TOP Lakeside Hotels in Upstate South Carolina, SC for 2026

A bench, a bicycle, and a lake surrounded by trees.

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Our top choices for Upstate South Carolina hotels on the lake

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

A modern lobby with a reception desk, seating area, and a vending machine.

A modern cafe interior with round tables and chairs, a counter with a beverage dispenser, and a wall-mounted TV.

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Angela

£100

includes taxes & fees

11 Oct - 12 Oct

A golf course with a water body, trees, and a distant view of a bridge.

An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.

A modern building with a central entrance, surrounded by a well-maintained lawn and trees.

A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

2. Clemson University's James F. Martin Inn

Clemson

Lilllian

£125

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with white countertops, grey cabinetry, and wooden shelves.

A backyard with a fire pit surrounded by four Adirondack chairs, a wooden table, and a covered grill.

A modern living room with a brown leather sofa, a wooden chair, and a black coffee table.

A dining area with a wooden table, chairs, and a chandelier. There is a fireplace, a television, and framed pictures on the wall.

3. Swamp Rabbit | Furman | Bikes | Pass | Fenced | EV

Greenville

David P.

£387

includes taxes & fees

3 Nov - 4 Nov

A lodge with three cabins, a central building with a covered seating area, and a fire pit in the center.

A playground with a slide and monkey bars, located near a body of water.

A cozy room with a wooden floor, a sofa, a table with a microwave, and a television on the wall.

Kitchenette with refrigerator, microwave and drip coffee maker.

4. Cabin 1/LAKE HARTWELL/Green Pond&Broyles Lndgs/Clemson/Lockable Shelter w/power

Townville

Julie I.

£156

includes taxes & fees

1 Nov - 2 Nov

A two-story wooden cabin with a balcony on the upper floor, surrounded by trees.

A two-story wooden cabin with balconies, surrounded by tall pine trees.

A kitchen counter with a bottle of wine, a glass, and a house rules sign.

A modern living room with a grey sofa, a coffee table, and a ceiling fan. There is a kitchen area in the background with white cabinets and a dining table.

5. Keowee Key ~ Cozy Condo ~ Golf Course View - Amenities

Salem

Mary L.

£299

includes taxes & fees

1 Nov - 2 Nov

A hot tub with a wooden deck and a step for access.

A two-story house with a gabled roof, a front porch, and a small front yard with plants and mulch.

A living room with a fireplace, a sofa, a red chair, and a television.

A wooden staircase leading up to a house surrounded by trees.

6. Lake Hartwell cottage - Hot Tub! ~ we have no lake water till it rains

Anderson

Hannah

£229

includes taxes & fees

5 Oct - 6 Oct

A room with a door leading to a driveway, a welcome mat, and a window with blinds.

A modern kitchen with a stainless steel refrigerator, a wooden dining table with four chairs, and a large window with blinds.

A modern kitchen with white cabinets, stainless steel appliances, and a granite countertop.

A bedroom with a bed, desk, chair, and a ceiling fan.

7. 2BR Home w/ Private Baths | Pets | Anderson SC

Anderson

£257

includes taxes & fees

3 Nov - 4 Nov

A cabin-style building with a wooden exterior, large windows, and a view of the water.

A cozy cabin interior with a dining area, sofa, kitchen, and a ceiling fan.

A compact kitchen with a refrigerator, stove, and wooden cabinets.

A residential building with a covered patio, a red garden hose, and a black grill.

8. 2 Bedroom Lake Front Tiny Home in Anderson, beside Legendary Green Pond Landing

Anderson

Lisa B.

£259

includes taxes & fees

4 Oct - 5 Oct

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Top Upstate South Carolina Hotel Reviews

Comfort Inn Greenville - Haywood Mall

10/10 Excellent

"Worked well for what we needed"

Clemson University's James F. Martin Inn

10/10 Excellent

"We had a wonderful stay at the James F. Maren Inn in Clemson! The inn has a warm, welcoming atmosphere and is a beautiful place to stay while visiting the area. The rooms were comfortable and inviting, and the overall experience felt relaxing and special. The location was convenient for enjoying Clemson and everything the area has to offer. The hospitality and attention to detail really made our visit memorable. We truly enjoyed our time here and would happily stay at the James F. Maren Inn again. Highly recommended for anyone looking for a comfortable and charming place to stay in Clemson!"

Hilton Greenville

10/10 Excellent

"Food was awful and when they asked we told them but they did not do anything about it. I paid for $50 worth of food we didn’t eat."

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

10/10 Excellent

"Great property great front desk quiet clean"

Frequently asked questions

How much do lakeside hotels in Upstate South Carolina cost?

You'll pay between £100 and £387 per night for lakeside hotels in Upstate South Carolina. Whatever your budget, an ideal stay by the water is only a few keystrokes away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.

Why book your lakeside hotel in Upstate South Carolina with Expedia?

Finding your ideal lakeside hotel in Upstate South Carolina is a piece of cake with Expedia. Getting away with the kids? Take advantage of our filters to search for properties with family-friendly amenities. If you're sticking to a budget, click on how much you want to spend and your desired hotel star rating. Whatever your waterside holiday plans, you'll always get the best deal possible.

How can I find cheap lakeside hotels in Upstate South Carolina?

Spend your break near the water without spending a fortune with Expedia. To find cheap lakeside hotels in Upstate South Carolina, use our filter tool to select your price per night budget. Eager to stay in a particular area? Our convenient "neighbourhood" filter will search for properties in your desired part of town.

What is there to do in Upstate South Carolina near my lakeside hotel?

The most important travel accessory for your Upstate South Carolina getaway is a well-organised itinerary! Greenville Zoo, The Children's Museum of the Upstate and Shoeless Joe Jackson Museum are among the well-known sights if you're heading to Greenville. Spartanburg also has lots of terrific attractions, such as Spartanburg Regional History Museum. Eager to explore more? Stop by Wofford College and Converse College too.

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Room 1

Change your mind

Treat yourself

Be picky

Check availability on Upstate South Carolina Lakeside Hotels

Our top choices for Upstate South Carolina hotels on the lake

1. Fairfield Inn & Suites Seneca Clemson Univ Area

2. Clemson University's James F. Martin Inn

3. Swamp Rabbit | Furman | Bikes | Pass | Fenced | EV

4. Cabin 1/LAKE HARTWELL/Green Pond&Broyles Lndgs/Clemson/Lockable Shelter w/power

5. Keowee Key ~ Cozy Condo ~ Golf Course View - Amenities

6. Lake Hartwell cottage - Hot Tub! ~ we have no lake water till it rains

7. 2BR Home w/ Private Baths | Pets | Anderson SC

8. 2 Bedroom Lake Front Tiny Home in Anderson, beside Legendary Green Pond Landing

9. WATERFRONT! 15 feet to Shoreline. Includes BOAT SLIP. FSBO on Zillow.