Title: TOP Boutique Hotels in Mission District, CA for 2026 | Expedia.co.uk [Mission District Travel Guide](https://expedia.co.uk/San-Francisco-Mission-District.dx134035)[Holiday Rentals in San Francisco](https://expedia.co.uk/San-Francisco-Holiday-Rentals.d178305.Travel-Guide-HolidayRentals)[Flights to San Francisco](https://expedia.co.uk/Cheap-Flights-To-San-Francisco.d178305.Travel-Guide-Flights)[Things to do in San Francisco](https://expedia.co.uk/Things-To-Do-In-San-Francisco.d178305.Travel-Guide-Activities)[Mission District Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mission-District.d134035.Car-Hire-Guide)[Mission District Holidays](https://expedia.co.uk/Mission-District.d134035.Holidays-City-Breaks) ![Mission District which includes outdoor art](https://images.trvl-media.com/place/134035/1fb7195b-23e3-4a0f-a5ef-22b484069f64.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/134035/1fb7195b-23e3-4a0f-a5ef-22b484069f64.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission District Boutique Hotels Tonight [5 Mar - 6 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=134035&startDate=2026-03-05&endDate=2026-03-06&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [6 Mar - 7 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=134035&startDate=2026-03-06&endDate=2026-03-07&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=134035&startDate=2026-03-06&endDate=2026-03-08&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=134035&startDate=2026-03-13&endDate=2026-03-15&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mission District boutique hotels ![Property grounds](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/78023bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/246bb663.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/7814d514.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1180000/1175900/1175858/5bd0b8bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Berkeley City Club [](https://www.expedia.co.uk/Oakland-Hotels-Berkeley-City-Club.h1175858.Hotel-Information) Telegraph District 8.8/10 Excellent (703 reviews) "Fabulous historic property just steps from bars, restaurants, etc." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bjorn [](https://www.expedia.co.uk/Oakland-Hotels-Berkeley-City-Club.h1175858.Hotel-Information) ![City view](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/e1f91bcd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/2d47f36f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/568efffa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Water view](https://images.trvl-media.com/lodging/1000000/920000/915600/915510/7158d83b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Argonaut Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Argonaut-Hotel-A-Noble-House-Hotel.h915510.Hotel-Information) Fisherman's Wharf 9.4/10 Exceptional (1,256 reviews) "The stay was very nice and the food was good as well. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Harry £256 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Argonaut-Hotel-A-Noble-House-Hotel.h915510.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/173b8dfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/4817709a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/7bc06dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/a3393d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Zephyr San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information) Fisherman's Wharf 8.6/10 Excellent (2,455 reviews) "Great location on the wharf, with many restaurants, and activities in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Frank £160 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/900/864/25ea6e9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/10000/900/864/8b2202a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Concierge desk](https://images.trvl-media.com/lodging/1000000/10000/900/864/167bd1f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; local cuisine ](https://images.trvl-media.com/lodging/1000000/10000/900/864/3643cf3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Huntington Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Huntington-Hotel.h864.Hotel-Information) Downtown San Francisco £743 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Huntington-Hotel.h864.Hotel-Information) ![Hot tub, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/2000000/1890000/1886700/1886656/210c1f9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hot tub, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/2000000/1890000/1886700/1886656/06b8ed26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1890000/1886700/1886656/a9ed4837.