Mission District Holidays from £712
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your Mission District Holiday
Make travel planning easy by reserving a holiday package to Mission District. Let us take care of the small stuff, so you can focus on soaking up everything this neighbourhood can offer. Your trip to Mission District wouldn't be complete without seeing top attractions nearby such as Lombard Street, University of San Francisco and University of California, San Francisco. No matter what your dream Mission District holiday may look like, you can turn it into reality with Expedia.
Price found within the past 48 hours. Click for updated prices.
Grand Hyatt San Francisco
Union Square
£869
per person
25 Oct - 30 Oct
found 1 day ago
Return flight included
London (LHR) to San Francisco (SFO)
9/10 Wonderful! (1,012 reviews)
Beautiful hotel in a perfect location. Loved going to the lounge everyday for a cocktail and the food was delicious when we decided to eat there.
Reviewed on 12 Aug 2026
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
£910
per person
25 Oct - 30 Oct
found 1 day ago
Return flight included
London (LHR) to San Francisco (SFO)
9/10 Wonderful! (7,581 reviews)
Great location. Well organized breakfast with good food. My biggest complaint is the pillows. One is not enough and two are too many causing a very sore neck. Toilet tank in our bathroom took forever to turn off after flushing.
Reviewed on 13 Aug 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Fisherman's Wharf
1 out of top 10 points of interest in this area
This waterfront neighborhood dates back to the gold rush era and is a hub for tourist activities, sea lions and seafood restaurants.
Union Square
Fashion puts on its finest face in one of the country’s largest shopping plazas.
Downtown San Francisco
3 out of top 10 points of interest in this area
Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Examine architecturally significant buildings, visit the Cable Car Museum and enjoy magnificent views of greater San Francisco in this affluent district.
Top hotels in Mission District
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundable
£132
31 Aug - 1 Sept
includes taxes & fees
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
£145
31 Aug - 1 Sept
includes taxes & fees
9/10 Wonderful! (7,602 reviews)
"Great location. Well organized breakfast with good food. My biggest complaint is the pillows. One is not enough and two are too many causing a very sore neck. Toilet tank in our bathroom took forever to turn off after flushing."
Reviewed on 13 Aug 2026
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
£143
17 Aug - 18 Aug
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Mission District travel package cost?
Cross off another part of the world with our Mission District travel packages, which start from just £712. Pick the flights and hotels that suit your plans. Then, add on a couple of sightseeing activities for a one-of-a-kind getaway.
If I'm not able to travel, can I cancel my Mission District travel package?
Certainly, and we'll help you every step of the way. You may be able to cancel or change your Mission District travel package at no cost within 24 hours of booking. But you may be charged a fee by your airline, hotel or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, visit our Customer Service Portal for more information.
How do I get a cheap travel package to Mission District?
You'll save loads of cash if you combine your car rentals, flights and hotels into a Mission District travel package. Sometimes cheap packages mean fewer options. But that's not the case with Expedia. We offer over 550 partner airlines and 1,000,000 properties across the world, which means you'll always have plenty of variety to choose from. Want to save even more? Add some popular activities to your package deal and unlock even more bargains! After all, travel is about more than just getting to your destination.
Does Expedia offer Book Now, Pay Later Mission District holidays?
Yes. Expedia has joined forces with online lender Klarna to help you easily pay for your holiday in instalments. Simply pick the payment plan that suits you best during the checkout process and take away the stress of budgeting for your next trip. Remember to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your travel buck. Consider these flexible payment options below:
- Pay monthly holidays: Klarna has easy monthly payment plans that suit all budgets, so you can book that well-deserved holiday sooner.
- Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it possible to pay off your holiday in multiple transactions.
- Low deposit holidays: Pressing the "book now" button is easier with this plan. Simply put down a small deposit on your booking and then start working on your travel itinerary.
Where should I stay in Mission District?
Most who travel to Mission District put both Golden Gate Bridge and Pier 39 on their to-do lists. Why not book a hotel near these fantastic attractions?
What are the top hotels in Mission District?
Book a stay at Hilton San Francisco Financial District. It's one of this area's most sought-after hotels. Another reputable option in Mission District is San Francisco Marriott Marquis.
How far in advance should I book my Mission District holiday?
Travellers are normally able to browse international flights on Expedia up to a year in advance of departure. Booking last minute? With a stroke of luck, it's still possible to purchase an affordable ticket only weeks before your journey.
What does an Expedia Mission District travel package include?
Rental cars, hotels and flights, or any combination of them — it's your choice. Whether you're headed to Mission District with the family or travelling with your friends, there's a bundle to fit your budget and style. Once you've made your booking, why not add on a few tours as well?
What should I know before booking a Mission District travel package?
So many places to wander around, so many things to experience. With a package, you'll be able to cross more of them off your list. Bundle your flights, rental cars and hotels and get ready to save.
Can I choose my airline with a Mission District Expedia travel package?
The choice is all yours! We offer more than 550 airlines around the world, so you can design your Mission District adventure according to your budget and travel needs.
Stay near popular Mission District attractions
Mission Dolores Park
9.4/10 (3 reviews)
Mission Dolores Park is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Discover the beautiful sunsets and top-notch restaurants in this vibrant area.
Photo by Donny Campos
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed theatre scene and fascinating museums in this vibrant area.
San Francisco Public Library
After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the entertainment choices and notable monuments in this vibrant area.
SF Armory
You can learn about the history of San Francisco with a stop at SF Armory. Experience the acclaimed art galleries and fascinating museums in this vibrant area.
Southern Exposure
You can spend time studying the exhibits at Southern Exposure during your travels in San Francisco. Take in the acclaimed theatre scene and beautiful sunsets in this vibrant area.
Brick & Mortar Music Hall
You can make plans for a show at Brick & Mortar Music Hall during your trip to San Francisco. You can enjoy the bars while in the area.
The Great Northern
After visiting The Great Northern, make a plan to see the other sights and activities in San Francisco. You can enjoy the bars while in the area.
Things to do
Go City: San Francisco All-Inclusive Pass with 30+ Attractions
£82
per adult
88% of travellers recommend
California Academy of Sciences Daytime Admission
£41
per adult
86% of travellers recommend
California Sunset Cruise (2-hours)
£44
per adult
94% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.