Upstate South Carolina Holidays from £1,068

Book a Hotel + Flight or Car together to unlock savings

Photo by Victoria S

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to £335 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Packages with flights are ATOL protected

Your Upstate South Carolina Holiday

Leave the planning to us with a Upstate South Carolina holiday package. With everything arranged before you go, the only thing left for you to do is relax and experience this destination's culture and beauty. With so much to see on a trip to Upstate South Carolina, it can be difficult to know where to begin. Kick off your travels in Greenville at Falls Park on the Reedy and Bon Secours Wellness Arena — two much-loved attractions here. Another city worth adding to your itinerary is Spartanburg. Don't miss WestGate Mall and Tyger River Park. Expedia has flights, hotels and everything else you need to help you curate your own tailored Upstate South Carolina holiday today.

Top Upstate South Carolina Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Motel 6 Spartanburg, Sc – Northwest / Business 85

Motel 6 Spartanburg, Sc – Northwest / Business 85

2 out of 5
Price was £1,076, price is now £1,068 per person
£1,068
per person
23 Oct - 25 Oct
just found
Return direct flight included
Manchester (MAN) to Greenville (GSP)
7.4/10 Good! (68 reviews)
It’s a quiet laid back hotel with clean rooms!

Reviewed on 1 Sept 2025

The Lodge at Banner Elk

The Lodge at Banner Elk

2.5 out of 5
Price was £1,251, price is now £1,210 per person
£1,210
per person
23 Oct - 25 Oct
just found
Return direct flight included
Manchester (MAN) to Asheville (AVL)
8.6/10 Excellent! (1,006 reviews)
Obvious it is an older motel, so showing some wear and tear. Our room was clean and the bed was comfortable! Staff was very friendly.

Reviewed on 14 Sept 2025

Where to stay in Upstate South Carolina

Find the best Upstate South Carolina areas and neighborhoods for the activities you enjoy most. Learn more about Upstate South Carolina
Greenville which includes a bridge, a garden and autumn leaves

Greenville Downtown

3 out of top 10 points of interest in this area

The ample dining options and beautiful river views are top of the list for many visitors to Greenville Downtown. A stop by The Peace Center or Bon Secours Wellness Arena might round out your trip.

Find hotels in Greenville Downtown

Upstate South Carolina Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Charlotte-Douglas Intl. Airport (CLT)

Top hotels in Upstate South Carolina

Hilton Greenville

Hilton Greenville

3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
The price is £91 per night from 21 Sept to 22 Sept
£91
21 Sept - 22 Sept
includes taxes & fees
8/10 Very Good! (1,000 reviews)
"Great value! Would stay here again"

Reviewed on 8 Sep 2025

Hilton Greenville
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
Clemson
Get rates
Wooded Cottage - 3 Mi to Clemson University
La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

3 out of 5
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is £57 per night from 21 Sept to 22 Sept
£57
21 Sept - 22 Sept
includes taxes & fees
7.2/10 Good! (1,044 reviews)
"I love that it was close to many dinning areas and it has a lobby with small tables that are accessible at any time. I had a meeting in the lobby and no one came and interrupted me talking with my colleague which is priceless to me. They also spoke English and Spanish which is a plus in my book."

Reviewed on 9 Sep 2025

La Quinta Inn & Suites by Wyndham Greenville Haywood
See all 2,825 properties in Upstate South Carolina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Popular places to visit

Fred W. Symmes Chapel

Fred W. Symmes Chapel

You can find out about the history of Cleveland with a visit to Fred W. Symmes Chapel. Wander the lakeside and forests in this relaxing area.

Fred W. Symmes Chapel
Devils Fork State Park

Devils Fork State Park

You can take time to visit Devils Fork State Park during your travels to Salem. Wander the lakeside or discover the area's mountain views.

Devils Fork State Park

What to do in Upstate South Carolina

Paranormal Walking Tour by Greenville Ghost Tours

Paranormal Walking Tour by Greenville Ghost Tours

£26
per adult
Paranormal Walking Tour by Greenville Ghost Tours
Just Desserts Tour In Greenville

Just Desserts Tour In Greenville

£70
per adult
Just Desserts Tour In Greenville
Delicious breakfast on a sunny Saturday morning on the terrace

Small-Group Walking Tour in Greenville with Breakfast

£70
per adult
100% of travellers recommend
Small-Group Walking Tour in Greenville with Breakfast
See all activities in Upstate South Carolina

Frequently asked questions

Can I cancel my flight booking to Upstate South Carolina due to COVID-19?
Head to our Customer Service Portal for important information about changing or cancelling flights due to COVID-19. Make sure you also read through the terms and conditions of your chosen airline before booking your fare to Upstate South Carolina.
What's the best way to find cheap flights to Upstate South Carolina that have flexible change policies?
We understand that travel plans can change in the blink of an eye, so reserving a flexible ticket with Expedia is a sensible idea. Simply tick the "No change fee" box under the "Flexible change policies" filter. Your low-cost, flexible flight to Upstate South Carolina is just a few clicks away.
What are some of the general tips for travellers to Upstate South Carolina during the COVID-19 outbreak?
COVID-19 has affected how the world works in endless ways, and travel has changed with it. These tips will help you navigate these new challenges and prepare you for your trip to Upstate South Carolina:
  • Before booking anything, see if any travel bans or restrictions apply — in both your origin and destination. Get up-to-date information by reviewing government and travel websites.
  • Wear a face mask even during airport screening. A TSA employee will require you to lower your mask temporarily to verify your identity.
  • You're no longer required to hand your boarding pass (paper or electronic) directly to a TSA officer. Rather, place your pass on the scanner and then hold it up for inspection.
  • One container of liquid hand sanitizer is now allowed in your carry-on luggage. It must not be larger than 12 oz (350 ml), and you'll need to remove it from your bag for screening.
  • To reduce handling during screening, place items such as your phone and loose change into your carry-on rather than the bins.
  • Separate any food you're carrying for X-ray screening. Placing it in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Upstate South Carolina?
Secure your ticket with American Airlines and then start piecing together your Upstate South Carolina itinerary. This leading carrier offers 19932 flights each month to Charlotte-Douglas Intl. Airport (CLT), a key gateway.
How can I find cheap tickets to Upstate South Carolina?
You'll always nab a fabulous deal with Expedia, but our "flexible dates" feature makes it that much easier. Enter your preferred flight date, then check the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Upstate South Carolina in the last seven days.
How much is a flight to Upstate South Carolina?
One-way trips departing from () sold for as little as in the last seven days. During this period, the price of a round-trip fare to Upstate South Carolina ranged between and . If you find a bargain ticket, book as fast as you can — these prices don't stick around.
What are the most popular airports to fly into in Upstate South Carolina?
Book your flight to Charlotte-Douglas Intl. Airport (CLT) and experience everything that Upstate South Carolina has to offer. As the region's primary entry point, about 21666 flights touch down here every month.
When is the cheapest time to fly to Upstate South Carolina?
If you'd prefer to spend your hard-earned holiday money experiencing the delights of Upstate South Carolina rather than on your trip there, leave early in the week. The most affordable day to travel is normally Tuesday, with Monday coming in second. With many people travelling over the weekend, Saturday often has the costliest fares.
How much is a plane ticket to Upstate South Carolina?
Plane fares ranged anywhere from to in the last seven days. When you're ready to book, we'll help you find a low-cost flight to Upstate South Carolina.
Which airlines with flights to Upstate South Carolina employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, many airlines have introduced new rules and standards to help everybody get back in the skies. These carriers include:
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.