
Mission District Holidays from £932
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your Mission District Holiday
Make travel planning easy by reserving a holiday package to Mission District. Let us take care of the small stuff, so you can focus on soaking up everything this neighbourhood can offer. Your trip to Mission District wouldn't be complete without seeing top attractions nearby such as Lombard Street, University of San Francisco and University of California, San Francisco. No matter what your dream Mission District holiday may look like, you can turn it into reality with Expedia.




Fairmont San Francisco
Reviewed on 14 Nov 2026

Handlery Union Square Hotel
Reviewed on 15 Nov 2026
Where to stay in Mission District

Union Square
Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.
Top hotels in Mission District

Holiday Inn Golden Gateway by IHG

Hotel Riu Plaza Fisherman's Wharf

Hilton San Francisco Union Square
Frequently asked questions
Stay near popular Mission District attractions
Things to do

Alcatraz Inside tour with Round trip ferry & Audio App Packages

San Francisco Bay Sightseeing Cruise International Narration

California Academy of Sciences Daytime Admission
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.
















