A bench, a bicycle, and a lake surrounded by trees.

Compare and book 4 Star hotels in Upstate South Carolina, South Carolina

Check availability on Upstate South Carolina 4 Star Hotels

Tonight
2 Sept - 3 Sept
Tomorrow
3 Sept - 4 Sept
This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

Our top choices for Upstate South Carolina 4-star hotels

A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a fireplace, plush seating, and a stone accent wall.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
David
£293
includes taxes & fees
27 Sept - 28 Sept
Grand Bohemian Lodge Greenville, Autograph Collection
A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A bar with multiple shelves of liquor bottles and glasses hanging above.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.

2. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
£152
includes taxes & fees
3 Sept - 4 Sept
Hotel Hartness
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
An outdoor patio with wicker furniture, a round table, and a fountain.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

3. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
£188
includes taxes & fees
6 Sept - 7 Sept
The Shepherd Hotel Downtown Clemson
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A lobby with patterned flooring, a grand staircase, and elegant furniture.
A banquet hall with round tables, chandeliers, and ornate windows.

4. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Andre
£152
includes taxes & fees
13 Sept - 14 Sept
The Westin Poinsett Greenville
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.

5. Greenville Marriott

Greenville Marriott
Greenville
United States
John
£100
includes taxes & fees
14 Sept - 15 Sept
Greenville Marriott
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.

6. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Kenneth
£103
includes taxes & fees
7 Sept - 8 Sept
Mint House Greenville Downtown by Kasa
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

7. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
£125
includes taxes & fees
7 Sept - 8 Sept
The Abernathy of Clemson
A modern building with outdoor seating and a garden.
A row of modern, two-story buildings with a covered patio area.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.

8. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveller
£236
includes taxes & fees
14 Sept - 15 Sept
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A bar with a large window view of mountains and a chandelier.
A restaurant with a stone fireplace, hanging crystal chandelier, and multiple dining tables set with white tablecloths and wine glasses.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.

9. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
£300
includes taxes & fees
7 Sept - 8 Sept
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A multi-story residential building with balconies, a stone archway entrance, and a sign indicating it is part of Century Park at Taft Community.

10. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.
A modern living room with a sofa, a coffee table, and a fireplace.

11. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A modern kitchen with stainless steel appliances, a granite countertop, and large windows offering a view of the outdoors.

12. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
A swimming pool with a view of a lake and docked boats.
A spacious living room with a grey sofa, a wooden coffee table, and a blue rug. There is a dining area with a wooden table and chairs.

13. Private Balcony: Lake Keowee Home w/ Pool Access

Private Balcony: Lake Keowee Home w/ Pool Access
Salem
Private Balcony: Lake Keowee Home w/ Pool Access
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A multi-story building with a symmetrical facade, large windows, and two flags on top.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.

14. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.
A marina with boats docked, a wooden pier, and a clear sky.

15. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A swimming pool with a view of the lake and docked boats.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A modern kitchen with a central island, stainless steel appliances, wooden cabinets, and a window providing natural light.
A marina with boats docked, surrounded by greenery and trees.

16. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.
A swimming pool with a view of a lake and docked boats.
A marina with boats docked, surrounded by greenery and trees.

17. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
An indoor swimming pool with clear lanes, a covered roof, and a bench area.
A multi-story hotel with a parking lot and a view of a lake.
A sandy beach with a calm lake surrounded by trees.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A sandy beach with a calm lake surrounded by trees.
A large indoor swimming pool with clear lanes, a covered roof, and seating areas along the sides.
A marina with boats docked, a lifeguard station, and a view of a lake surrounded by trees.

19. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
A spacious kitchen with a large island, wooden cabinets, and pendant lighting.
A residential house with a covered porch, a well-maintained lawn, and a clear sky.
A modern kitchen with a central island, bar stools, and pendant lighting.
A spacious living area with a large flat-screen TV, a wooden cabinet, a grey sofa set, and a patterned ottoman.

20. 5 Mi to Memorial Stadium & Beach: Modern Townhome

5 Mi to Memorial Stadium & Beach: Modern Townhome
Central
5 Mi to Memorial Stadium & Beach: Modern Townhome
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Frankie's Fun Park to Conestee Nature Preserve.

See all hotels in Upstate South Carolina
An aerial view of a park with a winding path, trees in autumn colors, and a bridge.
Photo by Visit Greenville, South Carolina

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

8/10 Good
"Nice property that is extremely well located relative to downtown Greenville. Staff and facilities were first rate but I found the decor slightly tacky."
Henry R 1-night trip
Posted 5 days ago
Grand Bohemian Lodge Greenville, Autograph Collection

Find out more about Upstate South Carolina

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.
  • Search for the lowest price from £100
What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodation generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.

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