South Carolina Midlands Holidays from £1,353

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Your South Carolina Midlands Holiday

Satisfy your travel cravings with a South Carolina Midlands holiday package. From its rich history to its spectacular views and more, this destination will capture your imagination and feed your intrepid spirit. With so much to do and see on a trip to South Carolina Midlands, it can be tricky to know where to begin. Kick off your journey in Columbia at Riverbanks Zoo and Garden and Williams Brice Stadium — two much-loved attractions here. Another top city worth adding to your itinerary is Florence. Don't miss Magnolia Mall and Mcleod Regional Medical Centre. Expedia is a one-stop shop for planning your South Carolina Midlands holiday. From accommodation and flights, to car rentals and activities, we know how to curate a travel experience like no other.

Top South Carolina Midlands Flight + Hotel Deals

Price found within the past 48 hours. Click for updated prices.
Imperial motel
Coastal Comfort Hotel
Americas Best Value Inn Bishopville
The Inn at the Crossroads
The Mantissa Hotel

Where to stay in South Carolina Midlands

Find the best South Carolina Midlands areas and neighborhoods for the activities you enjoy most. Learn more about South Carolina Midlands

South Carolina Midlands Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Charlotte-Douglas Intl. Airport (CLT)

Top hotels in South Carolina Midlands

Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr Columbia SC
Fully refundableReserve now, pay when you stay
The price is £80 per night from 31 May to 1 Jun
£80
31 May - 1 Jun
includes taxes & fees
9/10 Wonderful! (2,044 reviews)
Yes

Reviewed on 6 May 2026

Hilton Garden Inn Columbia/Harbison
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
The price is £55 per night from 24 May to 25 May
£55
24 May - 25 May
includes taxes & fees
8.6/10 Excellent! (2,663 reviews)
Lieu très propre lit confortable tapis au plancher mais propre et déjeuner de base

Reviewed on 5 May 2026

Howard Johnson by Wyndham Florence
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
1901 Rockland Rd Columbia SC
Fully refundable
The price is £67 per night from 1 Jun to 2 Jun
£67
1 Jun - 2 Jun
includes taxes & fees
8.2/10 Very Good! (1,065 reviews)
Everything was great and I especially liked the No Smoking rule. Finally a Hotel that doesn't smell like a smoke shop. We felt very safe staying here and of we need a Hotel in this area again, it will be this one

Reviewed on 6 May 2026

Sleep Inn Columbia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Frequently asked questions

Can I cancel my flight booking to South Carolina Midlands due to COVID-19?
Many airlines now provide more flexibility due to COVID-19. Our Customer Service Portal will help you answer most queries about which policies apply to your South Carolina Midlands flight. It's also a good idea to check the terms and conditions of your chosen carrier — preferably before you make a booking!
What's the best way to find cheap flights to South Carolina Midlands that have flexible change policies?
It's quick and easy with Expedia. Step 1: Enter your preferred dates and destination and hit "Search." Step 2: Check "No change fee" below the "Flexible change policies" subheading on the left-hand side of your screen. Step 3. Snag a cheap and flexible ticket to South Carolina Midlands.
What are some of the general tips for travellers to South Carolina Midlands during the COVID-19 outbreak?
COVID-19 may have changed how we travel, but it hasn't shut down our lust for exploring. Here are some tips on how to cope with the new challenges of travelling:
  • Understand what rules and restrictions apply to both your origin and destination. You may not be able to travel depending on local circumstances, so don't forget to check before you book your flight.
  • Wear a face mask during airport screening. A TSA employee will require you to temporarily lower your mask to verify your identity.
  • Instead of handing a TSA agent your boarding pass, position it directly on the scanner yourself. After that, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on luggage. It must be no bigger than 12 oz (350 ml), and you'll need to remove it from your bag for screening.
  • To minimize handling during screening, place personal items such as your phone and loose change into your carry-on instead of the bins.
  • Transport any food items in a clear plastic bag and also place them in a screening bin. Keeping your food separate from your carry-on makes it less likely that a TSA employee will need to open your bag for inspection.

Which airlines fly to South Carolina Midlands?
Lock in your airfare with Delta and then begin planning your South Carolina Midlands itinerary. This top carrier offers 221 flights per month to Columbia Metropolitan Airport (CAE), a central gateway.
How can I find cheap tickets to South Carolina Midlands?
In the last seven days, was the lowest price for a flight to South Carolina Midlands. If you'd love to save even more, book in advance and be flexible with your dates. Search for your airfare to South Carolina Midlands, then see prices for nearby days by clicking on the "flexible dates" link above.
How much is a flight to South Carolina Midlands?
If you were flying one way from (), you could've snapped up a low-cost fare for just in the last seven days. Round-trip journeys to South Carolina Midlands ranged from to over the same period.
What are the most popular airports to fly into in South Carolina Midlands?
Start organising your South Carolina Midlands getaway by booking one of the 742 flights a month to Columbia Metropolitan Airport (CAE). This is the region's main entryway.
When is the cheapest time to fly to South Carolina Midlands?
If you're not fixed on what date you jet off to South Carolina Midlands, try to leave early on in the week. The most economical day to take off is generally Tuesday, closely followed by Monday. Saturday is typically the most expensive day, with many holiday makers preferring to take off on the weekend.
How much is a plane ticket to South Carolina Midlands?
In the last seven days, plane fares to South Carolina Midlands varied between and . Prices usually rise as your travel date nears, so land yourself a bargain today.
Which airlines with flights to South Carolina Midlands employ COVID-19 cleanliness policies?
To help limit contact between passengers and flight crew during the COVID-19 outbreak, airlines have taken physical distancing and other protective measures to the skies. A great example of these are:
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.