Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured San Francisco Boutique Hotels

See all 583 Hotels in San Francisco
Hotel Rex San Francisco

Hotel Rex San Francisco

562 Sutter St, San Francisco
4.0 out of 5.0
4.2 out of 5 (1,581 reviews)
Nice, reasonably priced older hotel in Union SqWe were very satisfied with our stay at the Hotel Rex. It is an older (I would call it an "old school" East Coast-style smaller hotel right in Union Square. The price was excellent and the room very comfortable and claen, larger than many other comparably priced SF hotels. The location is fantastic. ...
  2 Jan 2018

£107

£107
Inn At Union Square - A Greystone Hotel

Inn At Union Square - A Greystone Hotel

440 Post St, San Francisco
3.5 out of 5.0
4.6 out of 5 (1,052 reviews)
Nice hotelNice and close to all the tourist attractions but very quiet and comfortable
  30 Dec 2017

£163

£163
Mystic Hotel by Charlie Palmer

Mystic Hotel by Charlie Palmer

417 Stockton St, San Francisco
4.0 out of 5.0
4.0 out of 5 (2,404 reviews)
Great location Nicw staff, two blocks away of Union Square, i would definitely recommend it
  27 Dec 2017

£142

£142
Hotel Diva

Hotel Diva

440 Geary St, San Francisco
4.5 out of 5.0
3.9 out of 5 (2,814 reviews)
Great location; friendly and helpful staff. Room was just what we needed. Might be a little small for a longer stay in the City.
  15 Jan 2018

£100

£100
Hotel Abri - Union Square

Hotel Abri - Union Square

127 Ellis Street, San Francisco
4.0 out of 5.0
4.2 out of 5 (1,978 reviews)
Close to Union Square, great locationThe suite was a nice two room unit with a separate living room for entertaining guests. The staff was very accomodating and knew the area very well, giving recommendations as to where I can grab food and cigarettes. I stayed in this very same hotel when it was the Monticello, and had a glowing review ...
  15 Jan 2018

£106

£106
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
4.0 out of 5.0
4.2 out of 5 (2,482 reviews)
Hotel was very close to the beachIt was my first time going over to San Francisco and this hotel was great we walked mostly to the attractions because they weren't that far away from the hotel. My parents were very satisfied with the stay also.
  12 Jan 2018

£112

£112
Clift

Clift

495 Geary St, San Francisco
4.5 out of 5.0
4.1 out of 5 (3,459 reviews)
Excellent service and roomAfter an exhaustive amount of research, I decided to book a room in this hotel because of its location, its more new-ish look, and the relative price of a medium-range room. It was important for me that I could select the type of room we were going to get. Some hotels/websites give you very nice ...
  3 Jan 2018

£139

£139
The Marker San Francisco, a Joie de Vivre Hotel

The Marker San Francisco, a Joie de Vivre Hotel

501 Geary St, San Francisco
4.5 out of 5.0
4.4 out of 5 (2,040 reviews)
Staff was amazing, hotel and room were beautiful, location was perfect! 5 stars all around, I would highly recommend staying here!
  12 Jan 2018

£130

£130
Villa Florence San Francisco on Union Square

Villa Florence San Francisco on Union Square

225 Powell St, San Francisco
4.0 out of 5.0
4.0 out of 5 (3,556 reviews)
Great Staff and Central LocationThe entire staff at the hotel were amazing, everyone from the front desk to the cleaning service were very friendly and helpful. The hotel's location is very centrally located and we loved the hustle and bustle of the area. Some may say the street noise it too much, but we didn't mind at all, that's ...
  8 Jan 2018

£79

£79
Argonaut Hotel - a Noble House Hotel

Argonaut Hotel - a Noble House Hotel

495 Jefferson St, San Francisco
5.0 out of 5.0
4.6 out of 5 (5,670 reviews)
Clean and Friendly Hotel in a great location. Stayed for a conference but will bring my family back for a vacation.
  12 Jan 2018

£156

£156
Map

Recently booked San Francisco hotels

Best Western Plus Lighthouse Hotel
3.5 out of 5.0
Last booking: 4 minutes ago
Hotel Whitcomb
4.0 out of 5.0
Last booking: 4 minutes ago
Travelodge at the Presidio
2.5 out of 5.0
Last booking: 12 minutes ago
Ramada San Bruno SFO Airport
2.5 out of 5.0
Last booking: 12 minutes ago
Holiday Inn Hotel & Suites San Mateo-San Francisco SFO
3.5 out of 5.0
Last booking: 14 minutes ago
Good Nite Inn - Redwood City
2.5 out of 5.0
Last booking: 16 minutes ago
Rodeway Inn and Suites
0.0 out of 5.0
Last booking: 19 minutes ago
San Mateo SFO Airport Hotel
3.0 out of 5.0
Last booking: 22 minutes ago
Travelodge By The Bay
2.5 out of 5.0
Last booking: 23 minutes ago

Pocket Guide: Boutique Hotels Hotels in San Francisco

San Francisco is California’s ‘city and county’ is the state’s cultural and financial hub. It is loved by visitors and tourists for its diversity, iconic landmarks, distinctive districts, stunning walks, eclectic architecture and more.

The popular sunny Californian city lies on the state’s West Coast. Its Golden Gate bridge, cable cars and Alcatraz Island are unmistakeable attractions.

There is something to appeal to every visitor to San Francisco. Each district has a unique personality and special offering. Boutique hotels in San Francisco are also full of character and individuality.

Staying in a Union Square boutique hotel puts visitors close to some of the city’s commercial and cultural attractions such as shops, restaurants, bars, museums and major transport links.

If you seek to enjoy some of the city’s famous postcard attractions, a boutique hotel in the Fisherman’s Wharf neighbourhood gives you access to the renowned cable car, Alcatraz Island and sweet seaside wharf-side shops and restaurants.

A taste of Asian culture can be appreciated in San Francisco’s Japantown area. Here travellers can stay in a choice of stunning, well-designed Asian-inspired and influenced boutique hotels.

Further high end boutique hotels are located in and around iconic Russian Hill and Nob Hill. At the opposite end of the scale, for something completely different, the Haight provides a taste of the hippie way of life.

Wherever your boutique hotel base, be sure to get out and explore this stunning walking city the best way, on foot.