Title: South Carolina Business Hotels, United States of America: South Carolina Hotel Guide | Expedia.co.uk [South Carolina Travel Guide](https://expedia.co.uk/South-Carolina.dx242)[South Carolina Hotels](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Hotel-Destinations)[Holiday Rentals in South Carolina](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Holiday-Rental-Destinations)[South Carolina Flights](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Flight-Destinations)[South Carolina Car Hire](https://expedia.co.uk/Destinations-In-South-Carolina.d242.Car-Hire-Destinations)[South Carolina Holidays](https://expedia.co.uk/South-Carolina.d242.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/242/dbb303b5-35ae-4057-85af-2d617c5d6007.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/242/dbb303b5-35ae-4057-85af-2d617c5d6007.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## South Carolina Accommodation: Most Popular Cities to Stay ![Greenville featuring a bridge, a city and a river or creek](https://images.trvl-media.com/place/1388/2f1c4846-4013-4641-a8dd-db2da5ca5774.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Greenville [](https://expedia.co.uk/Greenville-Hotels-Business-Hotel.0-0-d1388-tBusinessHotel.Travel-Guide-Filter-Hotels) ## Check availability on South Carolina Business Hotels Tonight [4 Feb - 5 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2026-02-04&endDate=2026-02-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [5 Feb - 6 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2026-02-05&endDate=2026-02-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=242&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for South Carolina business-friendly hotels ![Coffee service](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/840ecd1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/44ceaa16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/e5e41512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/30000/25000/24994/3d48190d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Greenville - Haywood Mall [](https://www.expedia.co.uk/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) Greenville 8.0/10 Very good (1,001 reviews) "This is my go to hotel when in greenville. Nice, clean hotel. Great breakfast. Very attentive staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yer £73 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2310000/2301400/2301351/53753aae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed with Sofa bed | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/3000000/2310000/2301400/2301351/d1fbb4ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, pool loungers](https://images.trvl-media.com/lodging/3000000/2310000/2301400/2301351/w5568h3709x0y3-363bb482.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/3000000/2310000/2301400/2301351/524d1aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Charleston Airport/Convention Center [](https://www.expedia.co.uk/Charleston-Hotels-Hyatt-Place-Charleston-AirportConvention-Center.h2301351.Hotel-Information) North Charleston 9.4/10 Exceptional (1,171 reviews) "Great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendi £84 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/Charleston-Hotels-Hyatt-Place-Charleston-AirportConvention-Center.h2301351.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/60e6167a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/61b347da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/5e830f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1805100/1805074/24bdaf71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Columbia Downtown Hotel [](https://www.expedia.co.uk/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) Downtown Columbia 8.4/10 Very good (1,001 reviews) "Everything was perfect." ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) William £104 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/Columbia-Hotels-Sheraton-Columbia-Downtown-Hotel.h1805074.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/910000/908300/908272/6d631e80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/910000/908300/908272/0ce8de6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/910000/908300/908272/bf620659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; southern cuisine ](https://images.trvl-media.com/lodging/1000000/910000/908300/908272/dc88e68d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town & Country Inn and Suites [](https://www.expedia.co.uk/Charleston-Hotels-Town-Country-Inn-And-Suites.h908272.Hotel-Information) West Ashley 9.2/10 Wonderful (1,461 reviews) "Excellent place to stay while visiting Charleston " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adam £99 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Charleston-Hotels-Town-Country-Inn-And-Suites.h908272.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/67500/67407/2dc76eaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/70000/67500/67407/9a057b8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/70000/67500/67407/aae81735.