Title: The 10 Best 5 Star Hotels in Greenville - 2025 Updated Prices | Expedia.co.uk [Greenville Travel Guide](https://expedia.co.uk/Greenville.dx1388)[Hotels in Greenville](https://expedia.co.uk/Greenville-Hotels.d1388.Travel-Guide-Hotels)[Holiday Rentals in Greenville](https://expedia.co.uk/Greenville-Holiday-Rentals.d1388.Travel-Guide-HolidayRentals)[Flights to Greenville](https://expedia.co.uk/Cheap-Flights-To-Greenville.d1388.Travel-Guide-Flights)[Things to do in Greenville](https://expedia.co.uk/Things-To-Do-In-Greenville.d1388.Travel-Guide-Activities)[Greenville Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Greenville.d1388.Car-Hire-Guide)[Greenville Holidays](https://expedia.co.uk/Greenville.d1388.Holidays-City-Breaks) ![Greenville featuring a bridge, a city and a river or creek](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63754-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Greenville, South Carolina ## Check availability on Greenville 5 Star Hotels Tonight [9 Oct - 10 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-09&endDate=2025-10-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Oct - 11 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-10&endDate=2025-10-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=1388&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Greenville 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Greenville-Hotels.s50-0-d1388.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Greenville-Hotels.s50-0-d1388.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Greenville. ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Grand Bohemian Lodge Greenville, Autograph Collection 44 EAST CAMPERDOWN WAY, Greenville, SC £244 26 Oct - 27 Oct includes taxes & fees 9.4/10 Exceptional! (389 reviews) [](https://expedia.co.uk/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ![The Westin Poinsett Greenville](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/3e47bf88_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Westin Poinsett Greenville 120 South Main St, Greenville, SC £139 19 Oct - 20 Oct includes taxes & fees 9.2/10 Wonderful! (1,000 reviews) [](https://expedia.co.uk/Greenville-Hotels-The-Westin-Poinsett-Greenville.h575983.Hotel-Information) ![Mint House Greenville - Downtown](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/a4b477d7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Mint House Greenville - Downtown 101 Falls Park Dr, Greenville, SC £109 26 Oct - 27 Oct includes taxes & fees 9.2/10 Wonderful! (742 reviews) [](https://expedia.co.uk/Greenville-Spartanburg-Hotels-Mint-House-Downtown-Greenville.h38593248.Hotel-Information) Still don't see what you're looking for? [See all properties in Greenville.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=1388&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=1388&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=1388&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=1388&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=1388&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=1388&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Greenville Falls Park on the Reedy offers a stunning urban oasis with waterfalls right in the heart of city centre. Bike the Swamp Rabbit Trail in the morning, then explore Main Street's locally-owned shops and farm-to-table restaurants by afternoon. [See all hotels in Greenville](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-23&endDate=2025-10-24&adults=2®ionId=1388) ![Greenville featuring a bridge, a city and a river or creek](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63754-Greenville-Spartanburg.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) Photo by Visit Greenville, South Carolina ## Top Greenville Hotel Reviews ## Find out more about Greenville ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Greenville? > How much you pay for a 5-star hotel in Greenville depends on factors like when you plan to travel and the length of your getaway. Our top tip for bagging the best deal? Use our pricing filters to check out all of the available options for your chosen dates. > > > > - Search for the lowest price per night from £109 ### What makes a hotel 5 stars in Greenville? > From gourmet restaurants and 24-hour gyms to pools and luxury bedding, the 5-star experience in Greenville is all about luxury and relaxation. But it takes more than just upscale conveniences to get a 5-star rating. Hotels must also deliver remarkable guest services like in-room beauty treatments, laundry and dry cleaning and 24-hour concierge services. ### Are there any 5-star all-inclusive resorts in Greenville? > Use Expedia's filters to find a high-end getaway in Greenville where most of what you need is included in the price. Next, refine your results for hotels that have 5 stars and are listed as "All inclusive." The first thing on the schedule at these stays? 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