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Check availability on Upstate South Carolina 4 Star Hotels

Top Upstate South Carolina 4 Star Hotels

The Shepherd Hotel Downtown Clemson
Two large beds with white linens and a neutral-toned headboard, set against a backdrop of city views through large windows.

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (633)
"Beautiful property, amazing staff and service, will always be my first pick when in town. "
The price is £156
includes taxes & fees
3 Aug - 4 Aug
The Shepherd Hotel Downtown Clemson
Grand Bohemian Lodge Greenville, Autograph Collection
Cozy seating areas surround a central fireplace, flanked by natural stone and wood elements.

Grand Bohemian Lodge Greenville, Autograph Collection

4.0 star property
9.6 out of 10, Exceptional, (360)
"We had a wonderful 3 night stay in Greenville, and the location of the Grand Bohemian made it a perfect location for walking and biking on the path and enjoying the lover river flowing through the middle of the city. We loved every moment of our stay, and we will definitely be back soon!"
The price is £198
includes taxes & fees
11 Aug - 12 Aug
Grand Bohemian Lodge Greenville, Autograph Collection
The Westin Poinsett Greenville
Banquet hall with high ceilings and ornate details, featuring round tables and patterned carpet.

The Westin Poinsett Greenville

4.0 star property
9.2 out of 10, Wonderful, (1001)
"Every person from front desk to wait staff were personable and friendly. Wonderful stay. "
The price is £125
includes taxes & fees
3 Aug - 4 Aug
The Westin Poinsett Greenville
Mint House Greenville - Downtown
Relax in a spacious room with a large bed, two bedside tables, and a city view.

Mint House Greenville - Downtown

4.0 star property
9.2 out of 10, Wonderful, (693)
"Will definitely stay again!"
The price is £90
includes taxes & fees
17 Aug - 18 Aug
Mint House Greenville - Downtown
Hotel Hartness
Enjoy a sophisticated dining experience with a long table set for a meal, surrounded by leather chairs and expansive views of the lush landscape.

Hotel Hartness

4.0 star property
9.8 out of 10, Exceptional, (557)
"Beautiful property and a great price"
The price is £158
includes taxes & fees
20 Jul - 21 Jul
Hotel Hartness
Greenville Marriott
Enjoy a comfortable stay in this well-appointed room featuring a large bed, desk, and chair, with a window offering a view of the surrounding cityscape.

Greenville Marriott

4.0 star property
8.6 out of 10, Excellent, (581)
"The staff was excellent and the facility was user friendly"
The price is £104
includes taxes & fees
27 Jul - 28 Jul
Greenville Marriott
The Abernathy of Clemson
Enjoy meals in a spacious dining area with a large window offering views of the surrounding greenery.

The Abernathy of Clemson

4.0 star property
9.6 out of 10, Exceptional, (529)
"Very nice staff, beautiful rooms"
The Abernathy of Clemson
Barsala At The American Spinning Mill Apartments
Relax in this stylish living space with a sofa, armchair, and small table.

Barsala At The American Spinning Mill Apartments

4.0 star property
8.0 out of 10, Very good, (31)
"Great access to bike trail. No working elevator and 3 flights of stairs with luggage is a challenge. "
Barsala At The American Spinning Mill Apartments
The Station by Compo Hotels
Relax on a balcony with a pair of rocking chairs and a small table.

The Station by Compo Hotels

4.0 star property
10.0 out of 10, Exceptional, (7)
"Beautiful rooms and surroundings. Less than 5 minutes from Furman university and really close to delightful and quirky travelers rest! Great place to stay!"
The price is £195
includes taxes & fees
29 Jul - 30 Jul
The Station by Compo Hotels
Liberty Hall Bed and Breakfast
Enjoy meals in a stylish dining area with round tables, black chairs, and a decorative wall piece.

Liberty Hall Bed and Breakfast

4.0 star property
10.0 out of 10, Exceptional, (65)
"In town for a recent college visit. Great location in a stunning historic BNB. Breakfast was wonderful and customer service was exceptional. Would absolutely recommend staying here and plan to stay again."
The price is £90
includes taxes & fees
31 Jul - 1 Aug
Liberty Hall Bed and Breakfast
Hotel Domestique
Enjoy a drink with a mountain view at this stylish bar.

Hotel Domestique

4.0 star property
9.6 out of 10, Exceptional, (29)
"This place is a hidden gem. It is beautiful in every way. The staff is wonderful. The restaurant was incredible. Can’t wait to go back for a longer stay."
The price is £351
includes taxes & fees
20 Jul - 21 Jul
Hotel Domestique
Southern Sunshine Retreat
Cozy living room with a fireplace, comfortable sofa, and flat-screen TV.

Southern Sunshine Retreat

4.0 star property
Southern Sunshine Retreat
Lake Hartwell Frank Howard Home Clemson
Relax in this stylish living room with a large L-shaped sofa, ottoman, and coffee table on a patterned rug.

Lake Hartwell Frank Howard Home Clemson

4.0 star property
The price is £327
includes taxes & fees
20 Jul - 21 Jul
Lake Hartwell Frank Howard Home Clemson
Belvedere
Enjoy outdoor seating on the covered patio with a ceiling fan overhead.

Belvedere

4.0 star property
8.0 out of 10, Very good, (1)
"Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why??? "
Belvedere
228 Lakeland
Relax on the lakeside deck with lounge chairs, overlooking the calm water and lush surroundings.

228 Lakeland

4.0 star property
228 Lakeland
140 Catlin Circle
House | Exterior

140 Catlin Circle

4.0 star property
140 Catlin Circle
Randall St , 202/204
House (202 / 204 Randall St Full Duplex) | Private kitchen | Coffee/tea maker, high chair, blender, cookware/dishes/utensils

Randall St , 202/204

4.0 star property
Randall St , 202/204
34 Allen St
Stovetop, dishwasher, coffee/tea maker, toaster

34 Allen St

4.0 star property
34 Allen St
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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina
Greenville - Spartanburg which includes views, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"The property was beautiful - a gorgeous hotel with a river view - it was on the river right by a small falls - the park was great to walk through - very tranquil - hoping they build up the neighborhood around it for more shopping and dining options - the hotel bar was great too."
Jennifer 2-night trip
Posted 5 days ago
Grand Bohemian Lodge Greenville, Autograph Collection
Mint House Greenville - Downtown

Mint House Greenville - Downtown

10/10 Excellent
"Great location. Have stayed here several times. Clean. "
Pam 1-night trip
Posted 8 days ago
Mint House Greenville - Downtown

Frequently asked questions

What are the best 4-star hotels in Upstate South Carolina?
Stay at Greenville Marriott and get ready for upscale comfort and plenty of handy amenities. This 4-star hotel in Greer, Upstate South Carolina, is highly recommended by Expedia guests.
How much does it cost to stay in a 4-star hotel in Upstate South Carolina?
Expedia can help you quickly locate the perfect 4-star hotel for your getaway in Upstate South Carolina. Use our handy filter tool to tailor your search by things like amenities, budget and property star rating and get access to fabulous deals in a few clicks.

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What's the difference between 5-star and 4-star hotels in Upstate South Carolina?
Offering a friendly guest experience and upmarket décor, 4-star hotels are a wonderful option for your Upstate South Carolina trip. These kinds of accommodation generally come with loads of handy amenities that make it simple to kick back and relax — think large beds, bathrobes, restaurants and pools. Or live the high life at a 5-star hotel designed to pamper with exclusive perks and amenities. Full-service health clubs, premium toiletries and fine dining are typically featured at these deluxe retreats.