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; Californian cuisine ](https://images.trvl-media.com/lodging/2000000/1890000/1886700/1886656/4fd492a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cavallo Point [](https://www.expedia.co.uk/Sausalito-Hotels-Cavallo-Point.h1886656.Hotel-Information) Sausalito 9.2/10 Wonderful (1,001 reviews) "Fantastic place! Coming back in a month." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Béatrice £402 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Sausalito-Hotels-Cavallo-Point.h1886656.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/69c56718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves dinner and happy hour](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/da0bd574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/1656ff5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/700000/693700/693658/e282d47e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Clancy, Autograph Collection by Marriott [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) Downtown San Francisco 9.2/10 Wonderful (1,000 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Corey £176 includes taxes & fees 14 Mar - 15 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-The-Clancy.h693658.Hotel-Information) ![Suite (Skyline Waterfront Penthouse) | View from room](https://images.trvl-media.com/lodging/1000000/10000/400/384/1b7910ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/1000000/10000/400/384/df9b3b05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/384/6dda3257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness studio](https://images.trvl-media.com/lodging/1000000/10000/400/384/a04417ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Harbor Court Hotel [](https://www.expedia.co.uk/San-Francisco-Hotels-Harbor-Court-Hotel.h384.Hotel-Information) Downtown San Francisco 9.0/10 Wonderful (1,004 reviews) "Beautifully remodeled, convenient, great staff. Room was nicely furnished and comfortable bed. Would definitely stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Analea £155 includes taxes & fees 21 Mar - 22 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Harbor-Court-Hotel.h384.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/4ff57257.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom (Campton) | Premium bedding, minibar, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/0d62a8a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Union Square Deluxe King Bed | City view](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/e55a857c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23400/23383/d5b628f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Taj Campton Place [](https://www.expedia.co.uk/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information) Union Square 9.2/10 Wonderful (1,004 reviews) "It was a perfect stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Travel To Explore £183 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Taj-Campton-Place.h23383.Hotel-Information) ![Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/dd6a8571.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/1c71b5a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/badb47f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/1600/1511/2050e962.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn At Union Square [](https://www.expedia.co.uk/San-Francisco-Hotels-Inn-At-Union-Square.h1511.Hotel-Information) Union Square 9.2/10 Wonderful (1,009 reviews) "The breakfast was fresh and good and internal amenities are very comfortable" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ramesh Murthy £110 includes taxes & fees 30 Mar - 31 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Inn-At-Union-Square.h1511.Hotel-Information) ![Cocktail bar](https://images.trvl-media.com/lodging/1000000/10000/700/660/27f19182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/1d0c1fa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/87dba6c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/700/660/7ebf7bbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Emblem San Francisco [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information) Union Square 9.4/10 Exceptional (1,005 reviews) "Clean room, fun amenities, personal service, we love staying here!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anne £158 includes taxes & fees 27 Mar - 28 Mar [](https://www.expedia.co.uk/San-Francisco-Hotels-Hotel-Emblem-San-Francisco.h660.