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/70000/67500/67407/8650673e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn at Greenville Convention Cente [](https://www.expedia.co.uk/Greenville-Hotels-Sleep-Inn-At-Greenville-Convention-Cente.h67407.Hotel-Information) Greenville 7.8/10 Good (1,003 reviews) "It was good just needed to update and remodel rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joy £56 includes taxes & fees 2 Mar - 3 Mar [](https://www.expedia.co.uk/Greenville-Hotels-Sleep-Inn-At-Greenville-Convention-Cente.h67407.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/877cf1bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/cde26095.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast ](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/96c48b79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/170000/165800/165759/b4bc2621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta by Wyndham Haywood Mall-Near Greenville Downtown [](https://www.expedia.co.uk/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) Greenville 7.4/10 Good (1,122 reviews) "Kind staff, clean room, tasty continental breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen £57 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/16000000/15220000/15217400/15217348/75fc615c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LCD TV](https://images.trvl-media.com/lodging/16000000/15220000/15217400/15217348/w3837h2561x3y0-661c4c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-sized fridge, microwave, dishwasher, cookware/dishes/utensils](https://images.trvl-media.com/lodging/16000000/15220000/15217400/15217348/w3837h2561x3y0-3c4485c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/16000000/15220000/15217400/15217348/6ae45980.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites by Hilton Greenville Downtown [](https://www.expedia.co.uk/Greenville-Hotels-Home2-Suites-By-Hilton-Greenville-Downtown.h15217348.Hotel-Information) Greenville Downtown 9.2/10 Wonderful (1,000 reviews) "It was clean breakfast was good rooms clean staff were wonderful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert £111 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Greenville-Hotels-Home2-Suites-By-Hilton-Greenville-Downtown.h15217348.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/w3840h2556x0y3-09ad394d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/w3836h2877x4y3-4bdebee1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/w3840h2556x0y3-b1b0c195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mini fridge](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/3e1f2562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Greenville/Haywood [](https://www.expedia.co.uk/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) Greenville 7.8/10 Good (1,005 reviews) "Perfect stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kasey £70 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/2700/2618/w3840h2872x0y4-3cb0e9e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2700/2618/e369fde7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2700/2618/w3837h2561x3y0-d0889314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/2700/2618/a1982b07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sonesta Resort Hilton Head Island [](https://www.expedia.co.uk/Hilton-Head-Hotels-Sonesta-Resort-Hilton-Head-Island.h2618.Hotel-Information) South End 8.6/10 Excellent (1,229 reviews) "Top notch resort! Outstanding staff and room was spotless. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stan £124 includes taxes & fees 12 Feb - 13 Feb [](https://www.expedia.co.uk/Hilton-Head-Hotels-Sonesta-Resort-Hilton-Head-Island.h2618.Hotel-Information) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/17600/17541/5be6ae86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/17600/17541/34ad55ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/17600/17541/dadb43c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast on weekdays ](https://images.trvl-media.com/lodging/1000000/20000/17600/17541/03762d6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Columbia Northwest [](https://www.expedia.co.uk/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Northwest.h17541.Hotel-Information) Seven Oaks 5.4/10 (1,001 reviews) "Friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph £42 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Northwest.h17541.