A bench, a bicycle, and a lake surrounded by trees.

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Check availability on Upstate South Carolina Business Hotels

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Upstate South Carolina business-friendly hotels

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.
A reception area with a stone counter, a laptop, and a sign indicating a Chairman's Award.
A pool area with lounge chairs and a sign for Best Western Plus.
A hotel room with a large bed, a desk with a chair, a blue armchair, a wooden nightstand with a lamp, and a wardrobe with a mirror.

1. Best Western Plus Greenville I-385 Inn & Suites

Best Western Plus Greenville I-385 Inn & Suites
Greenville
United States
Stephanie
£65
includes taxes & fees
25 Oct - 26 Oct
Best Western Plus Greenville I-385 Inn & Suites
A multi-level hotel atrium with a central open area, multiple balconies, and a variety of seating arrangements.
A large hotel with a central courtyard, surrounded by manicured lawns and trees.
An outdoor patio area with tables and chairs, a covered seating area, and a building in the background labeled "Embassy Suites."
A spacious lobby with multiple seating areas, a glass railing overlooking a green space, and a modern interior design.

2. Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center
Greenville
United States
Ethan
£91
includes taxes & fees
18 Oct - 19 Oct
Embassy Suites Greenville Golf Resort & Conference Center
An outdoor patio area with a fire feature, wicker furniture, and potted plants.
A conference room with a large table, green chairs, a sofa, and large windows offering a view of trees and a parking lot.
A row of Tesla electric vehicle charging stations.
A conference room with rows of chairs, a flat-screen TV, a door, and a carpeted floor.

3. Hilton Garden Inn Greenville

Hilton Garden Inn Greenville
Greenville
United States
Leroy
£85
includes taxes & fees
8 Nov - 9 Nov
Hilton Garden Inn Greenville
A modern kitchen with hanging light fixtures and bar seating.
A modern lobby with a curved reception desk, comfortable seating, and a large wall-mounted TV.
A hotel patio with outdoor seating, stone pillars, and a modern building in the background.
A modern hotel room with a large desk, a comfortable sofa, and a bed.

4. DoubleTree by Hilton Greenville Woodruff Road

DoubleTree by Hilton Greenville Woodruff Road
Greenville
United States
Jeffery
£95
includes taxes & fees
18 Oct - 19 Oct
DoubleTree by Hilton Greenville Woodruff Road
A hotel with a stone facade, multiple windows, and a sign indicating it's a Wyndham hotel.
A modern kitchen with a granite countertop, a built-in grill, a microwave, and a coffee maker. There are two framed artworks on the wall and a refrigerator with a built-in ice maker.
A room with a wall-mounted ATM, decorative wall panels, a window with red curtains, and a tiled floor.
A hotel room with a bed, a television, a window with curtains, and a wardrobe.

5. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
Greenville
United States
Terry
£59
includes taxes & fees
3 Nov - 4 Nov
Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
A modern hotel room with a large bed, a separate bathroom with a bathtub, a nightstand, a lamp, and a wall-mounted artwork.
A reception desk with a stone facade, a peacock wall decoration, and a large potted plant.
A reception area with two beige armchairs, a glass-top table, and a vibrant geometric wall art.
A spacious dining area with a central table and chairs, a kitchen in the background, and a sign indicating a breakfast area.

6. Days Inn by Wyndham Greenville South/Mauldin

Days Inn by Wyndham Greenville South/Mauldin
Mauldin
United States
Martel
£59
includes taxes & fees
11 Oct - 12 Oct
Days Inn by Wyndham Greenville South/Mauldin
A modern lounge area with a blue sofa, a round coffee table, a patterned ottoman, and a wooden reception desk.
A hotel room with two beds, a desk, a TV, and a patterned carpet.
A modern lobby with a blue sofa, a round coffee table, and a brown armchair.
A gym with treadmills, stationary bikes, and exercise balls.

7. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Fairfield Inn & Suites by Marriott Greenville Simpsonville
Simpsonville
United States
Jonathan
£70
includes taxes & fees
18 Oct - 19 Oct
Fairfield Inn & Suites by Marriott Greenville Simpsonville
An outdoor patio with a stone fire feature, seating, and a view of the city skyline.
A modern bar area with a wooden counter, a digital menu board, and a variety of liquor bottles.
A modern hotel lobby with a bar area, seating, and a large window providing natural light.
A Courtyard by Marriott hotel with a modern facade, a covered entrance, and landscaped flower beds.

8. Courtyard by Marriott Greenville Mauldin

Courtyard by Marriott Greenville Mauldin
Greenville
United States
Leticia
£91
includes taxes & fees
18 Oct - 19 Oct
Courtyard by Marriott Greenville Mauldin
A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.
A snack and beverage display with various snacks and drinks.
A cafe with a checkered floor, wooden cabinets, and hanging pendant lights.
A hotel room with a large bed, a television on a dresser, a nightstand with a lamp, and a window with curtains.

9. Hampton Inn Greenville I-385 - Woodruff Rd.

Hampton Inn Greenville I-385 - Woodruff Rd.
Greenville
United States
Stephen
£87
includes taxes & fees
25 Oct - 26 Oct
Hampton Inn Greenville I-385 - Woodruff Rd.
An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a red accent wall.
A modern restaurant with high ceilings, large windows, and a mix of seating options including booths and tables.
A modern hotel lobby with a wooden cabinet, a flat-screen TV, a sofa, and a table.

10. Drury Inn & Suites Greenville

Drury Inn & Suites Greenville
Greenville
United States
Kara
£96
includes taxes & fees
8 Nov - 9 Nov
Drury Inn & Suites Greenville
View all properties

Top Upstate South Carolina Hotel Reviews

Hyatt Place Greenville/Haywood

Hyatt Place Greenville/Haywood

10/10 Excellent
"The room was very clean. Staff was very helpful when our key did not work. The hotel was under renovation. They did a great job at keeping it clean and quiet. My husband and granddaughter had the breakfast. They liked it. Parking was tight due to the construction. Otherwise, good. We would stay there again. Highly recommend staying here."
Kevin 4-night trip
Posted 6 hours ago
Hyatt Place Greenville/Haywood
Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

10/10 Excellent
"Clean room, very convenient to 385, great breakfast, nice staff, plenty of parking."
Paul 1-night trip
Posted 16 hours ago
Comfort Inn Greenville - Haywood Mall
Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

10/10 Excellent
"The rooms are clean and the hotel staff are friendly, Plenty of parking, Restaurants in walking distance and shopping. Hotel has been remodeled also 👍"
Terry 1-night trip
Posted 18 hours ago
Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

10/10 Excellent
"Very clean"
Brittany 1-night trip
Posted 18 hours ago
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Frequently asked questions

How much do business hotels in Upstate South Carolina cost?
Rates for business hotels in Upstate South Carolina range between £59 and £96 per night. Whatever your budget, Expedia can help you find the right space to get the work done. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
How many business hotels are there in Upstate South Carolina?
When work takes you travelling throughout Upstate South Carolina, there are 144 business hotels to choose from.
Why book your business hotel in Upstate South Carolina with Expedia?
At Expedia, it's our job to help you land an amazing stay at the right price. From upmarket, corporate-friendly retreats to affordable motels loaded with conveniences, you'll have your next work trip arranged in a few simple clicks.
How can I find cheap business hotels in Upstate South Carolina?
Expedia can help you search for cheap business hotels in Upstate South Carolina. Simply go to the "traveller experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work comfortably, like included breakfast and free WiFi. You can also choose your preferred star rating and budget to keep your costs in check.

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