Title: TOP Business Hotels in Upstate South Carolina, SC for 2026 | Expedia.co.uk [Upstate South Carolina Travel Guide](https://expedia.co.uk/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Holiday Rentals in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Holiday-Rentals.d6057939.Travel-Guide-HolidayRentals)[Flights to Upstate South Carolina](https://expedia.co.uk/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.co.uk/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Upstate-South-Carolina.d6057939.Car-Hire-Guide)[Upstate South Carolina Holidays](https://expedia.co.uk/Upstate-South-Carolina.d6057939.Holidays-City-Breaks) ![The view from Caesars Head after a storm](https://images.trvl-media.com/place/553248621532656715/293b23c7-6024-49ab-80cb-4ee292c1b5a3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Michelle Hendrix # Search Business Hotels in Upstate South Carolina - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina Business Hotels Tonight [11 Jan - 12 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-01-11&endDate=2026-01-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [12 Jan - 13 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-01-12&endDate=2026-01-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6057939&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Upstate South Carolina business-friendly hotels ![Free daily full breakfast ](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/589dc000.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, desk, blackout curtains](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/39d93722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/b9808144.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71520000/71515100/71515054/a9c6228a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Gaffney by IHG [](https://www.expedia.co.uk/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) Gaffney 8.8/10 Excellent (434 reviews) "Great people n place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Janice £63 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Gaffney-Hotels-Holiday-Inn-Express-Gaffney.h71515054.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/3ff858d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/4bac382e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/561d946e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/59000000/58950000/58945900/58945857/015cc42b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Greenville Mauldin [](https://www.expedia.co.uk/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Mauldin.h58945857.Hotel-Information) Greenville 9.0/10 Wonderful (308 reviews) "Courteous and friendly front desk" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bernard £85 includes taxes & fees 16 Jan - 17 Jan [](https://www.expedia.co.uk/Greenville-Hotels-Courtyard-By-Marriott-Greenville-Mauldin.h58945857.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/b3b1b4a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/84ae320a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/e7b52d93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/49000000/48260000/48251500/48251408/1ac2fb4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Spartanburg [](https://www.expedia.co.uk/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) Spartanburg 9.2/10 Wonderful (835 reviews) "The place was perfect for our, trip" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald £86 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Greenville-Spartanburg-Hotels-Tru-By-Hilton-Spartanburg.h48251408.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/5971f25f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/1d70fbe2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast ](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/9966f479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/23000000/22520000/22513500/22513453/92684d2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd. [](https://www.expedia.co.uk/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) Greenville 8.6/10 Excellent (94 reviews) "Great room, very clean and staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £63 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h22513453.Hotel-Information) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/f09ffe86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/e91d409a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/fea97b11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/b54ae3f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Greenville I-385 Inn & Suites [](https://www.expedia.co.uk/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) Greenville 9.0/10 Wonderful (1,428 reviews) "Excellent hotel nice and clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Irasema £64 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/34438b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/462068d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/f1cbacdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn @ Clemson [](https://www.expedia.co.uk/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) Clemson 8.0/10 Very good (1,006 reviews) "Staff and hotel was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Keren [](https://www.expedia.co.uk/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/59f41330.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/7796ec2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/0a2d26b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/3000000/2740000/2739300/2739237/2b4321e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Anderson/Clemson [](https://www.expedia.co.uk/Anderson-Hotels-Microtel-Inn-Suites-By-Wyndham-AndersonClemson.h2739237.Hotel-Information) Anderson 8.2/10 Very good (1,000 reviews) "Room was clean, front desk people were very nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Caressa £63 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Anderson-Hotels-Microtel-Inn-Suites-By-Wyndham-AndersonClemson.h2739237.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/2c84c92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/cc35e730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/81e73e39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Seneca Clemson Univ Area [](https://www.expedia.co.uk/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) Seneca 9.4/10 Exceptional (205 reviews) "Nice hotel by the lake" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike £103 includes taxes & fees 15 Jan - 16 Jan [](https://www.expedia.co.uk/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/246311c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, in-room safe, individually furnished, desk](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/29c7f0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/2183f59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/70000/67500/67445/5a73d893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Greer - Greenville [](https://www.expedia.co.uk/Greer-Hotels-Comfort-Inn-Suites-Greer-Greenville.h67445.Hotel-Information) Greer 8.6/10 Excellent (743 reviews) "this is the best hotel friendly clean rooms, quiet and the staff is great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) pamela £72 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Greer-Hotels-Comfort-Inn-Suites-Greer-Greenville.h67445.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/2fa8ed98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/a1ae62a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/bd6af703.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/290000/281700/281618/33c2ff7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Spartanburg-North I-85 [](https://www.expedia.co.uk/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) Spartanburg 8.6/10 Excellent (1,000 reviews) "Great staff, clean room, good location. Would definitely stay here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Randall £66 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Spartanburg-Hotels-Hampton-Inn-Spartanburg-North-I-85.h281618.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-25&endDate=2026-01-26®ionId=6057939&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Upstate South Carolina Hotel Reviews ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Room was ckean, staff was friendy, breakfast was great, and hotel was quiet." [](https://expedia.co.uk/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "Great" [](https://expedia.co.uk/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "It was wonderful, staff was very nice" [](https://expedia.co.uk/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Embassy Suites by Hilton Greenville Downtown Riverplace](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051911/b5c8aa89_y.jpg) ### Embassy Suites by Hilton Greenville Downtown Riverplace 10/10 Excellent "Clean and Comfortable" [](https://expedia.co.uk/Greenville-Hotels-Embassy-Suites-By-Hilton-Greenville-Downtown-Riverplace.h15051911.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "The staff especially stood out. The online check in and the front desk was an absolute breeze! I am pleased as all heck. The room was clean and is well laid out for me to work. I greatly appreciate it." [](https://expedia.co.uk/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/9a71f6a4_y.jpg) ### Hyatt Place Greenville/Haywood 10/10 Excellent "Staff was really nice " [](https://expedia.co.uk/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Hilton Greenville](https://images.trvl-media.com/lodging/1000000/30000/23200/23172/401b294d_y.jpg) ### Hilton Greenville 10/10 Excellent "Breakfast is extra" [](https://expedia.co.uk/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Haywood](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "Great service, good price, staff very friendly" [](https://expedia.co.uk/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Best Western Greenville Airport Inn](https://images.trvl-media.com/lodging/1000000/10000/800/708/338fc74f_y.jpg) ### Best Western Greenville Airport Inn 10/10 Excellent "It was clean nice peaceful and quiet no disturbance rest well great" [](https://expedia.co.uk/Greenville-Hotels-Best-Western-Greenville-Airport-Inn.h708.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Upstate South Carolina cost? ### How many business hotels are there in Upstate South Carolina? ### Why book your business hotel in Upstate South Carolina with Expedia? ### How can I find cheap business hotels in Upstate South Carolina? ## Explore a world of travel with Expedia - 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