Mission District Holidays from £847

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Your Mission District Holiday

Make travel planning easy by reserving a holiday package to Mission District. Let us take care of the small stuff, so you can focus on soaking up everything this neighbourhood can offer. Your trip to Mission District wouldn't be complete without seeing top attractions nearby such as Lombard Street, University of San Francisco and University of California, San Francisco. No matter what your dream Mission District holiday may look like, you can turn it into reality with Expedia.

Price found within the past 48 hours. Click for updated prices.
Star Motel

Star Motel

2 out of 5
Cow Hollow
Price was £1,385, price is now £847 per person
£847
per person
15 Mar - 20 Mar
found 1 day ago
Return flight included
London (LHR) to San Francisco (SFO)
9.4/10 Exceptional! (258 reviews)
Very clean rooms, great location, convenient parking and friendly staff

Reviewed on 2 Feb 2026

Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown

3 out of 5
Downtown San Francisco
Save 100% on your flight
Price was £2,546, price is now £1,532 per person
£1,532
per person
21 Mar - 26 Mar
found 1 day ago
Return flight included
London (LHR) to San Francisco (SFO)
9.4/10 Exceptional! (1,810 reviews)
Clean room and friendly, courteous staff!

Reviewed on 8 Feb 2026

Orchard Hotel

Orchard Hotel

4 out of 5
Union Square
Price was £1,458, price is now £905 per person
£905
per person
19 Apr - 24 Apr
found 1 day ago
Return flight included
London (LHR) to San Francisco (SFO)
9.4/10 Exceptional! (1,003 reviews)
The room was lovely, and the staff was genuinely friendly. The social space seems to have never fully recovered from Covid, as there was no bar at all, and while it said that breakfast was available, the dining area was "dead". For someone like me who didn't appreciate that the area was not at all car friendly, the parking situation was expensive and less than convenient. The nighttime environment was a bit sketchy, and I feel that perhaps a locked front entrance requiring your key card for entrance would have made me feel safer.

Reviewed on 6 Feb 2026

1 Hotel San Francisco

1 Hotel San Francisco

5 out of 5
Downtown San Francisco
Save 100% on your flight
Price was £2,671, price is now £1,679 per person
£1,679
per person
11 Apr - 16 Apr
found 1 day ago
Return flight included
London (LHR) to San Francisco (SFO)
9.2/10 Wonderful! (470 reviews)
My husband and I really enjoyed our stay.

Reviewed on 15 Jan 2026

Lombard Plaza Motel

Lombard Plaza Motel

2 out of 5
Marina District
Price was £1,787, price is now £1,171 per person
£1,171
per person
23 Mar - 28 Mar
found 1 day ago
Return flight included
London (LHR) to San Francisco (SFO)
8.8/10 Excellent! (1,003 reviews)
Great location! Free self-parking was great.

Reviewed on 31 Jan 2026

Where to stay in Mission District

Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Union Square featuring a skyscraper and a city

Union Square

4/5(287 area reviews)

Fashion puts on its finest face in one of the country’s largest shopping plazas.

Find hotels in Union Square

Top hotels in Mission District

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £106 per night from 16 Feb to 17 Feb
£106
16 Feb - 17 Feb
includes taxes & fees
8.8/10 Excellent! (5,234 reviews)
We arrived early and was able to get an early check in. Checkout was a breeze.

Reviewed on 4 Feb 2026

Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £136 per night from 10 Feb to 11 Feb
£136
10 Feb - 11 Feb
includes taxes & fees
8.8/10 Excellent! (7,302 reviews)
Clean, friendly staff, great breakfast.

Reviewed on 7 Feb 2026

Hotel Riu Plaza Fisherman's Wharf
Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown

3 out of 5
701 3rd St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £155 per night from 13 Feb to 14 Feb
£155
13 Feb - 14 Feb
includes taxes & fees
9.2/10 Wonderful! (1,982 reviews)
Rumor's clean and comfortable. This part of SF is desamp without much homelessness

Reviewed on 5 Feb 2026

Hyatt Place San Francisco Downtown
See all 4,953 properties in Mission District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Mission District travel package cost?
Cross off another part of the world with our Mission District travel packages, which start from just £847. Pick the flights and hotels that suit your plans. Then, add on a couple of sightseeing activities for a one-of-a-kind getaway.
If I'm not able to travel, can I cancel my Mission District travel package?
Certainly, and we'll help you every step of the way. You may be able to cancel or change your Mission District travel package at no cost within 24 hours of booking. But you may be charged a fee by your airline, hotel or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, visit our Customer Service Portal for more information.
How do I get a cheap travel package to Mission District?
You'll save loads of cash if you combine your car rentals, flights and hotels into a Mission District travel package. Sometimes cheap packages mean fewer options. But that's not the case with Expedia. We offer over 550 partner airlines and 1,000,000 properties across the world, which means you'll always have plenty of variety to choose from. Want to save even more? Add some popular activities to your package deal and unlock even more bargains! After all, travel is about more than just getting to your destination.
Does Expedia offer Book Now, Pay Later Mission District holidays?
Yes. Expedia has joined forces with online lender Klarna to help you easily pay for your holiday in instalments. Simply pick the payment plan that suits you best during the checkout process and take away the stress of budgeting for your next trip. Remember to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your travel buck. Consider these flexible payment options below:

  • Pay monthly holidays: Klarna has easy monthly payment plans that suit all budgets, so you can book that well-deserved holiday sooner.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it possible to pay off your holiday in multiple transactions.
  • Low deposit holidays: Pressing the "book now" button is easier with this plan. Simply put down a small deposit on your booking and then start working on your travel itinerary.

Where should I stay in Mission District?
Most who travel to Mission District put both Golden Gate Bridge and Pier 39 on their to-do lists. Why not book a hotel near these fantastic attractions?
What are the top hotels in Mission District?
Book a stay at Hilton San Francisco Financial District. It's one of this area's most sought-after hotels. Another reputable option in Mission District is San Francisco Marriott Marquis.
How far in advance should I book my Mission District holiday?
Travellers are normally able to browse international flights on Expedia up to a year in advance of departure. Booking last minute? With a stroke of luck, it's still possible to purchase an affordable ticket only weeks before your journey.
What does an Expedia Mission District travel package include?
Rental cars, hotels and flights, or any combination of them — it's your choice. Whether you're headed to Mission District with the family or travelling with your friends, there's a bundle to fit your budget and style. Once you've made your booking, why not add on a few tours as well?
What should I know before booking a Mission District travel package?
So many places to wander around, so many things to experience. With a package, you'll be able to cross more of them off your list. Bundle your flights, rental cars and hotels and get ready to save.
Can I choose my airline with a Mission District Expedia travel package?
The choice is all yours! We offer more than 550 airlines around the world, so you can design your Mission District adventure according to your budget and travel needs.

Popular places to visit

Southern Exposure

You can spend time studying the exhibits at Southern Exposure during your travels in San Francisco. Take in the acclaimed theatre scene and beautiful sunsets in this vibrant area.

Southern Exposure

Things to do

California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

£37
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
San Francisco City Lights Cruise

San Francisco City Lights Cruise (2-hours)

£43
per adult
94% of travellers recommend
San Francisco City Lights Cruise (2-hours)
Go City: San Francisco All-Inclusive Pass with 25+ Attractions

Go City: San Francisco All-Inclusive Pass with 30+ Attractions

£77
per adult
88% of travellers recommend
Go City: San Francisco All-Inclusive Pass with 30+ Attractions
See all activities in San Francisco

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.