Title: TOP Boutique Hotels in South Carolina Midlands, SC for 2026 | Expedia.co.uk [South Carolina Midlands Travel Guide](https://expedia.co.uk/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Holiday Rentals in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Holiday-Rentals.d6057938.Travel-Guide-HolidayRentals)[Flights to South Carolina Midlands](https://expedia.co.uk/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.co.uk/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-Carolina-Midlands.d6057938.Car-Hire-Guide)[South Carolina Midlands Holidays](https://expedia.co.uk/South-Carolina-Midlands.d6057938.Holidays-City-Breaks) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Boutique Hotels Tonight [13 Jan - 14 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-13&endDate=2026-01-14&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [14 Jan - 15 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-14&endDate=2026-01-15&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-16&endDate=2026-01-18&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in South Carolina Midlands ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2544034c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds | Free cots/infant beds, free rollaway beds, bed sheets](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/949b4986.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/fcf4fdd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2a6d6c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Latta by IHG [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) Latta 9.6/10 Exceptional (538 reviews) "The staff was great and the room was very clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark Whitehurst £98 includes taxes & fees 19 Jan - 20 Jan [](https://www.expedia.co.uk/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/6df606aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fefdad76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fad493a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1,184 reviews) "Great location, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Defelicio £82 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0c64863b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) Florence 9.0/10 Wonderful (2,235 reviews) "Room was clean, staff friendly, and the includes breakfast was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha £71 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/99021580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.co.uk/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (675 reviews) "Stay was great felt so welcomed " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jesse £89 includes taxes & fees 26 Jan - 27 Jan [](https://www.expedia.co.uk/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/2f1f8cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/1aef51e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard king non smoking | In-room safe, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/b241d6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/5f4afc1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Rock Hill [](https://www.expedia.co.uk/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) Rock Hill 9.2/10 Wonderful (1,003 reviews) "We have stayed here several times and it never disappoints! Room is clean, staff very friendly, and they provide a great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erma £67 includes taxes & fees 19 Jan - 20 Jan [](https://www.expedia.co.uk/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/756b4cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1c5cc7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very good (1,434 reviews) "Always a great stay. Clean room, friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela £62 includes taxes & fees 14 Jan - 15 Jan [](https://www.expedia.co.uk/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/eb4d1288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) Orangeburg 9.2/10 Wonderful (1,007 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas £88 includes taxes & fees 26 Jan - 27 Jan [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/0e00b7af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/a93e569b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves lunch and dinner](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/e2ea309a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) Florence 9.0/10 Wonderful (1,003 reviews) "Only stayed for a night, but everything was excellent." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nelson £83 includes taxes & fees 19 Jan - 20 Jan [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/713b3c0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, Multiple Beds | Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/cff7c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/55a9de69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/0ec38ec3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Springhill Suites by Marriott Columbia near Fort Jackson [](https://www.expedia.co.uk/Columbia-Hotels-Springhill-Suites-By-Marriott-Columbia-Southeast.h91267861.Hotel-Information) Columbia 9.4/10 Exceptional (584 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Howard £82 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Columbia-Hotels-Springhill-Suites-By-Marriott-Columbia-Southeast.h91267861.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Santee 9.8/10 Exceptional (1,003 reviews) "Clean spacious room, nice amenities and good breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Donna £100 includes taxes & fees 20 Jan - 21 Jan [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-27&endDate=2026-01-28®ionId=6057938&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top South Carolina Midlands Hotel Reviews ![Hyatt Place Columbia/Downtown/The Vista](https://images.trvl-media.com/lodging/9000000/8700000/8690600/8690567/c2bace01_y.jpg) ### Hyatt Place Columbia/Downtown/The Vista 10/10 Excellent "The staff were extremely friendly and accommodating! " [](https://expedia.co.uk/Columbia-Hotels-Hyatt-Place-ColumbiaDowntownThe-Vista.h8690567.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Loved our stay ." [](https://expedia.co.uk/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [5 Star Hotels in Columbia ](https://www.expedia.co.uk/5Star-Columbia-Hotels.s50-0-d764.Travel-Guide-Filter-Hotels) - [Spa Hotels in Blythewood ](https://www.expedia.co.uk/Blythewood-Hotels-Spa-Hotels.0-0-d180657-tSpaHotels.Travel-Guide-Filter-Hotels) - [Blythewood Hotels ](https://www.expedia.co.uk/Blythewood-Hotels.d180657.Travel-Guide-Hotels) - [Adults Only Resorts & in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Adults-Only-Resorts.0-0-d764-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Budget-Hotels.0-0-d764-tBudgetHotels.Travel-Guide-Filter-Hotels) - [Gay-Friendly Hotels in Columbia ](https://www.expedia.co.uk/Columbia-Hotels-Gay-Friendly-Hotel.0-0-d764-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - 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[Things to do in Columbia ](https://www.expedia.co.uk/Things-To-Do-In-Columbia.d764.Travel-Guide-Activities) - [Things to do in South Carolina ](https://www.expedia.co.uk/Things-To-Do-In-South-Carolina.d242.Travel-Guide-Activities) - [Book Boutique Hotels in South Carolina Midlands on Expedia.com ](https://www.expedia.com/South-Carolina-Midlands-Hotels-Boutique-Hotel.0-0-d6057938-tBoutiqueHotel.Travel-Guide-Filter-Hotels)