Photo by Visit Greenville, South Carolina
Find hotels in Upstate South Carolina, SC from £52
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Our top choices for Upstate South Carolina hotels
Carolina Camp Cedar
Carolina Camp CedarPickens
10.0 out of 10, Exceptional, (3 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
Katlynn
The price is £192
includes taxes & fees
11 May - 12 May
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
9.4 out of 10, Exceptional, (222 reviews)
"Excellent in every way … staff, room, amenities and very comfortable bed!"
Sarah
The price is £105
includes taxes & fees
11 May - 12 May
Holiday Inn Express Gaffney by IHG
Holiday Inn Express Gaffney by IHGGaffney
8.8 out of 10, Excellent, (477 reviews)
"Very clean and staff the super kind and friendly 10/10 stay"
Kevin
The price is £63
includes taxes & fees
3 May - 4 May
Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,004 reviews)
"Lovely place to stay right on the lake. "
Sara
The price is £82
includes taxes & fees
11 May - 12 May
Best Western Travelers Rest Greenville
Best Western Travelers Rest GreenvilleTravelers Rest
7.6 out of 10, Good, (1,000 reviews)
"It was very clean. The staff was very friendly."
JEANNETTE
The price is £72
includes taxes & fees
13 May - 14 May
Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123Downtown
8.0 out of 10, Very good, (696 reviews)
"Very pleasant and helpful staff. Comfortable room though fairly small."
William
The price is £75
includes taxes & fees
20 May - 21 May
Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,000 reviews)
"This place is tops! The area is great, rooms were wonderful, and amenities were amazing. Definitely plan on staying again asap!"
Valarie Tina
The price is £100
includes taxes & fees
9 May - 10 May
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
9.2 out of 10, Wonderful, (1,458 reviews)
"great stay"
Gordon
The price is £77
includes taxes & fees
5 May - 6 May
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.Greenville
8.8 out of 10, Excellent, (202 reviews)
"Great place to stay"
LOUIS
The price is £64
includes taxes & fees
11 May - 12 May
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca ClemsonSeneca
9.2 out of 10, Wonderful, (834 reviews)
"Great location and facilities"
Brian
The price is £95
includes taxes & fees
18 May - 19 May
Hampton Inn Gaffney
Hampton Inn GaffneyGaffney
8.8 out of 10, Excellent, (706 reviews)
"Would stay again breakfast was amazing "
Theresa
The price is £69
includes taxes & fees
31 May - 1 Jun
Comfort Inn & Suites Greer - Greenville
Comfort Inn & Suites Greer - GreenvilleGreer
8.6 out of 10, Excellent, (783 reviews)
"The staff was very friendly, great breakfast and the room was very clean. Great stay. "
susan
The price is £84
includes taxes & fees
11 May - 12 May
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
Holiday Inn Express Hotel & Suites Spartanburg-North by IHGSpartanburg
8.6 out of 10, Excellent, (907 reviews)
"Very friendly staff"
Katie
The price is £74
includes taxes & fees
10 May - 11 May
Best Western Seneca-Clemson
Best Western Seneca-ClemsonSeneca
8.4 out of 10, Very good, (655 reviews)
"Room was clean and staff was very efficient. "
Judith
The price is £76
includes taxes & fees
13 May - 14 May
Quality Inn Clinton - Laurens I-26
Quality Inn Clinton - Laurens I-26Clinton
7.4 out of 10, Good, (545 reviews)
"Clean room, easy parking, we were plenty comfortable."
Christine
The price is £68
includes taxes & fees
5 May - 6 May
Holiday Inn Anderson by IHG
Holiday Inn Anderson by IHGAnderson
8.8 out of 10, Excellent, (724 reviews)
"Great hotel in all regards"
Dan
The price is £91
includes taxes & fees
31 May - 1 Jun
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
9.0 out of 10, Wonderful, (1,170 reviews)
"I have stayed here twice now and absolutely love it!! It has a great workspace and the room is spacious. The breakfast is excellent! "
Amy
The price is £89
includes taxes & fees
25 May - 26 May
Microtel Inn & Suites by Wyndham Anderson/Clemson
Microtel Inn & Suites by Wyndham Anderson/ClemsonAnderson
8.2 out of 10, Very good, (1,001 reviews)
"Front desk staff were very friendly. We had a welcoming and quiet 1 night stay."
Nicole
The price is £66
includes taxes & fees
13 May - 14 May
Aloft Greenville Downtown
Aloft Greenville DowntownGreenville Downtown
9.2 out of 10, Wonderful, (1,001 reviews)
"Nice hotel very well located"
Danilo
The price is £106
includes taxes & fees
25 May - 26 May
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Holiday Rentals in Upstate South Carolina
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (71 reviews)
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Stay near popular Southeastern United States attractions
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina
Top Upstate South Carolina Hotel Reviews
La Quinta by Wyndham Haywood Mall-Near Greenville Downtown
2/10 Terrible
More cheap stays in Upstate South Carolina
Sleep Inn Spartanburg Southwest
501 South Blackstock Rd Spartanburg SC
The price is £52 per night from 28 May to 29 May
£52
28 May - 29 May
includes taxes & fees
6/10 (593 reviews)
Hotels in Upstate South Carolina with star rating
4 Star Hotels
18 properties
Explore a world of travel with Expedia
- Brookhaven Hotels
- Chick Springs Hotels
- Colonel Elias Earle Historic District Hotels
- Hotels near Discovery Island Water Park
- Hotels near Donaldson Center
- Duncan Hotels
- Easley Hotels
- Hotels near Eugene Stone Soccer Stadium
- Fountain Inn Hotels
- Hotels near Frankie's Fun Park
- Gay-Friendly Hotels in Green Avenue
- Capsule Hotels in Greenville
- Caravan Parks in Greenville
- Condo Rentals in Greenville
- Hotels near Greenville Downtown
- Hotels with Connecting Rooms in Greenville Downtown
- Pet-Friendly Hotels in Greenville Downtown
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- Beach Resorts & in Greenville
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