769/f7f8ad11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Planters Inn Charleston Historic District 9.6/10 Exceptional (1008) "Great location and great hotel" £268 includes taxes & fees 26 Oct - 27 Oct [](https://www.expedia.co.uk/Charleston-Hotels-Planters-Inn.h4769.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/920000/910100/910028/eade1e6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/920000/910100/910028/w457h792x77y0-8015fdf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/910100/910028/d9089ae9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/1000000/920000/910100/910028/b13f86cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Market Pavilion Hotel Charleston Historic District 9.4/10 Exceptional (1003) "Beautiful hotel" [](https://www.expedia.co.uk/Charleston-Hotels-Market-Pavilion-Hotel.h910028.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/1f0407e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/598f5b2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/53680281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/24c29149.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Domestique Travelers Rest 9.6/10 Exceptional (30) "Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away." £379 includes taxes & fees 29 Oct - 30 Oct [](https://www.expedia.co.uk/Travelers-Rest-Hotels-Hotel-Domestique.h9704647.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42900/42874/7a3da7fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room 11, King Room (The Cottage) | Premium bedding, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/1000000/50000/42900/42874/26e9a1be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/50000/42900/42874/8699ffeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast served](https://images.trvl-media.com/lodging/1000000/50000/42900/42874/626fd5a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rhett House Inn Historic District 9.2/10 Wonderful (630) "Great experience!" £163 includes taxes & fees 13 Nov - 14 Nov [](https://www.expedia.co.uk/Beaufort-Hotels-Rhett-House-Inn.h42874.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-28&endDate=2025-10-29®ionId=242&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-South-Carolina-Boutique-Hotel.0-0-d242-tBoutiqueHotel.Hotel-Filter-Destinations)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-South-Carolina-Boutique-Hotel.0-0-d242-tBoutiqueHotel.Hotel-Filter-Destinations) ## Top South Carolina Hotel Reviews ![Hilton Grand Vacations Club Ocean Enclave Myrtle Beach](//images.trvl-media.com/lodging/34000000/33220000/33213200/33213151/d233caaf_y.jpg) ### Hilton Grand Vacations Club Ocean Enclave Myrtle Beach 10/10 Excellent "Took my 5 yr old son for fall break! We loved it!!! You really don’t have to leave the hotel for anything, although we did go explore the city, the hotel had everything we needed. " [](https://expedia.co.uk/Myrtle-Beach-Hotels-Ocean-Enclave-By-Hilton-Grand-Vacations.h33213151.Hotel-Information) ![Cambria Hotel Mount Pleasant – Charleston](//images.trvl-media.com/lodging/25000000/24220000/24216500/24216478/247bf02b_y.jpg) ### Cambria Hotel Mount Pleasant – Charleston 10/10 Excellent "I will always stay at a cambria when available. The other guests were a bit loud but overall we couldn’t have asked for better from the hotel. We will be staying again!" [](https://expedia.co.uk/Charleston-Hotels-Cambria-Hotel-Mount-Pleasant-Charleston.h24216478.Hotel-Information) ![Drury Plaza Hotel North Charleston](//images.trvl-media.com/lodging/1000000/10000/4100/4063/73f465f4_y.jpg) ### Drury Plaza Hotel North Charleston 10/10 Excellent "Great staff and friendly!" [](https://expedia.co.uk/Charleston-Hotels-North-Charleston-Inn.h4063.Hotel-Information) ![Crown Reef Beach Resort and Waterpark](//images.trvl-media.com/lodging/1000000/900000/893400/893307/287ccc55_y.jpg) ### Crown Reef Beach Resort and Waterpark 10/10 Excellent "The room had a nice view, and our grandchildren loved the activities." [](https://expedia.co.uk/Myrtle-Beach-Hotels-Crown-Reef-Beach-Resort-And-Waterpark.h893307.Hotel-Information) ![Hilton Beachfront Resort & Spa Hilton Head Island](//images.trvl-media.com/lodging/1000000/590000/583400/583363/484680bc_y.jpg) ### Hilton Beachfront Resort & Spa Hilton Head Island 10/10 Excellent "This is a beautiful place to stay!" [](https://expedia.co.uk/Hilton-Head-Hotels-Marriott-Hilton-Head-Resort-Spa.h583363.Hotel-Information) ![Anderson Ocean Club and Spa by Oceana Resorts](//images.trvl-media.com/lodging/2000000/1780000/1773500/1773482/c3e5f34d_y.jpg) ### Anderson Ocean Club and Spa by Oceana Resorts 10/10 Excellent "Location" [](https://expedia.co.uk/Myrtle-Beach-Hotels-Anderson-Ocean-Club-And-Spa-By-Oceana-Resorts.h1773482.Hotel-Information) ![Planters Inn](//images.trvl-media.com/lodging/1000000/10000/4800/4769/c138e1de_y.jpg) ### Planters Inn 10/10 Excellent "Close to everything. Try the coconut cake! Best I have ever had. " [](https://expedia.co.uk/Charleston-Hotels-Planters-Inn.h4769.Hotel-Information) ![Holiday Inn Express Hilton Head Island by IHG](//images.trvl-media.com/lodging/1000000/10000/1400/1341/e21613a3_y.jpg) ### Holiday Inn Express Hilton Head Island by IHG 10/10 Excellent "room was clean and very nice." [](https://expedia.co.uk/Hilton-Head-Hotels-Holiday-Inn-Express-Hilton-Head-Island.h1341.Hotel-Information) ![Sea Crest Oceanfront Resort](//images.trvl-media.com/lodging/1000000/900000/893800/893738/4bb1bf83_y.jpg) ### Sea Crest Oceanfront Resort 10/10 Excellent "I loved, loved, loved the unobstructed view from not only the balcony but the bed!!! The balcony was spacious and clean. I enjoyed not being able to see my neighbors that were right beside me while we both were on the balcony. I loved the four pools. You had options and they were never full." 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[Hotels with Restaurant in South Carolina Midlands](https://www.expedia.co.uk/South-Carolina-Midlands-Hotels-Hotel-With-Restaurant.0-0-d6057938-thotelwithrestaurant.Travel-Guide-Filter-Hotels) - [Luxury Hotels in South Carolina Midlands](https://www.expedia.co.uk/South-Carolina-Midlands-Hotels-Luxury-Hotel.0-0-d6057938-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in South Carolina Midlands](https://www.expedia.co.uk/South-Carolina-Midlands-Hotels-Romantic-Hotel.0-0-d6057938-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Springdale Hotels](https://www.expedia.co.uk/Springdale-Hotels.d6344271.Travel-Guide-Hotels) - [St. Andrews Hotels](https://www.expedia.co.uk/St-Andrews-Hotels.d553248634999240337.Travel-Guide-Hotels) - [Hotels with Airport Transfers in Sumter](https://www.expedia.co.uk/Sumter-Hotels-Hotel-With-Airport-Transfers.0-0-d6058099-thotelwithairporttransfers.Travel-Guide-Filter-Hotels) - [Hotels with Laundry Service in Sumter](https://www.expedia.co.uk/Sumter-Hotels-Hotel-With-Laundry-Service.0-0-d6058099-thotelwithlaundryservice.Travel-Guide-Filter-Hotels) - 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