Mission District Holidays from £243

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Mission District Holiday

Make travel planning easy by reserving a holiday package to Mission District. Let us take care of the small stuff, so you can focus on soaking up everything this neighbourhood can offer. Your trip to Mission District wouldn't be complete without seeing top attractions nearby such as Lombard Street, University of San Francisco and University of California, San Francisco. No matter what your dream Mission District holiday may look like, you can turn it into reality with Expedia.

Price found within the past 48 hours. Click for updated prices.
The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco

4 out of 5
Union Square
Price was £332, price is now £243 per person
£243
per person
22 Jul - 24 Jul
found 18 hours ago
Return flight included
Los Angeles (LAX) to San Francisco (SFO)
9.2/10 Wonderful! (1,439 reviews)
The hotel is with a long history but the room is luxurious, spacious and clean! Redwood Room Bar is definitely worth a visit, superb atmosphere!

Reviewed on 11 May 2026

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
Fisherman's Wharf
Save 100% on your flight
Price was £470, price is now £311 per person
£311
per person
22 Jul - 24 Jul
found 18 hours ago
Return flight included
Los Angeles (LAX) to San Francisco (SFO)
9/10 Wonderful! (7,441 reviews)
No lotion only soap in bathroom..no robes. Pool heated.. overall felt hotel tired..bad hallway carpet..room door not flush with door jam. Great breakfast!! Parking price add-on expensive!! Great location for tourist !

Reviewed on 12 May 2026

1 Hotel San Francisco

1 Hotel San Francisco

5 out of 5
Downtown San Francisco
Save 100% on your flight
Price was £710, price is now £486 per person
£486
per person
22 Jul - 24 Jul
found 18 hours ago
Return flight included
Los Angeles (LAX) to San Francisco (SFO)
9.2/10 Wonderful! (540 reviews)
Amazing ambiance. Great staff and Daily Breakfast.

Reviewed on 10 Apr 2026

Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel

4 out of 5
Union Square
Price was £398, price is now £282 per person
£282
per person
22 Jul - 24 Jul
found 18 hours ago
Return flight included
Los Angeles (LAX) to San Francisco (SFO)
9.2/10 Wonderful! (2,007 reviews)
Amazing hotel. Great restaurant and bar area. Everything was super classy and well done.

Reviewed on 11 May 2026

The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

4.5 out of 5
Union Square
Price was £360, price is now £264 per person
£264
per person
22 Jul - 24 Jul
found 18 hours ago
Return flight included
Los Angeles (LAX) to San Francisco (SFO)
8.8/10 Excellent! (2,374 reviews)
Clean room, welcoming staff

Reviewed on 10 May 2026

Top hotels in Mission District

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £159 per night from 25 May to 26 May
£159
25 May - 26 May
includes taxes & fees
9/10 Wonderful! (7,508 reviews)
No lotion only soap in bathroom..no robes. Pool heated.. overall felt hotel tired..bad hallway carpet..room door not flush with door jam. Great breakfast!! Parking price add-on expensive!! Great location for tourist !

Reviewed on 12 May 2026

Hotel Riu Plaza Fisherman's Wharf
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £101 per night from 25 May to 26 May
£101
25 May - 26 May
includes taxes & fees
8.8/10 Excellent! (2,748 reviews)
the website said there was a shuttle at the airport, called to find out they hadn't had one in years. Also the door to the bathroom goes off the track and gets stuck and is very heavy to move. Scary if you cant open the door and get stuck.

Reviewed on 12 May 2026

Hilton San Francisco Financial District
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St San Francisco CA
Fully refundableReserve now, pay when you stay
The price is £110 per night from 28 May to 29 May
£110
28 May - 29 May
includes taxes & fees
9/10 Wonderful! (3,148 reviews)
Perfect Nuce staff great location near san francisco chinatown

Reviewed on 11 May 2026

Club Quarters Hotel in San Francisco
See all 4,536 properties in Mission District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Mission District travel package cost?
Cross off another part of the world with our Mission District travel packages, which start from just £243. Pick the flights and hotels that suit your plans. Then, add on a couple of sightseeing activities for a one-of-a-kind getaway.
If I'm not able to travel, can I cancel my Mission District travel package?
Certainly, and we'll help you every step of the way. You may be able to cancel or change your Mission District travel package at no cost within 24 hours of booking. But you may be charged a fee by your airline, hotel or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, visit our Customer Service Portal for more information.
How do I get a cheap travel package to Mission District?
You'll save loads of cash if you combine your car rentals, flights and hotels into a Mission District travel package. Sometimes cheap packages mean fewer options. But that's not the case with Expedia. We offer over 550 partner airlines and 1,000,000 properties across the world, which means you'll always have plenty of variety to choose from. Want to save even more? Add some popular activities to your package deal and unlock even more bargains! After all, travel is about more than just getting to your destination.
Does Expedia offer Book Now, Pay Later Mission District holidays?
Yes. Expedia has joined forces with online lender Klarna to help you easily pay for your holiday in instalments. Simply pick the payment plan that suits you best during the checkout process and take away the stress of budgeting for your next trip. Remember to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your travel buck. Consider these flexible payment options below:

  • Pay monthly holidays: Klarna has easy monthly payment plans that suit all budgets, so you can book that well-deserved holiday sooner.
  • Pay in instalments holidays: With this Book Now, Pay Later option, Klarna makes it possible to pay off your holiday in multiple transactions.
  • Low deposit holidays: Pressing the "book now" button is easier with this plan. Simply put down a small deposit on your booking and then start working on your travel itinerary.

Where should I stay in Mission District?
Most who travel to Mission District put both Golden Gate Bridge and Pier 39 on their to-do lists. Why not book a hotel near these fantastic attractions?
What are the top hotels in Mission District?
Book a stay at Hilton San Francisco Financial District. It's one of this area's most sought-after hotels. Another reputable option in Mission District is San Francisco Marriott Marquis.
How far in advance should I book my Mission District holiday?
Travellers are normally able to browse international flights on Expedia up to a year in advance of departure. Booking last minute? With a stroke of luck, it's still possible to purchase an affordable ticket only weeks before your journey.
What does an Expedia Mission District travel package include?
Rental cars, hotels and flights, or any combination of them — it's your choice. Whether you're headed to Mission District with the family or travelling with your friends, there's a bundle to fit your budget and style. Once you've made your booking, why not add on a few tours as well?
What should I know before booking a Mission District travel package?
So many places to wander around, so many things to experience. With a package, you'll be able to cross more of them off your list. Bundle your flights, rental cars and hotels and get ready to save.
Can I choose my airline with a Mission District Expedia travel package?
The choice is all yours! We offer more than 550 airlines around the world, so you can design your Mission District adventure according to your budget and travel needs.

Popular places to visit

Southern Exposure

You can spend time studying the exhibits at Southern Exposure during your travels in San Francisco. Take in the fascinating museums and beautiful sunsets in this vibrant area.

Southern Exposure

Things to do

San Francisco City Lights Cruise

California Sunset Cruise (2-hours)

£43
per adult
94% of travellers recommend
California Sunset Cruise (2-hours)
California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

£36
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
San Francisco, Muir Woods, Sausalito and Optional Alcatraz Tour

San Francisco, Muir Woods, Sausalito and Optional Alcatraz Tour

£88
per adult
96% of travellers recommend
San Francisco, Muir Woods, Sausalito and Optional Alcatraz Tour
See all activities in San Francisco

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.