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-19&endDate=2026-03-20®ionId=134035&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Mission District Hotel Reviews ![Hilton San Francisco Union Square](https://images.trvl-media.com/lodging/1000000/30000/25700/25622/e6c58ddf_y.jpg) ### Hilton San Francisco Union Square 4/10 Poor "Found someone's eyelash within my sheets on my first day. I don't wear lashes. Luggage area is rude. The room is too bare and doesn't provide compete toiletries. Housekeeping doesn't come everyday. I stayed for 4 days and they only came once. " [](https://expedia.co.uk/San-Francisco-Hotels-Hilton-San-Francisco-Union-Square.h25622.Hotel-Information) ![Handlery Union Square Hotel](https://images.trvl-media.com/lodging/1000000/10000/6700/6666/b8dfc462_y.jpg) ### Handlery Union Square Hotel 10/10 Excellent "I liked it" [](https://expedia.co.uk/San-Francisco-Hotels-Handlery-Union-Square-Hotel.h6666.Hotel-Information) ![Chancellor Hotel on Union Square](https://images.trvl-media.com/lodging/1000000/30000/20600/20547/944f985c_y.jpg) ### Chancellor Hotel on Union Square 8/10 Good "Value for the money. My expectations were not high. It's a decent choice for a manageable price. Wall are not very good at screening sound. If your neighbors are quiet, it's not an issue." [](https://expedia.co.uk/San-Francisco-Hotels-Chancellor-Hotel-On-Union-Square.h20547.Hotel-Information) ![Hotel Riu Plaza Fisherman's Wharf](https://images.trvl-media.com/lodging/1000000/30000/24700/24625/6fb55356_y.jpg) ### Hotel Riu Plaza Fisherman's Wharf 8/10 Good "Great location, cozy seating areas with fire tables and huge buffet breakfast. Common area has sports bar. Only drawback are the dated rooms with tiny bathroom and lumpy mattresses. Overall good for the price " [](https://expedia.co.uk/San-Francisco-Hotels-Hotel-Riu-Plaza-Fishermans-Wharf.h24625.Hotel-Information) ![Club Quarters Hotel in San Francisco](https://images.trvl-media.com/lodging/1000000/920000/913000/912982/5ee1ba27_y.jpg) ### Club Quarters Hotel in San Francisco 8/10 Good "Clean, great location; free water and good coffee in lobby. Rooms are small but comfortable. And close to Waterfront and Birth Beach. Have to pay $45 a day for city parking. Staff friendly, good restaurant. Elevator very slow. Great value for SF!" [](https://expedia.co.uk/San-Francisco-Hotels-Club-Quarters-Hotel-In-San-Francisco.h912982.Hotel-Information) ![Bay Landing San Francisco Airport Hotel](https://images.trvl-media.com/lodging/2000000/1120000/1110800/1110785/b6378346_y.jpg) ### Bay Landing San Francisco Airport Hotel 10/10 Excellent "We stayed just one night for a flight the next day. It was such a lovely hotel. It is within a couple of miles of the airport, but it was quiet. I liked their climate control system. No noisy air or heating. The bed was extremely comfortable, and the breakfast was more than adequate. The airport shuttle service was timely and friendly." [](https://expedia.co.uk/San-Francisco-Hotels-Bay-Landing-San-Francisco-Airport-Hotel.h1110785.Hotel-Information) ![Hotel Zephyr San Francisco](https://images.trvl-media.com/lodging/10000000/9870000/9868900/9868852/fd976170_y.jpg) ### Hotel Zephyr San Francisco 10/10 Excellent "Great experience" [](https://expedia.co.uk/San-Francisco-Hotels-Hotel-Zephyr-San-Francisco.h9868852.Hotel-Information) ![The Marker Union Square San Francisco](https://images.trvl-media.com/lodging/1000000/20000/15800/15769/a6ba3784_y.jpg) ### The Marker Union Square San Francisco 10/10 Excellent "Very nice and clean hotel. Staff was amazing. Free bottle of wine. Will definitely stay again" [](https://expedia.co.uk/San-Francisco-Hotels-The-Marker-San-Francisco.h15769.Hotel-Information) ![Hotel Nikko San Francisco](https://images.trvl-media.com/lodging/1000000/30000/23500/23406/6c2cdc12_y.jpg) ### Hotel Nikko San Francisco 10/10 Excellent "Nice hotel, elegant public areas, and good exercise facilities. Breakfast and lunch restaurant was solid. " [](https://expedia.co.uk/San-Francisco-Hotels-Hotel-Nikko-San-Francisco.h23406.Hotel-Information) ## Frequently asked questions ### What's there to see and do in Mission District? ### What's the best way to get to my boutique hotel in Mission District? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Other - More ways to book - [Adults Only Resorts & in Bay Area ](https://www.expedia.co.uk/Bay-Area-Hotels-Adults-Only-Resorts.0-0-d6056043-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Green Hotels in Bay Area ](https://www.expedia.co.uk/Bay-Area-Hotels-Green-Sustainable.0-0-d6056043-tGreenSustainable.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Bay Area ](https://www.expedia.co.uk/Bay-Area-Hotels-Hotel-With-A-Bar.0-0-d6056043-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with Babysitting Services in Bay Area ](https://www.expedia.co.uk/Bay-Area-Hotels-Hotel-With-Babysitting-Services.0-0-d6056043-thotelwithbabysittingservices.Travel-Guide-Filter-Hotels) - 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