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20®ionId=242&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-South-Carolina-Business-Hotel.0-0-d242-tBusinessHotel.Hotel-Filter-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-South-Carolina-Business-Hotel.0-0-d242-tBusinessHotel.Hotel-Filter-Destinations) ## Top South Carolina Hotel Reviews ![Harborside at Charleston Harbor Resort and Marina](https://images.trvl-media.com/lodging/1000000/70000/67700/67652/0212aa65_y.jpg) ### Harborside at Charleston Harbor Resort and Marina 10/10 Excellent "Great service, great hotel! " [](https://expedia.co.uk/Charleston-Hotels-Harborside-At-Charleston-Harbor-Resort-And-Marina.h67652.Hotel-Information) ![The Francis Marion Hotel](https://images.trvl-media.com/lodging/1000000/50000/41300/41204/3ad3c4ea_y.jpg) ### The Francis Marion Hotel 10/10 Excellent "Everything good " [](https://expedia.co.uk/Charleston-Hotels-The-Francis-Marion-Hotel.h41204.Hotel-Information) ![Hilton Grand Vacations Club Ocean Enclave Myrtle Beach](https://images.trvl-media.com/lodging/34000000/33220000/33213200/33213151/d233caaf_y.jpg) ### Hilton Grand Vacations Club Ocean Enclave Myrtle Beach 10/10 Excellent "The room was excellent! If I had to critique anything it would be the water pressure inside the shower it was pretty low. But, other than that 10/10\. " [](https://expedia.co.uk/Myrtle-Beach-Hotels-Ocean-Enclave-By-Hilton-Grand-Vacations.h33213151.Hotel-Information) ![Dunes Village Resort](https://images.trvl-media.com/lodging/1000000/990000/983000/982925/a147d3c1_y.jpg) ### Dunes Village Resort 10/10 Excellent "Great staff, room was clean had a great ocean view. Definitely coming back!" [](https://expedia.co.uk/Myrtle-Beach-Hotels-Dunes-Village-Resort.h982925.Hotel-Information) ![Omni Hilton Head Oceanfront Resort](https://images.trvl-media.com/lodging/1000000/20000/14700/14690/c13a70d7_y.jpg) ### Omni Hilton Head Oceanfront Resort 10/10 Excellent "Room was clean quiet and large. The staff was very courteous. Would stay again. " [](https://expedia.co.uk/Hilton-Head-Hotels-Omni-Hilton-Head-Oceanfront-Resort.h14690.Hotel-Information) ![Emeline](https://images.trvl-media.com/lodging/1000000/10000/8900/8890/d17025e1_y.jpg) ### Emeline 10/10 Excellent "Lovely hotel in a great location. Friendly, helpful staff and lots of thoughtful touches." [](https://expedia.co.uk/Charleston-Hotels-Emeline.h8890.Hotel-Information) ![Planters Inn](https://images.trvl-media.com/lodging/1000000/10000/4800/4769/c138e1de_y.jpg) ### Planters Inn 10/10 Excellent "Perfect all around " [](https://expedia.co.uk/Charleston-Hotels-Planters-Inn.h4769.Hotel-Information) ![Sonesta Resort Hilton Head Island](https://images.trvl-media.com/lodging/1000000/10000/2700/2618/220ad345_y.jpg) ### Sonesta Resort Hilton Head Island 10/10 Excellent "Updated since last time I was there , upgraded my stay which was nice . Few people as was off season which was very nice " [](https://expedia.co.uk/Hilton-Head-Hotels-Sonesta-Resort-Hilton-Head-Island.h2618.Hotel-Information) ![Anderson Ocean Club and Spa by Oceana Resorts](https://images.trvl-media.com/lodging/2000000/1780000/1773500/1773482/c3e5f34d_y.jpg) ### Anderson Ocean Club and Spa by Oceana Resorts 10/10 Excellent "Clean rooms, full equipped and quite." 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[Flights from Chicago (ORD) to Columbia (CAE) ](https://www.expedia.co.uk/lp/flights/ord/cae/chicago-to-columbia) - [Flights from Philadelphia (PHL) to Columbia (CAE) ](https://www.expedia.co.uk/lp/flights/phl/cae/philadelphia-to-columbia) - [Flights from Seattle (SEA) to Columbia (CAE) ](https://www.expedia.co.uk/lp/flights/sea/cae/seattle-to-columbia) - [Flights from San Francisco (SFO) to Columbia (CAE) ](https://www.expedia.co.uk/lp/flights/sfo/cae/san-francisco-to-columbia) - [Flights from Toronto (YYZ) to Columbia (CAE) ](https://www.expedia.co.uk/lp/flights/yyz/cae/toronto-to-columbia) - [Visit Arcadia Lakes ](https://www.expedia.co.uk/Arcadia-Lakes.dx553248634998974994) - [Columbia Canal and Riverfront Park ](https://www.expedia.co.uk/Columbia-Canal-And-Riverfront-Park-Downtown-Columbia.d553248621532657312.Attraction) - [Columbia Holidays ](https://www.expedia.co.uk/Columbia.d764.Holidays-City-Breaks) - [Finlay Park ](https://www.expedia.co.uk/Finlay-Park-Downtown-Columbia.d6082683.Attraction) - [Fort Jackson ](https://www.expedia.co.uk/Fort-Jackson-Columbia.d6145263.Attraction) - [Palmetto Falls Water Park ](https://www.expedia.co.uk/Palmetto-Falls-Water-Park-Columbia.d553248621532657322.Attraction) - [Rental cars Columbia Metropolitan airport ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Columbia-Metropolitan.d4538691.Car-Hire-Guide) - [Car hire Columbia ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Columbia.d764.Car-Hire-Guide) - [Things to do in Columbia ](https://www.expedia.co.uk/Things-To-Do-In-Columbia.d764.Travel-Guide-Activities) - [Book Business Hotels in South Carolina on Expedia.com ](https://www.expedia.com/Destinations-In-South-Carolina-Business-Hotel.0-0-d242-tBusinessHotel.Hotel-Filter-Destinations) ## Frequently asked questions ### How much do business hotels in South Carolina cost? ### What are the best business hotels in South Carolina? ### How many business hotels are there in South Carolina? ### Are there any family-friendly hotels in South Carolina that are also business friendly? ### Are there any 5-star business hotels in South Carolina? ### Why book your business hotel in South Carolina with Expedia? ### How can I find cheap business hotels in South Carolina? ### What is there to do in South Carolina near my business hotel?