Beginning of main content

Book on the go and pay later.

Search over 1,000,000 properties worldwide and 550 airlines worldwide

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Check Prices on Hotels in Seneca

Tonight 18 Jul - 19 Jul
This weekend 19 Jul - 21 Jul
Next weekend 26 Jul - 28 Jul

Top 10 Hotels in Seneca

See all 294 properties in Seneca

Estimated price for 1 night/2 adults

Private Setting Close to Clemson University

Private Setting Close to Clemson University

503 Windy Oaks Cir, Seneca, South Carolina
Private Setting Close to Clemson University
     
     

    Situated in Seneca, this holiday home is 2.6 mi (4.2 km) from Little John Coliseum and 3 mi (4.7 km) from Memorial Stadium. Clemson University and Larry W. Abernathy ...

    Private Setting Close to Clemson UniversityGet Rates

    Panoramic Views, Best Location on Keowee, 150' of Shoreline, 10 Min. to Clemson

    Panoramic Views, Best Location on Keowee, 150' of Shoreline, 10 Min. to Clemson

    1710 Keowee Lakeshore Dr, Seneca, South Carolina
    Panoramic Views, Best Location on Keowee, 150' of Shoreline, 10 Min. to Clemson
       
       

      Located in the heart of Seneca, this historic holiday home is within 9 miles (15 km) of Little John Coliseum, Memorial Stadium and Fort Hill Plantation. Lake ...

      Panoramic Views, Best Location on Keowee, 150' of Shoreline, 10 Min. to ClemsonGet Rates

      Beautiful Lake Views at Lake Keowee House

      Beautiful Lake Views at Lake Keowee House

      23083 McDonald Point Rd, Seneca, South Carolina
      Beautiful Lake Views at Lake Keowee House
         
         

        Situated on a lake, this holiday home is within 12 miles (20 km) of Lake Keowee, Keowee Key and Oconee Station State Historic Site. Clemson University and Whitewater ...

        Beautiful Lake Views at Lake Keowee HouseGet Rates

        Perfect Lake Hartwell Getaway-gorgeous Lake Views!

        Perfect Lake Hartwell Getaway-gorgeous Lake Views!

        756 Lynnhaven Dr, Seneca, South Carolina
        Perfect Lake Hartwell Getaway-gorgeous Lake Views!
           
           

          Situated on a lake, this holiday home is in the same area as Walker Golf Course, Clemson University and Little John Coliseum. Area attractions also include Memorial ...

          Perfect Lake Hartwell Getaway-gorgeous Lake Views!Get Rates

          Beautiful Lake Keowee Waterfront Vacation Retreat

          Beautiful Lake Keowee Waterfront Vacation Retreat

          105 Windsong Way, Seneca, South Carolina
          Beautiful Lake Keowee Waterfront Vacation Retreat
             
             

            Situated on a lake, this bed & breakfast is within 12 miles (20 km) of Lake Keowee, Keowee Key and Oconee Station State Historic Site. Clemson University and ...

            Beautiful Lake Keowee Waterfront Vacation RetreatGet Rates

            Beautiful Lake Keowee Getaway In The Heart Of South Carolina's Oconee County!

            Beautiful Lake Keowee Getaway In The Heart Of South Carolina's Oconee County!

            902 Loran Pointe Cir, Seneca, South Carolina
            Beautiful Lake Keowee Getaway In The Heart Of South Carolina's Oconee County!
               
               

              Located in the heart of Seneca, this historic condo is within 9 miles (15 km) of Little John Coliseum, Clemson University and Larry W. Abernathy Waterfront Park. ...

              Beautiful Lake Keowee Getaway In The Heart Of South Carolina's Oconee County!Get Rates

              Perfect Lake Keowee Waterfront Vacation Home With Boat and Jet Ski Rentals

              Perfect Lake Keowee Waterfront Vacation Home With Boat and Jet Ski Rentals

              216 Petty Road, Seneca, South Carolina
              Perfect Lake Keowee Waterfront Vacation Home With Boat and Jet Ski Rentals
                 
                 

                Nestled on the beach, this Seneca holiday home is within 12 mi (20 km) of Lake Keowee, Keowee Key and Oconee Station State Historic Site. Walker Golf Course ...

                Perfect Lake Keowee Waterfront Vacation Home With Boat and Jet Ski RentalsGet Rates

                Spacious Lake Hartwell Home With Cozy Cabin Appeal, 15 Minutes From Clemson Wifi

                Spacious Lake Hartwell Home With Cozy Cabin Appeal, 15 Minutes From Clemson Wifi

                112 Snug Harbor Rd, Seneca, South Carolina
                Spacious Lake Hartwell Home With Cozy Cabin Appeal, 15 Minutes From Clemson Wifi
                   
                   

                  Located on a lake, this family-friendly holiday home is within 12 mi (20 km) of Walker Golf Course, Clemson University and South Carolina Botanical Gardens. ...

                  Spacious Lake Hartwell Home With Cozy Cabin Appeal, 15 Minutes From Clemson WifiGet Rates

                  Fall fun at the Cabin! Convenient to Lake Keowee and Clemson

                  Fall fun at the Cabin! Convenient to Lake Keowee and Clemson

                  121 Briar Court, Seneca, South Carolina
                  Fall fun at the Cabin! Convenient to Lake Keowee and Clemson
                     
                     

                    Set in Seneca, this family-friendly cabin is 10.1 mi (16.2 km) from Lake Keowee and 12.1 mi (19.5 km) from Keowee Key. Clemson University and Larry W. Abernathy ...

                    Fall fun at the Cabin! Convenient to Lake Keowee and ClemsonGet Rates

                    Tranquil Lakefront Setting Near Clemson SC

                    Tranquil Lakefront Setting Near Clemson SC

                    297 Sugarhill Rd, Seneca, South Carolina
                    Tranquil Lakefront Setting Near Clemson SC
                       
                       

                      Situated on a lake, this holiday home is within 12 miles (20 km) of Lake Keowee, Keowee Key and Oconee Station State Historic Site. Clemson University and Little ...

                      Tranquil Lakefront Setting Near Clemson SCGet Rates

                      Map

                      Seneca Hotel Reviews

                      Explore Seneca


                      Explore Seneca with Expedia's Travel Guides to find the best flights, cars, holiday packages and more!