Title: TOP Boutique Hotels in Upstate South Carolina, SC for 2026 | Expedia.co.uk [Upstate South Carolina Travel Guide](https://expedia.co.uk/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Holiday Rentals in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Holiday-Rentals.d6057939.Travel-Guide-HolidayRentals)[Flights to Upstate South Carolina](https://expedia.co.uk/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.co.uk/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Upstate-South-Carolina.d6057939.Car-Hire-Guide)[Upstate South Carolina Holidays](https://expedia.co.uk/Upstate-South-Carolina.d6057939.Holidays-City-Breaks) ![Greenville - Spartanburg](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Visit Greenville, South Carolina ![](https://images.trvl-media.com/place/6035267/cb556cb0-09f4-48a1-92a0-474aceebaeea.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina Boutique Hotels Tonight [12 Feb - 13 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-02-12&endDate=2026-02-13&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [13 Feb - 14 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-02-13&endDate=2026-02-14&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-02-13&endDate=2026-02-15&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-02-20&endDate=2026-02-22&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Upstate South Carolina boutique hotels ![Courtyard](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/96abb166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/b8d82b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/1f0407e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/53680281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Domestique [](https://www.expedia.co.uk/Travelers-Rest-Hotels-Hotel-Domestique.h9704647.Hotel-Information) Travelers Rest 9.8/10 Exceptional (31 reviews) "Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chuck £314 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/Travelers-Rest-Hotels-Hotel-Domestique.h9704647.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/8000000/7420000/7416700/7416620/36baf331.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (09 Witham Point Room) | Individually decorated, individually furnished, iron/ironing board](https://images.trvl-media.com/lodging/8000000/7420000/7416700/7416620/c94345b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/8000000/7420000/7416700/7416620/b1815eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/8000000/7420000/7416700/7416620/63dd807c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Rabun Hotel & Restaurant [](https://www.expedia.co.uk/Helen-Hotels-Lake-Rabun-Hotel-Restaurant.h7416620.Hotel-Information) Lakemont 8.6/10 Excellent (648 reviews) "The staff were so friendly and also helpful in suggesting where to go to see waterfalls and where to dine as the restaurant was closed the evenings that we stayed. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan S £114 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/Helen-Hotels-Lake-Rabun-Hotel-Restaurant.h7416620.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/12000000/11890000/11881100/11881029/ffb3168c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11890000/11881100/11881029/6f92d1db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11890000/11881100/11881029/c1d03358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![The Grand | Premium bedding, individually decorated, individually furnished](https://images.trvl-media.com/lodging/12000000/11890000/11881100/11881029/226ecfd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Outpost Inn [](https://www.expedia.co.uk/Highlands-Hotels-The-Wells-Hotel.h11881029.Hotel-Information) Highlands 8.6/10 Excellent (295 reviews) "Very clean room, excellent staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pamela £157 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/Highlands-Hotels-The-Wells-Hotel.h11881029.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-26&endDate=2026-02-27®ionId=6057939&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_6057939) ## Top Upstate South Carolina Hotel Reviews ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/9a71f6a4_y.jpg) ### Hyatt Place Greenville/Haywood 10/10 Excellent "Room was very clean & the front desk staff were wonderful. So welcoming and polite!" [](https://expedia.co.uk/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Hotels with a View in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-A-View.0-0-d242-thotelwithaview.Hotel-Filter-Destinations) - [Hotels with Air Conditioning in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-Air-Conditioning.0-0-d242-thotelwithairconditioning.Hotel-Filter-Destinations) - [Hotels with Breakfast in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-Breakfast.0-0-d242-thotelwithbreakfast.Hotel-Filter-Destinations) - [Hotels with Connecting Rooms in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-Connecting-Rooms.0-0-d242-thotelwithconnectingrooms.Hotel-Filter-Destinations) - [Hotels with Early Check-in in South Carolina ](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-Early-Check-In.0-0-d242-thotelwithearlycheckin.Hotel-Filter-Destinations) - 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[Flights to Greenville ](https://www.expedia.co.uk/Cheap-Flights-To-Greenville.d1388.Travel-Guide-Flights) - [Flights to Simpsonville ](https://www.expedia.co.uk/Cheap-Flights-To-Simpsonville.d6239.Travel-Guide-Flights) - [Flights from Donaldson Center ](https://www.expedia.co.uk/lp/airports/gdc/flights-from-donaldson-center-airport) - [Flights from Greenville Downtown ](https://www.expedia.co.uk/lp/airports/gmu/flights-from-greenville-downtown-airport) - [Flights from Greenville ](https://www.expedia.co.uk/lp/flights/1388/flights-from-greenville) - [Flights from Dunean ](https://www.expedia.co.uk/lp/flights/553248634999354841/flights-from-dunean) - [Flights from Simpsonville ](https://www.expedia.co.uk/lp/flights/6239/flights-from-simpsonville) - [Flights from Augusta (AGS) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/ags/gmu/augusta-to-greenville) - [Flights from Anderson (AND) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/and/gmu/anderson-to-greenville) - 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Airport (EWR) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/ewr/gmu/newark-liberty-intl-airport-to-greenville) - [Flights from Gaithersburg (GAI) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/gai/gmu/gaithersburg-to-greenville) - [Flights from Greenwood (GRD) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/grd/gmu/greenwood-to-greenville) - [Flights from Hagerstown (HGR) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/hgr/gmu/hagerstown-to-greenville) - [Flights from Hong Kong (HKG) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/hkg/gdc/hong-kong-to-greenville) - [Flights from Islip (ISP) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/isp/gmu/islip-to-greenville) - [Flights from Jacksonville (JAX) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/jax/gmu/jacksonville-to-greenville) - [Flights from Las Vegas (LAS) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/las/gmu/las-vegas-to-greenville) - [Flights from Los Angeles (LAX) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/lax/gmu/los-angeles-to-greenville) - [Flights from Pickens (LQK) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/lqk/gdc/pickens-to-greenville) - [Flights from Morgantown (MGW) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/mgw/gmu/morgantown-to-greenville) - [Flights from Dayton (MGY) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/mgy/gmu/dayton-to-greenville) - [Flights from Madison (MSN) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/msn/gdc/madison-to-greenville) - [Flights from New Orleans (MSY) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/msy/gmu/new-orleans-to-greenville) - [Flights from Paris (PAR) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/par/gdc/paris-to-greenville) - [Flights from Rocky Mount (RWI) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/rwi/gmu/rocky-mount-to-greenville) - [Flights from Louisville (SDF) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/sdf/gmu/louisville-to-greenville) - [Flights from St. Louis (STL) to Greenville (GMU) ](https://www.expedia.co.uk/lp/flights/stl/gmu/st-louis-to-greenville) - [Flights from Taipei (TPE) to Greenville (GDC) ](https://www.expedia.co.uk/lp/flights/tpe/gdc/taipei-to-greenville) - [Discovery Island Water Park ](https://www.expedia.co.uk/Discovery-Island-Water-Park-Greenville.d553248621532656705.Attraction) - [Frankie's Fun Park ](https://www.expedia.co.uk/Frankies-Fun-Park-Greenville.d553248621532656780.Attraction) - [Greenville Holidays ](https://www.expedia.co.uk/Greenville.d1388.Holidays-City-Breaks) - [Visit Greenville ](https://www.expedia.co.uk/Greenville.dx1388) - [Patewood Memorial Hospital ](https://www.expedia.co.uk/Patewood-Memorial-Hospital-Greenville.d6130783.Attraction) - [Simpsonville Holidays ](https://www.expedia.co.uk/Simpsonville.d6239.Holidays-City-Breaks) - [Warehouse Theatre ](https://www.expedia.co.uk/Warehouse-Theatre-Greenville-Downtown.d553248621532656721.Attraction) - [Car hire Greenville ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Greenville.d1388.Car-Hire-Guide) - [Car hire Simpsonville ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Simpsonville.d6239.Car-Hire-Guide) - [Gantt Holiday Rentals ](https://www.expedia.co.uk/Gantt-Holiday-Rentals.d553248634999376437.Travel-Guide-HolidayRentals) - [Greenville Holiday Rentals ](https://www.expedia.co.uk/Greenville-Holiday-Rentals.d1388.Travel-Guide-HolidayRentals) - [Mauldin Holiday Rentals ](https://www.expedia.co.uk/Mauldin-Holiday-Rentals.d183944.Travel-Guide-HolidayRentals) - [Things to do in Greenville ](https://www.expedia.co.uk/Things-To-Do-In-Greenville.d1388.Travel-Guide-Activities) - [Things to do in Simpsonville ](https://www.expedia.co.uk/Things-To-Do-In-Simpsonville.d6239.Travel-Guide-Activities) - [Book Boutique Hotels in Upstate South Carolina on Expedia.com ](https://www.expedia.com/Upstate-South-Carolina-Hotels-Boutique-Hotel.0-0-d6057939-tBoutiqueHotel.Travel-Guide-Filter-Hotels)